AR090906A1 - Conjugados que contienen tetragalnac y procedimientos para la administracion de oligonucleotidos - Google Patents
Conjugados que contienen tetragalnac y procedimientos para la administracion de oligonucleotidosInfo
- Publication number
- AR090906A1 AR090906A1 ARP130101481A ARP130101481A AR090906A1 AR 090906 A1 AR090906 A1 AR 090906A1 AR P130101481 A ARP130101481 A AR P130101481A AR P130101481 A ARP130101481 A AR P130101481A AR 090906 A1 AR090906 A1 AR 090906A1
- Authority
- AR
- Argentina
- Prior art keywords
- tetragalnac
- oligonucleotides
- administration
- procedures
- conjugates containing
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
En el presente documento se desvela una composición modular que comprende I) un oligonucleótido; II) uno o más ligandos de tetraGalNAc de fórmula (1), que pueden ser iguales o diferentes; opcionalmente, III) uno o más ligadores, que pueden ser iguales o diferentes; y opcionalmente IV) uno o más ligandos que eligen diana, agentes solubilizantes, agentes potenciadores de la farmacocinética, lípidos y/o agentes de enmascaramiento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261641761P | 2012-05-02 | 2012-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR090906A1 true AR090906A1 (es) | 2014-12-17 |
Family
ID=49514844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130101481A AR090906A1 (es) | 2012-05-02 | 2013-04-30 | Conjugados que contienen tetragalnac y procedimientos para la administracion de oligonucleotidos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9540639B2 (es) |
| EP (1) | EP2844663B1 (es) |
| JP (2) | JP6239592B2 (es) |
| AR (1) | AR090906A1 (es) |
| AU (1) | AU2013256400B2 (es) |
| CA (1) | CA2872100A1 (es) |
| HK (1) | HK1208227A1 (es) |
| TW (2) | TW201808342A (es) |
| WO (1) | WO2013166121A1 (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2751270B1 (en) | 2011-08-29 | 2018-08-22 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| AR090905A1 (es) * | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
| BR112015027322A8 (pt) | 2013-05-01 | 2018-01-02 | Isis Pharmaceuticals Inc | Compostos antissenso conjugados e sua utilização |
| EP4039278A1 (en) | 2013-07-11 | 2022-08-10 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| EP3065758B1 (en) * | 2013-11-06 | 2019-09-25 | Merck Sharp & Dohme Corp. | Peptide containing conjugates for dual molecular delivery of oligonucleotides |
| EP3065783A4 (en) * | 2013-11-06 | 2017-06-21 | Merck Sharp & Dohme Corp. | Dual molecular delivery of oligonucleotides and peptide containing conjugates |
| JP6466637B2 (ja) * | 2013-11-28 | 2019-02-06 | ソマール株式会社 | 糖鎖含有ポリマー、および、糖鎖含有ポリマー複合体 |
| US9926556B2 (en) | 2014-04-28 | 2018-03-27 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds |
| BR122020024446B8 (pt) | 2014-05-01 | 2022-06-28 | Ionis Pharmaceuticals Inc | Compostos para modulação da expressão do receptor do hormônio de crescimento |
| EP3845547A1 (en) | 2014-05-01 | 2021-07-07 | Ionis Pharmaceuticals, Inc. | Galnac3 conjugated modified oligonucleotide for modulating angiopoietin-like 3 expression |
| HUE052709T2 (hu) | 2014-05-01 | 2021-05-28 | Ionis Pharmaceuticals Inc | Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására |
| MX380866B (es) * | 2014-05-01 | 2025-03-12 | Ionis Pharmaceuticals Inc | Composiciones y métodos para modular la expresión del factor b del complemento. |
| US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US10436802B2 (en) | 2014-09-12 | 2019-10-08 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
