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WO2023167042A1 - Dispositif de remplissage de médicament liquide et instrument de remplissage - Google Patents

Dispositif de remplissage de médicament liquide et instrument de remplissage Download PDF

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Publication number
WO2023167042A1
WO2023167042A1 PCT/JP2023/006071 JP2023006071W WO2023167042A1 WO 2023167042 A1 WO2023167042 A1 WO 2023167042A1 JP 2023006071 W JP2023006071 W JP 2023006071W WO 2023167042 A1 WO2023167042 A1 WO 2023167042A1
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WO
WIPO (PCT)
Prior art keywords
cartridge
filling device
filling
plunger
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/006071
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English (en)
Japanese (ja)
Inventor
城司 内山
剛 山崎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of WO2023167042A1 publication Critical patent/WO2023167042A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps

Definitions

  • the present disclosure relates to a chemical filling device and a filling device.
  • the drug solution administration device Since the drug solution administration device is fixed to the patient's body and carried around, it is preferable that the drug solution administration device be small. On the other hand, if the cartridge of the drug solution administration device is downsized, the above-described drug solution filling operation tends to be complicated, and operability tends to deteriorate.
  • An object of the present disclosure is to provide a liquid medicine filling device and a filling device that are capable of both reducing the size of the cartridge and improving the operability of filling the liquid medicine into the cartridge.
  • a chemical solution filling device as a first aspect of the present disclosure includes a cartridge including a chemical solution reservoir having a chemical solution filling port; a filling device capable of executing an operation of filling the drug solution reservoir with the drug solution through a filling port, wherein the drug solution reservoir of the cartridge has the filling port and is capable of containing the drug solution; a plunger capable of moving axially, the filling device comprising: a holding portion for holding the cartridge so as to be in the mounted state; an engaging portion for engaging the plunger in the mounted state; and an operating portion capable of performing an operation of moving the plunger in the axial direction via the engaging portion in a mounted state.
  • the cartridge includes a cartridge housing that accommodates the cylindrical body and the plunger, and the holding portion of the filling device is configured to be able to hold the cartridge housing directly or indirectly. It is
  • a vertical posture of the cartridge is defined as a posture in which the axial direction of the cylindrical body is vertical so that the cylindrical body is vertically upward with respect to the plunger.
  • the holding portion of the filling device is configured to be able to directly or indirectly hold the cartridge housing of the cartridge in the vertical posture from both sides facing each other in the horizontal direction.
  • the cartridge housing includes a base plate portion extending along the axial direction, and the holding portion of the filling device is arranged in a horizontal direction with respect to the vertically oriented cartridge.
  • the cartridge housing is directly or indirectly held from opposite sides in a horizontal direction perpendicular to the thickness direction.
  • At least part of the cylindrical body of the cartridge is exposed without being covered by the filler in the mounted state.
  • the filling device includes an operation restricting portion capable of fixing the position of the plunger in the axial direction with respect to the cylindrical body of the cartridge by restricting the operation of the operating portion.
  • a drug solution filling device as one embodiment of the present disclosure includes a container connector to which a drug solution container can be connected, and an adapter that can be attached to the cartridge.
  • the adapter can directly lock the cartridge.
  • a filling device as a second aspect of the present disclosure is attachable to a cartridge comprising a chemical reservoir having a filling port for a chemical solution, and in the mounted state of being attached to the cartridge, the chemical solution flows through the filling port.
  • a filling device capable of performing an operation of filling a reservoir with a liquid medicine, wherein the liquid medicine reservoir of the cartridge includes a cylinder that is provided with the filling port and can accommodate the liquid medicine, and that is axially movable in the cylinder. a holding portion for holding the cartridge so as to be in the mounted state; an engaging portion for engaging the plunger in the mounted state; and a plunger in the mounted state via the engaging portion. and an operation unit capable of executing an operation to move the plunger in the axial direction.
  • a liquid medicine filling device and a filling device that are capable of both reducing the size of the cartridge and improving the operability of filling the liquid medicine into the cartridge.
  • FIG. 1 is a perspective view of a chemical filling device as an embodiment of the present disclosure
  • FIG. FIG. 2 is a perspective view of a cartridge and an adapter of the chemical filling device shown in FIG. 1
  • FIG. 2 is an exploded perspective view of the chemical filling device shown in FIG. 1
  • FIG. 2 is an exploded perspective view of a drug-solution administration device including the cartridge of the drug-solution filling device shown in FIG. 1
  • 5 is a top view of the cartridge shown in FIGS. 1-4
  • FIG. FIG. 6 is a bottom view of the cartridge shown in FIG. 5
  • FIG. 10 is an explanatory view showing an operation of sending air inside a cylindrical body of the cartridge into the liquid medicine container;
  • FIG. 7B is an explanatory diagram of a mechanism for executing the operation shown in FIG. 7A
  • FIG. 10 is an explanatory view showing an operation of filling the cylinder of the cartridge with the liquid medicine in the liquid medicine container.
  • FIG. 8B is an explanatory diagram of a mechanism for executing the operation shown in FIG. 8A
  • 1 is a front view of a chemical filling device as an embodiment of the present disclosure
  • FIG. 10 is an enlarged view showing the vicinity of an operation lever in FIG. 9
  • FIG. 10 is a view showing an operation restricting portion of the chemical filling device shown in FIG. 9
  • FIG. 10 is a view showing an operation restricting portion of the chemical filling device shown in FIG. 9;
  • FIG. 9 is a view showing an operation restricting portion of the chemical filling device shown in FIG. 9;
  • FIG. 9 is a view showing an operation restricting portion of the chemical filling device shown in FIG. 9;
  • FIG. 9 is a view showing an operation restricting portion of the chemical fill
  • FIG. 11B is a front view of a filling device provided with an operation restricting portion as a modified example of the operation restricting portion shown in FIGS. 11A and 11B;
  • FIG. 13 is a diagram showing details of an operation restricting unit shown in FIG. 12;
  • FIG. 13 is a diagram showing details of an operation restricting unit shown in FIG. 12;
  • FIG. 1 is a perspective view of a chemical filling device 100 as one embodiment of the chemical filling device according to the present disclosure.
  • FIG. 2 is a perspective view of the cartridge 2 and the adapter 4 of the chemical filling device 100.
  • FIG. FIG. 3 is an exploded perspective view of the chemical filling device 100.
  • the drug solution filling device 100 includes a cartridge 2, a filling device 3, and an adapter 4. As shown in FIGS.
