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WO2025249005A1 - Dispositif de remplissage avec une solution médicamenteuse - Google Patents

Dispositif de remplissage avec une solution médicamenteuse

Info

Publication number
WO2025249005A1
WO2025249005A1 PCT/JP2025/014786 JP2025014786W WO2025249005A1 WO 2025249005 A1 WO2025249005 A1 WO 2025249005A1 JP 2025014786 W JP2025014786 W JP 2025014786W WO 2025249005 A1 WO2025249005 A1 WO 2025249005A1
Authority
WO
WIPO (PCT)
Prior art keywords
holder
filling device
vial
reservoir
cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2025/014786
Other languages
English (en)
Japanese (ja)
Inventor
柳沢克哉
関口彰太
山本勝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of WO2025249005A1 publication Critical patent/WO2025249005A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Definitions

  • This disclosure relates to a drug solution filling device.
  • Japanese Patent Publication No. 5102350 discloses a drug solution filling device equipped with a reservoir for filling with drug solution.
  • the drug solution filling device includes a reservoir, a plunger movably mounted inside the reservoir, and a needle mounted at the tip of the reservoir.
  • a vial is connected to the tip of the reservoir, connecting the interior of the vial to the reservoir through the needle. Air is introduced into the vial by moving the plunger toward the vial. The air in the vial pushes the drug solution out of the vial, introducing the drug solution into the reservoir through the needle.
  • the purpose of this disclosure is to solve the above-mentioned problems.
  • An aspect of the present disclosure is a drug solution filling device comprising: a cartridge having a reservoir capable of containing a drug solution; a plunger that is movable in the axial direction of the reservoir to dispense the drug solution from the reservoir; and an adapter that is removably attached to the cartridge, wherein the adapter has a vial connection portion with a needle that can be connected to a vial, and an operating portion that moves the plunger along the axial direction of the reservoir.
  • the user can operate the operating unit to more efficiently fill the reservoir with medicinal liquid.
  • the operating unit may be engaged with the plunger and movable relative to the vial connection unit in the direction of movement of the plunger.
  • the plunger can be easily moved by operating the operating part on the adapter. After use, the operating part can be disposed of along with the adapter.
  • the vial connection unit and the operating unit may be arranged to be movable relative to each other, and the vial connection unit and the operating unit may each be independently detachable from the cartridge.
  • This configuration allows the drug solution filling device to be easily removed from the cartridge after use and discarded, while also allowing the drug solution filling device to be made more compact.
  • the adapter may include a holder that holds the cartridge, and the vial connection portion and the operating portion may be supported by the holder.
  • the vial connection portion and the holder may be arranged to be movable relative to each other, and the adapter may have an engagement structure that engages the vial connection portion and the holder with each other.
  • the engagement structure effectively prevents unintended relative movement between the holder and the vial connection portion.
  • the vial connection part may be movable relative to the holder from at least a first position to a second position in the direction of relative movement between the vial connection part and the holder, and when the vial connection part is located at the first position, the needle is in a disconnected state where it is not connected to the reservoir, and when the vial connection part is located at the second position, the needle is in a connected state where it is connected to the reservoir, and the engagement structure may include a first engagement part that engages the vial connection part with the holder at the first position, and a second engagement part that engages the vial connection part with the holder at the second position.
  • the first engagement portion effectively prevents connection between the needle and the reservoir
  • the second engagement portion effectively maintains the needle and the reservoir connected.
  • the adapter may have a locking portion that restricts relative movement between the vial connection portion and the holder at the first position, and the locking portion may be a protrusion that can be overcome when the vial connection portion and the holder move relative to each other from the first position toward the second position.
  • the protruding locking portion effectively maintains the vial connection portion and holder in the first position.
  • the adapter may include a switching structure that switches the engagement state between the vial connection portion and the holder via the engagement structure, and the switching structure may switch between the engagement state between the vial connection portion and the holder via a first engagement portion and the engagement state between the vial connection portion and the holder via a second engagement portion.
  • This configuration makes it possible to effectively switch between engagement by the first engagement portion and engagement by the second engagement portion as needed.
  • the holder may include a base to which the cartridge is attached, a lid formed integrally with the base and supported so as to be openable and closable relative to the base, and which covers the opening of the base when closed, and a storage section surrounded by the base and the lid to store the cartridge.