| US10351854B2 (en) | 2014-10-10 | 2019-07-16 | Dicerna Pharmaceuticals, Inc. | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| ES2917181T3 (es) | 2015-07-10 | 2022-07-07 | Ionis Pharmaceuticals Inc | Moduladores de diacilglicerol aciltransferasa 2 (DGAT2) |
| EP3353328A4 (en) | 2015-09-24 | 2019-06-12 | Ionis Pharmaceuticals, Inc. | MODULATORS OF KRAS EXPRESSION |
| PT4119569T (pt) | 2015-11-06 | 2024-10-23 | Ionis Pharmaceuticals Inc | Compostos antissentido conjugados para utilização em terapia |
| CN113952353A (zh) | 2015-11-06 | 2022-01-21 | Ionis制药公司 | 调节载脂蛋白(a)表达 |
| EP3409780B1 (en) | 2016-01-29 | 2021-01-20 | Kyowa Kirin Co., Ltd. | Nucleic acid complex |
| CN113797348A (zh) | 2016-03-07 | 2021-12-17 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
| AU2017296195A1 (en) | 2016-07-11 | 2019-01-24 | Translate Bio Ma, Inc. | Nucleic acid conjugates and uses thereof |
| PE20190513A1 (es) | 2016-07-15 | 2019-04-10 | Ionis Pharmaceuticals Inc | Compuestos y metodos para la modulacion de smn2 |
| US10294474B2 (en) | 2016-09-02 | 2019-05-21 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands |
| CN109661233A (zh) | 2016-10-06 | 2019-04-19 | Ionis 制药公司 | 缀合低聚化合物的方法 |
| JOP20190215A1 (ar) | 2017-03-24 | 2019-09-19 | Ionis Pharmaceuticals Inc | مُعدّلات التعبير الوراثي عن pcsk9 |
| KR102609396B1 (ko) | 2017-10-13 | 2023-12-01 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Ldha의 발현을 억제하기 위한 방법 및 조성물 |
| US12178855B2 (en) | 2018-01-10 | 2024-12-31 | Translate Bio Ma, Inc. | Compositions and methods for facilitating delivery of synthetic nucleic acids to cells |
| JP2021511072A (ja) | 2018-01-15 | 2021-05-06 | アイオニス・ファーマシューティカルズ・インコーポレイテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｄｎｍ２発現のモジュレーター |
| AU2019218987B2 (en) | 2018-02-12 | 2025-04-24 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| EP3775209A1 (en) * | 2018-04-05 | 2021-02-17 | Silence Therapeutics GmbH | Sirnas with at least two ligands at different ends |
| AU2019266207B2 (en) | 2018-05-07 | 2025-04-24 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| MY204000A (en) | 2018-05-09 | 2024-07-31 | Ionis Pharmaceuticals Inc | Compounds and methods for reducing fxi expression |
| EP3823725A4 (en) | 2018-07-17 | 2023-05-10 | Aronora, Inc. | METHODS FOR SAFELY REDUCING THROMBOPOIETIN |
| WO2020033748A1 (en) | 2018-08-08 | 2020-02-13 | Arcturus Therapeutics, Inc. | Compositions and agents against nonalcoholic steatohepatitis |
| TWI869213B (zh) | 2018-09-19 | 2025-01-01 | 美商Ionis製藥公司 | Pnpla3表現之調節劑 |
| MX2021007503A (es) | 2018-12-21 | 2021-08-05 | Ionis Pharmaceuticals Inc | Moduladores de la expresion de hsd17b13. |
| WO2020154342A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| TWI859184B (zh) | 2019-01-22 | 2024-10-21 | 美商科羅生物公司 | Ｒｎａ編輯之寡核苷酸及其用途 |
| EP3914261A4 (en) | 2019-01-22 | 2023-06-28 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| JP7757277B2 (ja) | 2019-10-14 | 2025-10-21 | アストラゼネカ・アクチエボラーグ | Ｐｎｐｌａ３発現のモジュレーター |
| JP7446443B2 (ja) | 2020-02-28 | 2024-03-08 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | Ｓｍｎ２を調節するための化合物及び方法 |
| AU2021241696A1 (en) | 2020-03-27 | 2022-12-01 | Generation Bio Co. | Novel lipids and nanoparticle compositions thereof |
| BR112022021462A2 (pt) | 2020-04-21 | 2023-01-17 | Flagship Pioneering Inc | Moléculas bifuncionais e métodos de sua utilização |
| CN111748005B (zh) * | 2020-06-24 | 2022-02-11 | 河北大学 | GalNAc修饰的美兰衍生物、制备方法与应用及肝靶向荧光探针、HClO检测方法 |