  • FIGS. 1 and 3 for convenience of explanation, the chemical container 300 is shown. be worn. 2 shows a state in which the adapter 4 is attached to the cartridge 2, and FIG. 3 shows a state in which the cartridge 2 and the adapter 4 are separated.
  • the cartridge 2 may be distributed with the adapter 4 attached in advance (see FIG. 2), or may be distributed with the adapter 4 separated (see FIG. 3).
  • liquid medicine filling device 100 even the downsized cartridge 2 can be easily filled with the liquid medicine. In other words, it is possible to achieve both the miniaturization of the cartridge 2 and the improvement in the operability of filling the cartridge 2 with the chemical solution.
  • FIG. 4 is an exploded perspective view showing an example of the drug solution administration device 10 including the cartridge 2 of the drug solution filling device 100 shown in FIGS. 1 to 3.
  • FIG. A drug-solution administration device 10 is a device that administers a drug solution into a living body using a cartridge 2 filled with a drug solution by a drug-solution filling device 100 shown in FIGS. 1 and 3 . First, an overview of the drug-solution administration device 10 will be described.
  • a drug-solution administration device 10 shown in FIG. 4 includes a seal portion 12 having an adhesive surface 12a that can be attached to the skin of a user such as a patient.
  • the drug-solution administration device 10 is used with the sticking surface 12a of the seal portion 12 stuck to the user's skin. More specifically, the drug-solution administration device 10 is a portable insulin pump capable of continuously or intermittently injecting the drug solution filled in the storage space 36b in the cylindrical body 36 into the living body under the pressing action of the plunger 38. .
  • the axial direction parallel to the central axis O of the cylinder 36 is simply referred to as the "axial direction A", or the longitudinal direction of the drug solution administration device 10 is simply referred to as the “device longitudinal direction B".
  • the thickness direction of the drug-solution administration device 10, which is orthogonal to the sticking surface 12a of the seal portion 12, is simply referred to as “device thickness direction C”.
  • the width direction of the drug-solution administration device 10, which is orthogonal to the device longitudinal direction B (the same direction as the axial direction A) and the device thickness direction C is simply referred to as "device width direction D".
  • the sticking surface 12a side (that is, the body surface side when the drug-solution administration device 10 is used) is simply referred to as the "lower side", and the side opposite to the sticking surface 12a side is simply referred to as “lower side”. It may be described as "upper”.
  • the medical-solution administration device 10 includes a cradle 14 having a seal portion 12 that can be attached to the skin of a user such as a patient, and a medical-solution administration device main body 16 detachably attached to the cradle 14. , is equipped with
  • the cradle 14 includes a substantially rectangular support plate 18 to which the seal portion 12 is fixed to the lower mold, and locking walls 20 rising from the outer peripheral edge of the support plate 18 .
  • a cannula mechanism 22 having a cannula to be indwelled in the living body using a puncture mechanism (not shown) is attached to substantially the center of the support plate 18 .
  • the drug-solution administration device main body 16 includes a cartridge 2 as a disposable part and a reusable reusable part 30 .
  • FIG. 5 is a top view of the cartridge 2 alone, viewed from above. In FIG. 5, part of the cartridge 2 is simplified for convenience of explanation.
  • FIG. 6 is a bottom view of the cartridge 2 as viewed from below.
  • the cartridge 2 has a flat box-shaped cartridge housing 32 whose upper side in the device thickness direction C is open.
  • the cartridge housing 32 has a substantially rectangular shape corresponding to the support plate 18 in plan view. More specifically, the cartridge housing 32 of this embodiment includes a base plate portion 32a extending along the axial direction A, and side wall portions 32b rising from the outer peripheral edge portion of the base plate portion 32a. As shown in FIG.
  • a concave portion serving as a housing portion 34 for housing the cannula mechanism 22 when the drug solution administration device main body 16 is mounted on the cradle 14. is formed.
  • the cartridge 2 includes a chemical reservoir 2a having a chemical filling port 36a.
  • the medicinal solution reservoir 2a includes a cylindrical body 36 defining an accommodation space 36b capable of accommodating medicinal solution, and a plunger 38 .
  • the cylindrical body 36 and the plunger 38 are held by the cartridge housing 32 while being housed in the cartridge housing 32 . More specifically, the cylindrical body 36 and the plunger 38 of this embodiment are held by the base plate portion 32a while being surrounded by the side wall portion 32b. However, the cylindrical body 36 and the plunger 38 may be held by the side wall portion 32b while being surrounded by the side wall portion 32b. That is, the cylindrical body 36 and the plunger 38 may be held by at least one of the base plate portion 32a and the side wall portion 32b while being surrounded by the side wall portion 32b.
  • the tubular body 36 extends cylindrically along the longitudinal direction B of the device.
  • the outer diameter and inner diameter of the distal end portion of the cylindrical body 36 decrease toward the distal end.
  • the tubular body 36 may be made of, for example, a transparent resin material so that the inside can be visually recognized from the outside.
  • a filling port 36a into which the liquid medicine is filled from the liquid medicine container 300 (see FIGS. 1 and 3) is formed at the tip of the cylindrical body 36 as described above.
  • the filling port 36 a communicates with a chemical liquid flow path 37 formed along the cartridge housing 32 .
  • a connection port 37a is provided at the other end of the chemical liquid flow path 37 opposite to the one end communicating with the filling port 36a.
  • the filling port 36 a of the cylinder 36 of the present embodiment also serves as a drug solution discharge port for discharging the drug solution inside the tube 36 toward the cannula mechanism 22 .
  • the plunger 38 is movable in the axial direction A inside the cylindrical body 36 .
  • the plunger 38 may be integrally molded, for example, from a resin material or the like.
  • the plunger 38 of this embodiment includes a plunger main body 52 that is liquid-tightly slidable along the axial direction A inside the cylindrical body 36 , and a plunger 54 that continues to the base end side of the plunger main body 52 .
  • the tip of the plunger body 52 has a substantially conical shape, and the outer diameter of the plunger main body 52 decreases toward the tip.
  • the plunger 38 of this embodiment further includes a seal member 53 that forms a seal with the inner surface of the cylinder 36 along the outer periphery of the plunger body 52 .
  • the pusher 54 extends from the plunger main body 52 toward the base end side and includes a pair of extensions 58 extending to the outside of the cylindrical body 36 .
  • the pair of extending portions 58 of the present embodiment are arranged apart from each other along the width direction D of the device. Further, each extending portion 58 is formed with a concave portion 58a as an engaged portion into which the convex portion 206b as the engaging portion 202 of the filling device 3 (see FIGS. 1 and 3) can be fitted. .
  • a base end portion of each extending portion 58 is provided with a contact surface 64 and a projection (not shown) with which the nut portion 42 described later contacts.
  • the cartridge 2 of this embodiment further includes a feed screw shaft 40 and a nut portion 42 in addition to the chemical reservoir 2a described above.
  • the feed screw shaft 40 is arranged coaxially with the plunger 38 .
  • the nut portion 42 is screwed onto the feed screw shaft 40 .
  • the feed screw shaft 40 and the nut portion 42 are also held by the cartridge housing 32 .
  • the feed screw shaft 40 is rotatably driven by the driving portion 76 while its tip end is supported by a bearing 74 provided in the cartridge housing 32 .
  • the drive unit 76 includes a battery 78 as a power source, a motor 80 driven by the battery 78, a gearbox (power transmission mechanism) 82 that reduces and transmits the rotational driving force of the motor 80, and an output gear of the gearbox 82.
  • a transmission shaft 88 to which a spur gear 86 meshing with 84 is fixed and locked to the feed screw shaft 40 so as to be integrally rotatable.
  • the battery 78 and the transmission shaft 88 of the drive section 76 of this embodiment are provided in the cartridge 2 . Further, the motor 80 and the gear box 82 of the driving section 76 of the present embodiment are provided on the lid body 90 of the reusable section 30 . However, it is not limited to this configuration.
  • the reusable part 30 may be configured to include the battery 78, for example.
  • the lid body 90 of the reusable part 30 of this embodiment is configured to be detachable from the cartridge housing 32 so as to close the upper opening of the cartridge housing 32 .
  • the battery 78 has a terminal 92 electrically connected to the motor 80 of the reusable section 30 when the cartridge 2 is attached to the reusable section 30 .
  • the transmission shaft 88 is supported by a pair of bearings 94 provided in the cartridge housing 32 so as to be coaxial with the feed screw shaft 40 .
  • the nut portion 42 may be integrally molded from a resin material, for example.
  • the nut portion 42 of the present embodiment includes a rectangular plate-shaped nut portion main body 102 and a slide portion 104 provided on the nut portion main body 102 .
  • a threaded hole 106 into which the feed screw shaft 40 is screwed is formed in the nut body 102 .
  • the screw hole 106 is located substantially in the center of the nut body 102 .
  • a reinforcing cover made of, for example, a metal material may be attached to the outer surface of the nut body 102 .
  • the slide portion 104 is slidable with respect to a guide wall 114 extending along the axial direction A provided on the cartridge housing 32 . Thereby, the nut portion 42 smoothly moves along the axial direction of the feed screw shaft 40 (the same direction as the axial direction A) under the rotating action of the feed screw shaft 40 .
  • the user fills the drug solution reservoir 2a of the cartridge 2 of the drug solution administration device 10 with the drug solution.
  • the chemical filling device 100 shown in FIGS. 1 and 3 is used. Details of this will be described later.
  • the reusable part 30 is attached to the cartridge 2 filled with the chemical solution by the chemical solution filling device 100 .
  • power from the battery 78 of the cartridge 2 is supplied to the components of the reusable section 30 , and the output gear 84 of the gear box 82 of the reusable section 30 meshes with the spur gear 86 of the cartridge 2 .
  • the drug solution administration device main body 16 is primed.
  • the motor 80 is rotationally driven by operating a remote controller (not shown) or the like.
  • the rotational driving force of the motor 80 is transmitted to the feed screw shaft 40 via the gear box 82, the spur gear 86, and the transmission shaft 88, so that the feed screw shaft 40 rotates and the nut portion 42 slides on the guide wall 114. while moving toward the plunger 38 side.
  • the nut portion 42 contacts the base end surface as the contact surface 64 of the extending portion 58 of the plunger 54 of the plunger 38 and the projection, and the projection is locked in the hole of the nut portion main body 102 .
  • the plunger 38 is engaged with the nut portion 42, and the nut portion 42 is in the use position where the plunger 38 can be pressed toward the distal end side in the axial direction A. As shown in FIG.
  • the user sticks the sticking surface 12a of the seal part 12 to a predetermined position on the skin, and uses the puncture mechanism to leave the cannula of the cannula mechanism 22 of the cradle 14 in the living body.
  • the user mounts the medical-solution administration device main body 16 on the cradle 14 .
  • the connection port 37 a of the drug solution flow path 37 of the drug solution administration device main body 16 is connected to the cannula mechanism 22 of the cradle 14 .
  • the drug solution in the cylindrical body 36 is discharged from the filling port 36a, which is also the drug solution outlet port, and continuously or intermittently enters the user's living body through the cannula of the cannula mechanism 22. administered.
  • the chemical filling device 100 of this embodiment will be described with reference to FIGS. 1 to 3 and the like.
  • the drug solution filling device 100 is used to fill the cartridge 2 of the drug solution administration device 10 with the drug solution.
  • the drug solution filling device 100 of this embodiment includes a cartridge 2 , a filling device 3 and an adapter 4 .
  • the drug solution filling device 100 includes the cartridge 2, like the drug solution administration device 10 described above. Therefore, in the following description of the chemical liquid filling device 100, the above-described “axial direction A”, “device longitudinal direction B”, “device thickness direction C” and “device width direction D” will continue to be used.
  • the longitudinal direction B of the liquid medicine filling device 100 is the longitudinal direction of the cartridge 2 .
  • the device thickness direction C in the liquid medicine filling device 100 is the thickness direction of the cartridge 2 .
  • the device width direction D in the liquid medicine filling device 100 is the width direction of the cartridge 2 .
  • the filling device 3 can be attached to the cartridge 2 .
  • the filling device 3 can be attached to the cartridge 2 means that the filling device 3 is configured to be fixed in a predetermined posture to the cartridge 2, and the filling device 3 can be attached directly to the cartridge 2. It is not limited to being able to be fixed to the cartridge 2 at any time. That is, the filling device 3 may be configured to be directly fixable to the cartridge 2, and as in the present embodiment, via the adapter 4 fixed to the cartridge 2, It may be configured so that it can be indirectly fixed to the support (see FIG. 1).
  • the filling device 3 is configured to be capable of performing an operation of filling the liquid medicine into the liquid medicine reservoir 2a through the filling port 36a in the state of being mounted on the cartridge 2 (see FIG. 1).
  • the state in which the filling device 3 is attached to the cartridge 2 may be simply referred to as the "attachment state”.
  • the filling device 3 of this embodiment includes a holding portion 201 , an engaging portion 202 and an operating portion 203 .
  • the holding part 201 can hold the cartridge 2 so as to be attached to the filling device 3 .
  • the mounting state in which the filling device 3 is mounted on the cartridge 2 is realized by appropriately holding the cartridge 2 by the holding portion 201 of the filling device 3 .
  • the holding portion 201 of this embodiment is a locking claw 205c and a convex receiving portion 205d1 provided on the filling device housing 205. As shown in FIG.
  • the filling device housing 205 of this embodiment includes a pedestal portion 205a that can be placed on a horizontal placement surface. Further, the filling device housing 205 of this embodiment includes a front cover plate portion 205b that rises vertically upward from the pedestal portion 205a in a state where the pedestal portion 205a is placed on the mounting surface. The front cover plate portion 205b covers at least part of the opening of the cartridge 2 in the attached state. Further, the filler housing 205 of this embodiment includes a locking pawl 205c protruding from one end of the front cover plate portion 205b.
  • the filling device housing 205 of this embodiment includes a convex receiving portion 205d1 provided on the side cover plate portion 205d that protrudes from the other end of the front cover plate portion 205b.
  • the convex receiving portion 205d1 is configured to be able to fit into a convex portion 215 provided on the adapter 4, which will be described later.
  • the convex receiving portion 205d1 may be, for example, a hole or recess formed in the side cover plate portion 205d.
  • the holding unit 201 of the present embodiment is configured to indirectly hold the cartridge 2 via the adapter 4 attached to the cartridge 2, but is not limited to this configuration. That is, the holding portion 201 may be configured to be able to directly hold the cartridge 2 .
  • the holding portion 201 of this embodiment can hold the cartridge housing 32 directly or indirectly.
  • the holding portion 201 of this embodiment is the locking claw 205c and the convex receiving portion 205d1.
  • the locking claw 205c and the convex receiving portion 205d1 of this embodiment can directly hold the adapter 4 attached to the cartridge housing 32.
  • the locking claw 205c and the convex receiving portion 205d1 of this embodiment are configured to indirectly hold the cartridge housing 32 via the adapter 4 attached to the cartridge housing 32.
  • the holding portion 201 may be configured to directly hold the cartridge housing 32 .
  • the holding portion 201 can directly or indirectly hold the cartridge housing 32 that holds the cylindrical body 36 and the plunger 38 of the cartridge 2, so that the mounting state of the cartridge 2 and the filling device 3 can be changed.
  • the engaging portion 202 and the plunger 38 can be positioned more reliably. That is, in the attached state, the engaging portion 202 can be more reliably engaged with a predetermined position of the plunger 38 (in this embodiment, a concave portion 58a which will be described later).
  • the attitude of the cartridge 2 in which the axial direction A of the cylinder 36 is vertical so that the cylinder 36 is vertically above the plunger 38 is simply referred to as the "vertical attitude of the cartridge 2.” ”.
  • the holding portion 201 of the present embodiment can directly or indirectly hold the cartridge housing 32 of the cartridge 2 in the vertical posture from both sides facing each other in the horizontal direction. By doing so, the filling device 3 can stably hold the cartridge 2 from both opposing sides. That is, the mounted state of the cartridge 2 and the filling device 3 can be further stabilized. More specifically, the holding portion 201 of the present embodiment can indirectly hold the cartridge housing 32 of the cartridge 2 in the vertical posture from the outside of the side wall portions 32b on both sides in the device width direction D via the adapter 4. It is configured.
  • the locking claw 205c and the convex receiving portion 205d1 as the holding portion 201 of the present embodiment are arranged in the thickness direction of the base plate portion 32a (in the present embodiment, the device thickness direction) in the horizontal direction with respect to the cartridge 2 in the vertical posture. C), the cartridge housing 32 can be held directly or indirectly.
  • the cartridge housing 32 can be held directly or indirectly.
  • the locking claw 205c and the convex receiving portion 205d1 move in a horizontal direction perpendicular to the thickness direction of the base plate portion 32a with respect to the cartridge 2 in a vertical posture (in this embodiment, the apparatus The cartridge housing 32 is held from both sides facing each other in the same direction as the width direction D).
  • the mounting operation of the filling device 3 with respect to the cartridge 2 is completed, and the cartridge 2 and the filling device 3 are put into the mounting state.
  • the convex portion 206b as the engaging portion 202 which will be described later, fits into the concave portion 58a formed in each extension portion 58 of the pusher 54 of the plunger 38. As shown in FIG.
  • the locking claw 205c and the convex receiving portion 205d1 of this embodiment indirectly lock the cartridge housing 32 via the adapter 4, but they may also lock the cartridge housing 32 directly.
  • mounting of the filling device 3 to the cartridge 2 can be realized by a simple operation.
  • the holding portion 201 of the present embodiment is configured to be able to hold the cartridge housing 32 of the cartridge 2 in the vertical posture at a position below the cylindrical body 36 in the vertical direction.
  • the holding portion 201 of the present embodiment is positioned on both sides of the plunger 54 of the plunger 38 in a plan view of the cartridge 2 along the thickness direction of the base plate portion 32a (see FIG. 5). is configured to be able to hold By doing so, the filling device 3 can more stably hold the portion of the cartridge 2, particularly the vicinity of the plunger 54 of the plunger 38. As shown in FIG. Therefore, the engagement relationship between the engaging portion 202 of the filling device 3 and the recessed portion 58a of the plunger 38 as the engaged portion of the cartridge 2 can be further stabilized.
  • the cylindrical body 36 of the cartridge 2 of the cartridge 2 is exposed without being covered with the filling device 3 in the mounted state.
  • the cylindrical body 36 of the cartridge 2 of this embodiment is exposed to the outside without being covered by the filling device housing 205 of the filling device 3 in the attached state. By doing so, the amount of the chemical liquid filled in the cylindrical body 36 can be easily visually recognized from the outside.
  • the engaging portion 202 engages with the plunger 38 in the mounted state. More specifically, the engaging portion 202 of the present embodiment is a convex portion 206b of the movable body 206 that fits into the concave portion 58a formed in each extending portion 58 of the pusher 54 of the plunger 38 in the attached state. is.
  • the movable body 206 is attached movably in the axial direction A with respect to the charger housing 205 . Also, the movable body 206 moves in the axial direction A following the rotation of an operation lever 207, which will be described later. More specifically, the movable body 206 of this embodiment includes a rack gear portion 206a as a torque receiving portion to which the rotational torque of the operating lever 207 is transmitted.
  • the operating portion 203 is configured to be able to perform an operation of moving the plunger 38 in the axial direction A via the convex portion 206b as the engaging portion 202 in the attached state.
  • the operating portion 203 of this embodiment is operably held with respect to the filler housing 205 .
  • the operating portion 203 of this embodiment comprises an operating lever 207 that is pivotally attached to the charger housing 205 .
  • the operating lever 207 has a pinion gear portion 207a as a torque transmitting portion that transmits the torque to rotate the filling device housing 205 to the movable body 206. As shown in FIG.
  • the movable body 206 and the operating lever 207 constitute a rack and pinion structure with the rack gear portion 206a and the pinion gear portion 207a.
  • the rotational movement of the operating lever 207 with respect to the filling device housing 205 can be converted into linear movement in the axial direction A of the movable body 206 .
  • the rod-shaped lever piece and the gear forming the pinion gear portion 207a are separately coaxially supported, but they may be integrally formed.
  • the operation of the engaging portion 202 by the operating portion 203 is not limited to the rack and pinion structure described above.
  • Other mechanisms may be used as long as the plunger 38 can be moved in the axial direction A via the engaging portion 202 by operating the operating portion 203 .
  • the operating portion 203 may further include a coil spring as a biasing member 208 that biases the operating lever 207 to one side in the rotation direction.
  • the adapter 4 can be attached to the cartridge 2 .
  • the adapter 4 of this embodiment includes a housing portion 211 that houses the cartridge 2 .
  • the housing portion 211 is defined by a back plate portion 220 , a pair of opposing side plate portions 221 , and a front plate portion 222 opposing the back plate portion 220 .
  • At least part of the cartridge 2 is accommodated in the accommodating portion 211 .
  • the lower surface of the cartridge 2 (the lower surface of the base plate portion 32a) is accommodated in the accommodating portion 211 toward one side (lower side in FIG. 3) in the axial direction A along the back plate portion 220 of the accommodating portion 211.
  • the side plate portions 221 are a pair of opposing walls rising in the device thickness direction C from the back plate portion 220 .
  • the side plate portion 221 is formed along the side wall portion 32 b of the cartridge 2 , and the surface in one direction defines the accommodating portion 211 .
  • the side plate portion 221 is formed with a claw receiving portion 214 and a convex portion 215 as a locking portion with respect to the filling device 3 .
  • the front plate portion 222 is provided to face the back plate portion 220 and partially covers the cartridge 2 .
  • the front plate portion 222 rises from the side plate portion 221 in the device width direction D and faces the back plate portion 220 .
  • the front plate portion 222 may be provided so as to rise from the pair of side plate portions 221 respectively, but it does not cover the plunger 38 and the cylindrical body 36 .
  • the cartridge 2 is accommodated in the accommodation portion 211 of the adapter 4 by being slid into the accommodation portion 211 from a predetermined direction.
  • the direction in which the cartridge 2 is inserted into the housing portion 211 of the adapter 4 is different from the direction in which the filler 3 is attached to the adapter 4 .
  • the direction in which the cartridge 2 is inserted into the adapter 4 is the axial direction A of the cylindrical body 36 of the cartridge 2 .
  • the mounting direction of the cartridge 2 with respect to the adapter 4 and the mounting direction of the filling device 3 with respect to the adapter 4 are substantially orthogonal.
  • the rear plate portion 220 and the front plate portion 222 may be provided with engagement portions for the cartridge 2 .
  • the rear plate portion 220 is provided with a protrusion 224 to hold the cartridge 2 in the axial direction A. As shown in FIG. As a result, even during the filling operation, a good connection between the connection port 37a and the tube portion 212 can be maintained.
  • the adapter 4 of this embodiment can directly lock the cartridge 2 .
  • the adapter 4 of this embodiment is configured to be able to directly engage the cartridge housing 32 of the cartridge 2 . More specifically, the adapter 4 of the present embodiment can directly lock the cartridge housing 32 of the cartridge 2 in the vertical position on both sides facing each other in the direction orthogonal to the thickness direction of the cartridge 2 in the horizontal direction. can.
  • the adapter 4 includes a tube portion 212 that fluidly connects the inside of the drug solution container 300 and the inside of the cylindrical body 36 of the cartridge 2 .
  • a tube portion 212 that fluidly connects the inside of the drug solution container 300 and the inside of the cylindrical body 36 of the cartridge 2 .
  • the cartridge 2 is housed in the housing portion 211 of the adapter 4, and the connection port 37a of the cartridge 2 communicates with the tube portion 212 of the adapter 4 in a liquid-tight manner. are doing.
  • the adapter 4 also includes a container connecting portion 213 to which a drug solution container 300 such as a vial in which a drug solution is hermetically stored by a plug member 301 can be connected.
  • a drug solution container 300 such as a vial in which a drug solution is hermetically stored by a plug member 301 can be connected.
  • the other end of the tube portion 212 is arranged in the container connection portion 213 .
  • the drug solution container 300 is connected to the container connecting portion 213 so that the other end of the tube portion 212 passes through the plug member 301 .
  • the adapter 4 of this embodiment includes a side plate portion 221 having a claw receiving portion 214 on which the locking claw 205c of the filling device 3 is caught.
  • the claw receiving portion 214 may be, for example, a hole or recess provided in the adapter 4 .
  • the adapter 4 of this embodiment has the side plate portion 221 provided with a convex portion 215 that fits into the convex receiving portion 205d1 of the filling device 3. As shown in FIG. A more stable mounting state can be realized by providing the locking portion so that the straight line connecting the claw receiving portion 214 and the convex portion 215 as the locking portion passes through the movable range of the engaging portion 202 .
  • the user takes out the cartridge 2 (see FIG. 2) with the adapter 4 attached from the packaging container.
  • the cartridge 2 and the adapter 4 may be packaged separately within the packaging container and attached to each other by the user after removal.
  • the cylindrical body 36 of the cartridge 2 is not filled with the liquid medicine after being removed from the packaging container. Therefore, the nut portion 42 is in the initial position where it does not contact the plunger 38 (see FIG. 5).
  • One end of the tube portion 212 of the adapter 4 communicates liquid-tightly with the connection port 37 a of the drug solution channel 37 of the cartridge 2 .
  • the user attaches the filler 3 to the cartridge 2 to which the adapter 4 is attached in order to fill the cylinder 36 with an appropriate amount of liquid medicine.
  • the filling device 3 is attached to the cartridge 2 so that the convex portion 206b as the engaging portion 202 fits into the concave portion 58a formed in each extending portion 58 of the pusher 54. As shown in FIG.
  • the drug solution container 300 in which the drug solution is hermetically stored is connected to the container connecting portion 213 of the adapter 4 .
  • the other end of the tube portion 212 of the adapter 4 passes through the plug member 301 and is positioned inside the drug solution container 300 . That is, the other end of the tube portion 212 of the adapter 4 communicates with the inside of the drug solution container 300 in a liquid-tight manner. That is, the inside of the cylindrical body 36 of the cartridge 2 and the inside of the drug solution container 300 are in communication with each other through the tube portion 212 of the adapter 4 .
  • the cartridge 2 is in a vertical posture in which the filling port 36a is vertically upward.
  • the drug solution container 300 connected to the container connecting portion 213 of the adapter 4 is arranged so that the plug member 301 faces vertically downward.
  • the nut portion 42 is in the initial position (see FIG. 5) where it does not come into contact with the plunger 38, so the position of the plunger 38 can be manually changed according to the filling amount of the chemical solution.
  • FIG. 7A is an explanatory diagram showing the operation of sending the air inside the cylindrical body 36 into the drug solution container 300 by operating the operating portion 203.
  • FIG. FIG. 7B is an explanatory diagram of a mechanism for executing the operation of sending the air inside the cylinder 36 into the drug solution container 300 shown in FIG. 7A.
  • the convex portion 206b of the movable body 206 as the engaging portion 202 is fitted into the concave portion 58a formed in each extending portion 58 of the pusher 54.
  • the pusher 54 also moves vertically upward together with the movable body 206 .
  • the air in the cylindrical body 36 is compressed by the plunger 38, and sent into the drug solution container 300 from the filling port 36a through the drug solution channel 37 (see FIG. 5) and the tube portion 212 of the adapter 4 ( See dashed arrow in FIG. 7A). Therefore, the pressure inside the chemical liquid container 300 can be increased.
  • FIG. 8A is an explanatory diagram showing the operation of filling the cylinder 36 with the chemical liquid in the chemical liquid container 300 by operating the operation unit 203.
  • FIG. FIG. 8B is an explanatory diagram of a mechanism for performing the operation of filling the cylinder 36 with the liquid medicine in the liquid medicine container 300 shown in FIG. 8A.
  • the operation lever 207 rotated in one direction by the operation shown in FIGS. 7A and 7B is rotated in the opposite direction.
  • the pusher 54 can be moved downward in the vertical direction.
  • the operating portion 203 of this embodiment includes a coil spring as the biasing member 208 .
  • This coil spring urges the pusher 54 downward in the vertical direction via the operating lever 207 . Therefore, the operation of the operating lever 207 shown in FIGS. 7A and 7B is performed against the restoring force of the coil spring. On the other hand, the operation of the operating lever 207 shown in FIGS. 8A and 8B may be performed by the restoring force of the coil spring.
  • the cylinder 36 is filled with the chemical solution.
  • the filling of the cylinder 36 with the chemical is completed.
  • the filling device 3 can fill the liquid medicine with a simple operation even in the cartridge 2 that is downsized. In other words, it is possible to achieve both the miniaturization of the cartridge 2 and the improvement in the operability of filling the cartridge 2 with the chemical solution.
  • the engagement of the filling device 3 is interlocked with the mounting operation of the filling device 3 to the cartridge 2 . Since the mating portion 202 is engaged with a predetermined position (recessed portion 58a in the present embodiment) of the plunger 38, the engagement operation is less complicated even for a small-sized cartridge 2. Therefore, the operability of filling the cartridge 2 with the chemical solution is unlikely to deteriorate.
  • the liquid medicine filling device 400 of the present embodiment differs from the liquid medicine filling device 100 of the first embodiment mainly in the presence or absence of an operation restricting section 504 .
  • the operation restricting unit 504 of the chemical filling device 400 will be mainly described, and the description of the configuration common to the chemical filling device 100 of the first embodiment will be omitted.
  • FIG. 9 is a front view of the chemical filling device 400.
  • FIG. FIG. 10 is an enlarged view showing the vicinity of the operating lever 207 of the operating section 503 in FIG. 11A and 11B are diagrams showing the motion restricting section 504.
  • FIG. 10 is an enlarged view showing the vicinity of the operating lever 207 of the operating section 503 in FIG. 11A and 11B are diagrams showing the motion restricting section 504.
  • the drug solution filling device 400 of this embodiment includes a cartridge 2, a filling device 403, and an adapter 4.
  • the cartridge 2 and the adapter 4 of the present embodiment are the same as those of the drug solution filling device 100 (see FIG. 1, etc.) of the first embodiment, and thus description thereof is omitted here.
  • the filling device 403 includes a holding portion 201, an engaging portion 202, an operating portion 203, and an operation restricting portion 504.
  • the holding portion 201, the engaging portion 202, and the operating portion 203 of the present embodiment are the same as those of the liquid medicine filling device 100 (see FIG. 1, etc.) of the first embodiment, and thus description thereof is omitted here.
  • the motion regulation unit 504 can regulate the motion of the operation unit 203 .
  • the motion restricting section 504 can restrict the motion of the plunger 38 interlocked with the motion of the operation section 203 . That is, the position of the plunger 38 in the axial direction A with respect to the cylindrical body 36 of the cartridge 2 can be fixed by the operation restricting portion 504 .
  • the motion restricting portion 504 of the present embodiment restricts the pivotal motion of the operating lever 207 with respect to the charging device housing 205 . More specifically, as shown in FIGS. 10, 11A, and 11B, the motion restricting portion 504 of this embodiment includes a swinging member 514 that is swingably attached to the operating lever 207, and a biasing member 515 that biases the swinging member 514 toward the filler housing 205 .
  • the swinging member 514 extends along the extending direction E of the operating lever 207 inside the operating lever 207 .
  • the swinging member 514 is pivotally supported at a substantially central position in the extending direction E so as to be swingable with respect to the operating lever 207 .
  • the swinging surface of the swinging member 514 intersects the pivoting surface of the operating lever 207 with respect to the charger housing 205 . More specifically, the swinging surface of the swinging member 514 is substantially orthogonal to the swinging surface of the operating lever 207 with respect to the filling device housing 205 .
  • the swinging member 514 of this embodiment is pivotally supported on a shaft member 516 inserted through the through hole of the operating lever 207 so as to be swingable.
  • the rocking member 514 may be attached to the operating lever 207 so as to be rockable, and the configuration of attachment to the operating lever 207 is not particularly limited.