  • the cartridge when removing a cartridge filled with liquid medicine, the cartridge can be easily removed from the holder by opening the lid.
  • the holder may have a hinge structure that rotatably supports the lid portion relative to the base portion.
  • This configuration allows the lid to be easily opened and closed relative to the base using the hinge structure.
  • the holder may have a locking structure that engages the base and the lid, and the locking structure may be provided on the side opposite the hinge structure across the storage section.
  • the locking structure effectively prevents the lid from opening relative to the base.
  • the cartridge may be disposed between the base and the lid, and the lid may have a pressing portion that extends toward the base and abuts against the cartridge when the opening of the base is closed by the lid.
  • the pressing portion presses the cartridge toward the base, preventing the cartridge from floating up within the holder and effectively holding it in place.
  • the operating unit may be attached to the lid.
  • This configuration allows the operating part to be detached from the plunger when the lid is opened, allowing the adapter to be efficiently removed from the cartridge.
  • the liquid medicine filling device described in (3) above may be housed in a container and sterilized. This configuration effectively maintains the liquid medicine filling device in a sterile state before use.
  • a device includes a cartridge having a reservoir and an adapter removably attached to the cartridge, and the adapter has a vial connection portion with a needle that can be connected to a vial, and an operating portion that moves the plunger along the axial direction of the reservoir, thereby enabling more efficient transfer of medicinal liquid from the vial to the reservoir.
  • FIG. 1 is an external perspective view of a drug solution filling device according to an embodiment of the present disclosure.
  • FIG. 2 is a plan view showing the first position of the drug solution filling device of FIG.
  • FIG. 3 is a perspective view of the cartridge. 4 is a bottom view of the drug solution filling device of FIG. 1.
  • FIG. 5 is a cross-sectional view taken along line VV in FIG.
  • FIG. 6 is a perspective view of the exterior of a container in which the adapter and the cartridge are housed.
  • FIG. 7 is a cross-sectional view taken along line VII-VII in FIG.
  • FIG. 8 is a cross-sectional view taken along line VIII-VIII in FIG.
  • FIG. 9 is a cross-sectional view taken along line IX-IX in FIG.
  • FIG. 10 is a plan view showing the second position of the drug solution filling device.
  • FIG. 11 is a cross-sectional view taken along line XI-XI in FIG.
  • FIG. 12 is a cross-sectional view taken along line XII-XII in FIG.
  • FIG. 13 is a cross-sectional view taken along line XIII-XIII in FIG.
  • FIG. 14 is a first explanatory diagram showing the operation of the chemical solution filling device.
  • FIG. 15 is a second explanatory diagram showing the operation of the chemical solution filling device.
  • FIG. 16 is an exploded perspective view showing a state in which the vial connecting portion is removed from the holder.
  • FIG. 17 is a perspective view showing a state in which the cover of the holder is open.
  • FIG. 18 is an explanatory diagram showing a state in which the cartridge is attached to the drug solution administration device.
  • the drug solution filling device 10 is used to aspirate drug solution M to be administered to living organism A (see FIG. 18) from vial B (see FIG. 15) and fill it into reservoir 18.
  • the cartridge 12 is housed inside the adapter 14. After being separated from the adapter 14, the cartridge 12 forms part of the medicinal liquid administration device 100 (see Figure 18), which will be described later.
  • the cartridge 12 includes a casing 16, a reservoir 18, a plunger 20, a drive unit 22, and a flow path forming member 24.
  • the casing 16 has a bottom 161 and a side 162.
  • the casing 16 is formed, for example, in a rectangular shape when viewed from above (see Figure 2). Note that the casing 16 is not limited to being formed in a rectangular shape when viewed from above.
  • the bottom 161 is formed flat.
  • the bottom 161 is provided with a cannula accommodating portion 163 that is recessed upward (see Figure 4).
  • the side 162 is formed in an annular shape and extends in the height direction from the periphery of the bottom 161.
  • the casing 16 further has an abutment portion 164.
  • the abutment portion 164 is provided in approximately the center of the casing 16 and is approximately parallel to the bottom 161.
  • the abutment portion 164 has a flat surface that extends in a direction perpendicular to the height direction of the side 162 (see Figure 7).
  • the reservoir 18 is a syringe type.