| CN116546989A (zh) * | 2020-10-09 | 2023-08-04 | 阿达尔克斯制药有限公司 | N-乙酰半乳糖胺（GalNAc）来源的化合物和寡核苷酸 |
| KR20230108728A (ko) | 2020-11-18 | 2023-07-18 | 아이오니스 파마수티컬즈, 인코포레이티드 | 앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법 |
| US20240175020A1 (en) | 2020-12-23 | 2024-05-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of modified trems and uses thereof |
| KR20240023420A (ko) | 2021-06-14 | 2024-02-21 | 제너레이션 바이오 컴퍼니 | 양이온성 지질 및 이의 조성물 |
| CA3233755A1 (en) | 2021-10-01 | 2023-04-06 | Adarx Pharmaceuticals, Inc. | Prekallikrein-modulating compositions and methods of use thereof |
| US20250101420A1 (en) * | 2022-03-08 | 2025-03-27 | Ohara Pharmaceutical Co., Ltd. | MODIFIED siRNA FOR SELECTIVELY INHIBITING EXPRESSION OF MUTANT FUS |
| WO2023250112A1 (en) | 2022-06-22 | 2023-12-28 | Flagship Pioneering Innovations Vi, Llc | Compositions of modified trems and uses thereof |
| WO2024040222A1 (en) | 2022-08-19 | 2024-02-22 | Generation Bio Co. | Cleavable closed-ended dna (cedna) and methods of use thereof |
| EP4663627A1 (en) * | 2023-02-06 | 2025-12-17 | NOF Corporation | Amine hydrochloride having maleimide group, and method for producing same |
| TW202448484A (zh) | 2023-04-20 | 2024-12-16 | 美商雅迪克斯製藥公司 | Ｍａｐｔ調節組合物及其使用方法 |
| TW202502385A (zh) | 2023-05-12 | 2025-01-16 | 美商雅迪克斯製藥公司 | Ｎｍｄａ配位體結合之化合物及其用途 |
| AU2024279767A1 (en) | 2023-05-26 | 2025-12-04 | Adarx Pharmaceuticals, Inc. | Sod1-modulating compositions and methods of use thereof |
| WO2024263694A1 (en) | 2023-06-20 | 2024-12-26 | Adarx Pharmaceuticals, Inc. | Lrrk2-modulating compositions and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1622572B1 (en) | 2003-04-30 | 2017-12-20 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| AU2005233387B2 (en) | 2004-04-15 | 2011-05-26 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
| WO2007125429A2 (en) | 2006-04-28 | 2007-11-08 | Centre National De La Recherche Scientifique | Method for the synthesis of triazole- containing oligonucleotide derivatives |
| US8252755B2 (en) | 2006-09-22 | 2012-08-28 | Dharmacon, Inc. | Duplex oligonucleotide complexes and methods for gene silencing by RNA interference |
| WO2009082607A2 (en) * | 2007-12-04 | 2009-07-02 | Alnylam Pharmaceuticals, Inc. | Targeting lipids |
| US8575123B2 (en) | 2008-04-11 | 2013-11-05 | Tekmira Pharmaceuticals Corporation | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| US8962580B2 (en) * | 2008-09-23 | 2015-02-24 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| US8247827B2 (en) | 2008-09-30 | 2012-08-21 | Bridgelux, Inc. | LED phosphor deposition |
| RS54578B1 (sr) * | 2010-02-24 | 2016-06-30 | Arrowhead Research Corporation | Preparati za ciljano dopremanje sirnk |
| US8691580B2 (en) * | 2010-04-09 | 2014-04-08 | Merck Sharp & Dohme Corp. | Single chemical entities and methods for delivery of oligonucleotides |
| AR090905A1 (es) * | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
-
2013
- 2013-04-30 TW TW106117248A patent/TW201808342A/zh unknown
- 2013-04-30 TW TW102115516A patent/TWI595885B/zh active
- 2013-04-30 AR ARP130101481A patent/AR090906A1/es unknown
- 2013-05-01 US US14/398,317 patent/US9540639B2/en active Active
- 2013-05-01 AU AU2013256400A patent/AU2013256400B2/en active Active
- 2013-05-01 CA CA2872100A patent/CA2872100A1/en not_active Abandoned
- 2013-05-01 JP JP2015510418A patent/JP6239592B2/ja active Active
- 2013-05-01 HK HK15108687.4A patent/HK1208227A1/xx unknown
- 2013-05-01 EP EP13784779.4A patent/EP2844663B1/en active Active
