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WO2023167044A1 - Dispositif de remplissage de médicament liquide et dispositif de remplissage - Google Patents

Dispositif de remplissage de médicament liquide et dispositif de remplissage Download PDF

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Publication number
WO2023167044A1
WO2023167044A1 PCT/JP2023/006073 JP2023006073W WO2023167044A1 WO 2023167044 A1 WO2023167044 A1 WO 2023167044A1 JP 2023006073 W JP2023006073 W JP 2023006073W WO 2023167044 A1 WO2023167044 A1 WO 2023167044A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
filling device
housing
plunger
drug solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/006073
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English (en)
Japanese (ja)
Inventor
城司 内山
剛 山崎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP2024504627A priority Critical patent/JPWO2023167044A1/ja
Publication of WO2023167044A1 publication Critical patent/WO2023167044A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps

Definitions

  • the present disclosure relates to a chemical filling device and a filling device.
  • the drug solution administration device Since the drug solution administration device is fixed to the patient's body and carried around, it is preferable that the drug solution administration device be small. On the other hand, if the cartridge of the drug solution administration device is downsized, the above-described drug solution filling operation tends to be complicated, and operability tends to deteriorate.
  • An object of the present disclosure is to provide a liquid medicine filling device and a filling device that are capable of both reducing the size of the cartridge and improving the operability of filling the liquid medicine into the cartridge.
  • a chemical solution filling device as a first aspect of the present disclosure includes a cartridge comprising a chemical solution reservoir having a chemical solution filling port; a viable filling device, wherein the drug reservoir of the cartridge comprises a barrel including the filling port and capable of containing the drug; and a plunger axially movable within the barrel;
  • the filling device includes an engaging portion engageable with the plunger, an operating portion capable of executing an operation of moving the plunger in the axial direction via the engaging portion engaged with the plunger,
  • An accommodating member defining an accommodating space capable of accommodating the cartridge, and a housing body supporting the accommodating member in a swingable manner are provided, and the engaging member is pivoted with respect to the housing body. a joint and a charger housing switchable between engaged and disengaged states of the plunger.
  • the containing member of the filling device housing includes an insertion portion that allows the cartridge to be inserted into the containing space.
  • the cartridge is arranged such that the axial direction of the cylinder is vertical so that the cylinder is vertically upward with respect to the plunger.
  • the insertion portion of the accommodating member of the filling device housing is configured so that the cartridge in the vertical posture can be inserted from the upper side to the lower side in the vertical direction.
  • the containing member of the filling device housing has a direction in which the other end side thereof with respect to one end side in which the insertion portion is provided is in a direction approaching the housing body and a direction away from the housing body. It is supported by the housing body so as to be able to swing in and out.
  • At least part of the cylindrical body of the cartridge is exposed without being covered by the filler in the engaged state of the engaging portion and the plunger.
  • the filling device includes an operation restricting portion capable of restricting the movement range of the plunger in the axial direction with respect to the cylindrical body of the cartridge by restricting the operation of the operating portion.
  • the device includes a container connecting portion to which a drug solution container can be connected, and an adapter that can be attached to the cartridge.
  • a filling device as a second aspect of the present disclosure is capable of holding a cartridge comprising a drug solution reservoir having a drug solution filling port, and capable of performing an operation of filling the drug solution into the drug solution reservoir through the filling port.
  • the drug solution reservoir of the cartridge includes a cylindrical body having the filling port and capable of containing the drug solution, and a plunger axially movable in the cylindrical body, and engageable with the plunger. an engaging portion, an operation portion capable of moving the plunger in the axial direction via the engaging portion engaged with the plunger, and an accommodating space capable of accommodating the cartridge.
  • An accommodating member and a housing body that rockably supports the accommodating member are provided, and by rocking the accommodating member with respect to the housing body, the engaged state and the non-engaged state of the engaging portion and the plunger are changed.
  • a liquid medicine filling device and a filling device that are capable of both reducing the size of the cartridge and improving the operability of filling the liquid medicine into the cartridge.
  • FIG. 1 is a perspective view of a chemical filling device as an embodiment of the present disclosure
  • FIG. 2 is a perspective view showing a state in which the cartridge and adapter of the drug solution filling device shown in FIG. 1 are separated
  • FIG. 2B is a perspective view showing a state in which the cartridge and adapter shown in FIG. 2A are attached
  • FIG. 2C is a perspective view showing the cartridge and adapter shown in FIG. 2B accommodated in an accommodating member in an unlocked position in the filler housing of the filler
  • FIG. 3B illustrates a mechanism for fixing the receiving member from the non-fixed position in the filler housing shown in FIG. 3A
  • FIG. 2 is an exploded perspective view of a drug-solution administration device including the cartridge of the drug-solution filling device shown in FIG.
  • FIG. 7B is a diagram showing a state in which the operation unit shown in FIG. 7A is operated and moved from the state shown in FIG. 7A;
  • FIG. FIG. 3 is a perspective view showing the housing member of the filling device alone;
  • FIG. 10 is an explanatory view showing an operation of sending air inside a cylindrical body of the cartridge into the liquid medicine container;
  • FIG. 10 is an explanatory view showing an operation of filling the cylinder of the cartridge with the liquid medicine in the liquid medicine container.
  • FIG. 1 is a perspective view of a chemical filling device as an embodiment of the present disclosure
  • FIG. FIG. 10 is a perspective view showing a state in which the housing member of the filling device of the drug solution filling device shown in FIG. 9 is in an unfixed posture
  • FIG. 10 is a perspective view showing one form of a filling device of the chemical filling device shown in FIG. 9
  • 11B is a perspective view showing a form different from that in FIG. 11A of the filling device of the drug solution filling device shown in FIG. 11A.
  • FIG. It is a figure which shows the operation
  • FIG. 13 is an explanatory diagram showing an operation restriction state by the operation restriction unit shown in FIG. 12;
  • FIG. 13 is an explanatory diagram showing an operation restriction state by the operation restriction unit shown in FIG. 12;
  • FIG. 13 is an explanatory diagram showing an operation unrestricted state by the operation restricting unit shown in FIG. 12; 13B is a diagram showing an example of a switching mechanism between the operation restricted state shown in FIG. 13A and the operation non-restricted state shown in FIG. 13B; FIG.
  • FIG. 1 is a perspective view of a chemical filling device 100 as one embodiment of the chemical filling device according to the present disclosure.
  • the drug solution filling device 100 includes a cartridge 2, a filling device 3, and an adapter 4.
  • FIG. 2A and 2B are diagrams showing only the cartridge 2 and adapter 4 of the drug solution filling device 100.
  • FIG. FIG. 2A shows a state in which the adapter 4 is not attached to the cartridge 2 and the cartridge 2 and the adapter 4 are separated.
  • FIG. 2B shows a state in which the adapter 4 is attached to the cartridge 2 from the state shown in FIG. 2A.
  • FIG. 3A is a perspective view of the chemical filling device 100.
  • FIG. FIG. 3B is a diagram showing a mechanism for changing the holding member 209 from the non-fixed position shown in FIG. 3A to the fixed position shown in FIG. 1 in the filler housing 205 .
  • the filling device housing 205 of the filling device 3 includes a housing member 209 and a housing body 210 , details of which will be described later.
  • the housing member 209 is supported by the housing body 210 so as to be swingable with respect to the housing body 210 between the non-fixed posture shown in FIG. 3A and the fixed posture shown in FIG.
  • FIG. 1 shows a state in which the drug solution container 300 is attached to the adapter 4 of the drug solution filling device 100 . is attached to the adapter 4 when filling the with a chemical solution.
  • the cartridge 2 may be distributed with the adapter 4 attached in advance (see FIG. 2B), or may be distributed with the adapter 4 separated (see FIG. 2A).
  • liquid medicine filling device 100 even the downsized cartridge 2 can be easily filled with the liquid medicine. In other words, it is possible to achieve both the miniaturization of the cartridge 2 and the improvement in the operability of filling the cartridge 2 with the chemical solution.
  • FIG. 4 is an exploded perspective view showing an example of the drug solution administration device 10 including the cartridge 2 of the drug solution filling device 100 shown in FIGS. 1 to 3A.
  • the drug solution administration device 10 is a device that administers a drug solution into a living body using the cartridge 2 filled with the drug solution by the drug solution filling device 100 shown in FIGS. 1 and 3A. First, an overview of the drug-solution administration device 10 will be described.
  • a drug-solution administration device 10 shown in FIG. 4 includes a seal portion 12 having an adhesive surface 12a that can be attached to the skin of a user such as a patient.
  • the drug-solution administration device 10 is used with the sticking surface 12a of the seal portion 12 stuck to the user's skin. More specifically, the drug-solution administration device 10 is a portable insulin pump capable of continuously or intermittently injecting the drug solution filled in the storage space 36b in the cylindrical body 36 into the living body under the pressing action of the plunger 38. .
  • the axial direction parallel to the central axis O of the cylinder 36 is simply referred to as the "axial direction A", or the longitudinal direction of the drug solution administration device 10 is simply referred to as the “device longitudinal direction B".
  • the thickness direction of the drug-solution administration device 10, which is orthogonal to the sticking surface 12a of the seal portion 12, is simply referred to as “device thickness direction C”.
  • the width direction of the drug-solution administration device 10, which is orthogonal to the device longitudinal direction B (the same direction as the axial direction A) and the device thickness direction C is simply referred to as "device width direction D".
  • the side of the sticking surface 12a (that is, the body surface side in the use state of the drug-solution administration device 10) is simply referred to as the “lower side”, and the side opposite to the sticking surface 12a side is simply referred to as “lower side”. It may simply be described as "upper”.
  • the medical-solution administration device 10 includes a cradle 14 having a seal portion 12 that can be attached to the skin of a user such as a patient, and a medical-solution administration device main body 16 detachably attached to the cradle 14. , is equipped with
  • the cradle 14 includes a substantially rectangular support plate 18 to which the seal portion 12 is fixed, and locking walls 20 rising upward from the outer peripheral edge of the support plate 18 .
  • a cannula mechanism 22 having a cannula to be indwelled in the living body using a puncture mechanism (not shown) is attached to substantially the center of the support plate 18 .
  • the drug-solution administration device main body 16 includes a cartridge 2 as a disposable part and a reusable reusable part 30 .
  • FIG. 5 is a top view of the cartridge 2 alone, viewed from above. In FIG. 5, part of the cartridge 2 is simplified for convenience of explanation.
  • FIG. 6 is a bottom view of the cartridge 2 as viewed from below.
  • the cartridge 2 has a flat box-shaped cartridge housing 32 whose upper side in the device thickness direction C is open.
  • the cartridge housing 32 has a substantially rectangular shape corresponding to the support plate 18 in plan view. More specifically, the cartridge housing 32 of this embodiment includes a base plate portion 32a extending along the axial direction A, and side wall portions 32b rising from the outer peripheral edge portion of the base plate portion 32a. As shown in FIG.
  • a concave portion serving as a housing portion 34 for housing the cannula mechanism 22 when the drug solution administration device main body 16 is mounted on the cradle 14. is formed.
  • the cartridge 2 includes a chemical reservoir 2a having a chemical filling port 36a.
  • the medicinal solution reservoir 2a includes a cylindrical body 36 defining an accommodation space 36b capable of accommodating medicinal solution, and a plunger 38 .
  • the barrel 36 and plunger 38 are housed in the cartridge housing 32 . More specifically, the cylindrical body 36 and the plunger 38 of this embodiment are held on the base plate portion 32a while being surrounded by the side wall portion 32b.
  • the cylindrical body 36 and the plunger 38 may be held by at least one of the base plate portion 32a and the side wall portion 32b while being surrounded by the side wall portion 32b.
  • the tubular body 36 extends cylindrically along the longitudinal direction B of the device.
  • the outer diameter and inner diameter of the distal end portion of the cylindrical body 36 decrease toward the distal end.
  • the tubular body 36 may be made of, for example, a transparent resin material so that the inside can be visually recognized from the outside.
  • a filling port 36a is formed at the tip of the cylindrical body 36, through which the liquid medicine passes when flowing into the cylindrical body 36 from the liquid medicine container 300 (see FIG. 1).
  • the filling port 36a communicates with a liquid medicine flow path 37 formed along the cartridge housing 32, and is located at one end of the cylindrical body 36 in the axial direction A (the vertically upper end in the vertical posture of the cartridge 2 described later). department).
  • connection port 37a is provided at the other end of the chemical liquid flow path 37 opposite to the one end communicating with the filling port 36a.
  • the filling port 36 a of the cylinder 36 of the present embodiment also serves as a drug solution discharge port for discharging the drug solution inside the tube 36 toward the cannula mechanism 22 .
  • the plunger 38 is movable in the axial direction A inside the cylindrical body 36 .
  • the plunger 38 may be integrally molded, for example, from a resin material or the like.
  • the plunger 38 of this embodiment includes a plunger main body 52 that is liquid-tightly slidable along the axial direction A inside the cylindrical body 36 , and a plunger 54 that continues to the base end side of the plunger main body 52 .
  • the tip of the plunger body 52 has a substantially conical shape, and the outer diameter of the plunger main body 52 decreases toward the tip.
  • the plunger 38 of this embodiment further includes a seal member 53 that forms a seal with the inner surface of the cylinder 36 along the outer periphery of the plunger body 52 .
  • the pusher 54 extends from the plunger main body 52 toward the base end side and includes a pair of extensions 58 extending to the outside of the cylindrical body 36 .
  • the pair of extending portions 58 of the present embodiment are arranged apart from each other along the width direction D of the device. Further, each extending portion 58 can be fitted with a convex portion 206b (see FIGS. 7A, 7B, etc.) as an engaging portion 202 of the filling device 3 (see FIGS. 1 and 3A).
  • a recess 58a is formed as a joint.
  • a base end portion of each extending portion 58 is provided with a contact surface 64 and a projection (not shown) with which the nut portion 42 described later contacts.
  • the cartridge 2 of this embodiment further includes a feed screw shaft 40 and a nut portion 42 in addition to the chemical reservoir 2a described above.
  • the feed screw shaft 40 is arranged coaxially with the plunger 38 .
  • the nut portion 42 is screwed onto the feed screw shaft 40 .
  • the feed screw shaft 40 and the nut portion 42 are also held by the cartridge housing 32 .
  • the feed screw shaft 40 is rotatably driven by the driving portion 76 while its tip end is supported by a bearing 74 provided in the cartridge housing 32 .
  • the drive unit 76 includes a battery 78 as a power source, a motor 80 driven by the battery 78, a gearbox (power transmission mechanism) 82 that reduces and transmits the rotational driving force of the motor 80, and an output gear of the gearbox 82.
  • a transmission shaft 88 to which a spur gear 86 meshing with 84 is fixed and locked to the feed screw shaft 40 so as to be integrally rotatable.
  • the battery 78 and the transmission shaft 88 of the drive section 76 of this embodiment are provided in the cartridge 2 . Further, the motor 80 and the gear box 82 of the driving section 76 of the present embodiment are provided on the lid body 90 of the reusable section 30 . However, it is not limited to this configuration.
  • the reusable part 30 may be configured to include the battery 78, for example.
  • the lid body 90 of the reusable part 30 of this embodiment is configured to be detachable from the cartridge housing 32 so as to close the upper opening of the cartridge housing 32 .
  • the battery 78 has a terminal 92 electrically connected to the motor 80 of the reusable section 30 when the cartridge 2 is attached to the reusable section 30 .
  • the transmission shaft 88 is supported by a pair of bearings 94 provided in the cartridge housing 32 so as to be coaxial with the feed screw shaft 40 .
  • the nut portion 42 may be integrally molded from a resin material, for example.
  • the nut portion 42 of the present embodiment includes a rectangular plate-shaped nut portion main body 102 and a slide portion 104 provided on the nut portion main body 102 .
  • a threaded hole 106 into which the feed screw shaft 40 is screwed is formed in the nut body 102 .
  • the screw hole 106 is located substantially in the center of the nut body 102 .
  • a reinforcing cover made of, for example, a metal material may be attached to the outer surface of the nut body 102 .
  • the slide portion 104 is slidable with respect to a guide wall 114 extending along the axial direction A provided on the cartridge housing 32 . Thereby, the nut portion 42 smoothly moves along the axial direction of the feed screw shaft 40 (the same direction as the axial direction A) under the rotating action of the feed screw shaft 40 .
  • the user fills the drug solution reservoir 2a of the cartridge 2 of the drug solution administration device 10 with the drug solution.
  • the chemical filling device 100 shown in FIGS. 1 and 3A is used. Details of this will be described later (see FIGS. 8A, 8B, etc.).
  • the reusable part 30 is loaded with the cartridge 2 filled with the chemical solution by the chemical solution filling device 100 .
  • power from the battery 78 of the cartridge 2 is supplied to the components of the reusable section 30 , and the output gear 84 of the gear box 82 of the reusable section 30 meshes with the spur gear 86 of the cartridge 2 .
  • the drug solution administration device main body 16 is primed.
  • the motor 80 is rotationally driven by operating a remote controller (not shown) or the like.
  • the rotational driving force of the motor 80 is transmitted to the feed screw shaft 40 via the gear box 82, the spur gear 86, and the transmission shaft 88, so that the feed screw shaft 40 rotates and the nut portion 42 slides on the guide wall 114. while moving toward the plunger 38 side.
  • the nut portion 42 contacts the base end surface as the contact surface 64 of the extension portion 58 of the plunger 54 of the plunger 38 and the projection (not shown), and the projection is locked in the hole of the nut portion main body 102.
  • the plunger 38 is engaged with the nut portion 42, and the nut portion 42 is in the use position where the plunger 38 can be pressed toward the distal end side in the axial direction A. As shown in FIG.
  • the user sticks the sticking surface 12a of the seal part 12 to a predetermined position on the skin, and uses the puncture mechanism to leave the cannula of the cannula mechanism 22 of the cradle 14 in the living body.
  • the user mounts the medical-solution administration device main body 16 on the cradle 14 .
  • the connection port 37 a of the drug solution flow path 37 of the drug solution administration device main body 16 is connected to the cannula mechanism 22 of the cradle 14 .
  • the drug solution in the cylindrical body 36 is discharged through the filling port 36a, which is also the drug solution outlet port, and is continuously or intermittently injected into the user's living body through the cannula of the cannula mechanism 22. dosed on a regular basis.
  • the chemical filling device 100 of this embodiment will be described with reference to FIGS. 1 to 3B and the like.
  • the drug solution filling device 100 is used to fill the cartridge 2 of the drug solution administration device 10 with the drug solution.
  • the drug solution filling device 100 of this embodiment includes a cartridge 2 , a filling device 3 and an adapter 4 .
  • the drug solution filling device 100 includes the cartridge 2, like the drug solution administration device 10 described above. Therefore, in the following description of the chemical liquid filling device 100, the above-described “axial direction A”, “device longitudinal direction B”, “device thickness direction C” and “device width direction D” will continue to be used.
  • the longitudinal direction B of the liquid medicine filling device 100 is the longitudinal direction of the cartridge 2 .
  • the device thickness direction C in the liquid medicine filling device 100 is the thickness direction of the cartridge 2 .
  • the device width direction D in the liquid medicine filling device 100 is the width direction of the cartridge 2 .
  • “axial direction A”, “device longitudinal direction B”, “device thickness direction C”, and “device width direction D” are defined based on the cartridge 2 housed in the housing member 209 in a fixed posture.
  • the filling device 3 can hold the cartridge 2 .
  • the cartridge 2 can be held by the filling device 3 means that the cartridge 2 can be detachably fixed to the filling device 3 in a predetermined posture.
  • the cartridge 2 may be fixed directly to the filler 3 or indirectly to the filler 3 via an adapter 4 fixed to the cartridge 2 as in this embodiment. It may be fixed (see FIGS. 1 and 3A).
  • the filler 3 comprises a filler housing 205 as shown in FIGS.
  • the filler housing 205 also includes a receiving member 209 and a housing body 210 .
  • the housing member 209 defines a housing space 209b in which the cartridge 2 can be housed.
  • the housing body 210 swingably supports the housing member 209 .
  • FIGS. 7A and 7B are diagrams showing details of the engaging portion 202 and the operating portion 203 of the filling device 3.
  • FIG. 7B is a diagram showing a state in which the operation unit 203 shown in FIG. 7A has been operated and moved from the state shown in FIG. 7A. 7A and 7B, for convenience of explanation, the containing member 209 of the filling device 3 is omitted.
  • the filling device 3 includes an engaging portion 202 and an operating portion 203 in addition to the filling device housing 205 described above.
  • the housing member 209 of the present embodiment has an unfixed posture (see FIGS. 3A and 3B) in which it can swing relative to the housing body 210, and a and a fixed posture (see FIG. 1) in which the position is fixed to the housing body 210 .
  • the housing member 209 and the housing main body 210 swing about an axis parallel to the device width direction D as a supporting shaft 240a.
  • the accommodating member 209 and the housing 210 in the axial direction A (upper side in the vertical direction when the filling device 3 holds the cartridge 2 in a vertical posture, which will be described later) is used as a fulcrum, and the accommodating member 209 so that the other side in the axial direction A of (vertically lower side when the filling device 3 holds a cartridge 2 in a vertical posture, which will be described later) moves away from the housing body 210 and approaches the housing body 210, swing.
  • the housing member 209 of this embodiment includes a locking claw 209a that locks onto the claw receiving portion 210a of the housing body 210. As shown in FIG.
  • the locking claws 209 a of the housing member 209 are locked to the claw receiving portions 210 a of the housing body 210 , thereby fixing the position of the housing member 209 with respect to the housing body 210 .
  • the posture of the housing member 209 changes from the non-fixed posture (see FIGS. 3A and 3B) to the fixed posture (see FIG. 1).
  • FIG. 7C is a perspective view showing the housing member 209 of the filling device 3 alone.
  • the housing member 209 of this embodiment includes an insertion portion 209b1 into which the cartridge 2 can be inserted into the housing space 209b.
  • the insertion portion 209b1 is an opening on one side in the axial direction A (upper side in the vertical direction when the filling device 3 holds the cartridge 2 in the vertical posture, which will be described later). By doing so, the operation of housing the cartridge 2 in the housing space 209b of the housing member 209 is facilitated.
  • the cartridge 2 and the adapter 4 attached to the cartridge 2 are inserted into the accommodation space 209b from the insertion portion 209b1 in one direction in a straight line in a state in which the adapter 4 attached to the cartridge 2 is integrally assembled. 209b.
  • the attitude of the cartridge 2 in which the axial direction A of the cylinder 36 is vertical so that the cylinder 36 is vertically above the plunger 38 is simply referred to as the "vertical attitude of the cartridge 2.” ”.
  • the insertion portion 209b1 of the housing member 209 is configured so that the vertical cartridge 2 can be inserted from the upper side to the lower side in the vertical direction. By doing so, the cartridge 2 can be accommodated in the accommodation space 209b of the accommodation member 209 while maintaining the vertical posture.
  • the housing member 209 of this embodiment has a substantially box-like shape with one open end.
  • the insertion portion 209b1 of this embodiment is an open end of the substantially box-shaped housing member 209 .
  • the housing member 209 of this embodiment includes a bottom wall portion 220a, two opposing side wall portions 220b, a back wall portion 220c, and a pressing wall portion 220d.
  • the accommodation space 209b of the accommodation member 209 of this embodiment is defined by a bottom wall portion 220a, two side wall portions 220b, a back wall portion 220c and a pressing wall portion 220d.
  • the bottom wall portion 220a is located on the side opposite to the opening end of the insertion portion 209b1.
  • the bottom wall portion 220a also serves as a receiving portion for receiving the cartridge 2 inserted in a predetermined insertion direction (from top to bottom in FIG. 7C) from the opening end of the insertion portion 209b1.
  • the bottom wall portion 220a of the present embodiment includes the above-described locking claws 209a.
  • the locking claws 209a of the present embodiment project from the bottom wall portion 220a toward the later-described front cover plate portion 210c (see FIGS. 7A and 7B) of the housing body 210. As shown in FIG.
  • the two side wall portions 220b are erected from the bottom wall portion 220a.
  • the two side wall portions 220b are arranged to face each other.
  • the two side wall portions 220b are configured to cover at least part of both outer sides in the device width direction D of the cartridge 2 housed in the housing space 209b.
  • Each side wall portion 220b has a swing shaft portion 220b1 protruding from its outer surface.
  • Each side wall portion 220b of the present embodiment includes two swing shaft portions 220b1, but the number is not particularly limited.
  • the swing shaft portion 220b1 is inserted through an elongated hole 210d1 of the housing body 210, which will be described later.
  • the swing shaft portion 220b1 of this embodiment can move in the longitudinal direction of the long hole 210d1 in the housing main body 210 within the long hole 210d1. That is, the housing member 209 of this embodiment can swing with respect to the housing main body 210 by moving the swing shaft portion 220b1 in the longitudinal direction of the long hole 210d1.
  • the rear wall portion 220c connects end portions of the two side wall portions 220b that are located away from a front cover plate portion 210c (see FIGS. 7A and 7B) of the housing body 210, which will be described later.
  • a concave adapter receiving portion 220c1 into which the adapter 4 is inserted is formed in the back wall portion 220c of the present embodiment.
  • the back wall portion 220c extends along the lower surface of the cartridge 2 (the surface on the sticking surface 12a side in the device thickness direction C).
  • the holding wall portion 220d protrudes from an end portion of each side wall portion 220b that is located closer to a front cover plate portion 210c (see FIGS. 7A and 7B) of the housing body 210, which will be described later.
  • the holding wall portion 220d protrudes in a direction parallel to the back wall portion 220c.
  • One holding wall portion 220d protruding from one side wall portion 220b protrudes in the direction toward the other side wall portion 220b.
  • the other holding wall portion 220d protruding from the other side wall portion 220b protrudes in the direction toward the one side wall portion 220b.
  • the cartridge 2 accommodated in the accommodation space 209b does not fall off toward the front cover plate portion 210c (see FIGS. 7A and 7B) of the housing main body 210 (see FIGS. 7A and 7B), which will be described later. 209b.
  • the two holding wall portions 220d protruding from the two side wall portions 220b are not connected to each other.
  • the length of protrusion of each pressing wall portion 220d from the side wall portion 220b is short enough to cover the end face of the side wall portion 32b of the cartridge 2 housed in the housing space 209b. Therefore, the pressing wall portion 220d of this embodiment is configured so as not to cover the opening of the cartridge 2 accommodated in the accommodation space 209b.
  • the pair of pressing wall portions 220d serve as guides when the cartridge 2 is accommodated in the accommodation space 209b, and are configured so as not to interfere with each component accommodated in the cartridge 2. As shown in FIG.
  • the housing member 209 of the present embodiment can be housed in the housing space 209b with the cartridge 2 and the adapter 4 attached to each other, but is not limited to this configuration.
  • the accommodation member 209 may be configured to accommodate, for example, the cartridge 2 alone.
  • the housing body 210 of this embodiment includes a pedestal portion 210b that can be placed on a horizontal placement surface. Further, the housing main body 210 of the present embodiment includes a front cover plate portion 210c that rises vertically upward from the pedestal portion 210b while the pedestal portion 210b is placed on the mounting surface. The front cover plate portion 210c covers the opening of the cartridge 2 when the housing member 209 is fixed (see FIG. 1). Further, the front cover plate portion 210c of this embodiment includes the claw receiving portion 210a described above.
  • the claw receiving portion 210a of the present embodiment is a hole through which the locking claw 209a of the housing member 209 is inserted and hooked on the edge thereof.
  • the housing main body 210 of the present embodiment has two side cover plate portions that protrude from both ends of the front cover plate portion 210c in the horizontal direction and face each other when the pedestal portion 210b is placed on the mounting surface. 210d.
  • Each side cover plate portion 210d is formed with an elongated hole 210d1 through which the swing shaft portion 220b1 of the housing member 209 is inserted.
  • Two long holes 210d1 are formed in each side cover plate portion 210d of the present embodiment, but the number is not particularly limited. The number of long holes 210d1 may be appropriately set according to the number of swing shaft portions 220b1 of the housing member 209. As shown in FIG.
  • the housing member 209 with the cartridge 2 housed in the housing space 209b is swung so as to approach the front cover plate portion 210c of the housing body 210, whereby the locking claws are engaged.
  • 209a is engaged with the pawl receiving portion 210a.
  • the housing members 209 are provided on one side of the side cover plate portions 210d on both sides in the axial direction A (upper side in the vertical direction when the cartridge 2 in the vertical posture is housed in the housing member 209). It is supported by the housing body 210 by a pair of supporting portions 240 . More specifically, the housing member 209 is supported by the support shafts 240a of the pair of support portions 240, respectively.
  • the housing member 209 is swung around a linear swing axis connecting the support shafts 240 a of the pair of support portions 240 . As a result, the housing member 209 assumes a fixed posture (see FIG. 1) that does not swing with respect to the housing body 210 . Although the details will be described later, at this time, convex portions 206b serving as engaging portions 202, which will be described later, are formed in the extension portions 58 of the plunger 54 of the plunger 38 of the cartridge 2 housed in the housing space 209b. It fits into the recessed portion 58a.
  • the user when using the liquid medicine filling device 100 of the present embodiment, first, the user performs a housing operation of housing the cartridge 2 in the housing member 209 in the non-fixed posture (see FIGS. 3A and 3B). After that, the user swings the containing member 209 containing the cartridge 2 with respect to the housing main body 210 to fix the containing member 209 to the housing main body 210 so as to assume a fixed posture. That is, according to the drug solution filling device 100 of the present embodiment, the accommodating operation for holding the cartridge 2 in the filling device 3 and the engaging portion 202 of the filling device 3 for engaging the plunger 38 of the cartridge 2 are performed. The fixing operation and the above can be performed separately.
  • the filling device 3 of the present embodiment can simplify each operation of the accommodating operation and the fixing operation, and can improve the operability for the user.
  • the risk of damage to the cartridge 2 can be reduced by adopting a configuration in which each operation of the accommodating operation and the fixing operation can be performed step by step. Therefore, it is possible to easily fill the cartridge 2 with the liquid medicine while protecting the parts of the cartridge 2 that are important for the operation of the liquid medicine administration device 10 .
  • the term "damage to the cartridge” as used herein means damage that may occur to the plunger 38, the drive unit 76, etc. of the cartridge due to, for example, the mounting position being incorrect or the cartridge being forcibly pushed in when the cartridge is mounted to the filling device. .