  • the plunger 20 ejects the medicinal liquid M (see Figure 15) from the reservoir 18.
  • the plunger 20 is provided so as to be movable in the axial direction of the reservoir 18.
  • the plunger 20 comprises a pressing body 201 and a rod 202 that presses the pressing body 201.
  • the pressing body 201 is movably housed inside the reservoir 18, and a rubber gasket (not shown) is provided around the pressing body 201.
  • the pressing body 201 is housed inside the reservoir 18 so as to be movable along the axial direction of the reservoir 18.
  • the pair of rods 202 are connected to the base ends of the pressing body 201.
  • a connecting plate 203 is connected to the base end of the rod 202.
  • a screw hole 28 penetrates the center of the connecting plate 203 in the thickness direction of the connecting plate 203.
  • the base end of the rod 202 has a groove 30 recessed in a direction perpendicular to the extension direction of the rod 202.
  • the groove 30 is provided toward the tip of the connecting plate 203.
  • the drive unit 22 is housed inside the casing 16. As shown in FIG. 5, the drive unit 22 is provided towards the base end of the reservoir 18.
  • the drive unit 22 has a shaft portion 221, a gear portion 222 provided at the base end of the shaft portion 221, and a connecting plate 203.
  • the shaft portion 221 extends along the axial direction, and the tip of the shaft portion 221 is supported by the casing 16 and the reservoir holder 26.
  • a thread is formed on the outer peripheral surface of the shaft portion 221. The shaft portion 221 is inserted into and engages with the threaded hole 28 of the connecting plate 203.
  • the gear portion 222 is provided at the base end of the shaft portion 221. Gear teeth are formed on the outer peripheral surface of the gear portion 222. The gear teeth of the gear portion 222 mesh with a motor (not shown) of the medicinal solution administration device 100, which will be described later.
  • a motor not shown
  • the gear portion 222 and the shaft portion 221 rotate, and the plunger 20 moves toward the tip via the connecting plate 203.
  • the plunger 20 moves toward the tip via the connecting plate 203.
  • the flow path forming member 24 is provided in a storage groove 165 formed in the bottom 161 of the casing 16.
  • the flow path forming member 24 has a flow groove 241 through which the medicinal solution M can flow.
  • the flow groove 241 is formed along the extension direction of the flow path forming member 24.
  • the tip of the flow path forming member 24 faces the medicinal solution outlet 182, and the tip of the flow groove 241 is connected to the medicinal solution outlet 182.
  • the base end of the flow path forming member 24 is positioned in the cannula storage section 163 (see FIG. 4).
  • the base end of the flow groove 241 can be connected to the cannula unit 104, which will be described later (see FIG. 18).
  • the holder 32 is formed in a hollow cylindrical shape. When viewed in the axial direction of the reservoir 18, the holder 32 has a rectangular cross-section with a width greater than its height. However, the holder 32 is not limited to being formed in a rectangular cross-section.
  • the holder 32 supports the vial connection portion 34 and the operating portion 36.
  • the holder 32 and the vial connection portion 34 are arranged so that they can move relative to each other in the axial direction of the reservoir 18.
  • the operating portion 36 (holder 32) and the vial connection portion 34 are detachably connected to the cartridge 12 independently of each other.
  • the holder 32 comprises a base 321, a lid 322, and a storage section 323.
  • the base 321 forms the lower part of the holder 32.
  • the base 321 has an opening 38 that opens upward (see Figure 17).
  • the cartridge 12 is attached to the bottom of the base 321.
  • the lid 322 is formed integrally with the base 321 and is supported so as to be openable and closable relative to the base 321 by a hinge structure 44 described below.
  • the lid 322 faces the base 321 and covers the opening 38 of the base 321.
  • the storage section 323 is surrounded by the base 321 and the lid 322.
  • the cartridge 12 is stored in the storage section 323. That is, in the height direction of the holder 32, the cartridge 12 is positioned between the base 321 and the lid 322.
  • the lid portion 322 further includes a pressing portion 40.
  • the pressing portion 40 is provided on the inner surface of the lid portion 322 facing the base portion 321.
  • the pressing portion 40 protrudes from the inner surface of the lid portion 322 toward the base portion 321.
  • the pressing portion 40 is perpendicular to the inner surface of the lid portion 322.
  • the tip of the pressing portion 40 has a pressing surface 401 that is perpendicular to the extension direction of the pressing portion 40.
  • the holder 32 further includes an insertion portion 42, a hinge structure 44 (see FIG. 7), and a locking structure 46.
  • the insertion portion 42 is provided at the tip of the holder 32.
  • the insertion portion 42 can be inserted into the vial connection portion 34.
  • the outer surface of the insertion portion 42 is formed in a stepped shape that is recessed inward from the outer surface of the holder 32 (see FIG. 5).
  • the insertion portion 42 is composed of a base portion 321 and a lid portion 322 (see FIG. 17).
  • the hinge structure 44 rotatably supports the lid portion 322 relative to the base portion 321 (see Figure 17). As shown in Figure 4, the hinge structure 44 is provided on a first side portion 481 on one side of the width direction of the holder 32, which is perpendicular to the axial direction of the reservoir 18. In other words, the hinge structure 44 is provided approximately parallel to the axial direction of the reservoir 18 (see Figure 2).
  • the hinge structure 44 connects the base 321 and the lid 322 at the first side 481 of the holder 32.
  • the rotation direction of the lid 322 intersects with the direction of relative movement between the vial connection portion 34 and the holder 32 (the axial direction of the reservoir 18) (see FIG. 17).
  • the vial connection portion 34 covers the base 321 and lid 322 that constitute the insertion portion 42 (see FIG. 13).
  • the rotation of the lid 322 via the hinge structure 44 is restricted by the vial connection portion 34. In other words, when the vial connection portion 34 is removed from the holder 32 and the insertion portion 42 is exposed (see FIG. 16), the lid 322 can rotate relative to the base 321.
  • the locking structure 46 includes a first locking portion 461 provided on the base 321 and a second locking portion 462 provided on the lid portion 322 that engages with the first locking portion 461.
  • the first locking portion 461 is a protrusion 50 that protrudes widthwise from the second side portion 482 of the base 321.
  • the second locking portion 462 has a gripping portion 52 that protrudes downward from the side of the lid portion 322 and a hole 54 that penetrates the gripping portion 52 in the thickness direction and engages with the protrusion 50.
  • the gripping portion 52 is supported on the lower end of the lid portion 322 and can tilt around the support position. In other words, the upper end of the gripping portion 52 is a fixed end fixed to the holder 32. With the opening 38 of the base 321 covered by the lid portion 322, the protrusion 50 engages with the hole 54 of the gripping portion 52.
  • first locking portion 461 is not limited to being a protrusion 50 and the second locking portion 462 is not limited to being a hole 54 provided in the gripping portion 52.
  • the first locking portion 461 may be a hole 54 and the second locking portion 462 may be a protrusion 50 provided in the gripping portion 52 that engages with the hole 54.
  • the vial connection part 34 is provided so as to be movable relative to the holder 32 in the axial direction of the reservoir 18.
  • the vial connection part 34 is provided on the tip side of the holder 32.
  • the vial connection part 34 has a cylindrical housing 56 and a needle 58 that can be connected to vial B (see FIG. 10).
  • the housing 56 When viewed in the axial direction of the reservoir 18, the housing 56 has a rectangular cross-section whose width is greater than its height. Note that the housing 56 is not limited to being formed with a rectangular cross-section. As shown in FIG. 9 , the housing 56 includes a cylindrical mounting portion 561 at the tip and an insertion hole 562 at the base end into which the holder 32 can be inserted. The mounting portion 561 is provided at the tip of the housing 56 and is configured to allow connection to a vial B. The base end of the mounting portion 561 has a support wall 563. A needle 58 is provided at the center of the mounting portion 561. As shown in FIG. 2 , the housing 56 further includes a window 564.
  • the window 564 is a hole that penetrates the housing 56 and is configured to allow the reservoir 18 contained inside the housing 56 to be viewed from the outside. In this way, when the vial connection portion 34 is connected to the reservoir 18, the interior of the reservoir 18 can be viewed from the outside of the vial connection portion 34.
  • the needle 58 is a hollow needle with an internal cavity.
  • the needle 58 is supported by a support wall 563 of the mounting part 561.
  • the needle 58 protrudes distally and proximally relative to the support wall 563.
  • the distal end 581 of the needle 58 protrudes distally beyond the support wall 563.
  • the distal end 581 of the needle 58 is exposed inside the mounting part 561.
  • the proximal end 582 of the needle 58 protrudes proximally beyond the support wall 563.
  • the proximal end 582 of the needle 58 faces the drug solution inlet 181 of the reservoir 18 and the sealing body 25.
  • the insertion hole 562 opens at the base end of the housing 56.
  • the insertion portion 42 of the holder 32 can be inserted into the insertion hole 562.
  • the vial connection portion 34 is movable relative to the holder 32 from at least a first position (see Figure 2) to a second position (see Figure 10).
  • the first position is the position in the initial state (shipment state) when the drug solution filling device 10 is unused. In the initial state, the interior of the reservoir 18 is maintained in a sterile state. In the first position, the base end 582 of the needle 58 and the drug solution inlet 181 of the reservoir 18 are spaced apart in the axial direction.
  • the first position is a position in which the vial connection portion 34 has moved a predetermined distance toward the tip relative to the holder 32. A portion of the insertion portion 42 is inserted into the insertion hole 562 of the housing 56.
  • the vial connection portion 34 when the vial connection portion 34 is located at the second position relative to the holder 32, the vial connection portion 34 and the holder 32 move relative to each other in a direction approaching each other relative to the first position.
  • the second position is a connected state in which the needle 58 is connected to the reservoir 18 (see Figure 11).
  • the base end 582 of the needle 58 punctures the drug solution inlet 181 of the reservoir 18, connecting the inner cavity of the needle 58 to the interior of the reservoir 18.
  • the insertion portion 42 of the holder 32 is inserted further in the distal direction than at the first position.
  • the operating unit 36 is provided on the lid portion 322 of the holder 32.
  • the operating unit 36 is provided so as to be movable along a guide hole 60 that opens into the outer surface of the lid portion 322.
  • the guide hole 60 extends along the axial direction of the reservoir 18.
  • the operating unit 36 has an operating unit main body 361 and an insertion piece 362.
  • the operating unit main body 361 is exposed to the outside of the holder 32 and can be operated by the user.
  • the operating unit main body 361 engages with the holder 32 so as to be movable along the guide hole 60.
  • the operating unit 36 is not limited to being provided on the lid portion 322.
  • the operating unit 36 may be provided on the base portion 321.
  • the insertion piece 362 protrudes from the operating unit main body 361 in a direction perpendicular to the movement direction of the holder 32.
  • the insertion piece 362 is positioned inside the holder 32 and inserted into the groove 30 of the rod 202.
  • the insertion piece 362 engages the rod 202 of the plunger 20 with the operating unit 36 in the axial direction of the reservoir 18.
  • the plunger 20 moves along the axial direction of the reservoir 18.
  • the operating unit 36 is engaged with the plunger 20 and can move relative to the holder 32 in the movement direction of the plunger 20.
  • the adapter 14 further includes an engagement structure 62, a switching structure 64, and a locking portion 66.
  • FIG. 12 is a cross-sectional view of the adapter 14 in the first position.
  • the engagement structure 62 engages the vial connection portion 34 and the holder 32 with each other.
  • the engagement structure 62 includes a first engagement portion 621 and a second engagement portion 622.
  • the first engagement portion 621 engages the vial connection portion 34 and the holder 32 with each other in the first position.
  • the second engagement portion 622 engages the vial connection portion 34 and the holder 32 with each other in the second position.
  • the first engagement portion 621 includes a protrusion 68 provided on the vial connection portion 34 and a first recess 701 provided on the bottom 161 of the cartridge 12 with which the protrusion 68 engages.
  • the first recess 701 is recessed into the bottom 161 of the cartridge 12.
  • the second engagement portion 622 includes a protrusion 68 provided on the vial connection portion 34 and a second recess 702 provided on the bottom 161 of the cartridge 12 with which the protrusion 68 engages (see FIG. 13).
  • the second recess 702 is recessed into the bottom 161 of the cartridge 12.
  • the second recess 702 is positioned closer to the base end than the first recess 701.
  • the first recess 701 and the second recess 702 are spaced apart in the axial direction of the reservoir 18 and are arranged linearly in the axial direction.
  • the convex portion 68 of the first engagement portion 621 and the convex portion 68 of the second engagement portion 622 are the same.
  • the convex portion 68 of the first engagement portion 621 and the convex portion 68 of the second engagement portion 622 may be different.
  • the first engagement portion 621 engages the convex portion 68 with the first recess 701 at the first position.
  • the first engagement portion 621 restricts relative movement between the vial connection portion 34 and the holder 32 along the axial direction of the reservoir 18 at the first position.
  • the second engagement portion 622 engages the convex portion 68 with the second recess 702 at the second position.
  • the second engagement portion 622 restricts relative movement between the vial connection portion 34 and the holder 32 along the axial direction of the reservoir 18 at the second position.
  • the engagement structure 62 is not limited to being composed of a protrusion 68 provided on the vial connection portion 34 and a first recess 701 and a second recess 702 provided on the cartridge 12.
  • a single recess may be provided on the vial connection portion 34, and a first protrusion and a second protrusion that engage with the recess may be provided on the cartridge 12.
  • the first recess 701 and the second recess 702 may each be provided on the bottom of the holder 32.
  • the switching structure 64 is provided in the housing 56 of the vial connection portion 34.
  • the switching structure 64 switches the engagement state between the vial connection portion 34 and the holder 32 via the engagement structure 62.
  • the switching structure 64 is not limited to being provided in the vial connection portion 34.
  • the switching structure 64 may be provided in the holder 32.
  • the locking portion 66 is provided on the insertion portion 42 of the holder 32.
  • the locking portion 66 restricts relative movement between the vial connection portion 34 and the holder 32 in the first position.
  • the locking portion 66 is a protrusion protruding from the outer surface of the insertion portion 42.
  • Multiple locking portions 66 are provided along the insertion portion 42. The number of locking portions 66 is not limited to multiple.
  • the locking portion 66 contacts the base end of the vial connection portion 34. The locking portion 66 prevents relative movement between the vial connection portion 34 and the holder 32.
  • the drug solution filling device 10 is used as follows.
  • a needle connection process is performed to connect the needle 58 to the reservoir 18.
  • the needle connection process is performed by moving the adapter 14 from the first position to the second position.
  • the vial connection portion 34 is pulled out toward the tip relative to the holder 32, as shown in FIG. 16.
  • the insertion portion 42 of the holder 32 and a portion of the cartridge 12 are exposed.
  • the needle 58 is removed from the reservoir 18 along with the vial connection portion 34.
  • the drug solution inlet 181 of the reservoir 18 is sealed by the seal 25.
  • the removed vial connection part 34 is discarded and not reused.
  • the user grasps the cartridge 12 and removes it upward from the base 321 of the holder 32 (see Figure 3).
  • the holder 32 including the operating unit 36 is discarded and not reused.
  • the holder 32 does not have to have the hinge structure 44.
  • the lid portion 322 may be completely detachable from the base 321.
  • the cartridge 12 which includes a reservoir 18 containing medicinal liquid M, is used as part of a medicinal liquid administration device 100, as shown in Figure 18.
  • the administration device main body 106 includes a cartridge 12 and a pump unit 105.
  • the pump unit 105 is detachable from the cartridge 12.
  • the pump unit 105 includes a cover member 114 and a motor (not shown) capable of driving the drive unit 22 of the cartridge 12.
  • the driving force of the motor (not shown) is transmitted to the gear portion 222 of the drive unit 22 via a transmission mechanism (not shown).
  • the pump unit 105 is attached to the cartridge 12 before the administration device main body 106 is attached to the mounting holder 102.
  • the attachment surface 107 of the mounting holder 102 is attached to a predetermined area of the skin of living body A in advance.
  • the tip of the cannula 110 attached to the mounting holder 102 is inserted subcutaneously together with the puncture needle, and the tip of the cannula 110 is left subcutaneously by removing the puncture needle.
  • the administration device main body 106 is attached to the mounting holder 102 fixed to living body A. Specifically, the bottom 161 of the cartridge 12 is aligned with the mounting holder 102, and the base end of the flow path forming member 24 is inserted into the connecting portion 112 of the cannula unit 104. This connects the cannula 110 and reservoir 18 via the flow groove 241 of the flow path forming member 24.
  • the drive unit 22 (see Figure 5) is driven in conjunction with the motor's operation, and the medicinal liquid M is supplied to the cannula unit 104 through the flow groove 241 of the flow path forming member 24 and administered subcutaneously to living body A by the cannula 110.
  • the medicinal liquid filling device 10 includes a cartridge 12 having a reservoir 18 capable of containing medicinal liquid M and a plunger 20 that is movable in the axial direction of the reservoir 18, and an adapter 14 that is removably attached to the cartridge 12.
  • the adapter 14 includes a vial connection portion 34 that has a needle 58 that can be connected to a vial B, and an operating portion 36 that moves the plunger 20 along the axial direction of the reservoir 18. This configuration allows the medicinal liquid M to be more efficiently filled from the vial B into the reservoir 18.
  • the operating part 36 is engaged with the plunger 20 and is movable relative to the vial connection part 34 in the direction of movement of the plunger 20. With this configuration, the plunger 20 can be easily moved by operating the operating part 36. After use, the operating part 36 can be detached from the plunger 20 and easily disposed of.
  • the adapter 14 has an engagement structure 62 that engages the vial connection portion 34 and the holder 32 with each other.
  • the engagement structure 62 effectively prevents unintended relative movement between the holder 32 and the vial connection portion 34 while the medicinal liquid M is being filled.
  • the engagement structure 62 includes a first engagement portion 621 that engages the vial connection portion 34 and the holder 32 with each other in a first position where the needle 58 is not connected to the reservoir 18, and a second engagement portion 622 that engages the vial connection portion 34 and the holder 32 with each other in a second position where the needle 58 is connected to the reservoir 18, as shown in FIG. 13 .
  • the first engagement portion 621 disconnects the needle 58 from the reservoir 18, allowing the interior of the reservoir 18 to be kept sterile.
  • the second engagement portion 622 connects the needle 58 and the reservoir 18, allowing the medicinal liquid M to be effectively filled.
  • the adapter 14 has a locking portion 66 that restricts relative movement between the vial connection portion 34 and the holder 32 when in the first position.
  • the locking portion 66 is a protrusion that can be overcome when the vial connection portion 34 and the holder 32 move relative to each other from the first position toward the second position. With this configuration, the locking portion 66 effectively maintains the vial connection portion 34 and the holder 32 in the first position.
  • the holder 32 comprises a base 321 to which the cartridge 12 is attached, and a lid 322 formed integrally with the base 321, supported so as to be openable and closable relative to the base 321, and covering the opening 38 of the base 321 when closed.
  • the components arranged inside the cartridge 12 can be physically protected until filling with the medicinal liquid M is complete.
  • the cartridge 12 can be easily removed from the holder 32 by opening the lid 322.
  • the holder 32 has a locking structure 46 that engages the base 321 and the lid 322 with each other, and the locking structure 46 is provided on the side opposite the hinge structure 44, with the storage section 323 in between. With this configuration, the locking structure 46 can effectively prevent the lid 322 from opening relative to the base 321.
  • the lid 322 has a pressing portion 40 that extends toward the base 321 and abuts against the cartridge 12. With this configuration, when the lid 322 is closed, the pressing portion 40 presses the cartridge 12 toward the base 321, preventing the cartridge 12 from floating up within the holder 32 and effectively holding it in place.
  • the operating unit 36 is attached to the lid 322. With this configuration, the operating unit 36 can be detached from the plunger 20 when the lid 322 is opened, allowing the adapter 14 to be efficiently removed from the cartridge 12.
  • the liquid medicine filling device 10 is housed and sterilized in a container C, so that the liquid medicine filling device 10 is effectively maintained in a sterile state before use.

Landscapes

  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif de remplissage (10) avec une solution médicamenteuse comprenant : une cartouche (12) ayant un réservoir (18) apte à recevoir une solution médicamenteuse (M), et un piston (20) disposé de façon à pouvoir se déplacer dans la direction axiale du réservoir (18) ; et un adaptateur (14) fixé de manière amovible à la cartouche (12). L'adaptateur (14) comprend : une partie de raccordement de flacon (34) ayant une aiguille (58) qui peut être reliée à un flacon (B) ; et une partie d'actionnement (36) pour déplacer le piston (20) le long de la direction axiale du réservoir (18).
PCT/JP2025/014786 2024-05-28 2025-04-15 Dispositif de remplissage avec une solution médicamenteuse Pending WO2025249005A1 (fr)

Applications Claiming Priority (2)

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