  • a first swinging portion 514a on one side of the swinging member 514 with respect to the shaft member 516 is provided with an operation convex portion 517 that can protrude outward from the operation lever 207 .
  • a second swinging portion 514 b on the other side of the swinging member 514 with respect to the shaft member 516 is provided with a locking convex portion 519 that can be fitted to the convex receiving portion 518 of the filling device housing 205 .
  • the biasing member 515 of this embodiment is, for example, a coil spring that biases the second swinging portion 514b of the swinging member 514 toward the filling device housing 205 .
  • the biasing member 515 may be, for example, a coil spring that biases the first swinging portion 514a of the swinging member 514 toward the side opposite to the filling device housing 205 side.
  • the operation regulation unit 504 of this embodiment operates as follows. As shown in FIG. 11B, the locking projection 519 of the swinging member 514 is fitted into the hole-shaped or concave projection receiving portion 518 of the filling device housing 205, thereby holding the swinging member 514 in the operation lever 207. can no longer rotate relative to the charger housing 205 . This state is hereinafter referred to as the “rotation restricted state” of the operating lever 207 . On the other hand, as shown in FIG. 11A, the locking projection 519 of the rocking member 514 is pulled out of the projection receiving portion 518 of the filling device housing 205, thereby moving the operating lever 207 relative to the filling device housing 205. becomes rotatable.
  • This state is hereinafter referred to as the “rotational allowable state” of the operating lever 207 .
  • the fitting state between the locking projection 519 of the swing member 514 and the projection receiving portion 518 of the filling device housing 205 is manipulated.
  • the operation lever 207 can be switched between the rotation permitted state (see FIG. 11A) and the rotation restricted state (see FIG. 11B).
  • the engagement projection 519 and projection receiving portion 518 can be operated by operating the operation projection 517 of the rocking member 514 .
  • the operation convex portion 517 of the swing member 514 protrudes outside the operation lever 207 when the operation lever 207 is in the rotation restricted state.
  • the operation convex portion 517 is pushed into the operation lever 207 against the biasing force of the biasing member 515 (the restoring force of the coil spring in this embodiment)
  • the swinging member 514 swings and the locking convex portion is engaged.
  • 519 exits from the convex receiving portion 518 .
  • the operation lever 207 switches from the rotation restricted state (see FIG. 11B) to the rotation permitted state (see FIG. 11A).
  • the biasing force of the biasing member 515 causes the second swinging portion 514 b of the swinging member 514 to move toward the filling device housing 205 . oscillate like At this time, the locking projection 519 and the projection receiving portion 518 are fitted to each other, so that the operation lever 207 returns from the rotation-allowing state (see FIG. 11A) to the rotation-restricting state (see FIG. 11B).
  • the operation of the operation unit 203 is restricted by the operation regulating unit 504 of the filling device 403 . Therefore, the movement of the plunger 38 of the cartridge 2 in the axial direction A, which is interlocked with the operation of the operation portion 203, is also restricted. Thereby, the position of the plunger 38 in the axial direction A can be suppressed from unintentionally fluctuating.
  • the operation restricting portion 504 is used, for example, to control the filling amount when filling the cylindrical body 36 of the cartridge 2 with the liquid medicine. For example, in the operation (see FIGS. 8A and 8B) of filling the cylinder 36 with the chemical from the chemical container 300 (see FIG.
  • the locking convex portion 519 of the present embodiment is designed to prevent the chemical in the cylinder 36 from It may be configured to fit into the convex receiving portion 518 at a position where the filling amount becomes the desired amount.
  • the filling amount of the chemical solution can be easily controlled, and overfilling or insufficient filling of the chemical solution is less likely to occur.
  • the filling device housing 205 of this embodiment is formed with a plurality of convex receiving portions 518 into which the engaging convex portions 519 can be fitted.
  • the plurality of convex receiving portions 518 are arranged on the same circumference of the circle around the rotation center axis of the operating lever 207 . Therefore, by rotating the operation lever 207 with respect to the filling device housing 205, the locking convex portion 519 can be fitted to a different convex receiving portion 518. As shown in FIG. As a result, for example, when it is necessary to change the filling amount of the liquid medicine in the cylindrical body 36 according to the patient's condition, etc., the filling amount of the liquid medicine can be easily switched by using the plurality of convex receiving portions 518 . can be done.
  • 12 to 13B are diagrams showing a motion restricting section 604 as a modified example of the motion restricting section 504 described above. 12 to 13B differs from the action restricting portion 504 shown in FIGS. 10 to 11B in the specific mechanism for restricting the operation of the operating lever 207 of the operating portion 203. .
  • the motion restricting portion 604 shown in FIGS. 12 to 13B includes a moving body 620 that can move linearly in the extending direction E of the operating lever 207. As shown in FIG., the operation restricting portion 604 includes a biasing member 621 that biases the moving body 620 in the extending direction E of the operating lever 207 in the direction away from the central axis of rotation of the operating lever 207 .
  • the moving body 620 is held by the operating lever 207 so as to be movable along the extending direction E of the operating lever 207 inside the operating lever 207 .
  • the moving body 620 includes a main body portion 622 and a swinging portion 623 connected to the main body portion 622 .
  • the body portion 622 extends like a rod along the extending direction E of the operating lever 207 .
  • the body portion 622 includes a force receiving portion 622 a that engages with the biasing member 621 and is pressed by the biasing member 621 .
  • the main body portion 622 includes an extension portion 622b extending in the extension direction E from the force receiving portion 622a toward the rotation center axis side of the operation lever 207. As shown in FIG. An end portion 622 b 1 of the extending portion 622 b on the side of the central axis of rotation of the operating lever 207 in the extending direction E can be fitted into a notch portion 205 e formed in the filling device housing 205 .
  • the body portion 622 has a projecting portion 622c projecting in the direction of rotation of the operating lever 207 with respect to the filling device housing 205 .
  • the projecting portion 622 c is configured to be movable in the extending direction E of the operating lever 207 within the guide recessed portion 207 b of the operating lever 207 .
  • the projecting portion 622c extends in the extending direction E with respect to the operation lever 207 from a position contacting the first wall portion 207b1 of the guide recess 207b to a position contacting the second wall portion 207b2 of the guide recess 207b. It is movable.
  • the first wall portion 207b1 of the guide recess 207b is a wall located on the rotation center axis side of the operation lever 207 in the extending direction E of the guide recess 207b.
  • the second wall portion 207b2 of the guide recess 207b is a wall located on the opposite side of the guide recess 207b from the rotation center axis side of the operation lever 207 in the extending direction E.
  • the first wall portion 207b1 and the second wall portion 207b2 of the guide recess 207b face each other in the extending direction E. As shown in FIG.
  • the swinging portion 623 is connected to an end portion 622d of the rod-shaped main body portion 622 on the side opposite to the rotation center axis side of the operation lever 207 .
  • the body portion 622 protrudes outward from the operation lever 207 on the side opposite to the rotation center axis side of the operation lever 207 in the extension direction E. As shown in FIG. That is, the end portion 622 d of the body portion 622 is exposed outside the operating lever 207 .
  • the swinging portion 623 extends from the end portion 622d of the rod-shaped main body portion 622 so as to be folded back toward the central axis of rotation of the operating lever 207 .
  • the swinging portion 623 can swing toward and away from the main body portion 622 with the end portion 622d of the main body portion 622 as a swinging fulcrum.
  • the swinging surface of the swinging portion 623 is substantially perpendicular to the swinging surface of the operating lever 207 with respect to the filling device housing 205 .
  • a claw portion 623 a that catches the claw receiving portion 207 c of the operation lever 207 is provided at the tip portion of the swing portion 623 located on the rotation center axis side of the operation lever 207 .
  • the portion folded back from the main body portion 622 to the swing portion 623 will be referred to as a "folded portion 624".
  • the biasing member 621 is a coil spring that biases the body portion 622 of the moving body 620 in the extending direction E of the operating lever 207 in the direction away from the central axis of rotation of the operating lever 207 .
  • the operation restricting section 604 shown in FIGS. 12 to 13B operates as follows.
  • the end portion 622b1 of the moving body 620 on the rotation center axis side of the operation lever 207 is fitted into the notch portion 205e of the charging device housing 205, so that the operating lever 207 holding the moving body 620 can move toward the charging device. It becomes impossible to rotate with respect to the housing 205 .
  • This state is hereinafter referred to as the “rotation restricted state” of the operating lever 207 .
  • the end portion 622b1 of the moving body 620 is pulled out of the notch portion 205e of the filling device housing 205, so that the operating lever 207 can rotate with respect to the filling device housing 205.
  • This state is hereinafter referred to as the “rotational allowable state” of the operating lever 207 . 12 to 13B, the fitting state between the end 622b1 of the moving body 620 and the notch 205e of the filling device housing 205 is manipulated. As a result, the operation lever 207 can be switched between the rotation permitted state (see FIG. 13A) and the rotation restricted state (see FIG. 13B).
  • the end portion 622b1 of the moving body 620 and the notch portion 205e of the filling device housing 205 are operated to be in a fitted state. It can be executed by operating a folded portion 624 that protrudes outward from the operating lever 207 on the opposite side. Specifically, the folded portion 624 is pushed toward the rotation center axis of the operation lever 207 in the extending direction E against the biasing force of the biasing member 621 (the restoring force of the coil spring in this example). Thereby, the end portion 622b1 of the moving body 620 can be fitted into the notch portion 205e of the filling device housing 205. As shown in FIG. That is, the operation lever 207 is switched from the rotation permitted state (see FIG. 13A) to the rotation restricted state (see FIG. 13B).
  • the moving body 620 is operated in the extension direction E by the biasing force of the biasing member 621.
  • the lever 207 moves to the side opposite to the central axis of rotation. That is, the operation lever 207 returns from the rotation restricted state (see FIG. 13B) to the rotation permitted state (see FIG. 13A).
  • the filling device housing 205 is formed with a plurality of notches 205e.
  • the plurality of cutouts 205e are arranged along the rotation center axis of the operation lever 207. As shown in FIG. Therefore, by rotating the operating lever 207 with respect to the filling device housing 205, the end portion 622b1 of the moving body 620 can be fitted to a different notch portion 205e. As a result, for example, when it is necessary to change the filling amount of the liquid medicine in the cylindrical body 36 according to the patient's condition or the like, the filling amount of the liquid medicine can be easily switched by using the plurality of notches 205e. can be done.
  • the present disclosure relates to a chemical filling device and a filling device.

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Abstract

Un dispositif de remplissage de médicament liquide selon la présente divulgation comprend : une cartouche pourvue d'un réservoir de médicament liquide qui est pourvu d'un orifice de remplissage de médicament liquide ; et un instrument de remplissage qui peut être monté sur la cartouche, et qui permet l'opération de remplissage du réservoir de médicament liquide avec un médicament liquide à travers l'orifice de remplissage tout en étant dans un état monté où l'instrument de remplissage est monté sur la cartouche. Le réservoir de médicament liquide de la cartouche est pourvu : d'un cylindre pourvu de l'orifice de remplissage et apte à contenir le médicament liquide ; et d'un piston mobile axialement à l'intérieur du cylindre. L'instrument de remplissage est pourvu : d'une partie de maintien qui maintient la cartouche de telle sorte que l'instrument de remplissage est dans l'état monté ; d'une partie de mise en prise qui, pendant que l'instrument de remplissage dans l'état monté, vient en prise avec le piston ; et d'une partie d'actionnement qui, pendant que l'instrument de remplissage dans l'état monté, permet l'opération de déplacement du piston dans la direction axiale par l'intermédiaire de la partie de mise en prise.
PCT/JP2023/006071 2022-03-01 2023-02-20 Dispositif de remplissage de médicament liquide et instrument de remplissage Ceased WO2023167042A1 (fr)

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JP2022031284 2022-03-01

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015115435A1 (fr) * 2014-01-30 2015-08-06 テルモ株式会社 Unité de remplissage de médicament liquide, instrument à réservoir de médicament liquide, et adaptateur de remplissage
WO2016051999A1 (fr) * 2014-09-29 2016-04-07 テルモ株式会社 Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux
WO2018092437A1 (fr) * 2016-11-21 2018-05-24 テルモ株式会社 Unité de remplissage de solution médicamenteuse, ensemble de remplissage de solution médicamenteuse et adaptateur de remplissage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015115435A1 (fr) * 2014-01-30 2015-08-06 テルモ株式会社 Unité de remplissage de médicament liquide, instrument à réservoir de médicament liquide, et adaptateur de remplissage
WO2016051999A1 (fr) * 2014-09-29 2016-04-07 テルモ株式会社 Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux
WO2018092437A1 (fr) * 2016-11-21 2018-05-24 テルモ株式会社 Unité de remplissage de solution médicamenteuse, ensemble de remplissage de solution médicamenteuse et adaptateur de remplissage

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