- 2013-05-01 WO PCT/US2013/039025 patent/WO2013166121A1/en not_active Ceased
-
2016
- 2016-11-29 US US15/363,490 patent/US10214742B2/en active Active
-
2017
- 2017-11-01 JP JP2017211436A patent/JP2018048186A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1208227A1 (en) | 2016-02-26 |
| JP2015520742A (ja) | 2015-07-23 |
| AU2013256400B2 (en) | 2017-09-21 |
| US20170233731A1 (en) | 2017-08-17 |
| CA2872100A1 (en) | 2013-11-07 |
| EP2844663A4 (en) | 2015-09-30 |
| WO2013166121A1 (en) | 2013-11-07 |
| JP2018048186A (ja) | 2018-03-29 |
| EP2844663A1 (en) | 2015-03-11 |
| JP6239592B2 (ja) | 2017-11-29 |
| EP2844663B1 (en) | 2020-03-25 |
| TW201350131A (zh) | 2013-12-16 |
| US9540639B2 (en) | 2017-01-10 |
| US10214742B2 (en) | 2019-02-26 |
| TW201808342A (zh) | 2018-03-16 |
| US20150203843A1 (en) | 2015-07-23 |
| TWI595885B (zh) | 2017-08-21 |
| AU2013256400A1 (en) | 2014-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR090906A1 (es) | Conjugados que contienen tetragalnac y procedimientos para la administracion de oligonucleotidos | |
| UY37145A (es) | Ligandos de direccionamiento | |
| CY1122761T1 (el) | Διαμορφωτες φαρμακοκινητικων ιδιοτητων θεραπευτικων παραγοντων | |
| UY37146A (es) | Ligandos de direccionamiento para compuestos terapéuticos | |
| CL2014001930A1 (es) | Formulacion farmacéutica que comprende un anticuerpo angiopoyetina 2 (anti-ang2). | |
| EA201290982A1 (ru) | Фармацевтические композиции, препятствующие злоупотреблению | |
| CO6531452A2 (es) | Piperidinas sustituidas que aumentan la actividad de p53 y sus usos | |
| CU20160006A7 (es) | Derivados de piperidinil-indol como inhibidores de factor de complemento b | |
| CR20150474A (es) | Inhibidores de bromodominios tetracíclicos | |
| CU20170172A7 (es) | 4,6-diaminoquinolin-3-carbonitrilos sustituidos útiles como agentes analgésicos, antipiréticos o antiinflamatorios y antineoplásicos | |
| CR20160271A (es) | Compuestos peptidométicos y sus conjugados de anticuerpo-fármaco | |
| CL2013003160A1 (es) | Compuestos derivados de 4h-cromen-4-ona moduladores de la proteina cinasa pi3k; compuestos intermediarios; composicion farmaceutica que los comprende; y utiles en el tratamiento del cancer, agentes antinflamatorios, inmunosupresores, esteroides, analgesicos, leucemia, entre otros. | |
| ECSP12012318A (es) | Inhibidores de pirazolil quinazolina cinasa | |
| MX393610B (es) | Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres | |
| MX336741B (es) | Composiciones farmaceuticas de moduladores de c-met. | |
| CL2011000454A1 (es) | Compuestos derivados de picolinamida, inhibidores de quinasa pim, asociada a tumorigenesis; composicion farmaceutica que los comprende; y su uso en el tratamiento del cancer. | |
| EA201890239A2 (ru) | Фумараты как пролекарства и их применение при лечении различных заболеваний | |
| UY34571A (es) | Composiciones herbicidas que contienen bentazón y el inhibidor als y el inhibidor accasa. | |
| MX2016000675A (es) | Derivados de amino-metil-biarilo como inhibidores del factor de complemento d y usos de los mismos. | |
| UY36075A (es) | Derivados de tubulisina | |
| GT200800285A (es) | Aminopirazolopiridinas sustituidas y sus sales, sus preparaciones y composiciones farmaceuticas que las comprenden | |
| CO7350640A2 (es) | Compuestos diméricos | |
| CU20130139A7 (es) | Derivados glocósidos y usos de los mismos | |
| AR112787A2 (es) | Compuestos 1,5-difenil-penta-1,4-dien-3-ona | |
| CO6341625A2 (es) | Derivados de indol como agentes anticáncer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |