|
US513030A
(en)
|
|
1894-01-16 |
|
Machine for waxing or coating paper |
|
US2878264A
(en)
|
|
1959-03-17 |
|
Substituted amino alcohols |
|
CH372667A
(en)
|
1957-09-26 |
1963-10-31 |
Robins Co Inc A H |
Process for the preparation of 3-aryl-3-pyrrolidinols
|
|
US3135766A
(en)
|
1961-10-03 |
1964-06-02 |
Mead Johnson & Co |
3-substituted-3-pyrrolidinols
|
|
US3484473A
(en)
|
1967-05-12 |
1969-12-16 |
Buckman Labor Inc |
Methylene bisesters of thiolsulfonic acids
|
|
DE1934150A1
(en)
|
1968-07-10 |
1970-01-15 |
Pennwalt Corp |
New 1-alkanoyloxy-1,2,4,5-tetrahydro-3H, 3-benzazepine
|
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US3745162A
(en)
|
1970-08-31 |
1973-07-10 |
Robins Co Inc A H |
1,2,3,4-tetrahydroisoquinoline-2-(thio)-carboxamides
|
|
GB1448437A
(en)
|
1973-02-24 |
1976-09-08 |
Beecham Group Ltd |
Diphenylpropylamines
|
|
US4022791A
(en)
|
1975-06-03 |
1977-05-10 |
Pfizer Inc. |
2-Aminomethyl-3,4-dihydronaphthalenes
|
|
GB1504424A
(en)
|
1975-08-09 |
1978-03-22 |
Beecham Group Ltd |
Isoquinoline-derived aminoethers
|
|
BR7807288A
(en)
|
1977-11-08 |
1979-06-12 |
Genentech Inc |
POLYNUCLEOTIDE SYNTHESIS PROCESS
|
|
DD133885B1
(en)
|
1978-01-04 |
1981-02-25 |
Hans Lehmann |
AGENTS FOR THE CONTROL OF PHYTOPATHOGENIC BACTERIA AND MUSHROOMS
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
US4542142A
(en)
|
1982-11-22 |
1985-09-17 |
Roussel Uclaf |
Insecticidal cyclopropane carboxylic acid derivatives with 3-unsaturated-side chain
|
|
DE3329892A1
(en)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
METHOD FOR PRODUCING OLIGONUCLEOTIDES
|
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
US5643889A
(en)
|
1984-07-11 |
1997-07-01 |
Temple University-Of The Commonwealth System Of Pennsylvania |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
|
|
FR2567892B1
(en)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
NOVEL OLIGONUCLEOTIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS MEDIATORS IN DEVELOPING THE EFFECTS OF INTERFERONS
|
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
FR2575751B1
(en)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
NOVEL ADENOSINE DERIVATIVE NUCLEOSIDES, THEIR PREPARATION AND THEIR BIOLOGICAL APPLICATIONS
|
|
FR2576898B1
(en)
|
1985-02-01 |
1988-01-08 |
Lafon Labor |
3-PHENYL-TETRAHYDROPYRIDINE DERIVATIVES, METHOD OF PREPARATION AND THERAPEUTIC USE
|
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
|
US4840956A
(en)
|
1986-02-18 |
1989-06-20 |
Warner-Lambert Company |
Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
|
|
US4735949A
(en)
|
1986-02-18 |
1988-04-05 |
Warner-Lambert Company |
Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
|
|
IL83663A0
(en)
|
1986-10-27 |
1988-01-31 |
Robins Co Inc A H |
Preparation of 3-pyrrolidinols
|
|
JP2828642B2
(en)
|
1987-06-24 |
1998-11-25 |
ハワード フローレイ インスティテュト オブ イクスペリメンタル フィジオロジー アンド メディシン |
Nucleoside derivative
|
|
EP0302349B1
(en)
|
1987-07-30 |
1993-09-29 |
Bar Ilan University |
Biologically active carboxylic acid esters
|
|
US4923901A
(en)
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
|
US4945158A
(en)
|
1988-08-12 |
1990-07-31 |
American Cyanamid Company |
Antidiabetic phosphonates
|
|
US4943629A
(en)
|
1988-08-12 |
1990-07-24 |
American Cyanamid Company |
Antidiabetic alpha-substituted phosphonates
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
CA2029273A1
(en)
|
1989-12-04 |
1991-06-05 |
Christine L. Brakel |
Modified nucleotide compounds
|
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
|
EP0507863A4
(en)
|
1989-12-28 |
1993-07-07 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
WO1991010671A1
(en)
|
1990-01-11 |
1991-07-25 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for detecting and modulating rna activity and gene expression
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US5457191A
(en)
|
1990-01-11 |
1995-10-10 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5635488A
(en)
|
1991-10-15 |
1997-06-03 |
Isis Pharmaceuticals, Inc. |
Compounds having phosphorodithioate linkages of high chiral purity
|
|
US5852188A
(en)
|
1990-01-11 |
1998-12-22 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5506212A
(en)
|
1990-01-11 |
1996-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides with substantially chirally pure phosphorothioate linkages
|
|
US5212295A
(en)
|
1990-01-11 |
1993-05-18 |
Isis Pharmaceuticals |
Monomers for preparation of oligonucleotides having chiral phosphorus linkages
|
|
US5620963A
(en)
|
1991-10-15 |
1997-04-15 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
|
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
US5036964A
(en)
|
1990-03-28 |
1991-08-06 |
Dana Corporation |
Armature assembly for an electromagnetic coupling
|
|
US5292875A
(en)
|
1990-04-20 |
1994-03-08 |
Lynx Therapeutics, Inc. |
Method of synthesizing sulfurized oligonucleotide analogs
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
KR960004931B1
(en)
|
1990-05-23 |
1996-04-18 |
아이시스 파마슈티칼스, 인코포레이티드 |
Composition and method for modulating ran activity through modification of the 5'cap structure of ran
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US6121433A
(en)
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
|
JPH0874B2
(en)
|
1990-07-27 |
1996-01-10 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
Nuclease-resistant, pyrimidine-modified oligonucleotides that detect and modulate gene expression
|
|
US5834607A
(en)
|
1990-07-27 |
1998-11-10 |
Isis Pharmaceuticals, Inc. |
Amines and methods of making and using the same
|
|
US5792844A
(en)
|
1990-07-27 |
1998-08-11 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent nitrogen atoms
|
|
US5223618A
(en)
|
1990-08-13 |
1993-06-29 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analog compounds
|
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
|
WO1994022886A1
(en)
|
1993-03-30 |
1994-10-13 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US6087482A
(en)
|
1990-07-27 |
2000-07-11 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5783682A
(en)
|
1990-07-27 |
1998-07-21 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide mimics having nitrogen-containing linkages
|
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
|
US5998603A
(en)
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
US5512668A
(en)
|
1991-03-06 |
1996-04-30 |
Polish Academy Of Sciences |
Solid phase oligonucleotide synthesis using phospholane intermediates
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
US20020183502A1
(en)
|
1991-05-21 |
2002-12-05 |
Mesmaeker Alain De |
Backbone-modified oligonucleotide analogs and methods for using same
|
|
US6414112B1
(en)
|
1991-05-24 |
2002-07-02 |
Ole Buchardt |
Peptide nucleic acids having 2,6-diaminopurine nucleobases
|
|
WO1992022655A1
(en)
|
1991-06-10 |
1992-12-23 |
Lucky Limited |
Hepatitis c diagnostics and vaccines
|
|
US5359052A
(en)
|
1991-08-05 |
1994-10-25 |
Polish Academy Of Sciences |
Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
|
|
US5646267A
(en)
|
1991-08-05 |
1997-07-08 |
Polish Academy Of Sciences |
Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
|
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
US5607923A
(en)
|
1991-10-15 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
|
|
US5654284A
(en)
|
1991-10-15 |
1997-08-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity
|
|
WO1993008296A1
(en)
|
1991-10-15 |
1993-04-29 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
|
US5576302A
(en)
|
1991-10-15 |
1996-11-19 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
|
|
US5599797A
(en)
|
1991-10-15 |
1997-02-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
EP0538194B1
(en)
|
1991-10-17 |
1997-06-04 |
Novartis AG |
Bicyclic nucleosides, oligonucleotides, their method of preparation and intermediates therein
|
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
KR940703846A
(en)
|
1991-12-24 |
1994-12-12 |
비. 린네 파샬 |
GAPED 2 'MODIFED OLIGONUCLEOTIDES
|
|
GB9213601D0
(en)
|
1992-06-26 |
1992-08-12 |
Mastico Robert A |
Protein based delivery system
|
|
US7067497B2
(en)
|
1992-09-29 |
2006-06-27 |
Isis Pharmaceuticals, Inc. |
Modulation of telomere length by oligonucleotides having a G-core sequence
|
|
US6444656B1
(en)
|
1992-12-23 |
2002-09-03 |
Biochem Pharma, Inc. |
Antiviral phosphonate nucleotides
|
|
US6005107A
(en)
|
1992-12-23 |
1999-12-21 |
Biochem Pharma, Inc. |
Antiviral compounds
|
|
JPH08508714A
(en)
|
1993-01-25 |
1996-09-17 |
ハイブライドン インコーポレイテッド |
Oligonucleotide alkyl phosphonates and alkyl phosphonothioates
|
|
EP0701564A1
(en)
|
1993-03-31 |
1996-03-20 |
Sanofi |
Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
|
|
CA2159632A1
(en)
|
1993-03-31 |
1994-10-13 |
Ashis Kumar Saha |
Novel 5'-substituted nucleosides and oligomers produced therefrom
|
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US6015886A
(en)
|
1993-05-24 |
2000-01-18 |
Chemgenes Corporation |
Oligonucleotide phosphate esters
|
|
EP0628394B1
(en)
|
1993-06-10 |
1998-08-26 |
Idemitsu Petrochemical Co. Ltd. |
Injection molding die
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US5643989A
(en)
|
1993-10-29 |
1997-07-01 |
Azdel, Inc. |
Fiber reinforced functionalized polyolefin composites
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
DE4435728A1
(en)
|
1994-01-19 |
1995-07-20 |
Boehringer Mannheim Gmbh |
Biotin silane compounds and binding matrix containing these compounds
|
|
US6117679A
(en)
|
1994-02-17 |
2000-09-12 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
|
JP3553958B2
(en)
|
1994-02-22 |
2004-08-11 |
ノボザイムス アクティーゼルスカブ |
Method for producing variant of lipolytic enzyme
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
EP0759073A1
(en)
|
1994-05-11 |
1997-02-26 |
Novo Nordisk A/S |
AN ENZYME WITH ENDO-1,3(4)-$g(b)-GLUCANASE ACTIVITY
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
HRP950288A2
(en)
|
1994-05-31 |
1997-08-31 |
Bayer Ag |
Oxalylamino-benzofuran- and benzothienyl-derivatives
|
|
DK0685475T3
(en)
|
1994-05-31 |
1999-08-30 |
Bayer Ag |
Amino-benzofuryl and thienyl derivatives
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
DK0772619T4
(en)
|
1994-07-15 |
2011-02-21 |
Univ Iowa Res Found |
Immunomodulatory oligonucleotides
|
|
AU3675195A
(en)
|
1994-09-07 |
1996-03-27 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
|
US5681940A
(en)
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
|
CN1175281A
(en)
|
1994-12-22 |
1998-03-04 |
海布里登公司 |
Synthesis of Stereospecific Phosphorothioate Oligonucleotides
|
|
GB9501465D0
(en)
|
1995-01-25 |
1995-03-15 |
King S College London |
Nucleoside phosphorothioate derivatives,synthesis and use thereof
|
|
AU5359496A
(en)
|
1995-03-06 |
1996-09-23 |
Isis Pharmaceuticals, Inc. |
Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom
|
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
|
EP0739983B1
(en)
|
1995-04-27 |
2009-12-30 |
Takara Bio Inc. |
Gene encoding lacto-n-biosidase
|
|
ES2220929T3
(en)
|
1995-05-11 |
2004-12-16 |
Applied Research Systems Ars Holding N.V. |
INHIBITOR OF ACTIVITY IL-6.
|
|
EP0828729A1
(en)
|
1995-05-19 |
1998-03-18 |
Glycomed Incorporated |
Collection of activated glycoside compounds and their biological use
|
|
AU5871196A
(en)
|
1995-05-23 |
1996-12-24 |
Hybridon, Inc. |
Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
|
|
ES2151173T3
(en)
|
1995-05-23 |
2000-12-16 |
Hybridon Inc |
NEW TUNES FOR STEREOSELECTIVE SYNTHESIS OF OLIGONUCLEOTIDES.
|
|
EP0831854A4
(en)
|
1995-06-06 |
2001-01-24 |
Isis Pharmaceuticals Inc |
HIGH CHIRAL PURITY OLIGONUCLEOTIDES WITH PHOSPHOROTHIOATE LINKS
|
|
US5932450A
(en)
|
1995-06-07 |
1999-08-03 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using digestible templates
|
|
US5824503A
(en)
|
1995-06-29 |
1998-10-20 |
Takara Shuzo Co, Ltd. |
Gene encoding endoglycoceramidase activator
|
|
DE69635849T2
(en)
|
1995-06-29 |
2006-10-19 |
Takara Bio Inc., Otsu |
Gene encoding endoglycoceramidase
|
|
US6017700A
(en)
|
1995-08-04 |
2000-01-25 |
Bayer Corporation |
Cationic oligonucleotides, and related methods of synthesis and use
|
|
US5936080A
(en)
|
1996-05-24 |
1999-08-10 |
Genta Incorporated |
Compositions and methods for the synthesis of organophosphorus derivatives
|
|
WO1997009443A1
(en)
|
1995-09-05 |
1997-03-13 |
Michigan State University |
PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
|
|
US6160109A
(en)
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
|
EP1007655A1
(en)
|
1996-02-15 |
2000-06-14 |
National Institutes Of Health |
Rnase l activators and antisense oligonucleotides effective to treat rsv infections
|
|
US6214805B1
(en)
|
1996-02-15 |
2001-04-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
RNase L activators and antisense oligonucleotides effective to treat RSV infections
|
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
|
US5824669A
(en)
|
1996-03-22 |
1998-10-20 |
Nitromed, Inc. |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
|
|
EP0898618B1
(en)
|
1996-05-10 |
2007-10-31 |
Novozymes A/S |
Method of providing novel dna sequences
|
|
US5856465A
(en)
|
1996-05-24 |
1999-01-05 |
Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych |
Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
DE19622783A1
(en)
|
1996-06-07 |
1997-12-11 |
Hoechst Ag |
Isolation of the biosynthetic genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O and their use
|
|
WO1998002582A2
(en)
|
1996-07-16 |
1998-01-22 |
Gen-Probe Incorporated |
Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
|
|
EP0960121B1
(en)
|
1996-07-24 |
2005-11-30 |
BUCHARDT, Dorte |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
WO1998007734A1
(en)
|
1996-08-21 |
1998-02-26 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
GB9621522D0
(en)
|
1996-10-16 |
1996-12-04 |
Biocompatibles Ltd |
Synthesis of phosphorus compounds
|
|
US6639062B2
(en)
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
|
US6369237B1
(en)
|
1997-03-07 |
2002-04-09 |
President And Fellows Of Harvard College |
DNA glycosylase inhibitors, and uses related thereto
|
|
US6015887A
(en)
|
1997-04-11 |
2000-01-18 |
Isis Pharmaceuticals, Inc. |
Chiral peptide nucleic acids and methods for preparing same
|
|
US6468983B2
(en)
|
1997-04-21 |
2002-10-22 |
The Cleveland Clinic Foundation |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
|
|
PL184612B1
(en)
|
1997-04-25 |
2002-11-29 |
Pan |
Method of obtaining p-chiral analoques of nucleotides
|
|
JP2001501975A
(en)
|
1997-05-28 |
2001-02-13 |
ペーター・エー・ニールセン |
Binding peptide nucleic acids with enhanced cellular uptake
|
|
BR9810946A
(en)
|
1997-06-27 |
2000-09-26 |
Procter & Gamble |
"cyclic acetals for fragrance"
|
|
AU8512598A
(en)
|
1997-07-25 |
1999-02-16 |
Hybridon, Inc. |
Oligonuclotides having 3' terminal stereospecific phosphorothioates
|
|
GB9717158D0
(en)
|
1997-08-13 |
1997-10-22 |
King S College London |
Solution synthesis of oligonucleotides and their phosphorothioate analogues
|
|
US6767739B2
(en)
|
2001-07-30 |
2004-07-27 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microsomal triglyceride transfer protein expression
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
DE19741715A1
(en)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
New pentopyranosyl nucleoside compounds
|
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
|
US6528640B1
(en)
|
1997-11-05 |
2003-03-04 |
Ribozyme Pharmaceuticals, Incorporated |
Synthetic ribonucleic acids with RNAse activity
|
|
US6080543A
(en)
|
1997-12-08 |
2000-06-27 |
E. & J. Gallo Winery |
Detection of fungal pathogens
|
|
US6582936B1
(en)
|
1997-12-12 |
2003-06-24 |
The Regents Of The University Of California |
Methods for making nucleic acids
|
|
US6248519B1
(en)
|
1998-03-11 |
2001-06-19 |
E & J Gallo Winery |
Detection of fermentation-related microorganisms
|
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
|
WO1999056755A1
(en)
|
1998-05-06 |
1999-11-11 |
University Of Iowa Research Foundation |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
|
JP2002514397A
(en)
|
1998-05-14 |
2002-05-21 |
コーリー ファーマシューティカル ゲーエムベーハー |
Methods for hematopoietic regulation using CpG oligonucleotides
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
JP2002521489A
(en)
|
1998-07-27 |
2002-07-16 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
Stereoisomers of CpG oligonucleotides and related methods
|
|
PT1104306E
(en)
|
1998-08-10 |
2006-05-31 |
Antigenics Inc |
CPG COMPOSITIONS AND SAPONIN ADJUVANTS AND THEIR METHODS
|
|
WO2000023444A1
(en)
|
1998-10-21 |
2000-04-27 |
Abbott Laboratories |
5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
|
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
|
US6451524B1
(en)
|
1998-11-25 |
2002-09-17 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
|
WO2000031110A1
(en)
|
1998-11-25 |
2000-06-02 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
|
AU1853600A
(en)
|
1999-01-06 |
2000-07-24 |
Choong-Chin Liew |
Method for the detection of gene transcripts in blood and uses thereof
|
|
US6265172B1
(en)
|
1999-02-08 |
2001-07-24 |
University Of Kentucky |
Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
|
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6506594B1
(en)
|
1999-03-19 |
2003-01-14 |
Cornell Res Foundation Inc |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
|
GB9907245D0
(en)
|
1999-03-29 |
1999-05-26 |
Goldsborough Andrew |
Cleavage of nucleic acids from solid supports
|
|
JP3072345B1
(en)
|
1999-03-31 |
2000-07-31 |
農林水産省家畜衛生試験場長 |
Swine erysipelas recombinant subunit vaccine
|
|
US5998148A
(en)
|
1999-04-08 |
1999-12-07 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microtubule-associated protein 4 expression
|
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US6300069B1
(en)
|
1999-05-03 |
2001-10-09 |
Qiagen Gmbh |
Generation and amplification of nucleic acids from ribonucleic acids
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
US6271004B1
(en)
|
1999-06-25 |
2001-08-07 |
Display Systems Biotech A/S |
Method for improved reverse transcription at high temperatures
|
|
US6066500A
(en)
|
1999-06-25 |
2000-05-23 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Beta catenin expression
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US20030092647A1
(en)
|
2001-08-08 |
2003-05-15 |
Crooke Rosanne M. |
Antisense modulation of cholesteryl ester transfer protein expression
|
|
US6147200A
(en)
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US7264932B2
(en)
|
1999-09-24 |
2007-09-04 |
Applera Corporation |
Nuclease inhibitor cocktail
|
|
PL354997A1
(en)
|
1999-09-25 |
2004-03-22 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acids
|
|
ATE333284T1
(en)
|
1999-09-27 |
2006-08-15 |
Coley Pharm Group Inc |
METHOD USING IMMUNOSTIMULATIVE INTERFERON INDUCED BY NUCLEIC ACIDS
|
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
US20020082227A1
(en)
|
1999-09-30 |
2002-06-27 |
Scott Henry |
Use of oligonucleotides for inhibition of complement activation
|
|
IL148922A0
(en)
|
1999-10-06 |
2002-09-12 |
Quark Biotech Inc |
Method for enrichment of natural antisense messenger rna
|
|
GB9924285D0
(en)
|
1999-10-14 |
1999-12-15 |
Avecia Ltd |
Process
|
|
US20010055761A1
(en)
|
1999-10-29 |
2001-12-27 |
Agilent Technologies |
Small scale dna synthesis using polymeric solid support with functionalized regions
|
|
FR2800750B1
(en)
|
1999-11-05 |
2003-01-31 |
Centre Nat Rech Scient |
MEMBRANE PROTEINS CTL (CHOLINE TRANSPORTER LIKE) INVOLVED IN THE TRANSPORT OF CHOLINE
|
|
WO2001040515A1
(en)
|
1999-11-12 |
2001-06-07 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6322985B1
(en)
|
1999-12-27 |
2001-11-27 |
Technion Research And Development Foundation Ltd. |
Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
|
|
EP1244906A1
(en)
|
1999-12-30 |
2002-10-02 |
Cabot Corporation |
Sensors with improved properties
|
|
WO2001050349A1
(en)
|
1999-12-30 |
2001-07-12 |
Rutgers, The State University Of New Jersey |
Electronic document customization and transformation utilizing user feedback
|
|
US6649750B1
(en)
|
2000-01-05 |
2003-11-18 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotide compounds
|
|
US6159697A
(en)
|
2000-01-19 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad7 expression
|
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
GB0004889D0
(en)
|
2000-03-01 |
2000-04-19 |
Avecia Ltd |
Synthesis of oligonucleotides
|
|
EP1130091A3
(en)
|
2000-03-01 |
2001-11-14 |
Message Pharmaceuticals, Inc. |
Bacterial RNaseP Proteins and their use in identifying antibacterial compounds
|
|
AU2001245823A1
(en)
|
2000-03-17 |
2001-10-03 |
Corixa Corporation |
Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
|
|
DE10019756A1
(en)
|
2000-04-20 |
2001-10-25 |
Bayer Ag |
Process for the production of superabsorbent polymers from polyacrylonitriles
|
|
EP1278728B1
(en)
|
2000-04-20 |
2004-08-25 |
F. Hoffmann-La Roche Ag |
Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders
|
|
AU2001259706A1
(en)
|
2000-05-09 |
2001-11-20 |
Reliable Biopharmaceutical, Inc. |
Polymeric compounds useful as prodrugs
|
|
US6492171B2
(en)
|
2000-05-16 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of TERT expression
|
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
|
US7238795B2
(en)
|
2000-08-03 |
2007-07-03 |
Roche Molecular Systems, Inc. |
Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
|
|
US6725412B1
(en)
|
2000-08-15 |
2004-04-20 |
Dolby Laboratories Licensing Corporation |
Low latency data encoder
|
|
US6809195B1
(en)
|
2000-08-16 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotides
|
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
|
US6943240B2
(en)
|
2000-09-15 |
2005-09-13 |
Coley Pharmaceuticals Gmbh |
Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
GB0024752D0
(en)
|
2000-10-10 |
2000-11-22 |
Univ Belfast |
Oxidative halogenation of aromatic compounds
|
|
IL155282A0
(en)
|
2000-10-18 |
2003-11-23 |
Glaxosmithkline Biolog Sa |
Vaccines
|
|
US6372492B1
(en)
|
2000-10-30 |
2002-04-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of talin expression
|
|
US6682889B1
(en)
|
2000-11-08 |
2004-01-27 |
Becton, Dickinson And Company |
Amplification and detection of organisms of the Chlamydiaceae family
|
|
NL1016978C2
(en)
|
2000-12-22 |
2002-06-25 |
Robert Jan Colenbrander |
Device and method for packaging and preparing food and method for manufacturing such a device.
|
|
CN1267446C
(en)
|
2001-01-22 |
2006-08-02 |
默克公司 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerases
|
|
US8008459B2
(en)
|
2001-01-25 |
2011-08-30 |
Evolva Sa |
Concatemers of differentially expressed multiple genes
|
|
DK1356037T3
(en)
|
2001-01-25 |
2011-06-27 |
Evolva Ltd |
Library with a collection of cells
|
|
EP1354035B1
(en)
|
2001-01-26 |
2016-08-24 |
Commonwealth Scientific and Industrial Research Organisation |
Methods and means for producing efficient silencing construct using recombinational cloning
|
|
US20050277133A1
(en)
|
2001-05-18 |
2005-12-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US20030207804A1
(en)
|
2001-05-25 |
2003-11-06 |
Muthiah Manoharan |
Modified peptide nucleic acids
|
|
GB0113523D0
(en)
|
2001-06-04 |
2001-07-25 |
Torotrak Dev Ltd |
An Hydraulic control circuit for a continuosly variable transmission
|
|
US20030069410A1
(en)
*
|
2001-06-14 |
2003-04-10 |
Isis Pharmaceuticals, Inc. |
Methods for preparing oligonucleotides having chiral phosphorothioate linkages
|
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
CN1636015A
(en)
|
2001-06-29 |
2005-07-06 |
希龙公司 |
HCV E1E2 vaccine composition
|
|
EP1499627A2
(en)
|
2001-07-03 |
2005-01-26 |
ISIS Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
|
US7205399B1
(en)
|
2001-07-06 |
2007-04-17 |
Sirna Therapeutics, Inc. |
Methods and reagents for oligonucleotide synthesis
|
|
US6440739B1
(en)
|
2001-07-17 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of glioma-associated oncogene-2 expression
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US7888324B2
(en)
|
2001-08-01 |
2011-02-15 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US6455308B1
(en)
|
2001-08-01 |
2002-09-24 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of serum amyloid A4 expression
|
|
US7259150B2
(en)
|
2001-08-07 |
2007-08-21 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein (a) expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
US7354909B2
(en)
|
2001-08-14 |
2008-04-08 |
The United States Of America As Represented By Secretary Of The Department Of Health And Human Services |
Method for rapid generation of mature dendritic cells
|
|
EP1418877A2
(en)
|
2001-08-24 |
2004-05-19 |
Massachusetts Institute Of Technology |
Reagents that facilitate the purification of compounds synthesized on a solid support
|
|
US7049122B2
(en)
|
2001-09-21 |
2006-05-23 |
Academia Sinica |
Mutant-type lipases and applications thereof
|
|
US6933288B2
(en)
|
2002-02-04 |
2005-08-23 |
Isis Pharmaceuticals, Inc. |
Pyranosyl cytosines: pharmaceutical formulations and methods
|
|
JP4348044B2
(en)
|
2002-02-12 |
2009-10-21 |
株式会社キラルジェン |
Method for producing highly stereoregular dinucleoside phosphorothioates
|
|
US20040149587A1
(en)
|
2002-02-15 |
2004-08-05 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
|
US20030159938A1
(en)
|
2002-02-15 |
2003-08-28 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US8232383B2
(en)
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003217863B9
(en)
|
2002-02-28 |
2009-10-29 |
Biota Scientific Management Pty Ltd |
Nucleotide mimics and their prodrugs
|
|
JP2005524662A
(en)
|
2002-02-28 |
2005-08-18 |
ビオタ インコーポレーティッド |
Nucleoside 5'-monophosphate mimetics and their prodrugs
|
|
US7288376B2
(en)
|
2002-03-22 |
2007-10-30 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants useful for prediction of predisposition to aspergillosis
|
|
US20040102394A1
(en)
|
2002-11-23 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of huntingtin interacting protein 2 expression
|
|
US7247621B2
(en)
|
2002-04-30 |
2007-07-24 |
Valeant Research & Development |
Antiviral phosphonate compounds and methods therefor
|
|
WO2003097662A1
(en)
|
2002-05-15 |
2003-11-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
|
US20040014957A1
(en)
|
2002-05-24 |
2004-01-22 |
Anne Eldrup |
Oligonucleotides having modified nucleoside units
|
|
US20040014108A1
(en)
|
2002-05-24 |
2004-01-22 |
Eldrup Anne B. |
Oligonucleotides having modified nucleoside units
|
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
|
AU2003248708A1
(en)
|
2002-06-17 |
2003-12-31 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
AU2003242742B2
(en)
|
2002-06-20 |
2009-04-30 |
Cytos Biotechnology Ag |
Packaged virus-like particles for use as adjuvants: method of preparation and use
|
|
WO2004003228A1
(en)
|
2002-07-01 |
2004-01-08 |
Unisearch Limited |
Genotyping method
|
|
ES2550609T3
(en)
|
2002-07-10 |
2015-11-11 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA interference by single stranded RNA molecules
|
|
US20040023905A1
(en)
|
2002-07-31 |
2004-02-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of LAR expression
|
|
US20050255086A1
(en)
|
2002-08-05 |
2005-11-17 |
Davidson Beverly L |
Nucleic acid silencing of Huntington's Disease gene
|
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
|
US8729036B2
(en)
|
2002-08-07 |
2014-05-20 |
University Of Massachusetts |
Compositions for RNA interference and methods of use thereof
|
|
AU2003259735A1
(en)
|
2002-08-08 |
2004-02-25 |
Sirna Therapeutics, Inc. |
Small-mer compositions and methods of use
|
|
AR040996A1
(en)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
IMMUNE STIMULATING NUCLEIC ACIDS
|
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
|
CA2498777C
(en)
|
2002-09-13 |
2015-01-13 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
|
DK2241325T3
(en)
|
2002-10-29 |
2012-04-10 |
Coley Pharm Group Inc |
Use of CPG oligonucleotides to treat Hepatitis Cvirus infection
|
|
AU2003291753B2
(en)
|
2002-11-05 |
2010-07-08 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
AU2003291721A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
EP2957568B1
(en)
|
2002-11-05 |
2016-12-21 |
Ionis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
CA2505090A1
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Conjugated oligomeric compounds and their use in gene modulation
|
|
US7381527B2
(en)
|
2002-11-06 |
2008-06-03 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants
|
|
WO2004044181A2
(en)
|
2002-11-13 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
|
US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
EP2213738B1
(en)
|
2002-11-14 |
2012-10-10 |
Dharmacon, Inc. |
siRNA molecules targeting Bcl-2
|
|
EP2239329A1
(en)
|
2003-03-07 |
2010-10-13 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
|
WO2004080466A1
(en)
|
2003-03-07 |
2004-09-23 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
GB0306657D0
(en)
|
2003-03-24 |
2003-04-30 |
Avecia Ltd |
Process and compounds
|
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
|
ZA200507562B
(en)
|
2003-03-26 |
2006-11-29 |
Cytos Biotechnology Ag |
HIV-peptide-carrier-conjugates
|
|
ITRM20030149A1
(en)
|
2003-04-02 |
2004-10-03 |
Giuliani Spa |
ANTISENSE OLIGONUCLEOTIDES (ODN) FOR SMAD7 AND THEIR USE IN THE MEDICAL FIELD
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
|
US20090247488A1
(en)
|
2003-04-25 |
2009-10-01 |
Carina Cannizzaro |
Anti-inflammatory phosphonate compounds
|
|
CN101410120A
(en)
|
2003-04-25 |
2009-04-15 |
吉里德科学公司 |
Anti-inflammatory phosphonate compounds
|
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
|
CA2523083C
(en)
|
2003-04-25 |
2014-07-08 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
|
WO2004096233A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates
|
|
WO2004096235A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
US7045306B2
(en)
|
2003-04-28 |
2006-05-16 |
The General Hospital Corporation |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
|
|
US7214491B2
(en)
|
2003-05-07 |
2007-05-08 |
E. I. Du Pont De Nemours And Company |
Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
|
|
US7589189B2
(en)
|
2003-05-14 |
2009-09-15 |
Japan Science And Technology Agency |
Inhibition of the expression of huntingtin gene
|
|
WO2005002507A2
(en)
|
2003-06-03 |
2005-01-13 |
Isis Pharmaceuticals, Inc. |
Modulation of survivin expression
|
|
BRPI0411514A
(en)
|
2003-06-20 |
2006-08-01 |
Coley Pharm Gmbh |
small molecule toll-like receptor antagonists
|
|
EP1648914A4
(en)
|
2003-07-31 |
2009-12-16 |
Regulus Therapeutics Inc |
OLIGOMER COMPOUNDS AND COMPOSITIONS FOR USE IN THE MODULATION OF SMALL NON-CODING RNAS
|
|
JP2011088935A
(en)
|
2003-08-08 |
2011-05-06 |
Chiralgen Ltd |
Optically-active nucleoside 3'-phosphoroamidite for production of phosphorus atom modified nucleotide analog
|
|
JP2005089441A
(en)
|
2003-08-08 |
2005-04-07 |
Toudai Tlo Ltd |
Method for producing phosphorus atom-modified nucleotide analogues with high stereoregularity
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
JP2007502779A
(en)
|
2003-08-21 |
2007-02-15 |
グリフィス ユニバーシティ |
New sulfenamide
|
|
BRPI0413682A
(en)
|
2003-08-21 |
2006-10-24 |
Univ Griffith |
compounds, pharmaceutical composition and methods of preparation, treatment of microbial infection and extermination of microorganism and uses
|
|
DE602004029904D1
(en)
|
2003-08-27 |
2010-12-16 |
Biota Scient Management |
NEW TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES THAN THERAPEUTIC AGENTS
|
|
ATE555118T1
(en)
|
2003-08-28 |
2012-05-15 |
Takeshi Imanishi |
NEW SYNTHETIC NUCLEIC ACIDS OF THE CROSS-LINKED N-O BOND TYPE
|
|
WO2005023828A1
(en)
|
2003-09-02 |
2005-03-17 |
Takeshi Wada |
Process for producing ribonucleotide or ribonucleotide derivative
|
|
JP4616175B2
(en)
|
2003-09-02 |
2011-01-19 |
株式会社キラルジェン |
Method for producing 5'-phosphitylated monomer and H-phosphonate oligonucleotide derivative
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
AU2004271215B2
(en)
|
2003-09-09 |
2009-07-16 |
Geron Corporation |
Modified oligonucleotides for telomerase inhibition
|
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
|
ES2969371T3
(en)
|
2003-09-12 |
2024-05-17 |
Univ Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
GB0323968D0
(en)
|
2003-10-13 |
2003-11-19 |
Glaxosmithkline Biolog Sa |
Immunogenic compositions
|
|
EA008741B1
(en)
|
2003-10-30 |
2007-08-31 |
Коли Фармасьютикал Гмбх |
C-class oligonucleotide analogs with enhanced immunostimulatory potency
|
|
US20050239102A1
(en)
|
2003-10-31 |
2005-10-27 |
Verdine Gregory L |
Nucleic acid binding oligonucleotides
|
|
US7846436B2
(en)
|
2003-11-28 |
2010-12-07 |
Chemgenes Corporation |
Oligonucleotides and related compounds
|
|
AU2003300239A1
(en)
|
2003-12-29 |
2005-07-21 |
Galapagos Genomics N.V. |
Modulators of bone homeostasis identified in a high-throughput screen
|
|
WO2005070859A1
(en)
|
2004-01-27 |
2005-08-04 |
Takeshi Wada |
Fluorous supports and processes for production of oligonucleotide derivatives with the same
|
|
US20050176045A1
(en)
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
|
WO2005076744A2
(en)
|
2004-02-18 |
2005-08-25 |
Frutarom Ltd. |
Method for the preparation of peptide-oligonucleotide conjugates
|
|
JP3976742B2
(en)
|
2004-02-27 |
2007-09-19 |
江守商事株式会社 |
Immunostimulatory oligonucleotides that induce interferon alpha
|
|
WO2005085272A1
(en)
|
2004-03-05 |
2005-09-15 |
Takeshi Wada |
Boranophosphate monomer and process for producing oligonucleotide derivative therefrom
|
|
WO2005092909A1
(en)
|
2004-03-25 |
2005-10-06 |
Toudai Tlo, Ltd. |
Processes for producing ribonucleotide analogue with high stereoregularity and deoxyribonucleotide analogue
|
|
CA2561741C
(en)
|
2004-04-05 |
2016-09-27 |
Alnylam Pharmaceuticals, Inc. |
Processes and reagents for oligonucleotide synthesis and purification
|
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
|
CA2572795A1
(en)
|
2004-05-27 |
2005-12-08 |
The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services |
Differential expression of molecules associated with acute stroke
|
|
US7759318B1
(en)
|
2004-05-28 |
2010-07-20 |
Isis Pharmaceuticals, Inc. |
Identification of novel pathways, genes and promoter motifs regulating adipogenesis
|
|
CA2569419A1
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
PL1766010T3
(en)
|
2004-06-28 |
2011-07-29 |
Univ Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
|
ES2663810T3
(en)
|
2004-08-10 |
2018-04-17 |
Kastle Therapeutics, Llc |
Methods to modulate the levels of lipoproteins and cholesterol in humans
|
|
MX2007002245A
(en)
|
2004-08-26 |
2007-04-20 |
Nippon Shinyaku Co Ltd |
Phosphoramidite compound and method for producing oligo-rna.
|
|
CA2578046A1
(en)
|
2004-09-07 |
2006-03-16 |
Archemix Corp. |
Aptamer medicinal chemistry
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
US20090203132A1
(en)
|
2004-09-09 |
2009-08-13 |
Swayze Eric E |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
|
EP1799859B1
(en)
|
2004-09-17 |
2014-07-02 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
|
AU2005295756B2
(en)
|
2004-10-13 |
2012-02-02 |
Isis Parmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US7608594B2
(en)
|
2004-11-03 |
2009-10-27 |
University Of Kansas |
Novobiocin analogues as anticancer agents
|
|
US9120774B2
(en)
|
2004-11-03 |
2015-09-01 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
US7622451B2
(en)
|
2004-11-03 |
2009-11-24 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
|
US8212012B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
US8212011B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues
|
|
KR100721928B1
(en)
|
2004-11-05 |
2007-05-28 |
주식회사 바이오씨에스 |
Pharmaceutical composition for the treatment or prevention of skin diseases containing CJ oligodeoxynucleotide
|
|
EP1657307A1
(en)
|
2004-11-16 |
2006-05-17 |
Immunotech S.A. |
Oligonucleotides that induce the secretion of GM-CSF
|
|
CA2589406A1
(en)
|
2004-12-09 |
2006-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas
|
|
WO2006065751A2
(en)
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
WO2006066260A2
(en)
|
2004-12-17 |
2006-06-22 |
Thiosense, Inc. |
Compositions of and methods for producing phosphorus-chiral monomers and oligomers
|
|
US20070099851A1
(en)
|
2004-12-30 |
2007-05-03 |
Linn Gregory S |
Stable analogues of ribose-1-phosphate and methods for treating diabetes and other metabolic disorders
|
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
|
JP4836145B2
(en)
|
2005-01-28 |
2011-12-14 |
クウォン，ヒュン−ジョ |
Oligonucleotide derived from mycobacteria for immune function stimulation, immune disease treatment, atopic dermatitis treatment and / or normal immune cell protection
|
|
AU2006216493A1
(en)
|
2005-02-24 |
2006-08-31 |
Coley Pharmaceutical Gmbh |
Immunostimulatory oligonucleotides
|
|
EP1866319B1
(en)
|
2005-04-01 |
2011-11-23 |
The Regents of The University of California |
Phosphono-pent-2-en-1-yl nucleosides and analogs
|
|
RU2427377C2
(en)
|
2005-05-05 |
2011-08-27 |
Антисенс Фарма Гмбх |
Oligonucleotide dosing
|
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
|
WO2006121960A2
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
|
EP3470072A1
(en)
|
2005-06-23 |
2019-04-17 |
Biogen MA Inc. |
Compositions and methods for modulation of smn2 splicing
|
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
|
ATE522626T1
(en)
|
2005-06-28 |
2011-09-15 |
Medtronic Inc |
METHODS AND NUCLEOTIDE SEQUENCES THAT PREFERENTIALLY SUPPRESS THE EXPRESSION OF A MUTATED HUNTINGTIN GENE
|
|
WO2007005941A2
(en)
|
2005-07-05 |
2007-01-11 |
President And Fellows Of Harvard College |
Liver targeted conjugates
|
|
JP4984634B2
(en)
|
2005-07-21 |
2012-07-25 |
ソニー株式会社 |
Physical information acquisition method and physical information acquisition device
|
|
EP1924252B1
(en)
|
2005-07-28 |
2011-09-07 |
ID-Fish Technology, Inc. |
Method for improving cell permeability to foreign particles
|
|
DE602006019455D1
(en)
|
2005-08-29 |
2011-02-17 |
Regulus Therapeutics Inc |
PROCESS FOR MIR-122A MODULATION
|
|
US8501703B2
(en)
|
2005-08-30 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
|
US20070077993A1
(en)
|
2005-09-30 |
2007-04-05 |
Midgley Timothy M |
Method and apparatus for collecting user game play data and crediting users in a gaming environment
|
|
EP2341059A1
(en)
|
2005-10-12 |
2011-07-06 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
US9308252B2
(en)
|
2005-10-27 |
2016-04-12 |
Cook Biotech, Inc. |
Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
|
|
WO2007049416A1
(en)
|
2005-10-28 |
2007-05-03 |
Tosoh Corporation |
Method for production of carotenoid-synthesizing microorganism and method for production of carotenoid
|
|
EP2325315B1
(en)
|
2005-10-28 |
2014-05-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
|
JP2009515896A
(en)
|
2005-11-11 |
2009-04-16 |
ファイザー・インク |
Combination therapy using immunomodulatory oligodeoxynucleotides
|
|
WO2007064291A1
(en)
|
2005-11-30 |
2007-06-07 |
Jyoti Chattopadhyaya |
Method and compounds for rna synthesis
|
|
AU2006320374B2
(en)
|
2005-12-02 |
2012-08-30 |
Isis Pharmaceuticals, Inc. |
Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
|
|
US8076303B2
(en)
|
2005-12-13 |
2011-12-13 |
Spring Bank Pharmaceuticals, Inc. |
Nucleotide and oligonucleotide prodrugs
|
|
JP4635089B2
(en)
|
2005-12-21 |
2011-02-16 |
ファイザー・プロダクツ・インク |
Carbonylaminopyrrolopyrazole, an effective kinase inhibitor
|
|
WO2007089611A2
(en)
|
2006-01-26 |
2007-08-09 |
Isis Pharmaceuticals Inc. |
Compositions and their uses directed to huntingtin
|
|
EP1984381B1
(en)
|
2006-01-27 |
2010-09-29 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
PT1991678E
(en)
|
2006-02-15 |
2015-11-25 |
Adiutide Pharmaceuticals Gmbh |
Compositions and methods for oligonucleotide formulations
|
|
JP4713514B2
(en)
|
2006-02-20 |
2011-06-29 |
エフ．ホフマン−ラ ロシュ アーゲー |
Improved labeling reagent
|
|
US8383660B2
(en)
|
2006-03-10 |
2013-02-26 |
Pfizer Inc. |
Dibenzyl amine compounds and derivatives
|
|
CN101454315B
(en)
|
2006-03-31 |
2016-08-17 |
应用生物系统有限责任公司 |
For synthesizing rhodamine bright-reagent of the oligonucleotide of labelling
|
|
WO2007118222A2
(en)
|
2006-04-06 |
2007-10-18 |
Ibis Biosciences, INC |
Compositions for the use in identification of fungi
|
|
CA2649636A1
(en)
|
2006-04-20 |
2007-11-01 |
F. Hoffmann-La Roche Ag |
Diazepan derivatives modulators of chemokine receptors
|
|
CN101432440B
(en)
|
2006-04-24 |
2013-08-21 |
西格马食品可变资本有限公司 |
Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction
|
|
US20100008937A1
(en)
|
2006-04-25 |
2010-01-14 |
Immune Disease Institute, Inc. |
Targeted delivery to leukocytes using non-protein carriers
|
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
|
WO2007131237A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of ptp1b
|
|
US8158598B2
(en)
|
2006-05-05 |
2012-04-17 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to PTPR alpha
|
|
US20090012120A1
(en)
|
2006-05-10 |
2009-01-08 |
Board Of Trustees Of Michigan State University |
Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
ES2389737T3
(en)
|
2006-05-11 |
2012-10-31 |
Isis Pharmaceuticals, Inc. |
5 'modified bicyclic nucleic acid analogs
|
|
CA2653939C
(en)
|
2006-05-31 |
2013-01-22 |
Toray Industries, Inc. |
Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
|
|
US8097596B2
(en)
|
2006-06-30 |
2012-01-17 |
Lakewood-Amedex, Inc. |
Compositions and methods for the treatment of muscle wasting
|
|
EP2046993A4
(en)
|
2006-07-07 |
2010-11-17 |
Univ Massachusetts |
RNA INTERFERENCE COMPOSITIONS AND METHOD FOR TREATING MORBUS HUNTINGTON
|
|
US20090093425A1
(en)
|
2006-07-12 |
2009-04-09 |
The Regents Of The University Of California |
Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
|
|
CA2659155A1
(en)
|
2006-07-20 |
2008-01-24 |
Amgen Inc. |
Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1
|
|
GB0614947D0
(en)
|
2006-07-27 |
2006-09-06 |
Isis Innovation |
Epitope reduction therapy
|
|
EP2057284A4
(en)
|
2006-08-04 |
2011-06-29 |
Isis Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR MODULATION OF JNK PROTEINS
|
|
AT504194B1
(en)
|
2006-09-07 |
2008-07-15 |
Oesterr Rotes Kreuz |
BACTERIA DETECTION
|
|
US8138330B2
(en)
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
|
MX2009003398A
(en)
|
2006-09-27 |
2009-08-12 |
Coley Pharm Gmbh |
Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity.
|
|
EP2410053B2
(en)
|
2006-10-18 |
2020-07-15 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
|
EP2078027A1
(en)
|
2006-10-23 |
2009-07-15 |
Irm Llc |
Cathepsin proteases inhibitors
|
|
JP2010507386A
(en)
|
2006-10-26 |
2010-03-11 |
コーリー ファーマシューティカル ゲーエムベーハー |
Oligoribonucleotides and uses thereof
|
|
FR2908414B1
(en)
|
2006-11-13 |
2012-01-20 |
Centre Nat Rech Scient |
IMMOBILIZATION OF MEMBRANE PROTEINS ON A SUPPORT THROUGH AN AMPHIPHILE MOLECULE
|
|
US8754107B2
(en)
|
2006-11-17 |
2014-06-17 |
Abbvie Inc. |
Aminopyrrolidines as chemokine receptor antagonists
|
|
KR20090103894A
(en)
|
2006-11-27 |
2009-10-01 |
아이시스 파마수티컬즈 인코포레이티드 |
Methods for treating hypercholesterolemia
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
WO2008073959A2
(en)
|
2006-12-12 |
2008-06-19 |
Idera Pharmaceuticals, Inc. |
Synthetic agonists of tlr9
|
|
UY30892A1
(en)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
AKT ACTIVITY INHIBITORS
|
|
EP2125852B1
(en)
|
2007-02-15 |
2016-04-06 |
Ionis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
|
KR20150090284A
(en)
|
2007-03-24 |
2015-08-05 |
젠자임 코포레이션 |
Administering antisense oligonucleotides complementary to human apolipoprotein b
|
|
US7960353B2
(en)
|
2007-05-10 |
2011-06-14 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
|
DK2158316T3
(en)
|
2007-05-11 |
2015-07-20 |
Adynxx Inc |
Gene expression and pain
|
|
EP2149571A4
(en)
|
2007-05-24 |
2010-09-01 |
Kyorin Seiyaku Kk |
MUTILINE DERIVATIVE HAVING CARBOXYLIC ACID STRUCTURE HETEROCYCLIC AROMATIC CORE SUBSTITUTED AT POSITION 14
|
|
GB0710186D0
(en)
|
2007-05-29 |
2007-07-04 |
Texas Instr Denmark |
PWM loop with minimum allasing error property
|
|
US8278425B2
(en)
|
2007-05-30 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
EP2155671B8
(en)
|
2007-06-05 |
2018-02-21 |
Integrative Research Laboratories Sweden AB |
Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
|
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
|
WO2008151833A2
(en)
|
2007-06-13 |
2008-12-18 |
Hochschule Mannheim |
Compounds for the modulation of huntingtin aggregation, methods and means for identifying such compounds
|
|
EP2014769B1
(en)
|
2007-06-18 |
2010-03-31 |
Commissariat à l'Energie Atomique |
Reversible siRNAa-based silencing of mutated and endogenous wild-type huntingtin gene and its application for the treatment of Huntington's disease
|
|
GB0712494D0
(en)
|
2007-06-27 |
2007-08-08 |
Isis Innovation |
Substrate reduction therapy
|
|
US8278283B2
(en)
|
2007-07-05 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
6-disubstituted or unsaturated bicyclic nucleic acid analogs
|
|
CN101795715A
(en)
|
2007-07-09 |
2010-08-04 |
艾德拉药物股份有限公司 |
Stabilized immune modulatory RNA (SIMRA) compounds
|
|
TWI413530B
(en)
|
2007-07-20 |
2013-11-01 |
Kao Corp |
Organopolysiloxane
|
|
CA2694718A1
(en)
|
2007-07-31 |
2009-02-05 |
University Of Saskatchewan |
Genetic variation in pro-melanin-concentrating hormone gene affects carcass traits in cattle
|
|
WO2009017803A2
(en)
|
2007-08-02 |
2009-02-05 |
The Texas A & M University System |
Antisense microrna and uses therefor
|
|
MX2010001785A
(en)
|
2007-08-15 |
2010-03-10 |
Idera Pharmaceuticals Inc |
Toll like receptor modulators.
|
|
US8486904B2
(en)
|
2007-10-01 |
2013-07-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
|
KR100886139B1
(en)
|
2007-11-13 |
2009-02-27 |
주식회사 삼천리제약 |
Method for preparing oligonucleotide
|
|
AR069869A1
(en)
|
2007-12-21 |
2010-02-24 |
Exelixis Inc |
BENZOFIDE DERIVATIVES [3,2-D] PROTEINQUINASE INHIBITING PYRIMIDINS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND USES OF THE SAME IN THE TREATMENT OF CANCER.
|
|
TWI340765B
(en)
|
2007-12-26 |
2011-04-21 |
Ind Tech Res Inst |
Oligonucleotide sequences and dna chip for identifying filamentous microorganisms and the identification method thereof
|
|
US20100309376A1
(en)
|
2008-01-15 |
2010-12-09 |
Yungchun Lei |
Multimedia Presenting System, Multimedia Processing Apparatus Thereof, and Method for Presenting Video and Audio Signals
|
|
WO2009089659A1
(en)
|
2008-01-18 |
2009-07-23 |
Shanghai Targetdrug Co., Ltd. |
Pyrollidine-based compounds
|
|
EP2240768A1
(en)
|
2008-02-04 |
2010-10-20 |
Galapagos N.V. |
Target sequences and methods to identify the same, useful in treatment of neurodegenerative diseases
|
|
JP2009190983A
(en)
|
2008-02-12 |
2009-08-27 |
Tokyo Institute Of Technology |
Oligonucleotide derivatives
|
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
WO2009142822A2
(en)
|
2008-03-26 |
2009-11-26 |
Alnylam Pharmaceuticals, Inc. |
2-f modified rna interference agents
|
|
KR101927905B1
(en)
|
2008-04-03 |
2018-12-11 |
스프링 뱅크 파마슈티칼스, 인크. |
Compositions and methods for treating viral infections
|
|
WO2009124238A1
(en)
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
US8350022B2
(en)
|
2008-04-04 |
2013-01-08 |
Universitaet Hamburg |
Method for the stereoselective synthesis of phosphorus compounds
|
|
US8679750B2
(en)
|
2008-05-09 |
2014-03-25 |
The University Of British Columbia |
Methods and compositions for the treatment of Huntington'S disease
|
|
CA2726866A1
(en)
|
2008-05-09 |
2009-11-12 |
The University Of British Columbia |
Methods and compositions for the treatment of huntington's disease
|
|
WO2009143391A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc |
Methods for modulation expression of creb
|
|
EP2291200A4
(en)
|
2008-05-22 |
2012-05-30 |
Isis Pharmaceuticals Inc |
METHODS OF MODULATING EXPRESSION OF RBP4
|
|
US8541387B2
(en)
|
2008-05-22 |
2013-09-24 |
Isis Pharmaceuticals, Inc. |
Modulation of SMRT expression
|
|
WO2009148605A2
(en)
|
2008-06-04 |
2009-12-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
JP2011526931A
(en)
|
2008-07-03 |
2011-10-20 |
エグゼリクシス， インコーポレイテッド |
CDK modulator
|
|
US8410070B2
(en)
|
2008-09-12 |
2013-04-02 |
University Of Louisville Research Foundation, Inc. |
Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
|
|
US8163707B2
(en)
|
2008-09-15 |
2012-04-24 |
Enanta Pharmaceuticals, Inc. |
4′-allene-substituted nucleoside derivatives
|
|
US8691971B2
(en)
|
2008-09-23 |
2014-04-08 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
EP2361256B1
(en)
|
2008-09-24 |
2013-04-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acid analogs
|
|
AU2009302385B2
(en)
|
2008-10-07 |
2015-12-03 |
President And Fellows Of Harvard College |
Telomerase inhibitors and methods of use thereof
|
|
WO2010048352A2
(en)
|
2008-10-22 |
2010-04-29 |
Quark Pharmaceuticals, Inc. |
Methods for treating eye disorders
|
|
CN102264374B
(en)
|
2008-10-24 |
2015-01-07 |
Isis制药公司 |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
KR101881596B1
(en)
|
2008-12-02 |
2018-07-24 |
웨이브 라이프 사이언시스 재팬 인코포레이티드 |
Method for the synthesis of phosphorous atom modified nucleic acids
|
|
EP2382227A1
(en)
|
2008-12-23 |
2011-11-02 |
Girindus America, Inc. |
Sulfurizing reagents and their use for oligonucleotides synthesis
|
|
WO2010080953A1
(en)
|
2009-01-08 |
2010-07-15 |
Isis Pharmaceuticals, Inc. |
Transgenic murine model of human lipoprotein metabolism, hypercholesterolemia and cardiovascular disease
|
|
KR20100087540A
(en)
|
2009-01-28 |
2010-08-05 |
삼성전자주식회사 |
Ink composition for inkjet recording
|
|
WO2010091301A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and excipients
|
|
US8202974B2
(en)
|
2009-02-10 |
2012-06-19 |
Idera Pharmaceuticals, Inc. |
Synthetic RNA-based agonists of TLR7
|
|
JP5766617B2
(en)
|
2009-02-20 |
2015-08-19 |
ユニバーシティ・オブ・カンザス |
Novobiocin analogs having modified sugar moieties
|
|
EP3424939A1
(en)
|
2009-03-02 |
2019-01-09 |
Alnylam Pharmaceuticals Inc. |
Nucleic acid chemical modifications
|
|
WO2010107838A1
(en)
|
2009-03-16 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Targeting apolipoprotein b for the reduction of apolipoprotein c-iii
|
|
US8653254B2
(en)
|
2009-03-31 |
2014-02-18 |
Takeda Pharmaceutical Company Limited |
Process for producing nucleoside
|
|
US8987222B2
(en)
|
2009-04-08 |
2015-03-24 |
University Of Massachusetts |
Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease
|
|
US20120156138A1
(en)
|
2009-04-14 |
2012-06-21 |
Smith Larry J |
Methods and Compositions for the Treatment of Medical Conditions Involving Cellular Reprogramming
|
|
WO2010129853A2
(en)
|
2009-05-07 |
2010-11-11 |
The Regents Of The University Of California |
TRANSDUCIBLE DELIVERY OF NUCLEIC ACIDS USING MODIFIED dsRNA BINDING DOMAINS
|
|
US20120142763A1
(en)
|
2009-06-01 |
2012-06-07 |
The Regents Of The University Of California |
Nucleic acid delivery compositions and methods of use thereof
|
|
PT2437753T
(en)
|
2009-06-05 |
2016-11-23 |
Infectious Disease Res Inst |
Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them
|
|
KR20120093138A
(en)
|
2009-06-17 |
2012-08-22 |
콜드스프링하버러보러토리 |
Composition and methods for modulating of smn2 splicing in a subject
|
|
JP5670097B2
(en)
|
2009-06-19 |
2015-02-18 |
花王株式会社 |
Two-layer separated hair cosmetic
|
|
EP2447273A4
(en)
|
2009-06-23 |
2013-06-19 |
Takeda Pharmaceutical |
METHOD OF SYNTHESIZING A NUCLEIC ACID
|
|
WO2011005764A1
(en)
|
2009-07-06 |
2011-01-13 |
Ada Technologies, Inc. |
Electrochemical device and method for long-term measurement of hypohalites
|
|
RU2612521C2
(en)
|
2009-07-06 |
2017-03-09 |
Онтории, Инк. |
Novel prodrugs of nucleic acids and their application methods
|
|
WO2011005860A2
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
5' phosphate mimics
|
|
WO2011005942A2
(en)
|
2009-07-08 |
2011-01-13 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
EP2458005A1
(en)
|
2009-07-23 |
2012-05-30 |
Galaxy Pharma Inc. |
Fgf21 cis-element binding substance
|
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
UA107360C2
(en)
|
2009-08-05 |
2014-12-25 |
Biogen Idec Inc |
Bicyclic aryl sphingosine 1-phosphate analogs
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US8927553B2
(en)
|
2009-08-10 |
2015-01-06 |
Daljit Singh Dhanoa |
Deuterium-enriched alkyl sulfonamides and uses thereof
|
|
EP3626823A1
(en)
|
2009-09-11 |
2020-03-25 |
Ionis Pharmaceuticals, Inc. |
Modulation of huntingtin expression
|
|
ES2586683T3
(en)
|
2009-09-16 |
2016-10-18 |
Wave Life Sciences Japan, Inc. |
Novel protective group to synthesize RNA and derivatives thereof
|
|
US20120270929A1
(en)
|
2009-09-25 |
2012-10-25 |
Isis Pharmaceuticals, Inc. |
Modulation of ttc39 expression to increase hdl
|
|
CA2776028C
(en)
|
2009-10-15 |
2015-12-01 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
TWI475051B
(en)
|
2009-11-18 |
2015-03-01 |
Kao Corp |
Organic polysiloxane
|
|
JP5809408B2
(en)
|
2009-11-25 |
2015-11-10 |
花王株式会社 |
Hair cosmetics
|
|
WO2011075560A1
(en)
|
2009-12-17 |
2011-06-23 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
|
BR112012016912A2
(en)
|
2009-12-28 |
2016-04-05 |
Achira Labs Pvt Ltd |
diagnostic gel composition, method for preparing a diagnostic gel composition
|
|
ES2677969T3
(en)
|
2010-01-08 |
2018-08-07 |
Ionis Pharmaceuticals, Inc. |
Modulation of angiopoietin 3 expression
|
|
US8750507B2
(en)
|
2010-01-25 |
2014-06-10 |
Cisco Technology, Inc. |
Dynamic group creation for managed key servers
|
|
EP3321361B1
(en)
|
2010-02-08 |
2019-03-27 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
EP3208347B1
(en)
|
2010-02-08 |
2019-08-14 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
CA2786973C
(en)
|
2010-02-10 |
2018-04-10 |
Robert Hermann Gibbon |
6-amino-2-{[(1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate
|
|
US8859755B2
(en)
|
2010-03-05 |
2014-10-14 |
Chiralgen, Ltd. |
Method for preparing ribonucleoside phosphorothioate
|
|
WO2011127175A1
(en)
|
2010-04-06 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cd130 (gp130) expression
|
|
JP2013527148A
(en)
|
2010-04-07 |
2013-06-27 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
Regulation of CETP expression
|
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
|
JP6005628B2
(en)
|
2010-04-28 |
2016-10-12 |
アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
Modified nucleosides, analogs thereof, and oligomeric compounds prepared therefrom
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
WO2011135396A1
(en)
|
2010-04-30 |
2011-11-03 |
Cellectis |
Method for modulating double-strand break-induced homologous recombination
|
|
GB201008902D0
(en)
|
2010-05-27 |
2010-07-14 |
Imp Innovations Ltd |
Membrane enhanced polymer sythesis
|
|
KR20130100278A
(en)
|
2010-08-31 |
2013-09-10 |
머크 샤프 앤드 돔 코포레이션 |
Novel single chemical entities and methods for delivery of oligonucleotides
|
|
JP5868324B2
(en)
|
2010-09-24 |
2016-02-24 |
株式会社Wave Life Sciences Japan |
Asymmetric auxiliary group
|
|
EP2623600A4
(en)
|
2010-09-30 |
2014-11-26 |
Lsip Llc |
Inhibitor of expression of dominantly mutated gene
|
|
KR101381048B1
(en)
|
2010-10-20 |
2014-04-14 |
씨제이제일제당 (주) |
Process for producing L-cysteine or derivatives thereof from O-phosphoseline producing strains and O-phosphoseline produced therefrom
|
|
EP2632472B1
(en)
|
2010-10-29 |
2017-12-13 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
|
|
EP2638163B1
(en)
|
2010-11-12 |
2017-05-17 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
WO2012073857A1
(en)
|
2010-11-30 |
2012-06-07 |
株式会社キラルジェン |
2'-o-modified rna
|
|
WO2012092367A1
(en)
|
2010-12-28 |
2012-07-05 |
University Of Rochester |
Nucleic acid binding compounds, methods of making, and use thereof
|
|
WO2012109395A1
(en)
|
2011-02-08 |
2012-08-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
EP2673286B1
(en)
|
2011-02-12 |
2019-07-03 |
University of Iowa Research Foundation |
Therapeutic compounds
|
|
US9353371B2
(en)
|
2011-05-02 |
2016-05-31 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
|
FR2975600B1
(en)
|
2011-05-24 |
2013-07-05 |
Assist Publ Hopitaux De Paris |
AGENTS FOR THE TREATMENT OF TUMORS
|
|
RU2014106024A
(en)
|
2011-07-19 |
2015-08-27 |
Юниверсити Оф Айдахо |
OPTIONS FOR IMPLEMENTING THE PROBE AND METHODS OF DIRECTED ACTION FOR NUCLEIC ACIDS
|
|
BR112014001244A2
(en)
|
2011-07-19 |
2017-02-21 |
Wave Life Sciences Pte Ltd |
methods for the synthesis of functionalized nucleic acids
|
|
EP3205725B1
(en)
|
2011-08-11 |
2019-03-27 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
US9282242B2
(en)
|
2011-08-24 |
2016-03-08 |
Htc Corporation |
Method and electric device for taking panoramic photograph
|
|
US9976138B2
(en)
|
2011-08-29 |
2018-05-22 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
US20140080896A1
(en)
|
2011-08-30 |
2014-03-20 |
The Regents Of The University Of California |
Identification of small molecules that facilitate therapeutic exon skipping
|
|
EP3202914B2
(en)
|
2011-08-31 |
2023-06-28 |
The University of Manchester |
Method for treating a neurodegenerative disease
|
|
US20140255936A1
(en)
|
2011-09-09 |
2014-09-11 |
Mayo Foundation For Medical Education And Research |
Detecting frontotemporal dementia and amyotrophic lateral sclerosis
|
|
WO2013082548A1
(en)
|
2011-11-30 |
2013-06-06 |
Sarepta Therapeutics, Inc. |
Oligonucleotides for treating expanded repeat diseases
|
|
CA2895077A1
(en)
|
2011-12-12 |
2013-06-20 |
Beverly Packard |
In vivo delivery of oligonucleotides
|
|
CN102675386B
(en)
|
2011-12-24 |
2014-07-02 |
河南科技大学 |
Method for separating and purifying gentiamarin
|
|
US8957042B2
(en)
|
2012-03-07 |
2015-02-17 |
The Texas A&M University System |
Cancer treatment targeting non-coding RNA overexpression
|
|
KR102068856B1
(en)
|
2012-03-13 |
2020-01-21 |
길리애드 사이언시즈, 인코포레이티드 |
2'- substituted carba-nucleoside analogs for antiviral treatment
|
|
KR20130114435A
(en)
|
2012-04-09 |
2013-10-17 |
삼성전자주식회사 |
Biomolecule detection apparatus including a plurality of electrode
|
|
EP2841578B1
(en)
|
2012-04-23 |
2017-06-07 |
BioMarin Technologies B.V. |
RNA modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders
|
|
BR112014029115A8
(en)
|
2012-05-22 |
2018-04-03 |
Idenix Pharmaceuticals Inc |
COMPOUND, PHARMACEUTICAL COMPOSITION, AND, USE OF A COMPOUND OR COMPOSITION
|
|
SG11201407967TA
(en)
|
2012-05-30 |
2015-01-29 |
Hokkaido System Science Co Ltd |
Oligonucleotide synthesis method using highly dispersible liquid-phase support
|
|
CN112007045A
(en)
|
2012-07-13 |
2020-12-01 |
波涛生命科学有限公司 |
Chiral control
|
|
BR112015000723A2
(en)
|
2012-07-13 |
2017-06-27 |
Shin Nippon Biomedical Laboratories Ltd |
chiral nucleic acid adjuvant
|
|
ES2862073T3
(en)
|
2012-07-13 |
2021-10-06 |
Wave Life Sciences Ltd |
Asymmetric auxiliary group
|
|
EP4253395A3
(en)
|
2012-08-06 |
2023-11-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for the preparation of carbohydrate conjugated rna agents
|
|
WO2014028739A1
(en)
|
2012-08-15 |
2014-02-20 |
Isis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
|
US20150275208A1
(en)
|
2012-10-12 |
2015-10-01 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
EP2906696B2
(en)
|
2012-10-15 |
2022-12-14 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating c9orf72 expression
|
|
EP2906697A4
(en)
|
2012-10-15 |
2016-06-22 |
Ionis Pharmaceuticals Inc |
METHODS OF MONITORING C9ORF72 EXPRESSION
|
|
RU2730677C2
(en)
|
2012-10-15 |
2020-08-24 |
Ионис Фармасьютикалз, Инк. |
Compound for modulation of c9orf72 gene expression and use thereof
|
|
EP2725029A1
(en)
|
2012-10-29 |
2014-04-30 |
Laboratoire Biodim |
New antibacterial compounds and biological applications thereof
|
|
BR112015009636A8
(en)
|
2012-10-29 |
2018-04-17 |
Cocrystal Pharma Inc |
compound, methods for treating an infected host, methods for preventing an infection, methods for reducing the biological activity of an infection, and using a compound
|
|
EP2915815B1
(en)
|
2012-10-31 |
2018-01-17 |
Takeda Pharmaceutical Company Limited |
New modified nucleic acid
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
WO2014080004A1
(en)
|
2012-11-26 |
2014-05-30 |
Santaris Pharma A/S |
Compositions and methods for modulation of fgfr3 expression
|
|
WO2014099941A1
(en)
|
2012-12-19 |
2014-06-26 |
Idenix Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
|
MX2015009056A
(en)
|
2013-01-30 |
2015-10-05 |
Hoffmann La Roche |
Lna oligonucleotide carbohydrate conjugates.
|
|
EP3778618A1
(en)
|
2013-02-04 |
2021-02-17 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
CA2900238A1
(en)
|
2013-02-22 |
2014-08-28 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) molecules containing a 2' internucleoside linkage
|
|
CN105120667A
(en)
|
2013-03-28 |
2015-12-02 |
先正达参股股份有限公司 |
Methods of controlling neonicotinoid resistant pests
|
|
CN105072911A
(en)
|
2013-03-28 |
2015-11-18 |
先正达参股股份有限公司 |
Methods of controlling neonicotinoid resistant pests
|
|
BR112015027322A8
(en)
|
2013-05-01 |
2018-01-02 |
Isis Pharmaceuticals Inc |
CONJUGATED ANTI-SENSE COMPOUNDS AND THEIR USE
|
|
JP2016520310A
(en)
|
2013-05-24 |
2016-07-14 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ |
Oligonucleotide modulator of B cell CLL / lymphoma 11A (BCL11A) and use thereof
|
|
JP6477464B2
(en)
|
2013-05-24 |
2019-03-06 |
味の素株式会社 |
Method for producing morpholino oligonucleotide
|
|
US20160122761A1
(en)
|
2013-06-21 |
2016-05-05 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
|
MX391977B
(en)
|
2013-06-27 |
2025-03-21 |
Roche Innovation Ct Copenhagen As |
Antisense oligomers and conjugates targeting pcsk9
|
|
TWI772856B
(en)
|
2013-07-19 |
2022-08-01 |
美商百健Ｍａ公司 |
Compositions for modulating tau expression
|
|
ES2750608T3
(en)
|
2013-07-25 |
2020-03-26 |
Exicure Inc |
Nucleic acid-based spherical constructs as immunostimulatory agents for prophylactic and therapeutic use
|
|
US10435430B2
(en)
|
2013-07-31 |
2019-10-08 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
JP2016534127A
(en)
|
2013-09-06 |
2016-11-04 |
シンジェンタ パーティシペーションズ アーゲー |
Insecticidal compounds
|
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
US10323076B2
(en)
|
2013-10-03 |
2019-06-18 |
Modernatx, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
WO2015051366A2
(en)
|
2013-10-04 |
2015-04-09 |
Novartis Ag |
Novel formats for organic compounds for use in rna interference
|
|
BR112016007751A2
(en)
|
2013-10-11 |
2017-09-12 |
Ionis Pharmaceuticals Inc |
c9orf72 expression modulation compositions
|
|
WO2015057727A1
(en)
|
2013-10-14 |
2015-04-23 |
Isis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2015057738A1
(en)
|
2013-10-14 |
2015-04-23 |
Isis Pharmaceuticals, Inc. |
Methods for modulating expression of c9orf72 antisense transcript
|
|
EP3068905A4
(en)
|
2013-11-11 |
2017-07-05 |
Sangamo BioSciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
KR20160083876A
(en)
|
2013-11-14 |
2016-07-12 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
Apob antisense conjugate compounds
|
|
EP2918275B1
(en)
|
2013-12-13 |
2016-05-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
EP3095460A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
|
CN113278617A
(en)
|
2014-01-16 |
2021-08-20 |
波涛生命科学有限公司 |
Chiral design
|
|
JP6756700B2
(en)
|
2014-03-18 |
2020-09-16 |
ユニバーシティ オブ マサチューセッツ |
RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
|
|
US9926556B2
(en)
|
2014-04-28 |
2018-03-27 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
EP3845547A1
(en)
|
2014-05-01 |
2021-07-07 |
Ionis Pharmaceuticals, Inc. |
Galnac3 conjugated modified oligonucleotide for modulating angiopoietin-like 3 expression
|
|
AU2015255877B2
(en)
|
2014-05-08 |
2020-03-26 |
Chdi Foundation, Inc. |
Methods and compositions for treating huntington's disease
|
|
RU2711147C2
(en)
|
2014-05-20 |
2020-01-15 |
Юниверсити Оф Айова Рисерч Фаундейшн |
Therapeutic compounds for treating huntington's disease
|
|
US20160017327A1
(en)
|
2014-07-11 |
2016-01-21 |
The Johns Hopkins University |
Phosphorodiamidate morpholino oligomers (pmos) and their use in suppression of mutant huntingtin expression and attenuation of neurotoxicity
|
|
WO2016011226A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
|
ES2799409T3
(en)
|
2014-08-07 |
2020-12-17 |
Takeda Pharmaceuticals Co |
Cationic lipid
|
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
|
WO2016037191A1
(en)
|
2014-09-05 |
2016-03-10 |
Health Research, Inc. |
Use of huntingtin-derived plasmids and peptides for active immunization as a huntington's disease (hd) therapeutic
|
|
JP2017536366A
(en)
|
2014-11-19 |
2017-12-07 |
ロシュ イノベーション センター コペンハーゲン エーエス |
LNA chiral phosphorothioate
|
|
US10815481B2
(en)
|
2014-12-16 |
2020-10-27 |
Roche Innovation Center Copenhagen A/S |
Chiral library screen
|
|
EA037696B1
(en)
|
2014-12-24 |
2021-05-12 |
ЮНИКЕР АйПи Б.В. |
Rna interference induced huntingtin gene suppression
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
CN115181778A
(en)
|
2015-02-04 |
2022-10-14 |
百时美施贵宝公司 |
Method for selecting therapeutic molecules
|
|
WO2016127002A1
(en)
|
2015-02-04 |
2016-08-11 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
|
MA40819B1
(en)
|
2015-02-10 |
2020-04-30 |
Genzyme Corp |
Variant of arni
|
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
EP3262174A4
(en)
|
2015-02-23 |
2018-10-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing antisense activity
|
|
US20180036335A1
(en)
|
2015-03-03 |
2018-02-08 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
|
WO2016145142A1
(en)
|
2015-03-10 |
2016-09-15 |
Emory University |
Nucleotide and nucleoside therapeutics compositions and uses related thereto
|
|
WO2016154096A1
(en)
|
2015-03-20 |
2016-09-29 |
Ionis Pharmaceuticals, Inc. |
Modulation of smggds expression
|
|
PL3277814T3
(en)
|
2015-04-03 |
2020-11-30 |
University Of Massachusetts |
Oligonucleotide compounds for targeting huntingtin mrna
|
|
WO2016164896A2
(en)
|
2015-04-10 |
2016-10-13 |
Ionis Pharmaceuticals, Inc. |
Modulation of smn expression
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
MX366128B
(en)
|
2015-04-16 |
2019-06-28 |
Ionis Pharmaceuticals Inc |
Compositions for modulating c9orf72 expression.
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
EP3313989B1
(en)
|
2015-06-29 |
2024-12-25 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
ES2917181T3
(en)
|
2015-07-10 |
2022-07-07 |
Ionis Pharmaceuticals Inc |
Diacylglycerol acyltransferase 2 (DGAT2) modulators
|
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
|
WO2017015109A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
MA43072A
(en)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES
|
|
WO2017019660A1
(en)
|
2015-07-27 |
2017-02-02 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
|
|
DK3329002T3
(en)
|
2015-07-31 |
2021-01-11 |
Alnylam Pharmaceuticals Inc |
TRANSTHYRETIN (TTR) IRNA COMPOSITIONS AND METHODS FOR USING IT FOR THE TREATMENT OR PREVENTION OF TTR-ASSOCIATED DISEASES
|
|
WO2017032726A1
(en)
|
2015-08-24 |
2017-03-02 |
Roche Innovation Center Copenhagen A/S |
Lna-g process
|
|
KR102793532B1
(en)
|
2015-08-25 |
2025-04-14 |
알닐람 파마슈티칼스 인코포레이티드 |
Methods and compositions for treating proprotein convertase subtilisin kexin (PCSK9) gene-related disorders
|
|
EA201890619A1
(en)
|
2015-09-02 |
2018-09-28 |
Элнилэм Фармасьютикалз, Инк. |
COMPOSITIONS of iRNA LIGANDA 1 PROTEIN PROGRAMMED DESTRUCTION OF CELLS 1 (PD-L1) AND METHODS OF THEIR APPLICATION
|
|
US20180273573A1
(en)
|
2015-10-01 |
2018-09-27 |
Memorial Sloan-Kettering Cancer Center |
Inhibitors of menaquinone biosynthesis
|
|
US10874686B2
(en)
|
2015-10-01 |
2020-12-29 |
Memorial Sloan-Kettering Cancer Center |
Anthranilyl-adenosinemonosulfamate analogs and uses thereof
|
|
KR20180073584A
(en)
|
2015-10-02 |
2018-07-02 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
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|
|
NZ781029A
(en)
|
2015-10-09 |
2025-07-25 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|
|
EP3183347A4
(en)
|
2015-10-17 |
2018-04-18 |
Lifesplice Pharma LLC |
Splice modulating oligonucleotides and methods of use thereof
|
|
US10955407B2
(en)
|
2015-10-22 |
2021-03-23 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
|
US11260073B2
(en)
|
2015-11-02 |
2022-03-01 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating C90RF72
|
|
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(en)
|
2015-11-12 |
2024-09-30 |
F. Hoffmann-La Roche Ag |
OLIGONUCLEOTIDES TO INDUCE EXPRESSION OF PATERNAL UBE3A
|
|
US11407775B2
(en)
|
2016-03-13 |
2022-08-09 |
Wave Life Sciences Ltd. |
Compositions and methods for phosphoramidite and oligonucleotide synthesis
|
|
HRP20210315T1
(en)
|
2016-03-14 |
2021-04-16 |
F. Hoffmann - La Roche Ag |
Oligonucleotides for reduction of pd-l1 expression
|
|
EP3430021A1
(en)
|
2016-03-18 |
2019-01-23 |
Roche Innovation Center Copenhagen A/S |
Acyl-protected l-lna-guanosine monomers
|
|
US11963972B2
(en)
|
2016-03-23 |
2024-04-23 |
Emory University |
Antiviral agents and nucleoside analogs for treatment of Zika virus
|
|
AU2017248637A1
(en)
|
2016-04-13 |
2018-09-27 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing C9ORF72 expression
|
|
EP3442983A1
(en)
|
2016-04-14 |
2019-02-20 |
H. Hoffnabb-La Roche Ag |
TRITYL-MONO-Ga1NAc COMPOUNDS AND THEIR USE
|
|
MA45290A
(en)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
PROCESSES AND COMPOSITIONS OF BIOLOGICALLY ACTIVE AGENTS
|
|
MA45270A
(en)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES
|
|
WO2017194498A1
(en)
|
2016-05-12 |
2017-11-16 |
Roche Innovation Center Copenhagen A/S |
Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide
|
|
CA3023621C
(en)
|
2016-05-13 |
2021-07-27 |
F. Hoffmann-La Roche Ag |
Protein-based sample collection matrices and devices
|
|
EP3458464A1
(en)
|
2016-05-18 |
2019-03-27 |
ETH Zurich |
Stereoselective synthesis of phosphorothioate oligoribonucleotides
|
|
MA45188A
(en)
|
2016-06-03 |
2019-04-10 |
Wave Life Sciences Ltd |
OLIGONUCLEOTIDES, ASSOCIATED COMPOSITIONS AND METHODS
|
|
WO2017221883A1
(en)
|
2016-06-20 |
2017-12-28 |
武田薬品工業株式会社 |
Antibody-drug conjugate
|
|
US20190264267A1
(en)
|
2016-07-25 |
2019-08-29 |
Wave Life Sciences Ltd. |
Phasing
|
|
MA46905A
(en)
|
2016-11-23 |
2019-10-02 |
Wave Life Sciences Ltd |
COMPOSITIONS AND SYNTHESIS OF PHOSPHORAMIDITES AND OLIGONUCLEOTIDES
|
|
JP7557941B2
(en)
|
2017-06-02 |
2024-09-30 |
ウェイブ ライフ サイエンシズ リミテッド |
Oligonucleotide compositions and methods of use thereof
|
|
WO2018223056A1
(en)
|
2017-06-02 |
2018-12-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
JP2020522265A
(en)
|
2017-06-02 |
2020-07-30 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
Oligonucleotide composition and method of using the same
|
|
WO2018237194A1
(en)
|
2017-06-21 |
2018-12-27 |
Wave Life Sciences Ltd. |
COMPOUNDS, COMPOSITIONS AND METHODS OF SYNTHESIS
|
|
CN110996968A
(en)
|
2017-08-08 |
2020-04-10 |
波涛生命科学有限公司 |
Oligonucleotide compositions and methods thereof
|
|
KR20200052369A
(en)
|
2017-09-18 |
2020-05-14 |
웨이브 라이프 사이언시스 리미티드 |
Oligonucleotide production technology
|
|
WO2019075357A1
(en)
|
2017-10-12 |
2019-04-18 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
CA3096667A1
(en)
|
2018-04-12 |
2019-10-17 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
AU2019265904A1
(en)
|
2018-05-11 |
2020-11-12 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
AU2019392928A1
(en)
|
2018-12-06 |
2021-06-17 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
CA3126845A1
(en)
|
2019-02-01 |
2020-08-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
CN113748116A
(en)
|
2019-03-20 |
2021-12-03 |
波涛生命科学有限公司 |
Techniques useful for oligonucleotide preparation
|
|
US20220307019A1
(en)
|
2019-03-25 |
2022-09-29 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded nucleic acid complex and use thereof
|
|
AU2020261434A1
(en)
|
2019-04-25 |
2021-11-11 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
MX2021012981A
(en)
|
2019-04-25 |
2022-01-18 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods of use thereof.
|
|
CN114502177A
(en)
|
2019-05-09 |
2022-05-13 |
波涛生命科学有限公司 |
Oligonucleotide compositions and methods of use thereof
|
|
AU2020363391A1
(en)
|
2019-10-06 |
2022-03-24 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
WO2021071788A2
(en)
|
2019-10-06 |
2021-04-15 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
TW202146650A
(en)
|
2020-03-01 |
2021-12-16 |
新加坡商波濤生命科學有限公司 |
Oligonucleotide compositions and methods thereof
|
|
JP2023526975A
(en)
|
2020-05-22 |
2023-06-26 |
ウェイブ ライフ サイエンシズ リミテッド |
Oligonucleotide composition and method
|
|
JP2023526533A
(en)
|
2020-05-22 |
2023-06-21 |
ウェイブ ライフ サイエンシズ リミテッド |
Double-stranded oligonucleotide compositions and related methods
|
|
EP4200616A1
(en)
|
2020-08-24 |
2023-06-28 |
Wave Life Sciences Ltd. |
Immunoassays for detecting wild type huntingtin protein and methods of treatment employing such immunoassays
|
|
WO2022046667A1
(en)
|
2020-08-24 |
2022-03-03 |
Wave Life Sciences Ltd. |
Cells and non-human animals engineered to express adar1 and uses thereof
|
|
EP4217363A4
(en)
|
2020-09-24 |
2024-09-25 |
Mayo Foundation for Medical Education and Research |
SCREENING PLATFORMS
|
|
CN116507724A
(en)
|
2020-11-08 |
2023-07-28 |
波涛生命科学有限公司 |
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|
|
MX2023005326A
(en)
|
2020-11-08 |
2023-07-31 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof.
|
|
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(en)
|
2021-09-26 |
2025-12-03 |
Wave Life Sciences Ltd |
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|
|
EP4404942A2
(en)
|
2021-09-26 |
2024-07-31 |
Wave Life Sciences Ltd. |
Compositions for editing mecp2 transcripts and methods thereof
|
|
CA3236136A1
(en)
|
2021-10-27 |
2023-05-04 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
WO2023076352A2
(en)
|
2021-10-27 |
2023-05-04 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
US20250154190A1
(en)
|
2022-02-11 |
2025-05-15 |
Wave Life Sciences Ltd. |
Stereoselective technologies for chiral compounds
|
|
IL315089A
(en)
|
2022-03-02 |
2024-10-01 |
Wave Life Sciences Ltd |
Compositions of oligonucleotides and their methods for exon skipping
|
|
WO2023201095A2
(en)
|
2022-04-15 |
2023-10-19 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods relating thereto
|
|
JP2025516659A
(en)
|
2022-05-12 |
2025-05-30 |
ウェイブ ライフ サイエンシズ リミテッド |
Oligonucleotide compositions and methods thereof
|
|
IL318761A
(en)
|
2022-08-11 |
2025-04-01 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|