  • the housing member 209 has one end side (upper side in FIG. 1) where the insertion portion 209b1 is provided, and the other end side (lower side in FIG. 1). , and is supported by the support portion 240 of the housing body 210 so as to be swingable in a direction approaching the housing body 210 and a direction away from the housing body 210 .
  • the cartridge 2 can be accommodated in the accommodation space 209b compared to the configuration in which one end side (upper side in FIG. 1) swings with respect to the other end side (lower side in FIG. 1) of the accommodation member 209. Due to the weight of the cartridge 2 when it is pushed, it is possible to prevent the housing body 210 of the filling device 3 from overturning.
  • the cylindrical body 36 of the cartridge 2 is exposed without being covered by the filling device 3 in an engaged state in which an engaging portion 202 (to be described later) engages the plunger 38 .
  • the cylindrical body 36 of the cartridge 2 of the present embodiment is engaged with the housing member 209 of the filling device housing 205 of the filling device 3 and the housing main body 210 in an engaged state in which the engaging portion 202 (to be described later) engages with the plunger 38 . exposed to the outside without being covered by By doing so, the amount of the chemical liquid filled in the cylindrical body 36 can be easily visually recognized from the outside.
  • the engaging portion 202 is configured to be engageable with the plunger 38 of the cartridge 2 . More specifically, the engaging portion 202 of the present embodiment protrudes in the device thickness direction C from the movable body 206 that fits into the concave portion 58a formed in each extending portion 58 of the pusher 54 of the plunger 38. This is the convex portion 206b.
  • the movable body 206 is attached movably in the axial direction A with respect to the housing body 210 of the charger housing 205 . Also, the movable body 206 moves in the axial direction A following the rotation of an operation lever 207, which will be described later. More specifically, the movable body 206 of this embodiment includes a rack gear portion 206a as a torque receiving portion to which the rotational torque of the operating lever 207 is transmitted.
  • the engagement state and non-engagement state of the engaging portion 202 of the filling device 3 and the plunger 38 of the cartridge 2 are defined by swinging the accommodating member 209 with respect to the housing main body 210 in the filling device housing 205 of the filling device 3 . It can be switched by moving. First, switching from the disengaged state to the engaged state will be described. First, the cartridge 2 is accommodated in the accommodation member 209 in the non-fixed posture (see FIG. 3A). After that, the housing member 209 is swung with respect to the housing body 210 .
  • the engaging claws 209a of the housing member 209 are engaged with the claw receiving portions 210a of the housing body 210, and the housing member 209 is fixed to the housing body 210 (see FIG. 1).
  • the movable body 206 attached to the housing body 210 of the filling device 3 functions as the engaging portion 202.
  • the convex portion 206 b fits into the concave portion 58 a of the plunger 38 of the cartridge 2 accommodated in the accommodation member 209 . In this manner, the engaging portion 202 of the filler 3 and the plunger 38 of the cartridge 2 are switched from the disengaged state to the engaged state.
  • the latched state between the locking claws 209a of the housing member 209 and the claw receiving portions 210a of the housing body 210 is released, the housing member 209 is swung with respect to the housing body 210, and the housing member 209 is in a fixed posture ( 1) to the unfixed position (see FIG. 3A).
  • the engaging portion 202 of the filling device 3 and the plunger 38 of the cartridge 2 are switched from the engaged state to the disengaged state.
  • the operating portion 203 is configured to be able to perform an operation of moving the plunger 38 in the axial direction A via a convex portion 206b as the engaging portion 202 that engages with the plunger 38.
  • the operation part 203 of this embodiment is operably held with respect to the housing body 210 of the filling device housing 205 .
  • the operating portion 203 of this embodiment comprises an operating lever 207 that is pivotally attached to the housing body 210 of the charger housing 205 .
  • the operating lever 207 has a rack gear portion 207a as a torque transmitting portion that transmits the torque of the charging device housing 205 to the housing body 210 to the movable body 206 via the pinion gear 221. As shown in FIG.
  • the movable body 206 and the operating lever 207 constitute a rack and pinion structure with the rack gear portions 206 a and 207 a and the pinion gear 221 .
  • the rotational movement of the operating lever 207 with respect to the housing body 210 of the filling device housing 205 can be converted into linear movement in the axial direction A of the movable body 206 .
  • the annular lever piece and the rack gear that constitutes the rack gear portion 207a are connected separately, but they may be formed integrally.
  • the operation of the engaging portion 202 by the operating portion 203 is not limited to the rack and pinion structure described above.
  • Other mechanisms may be used as long as the plunger 38 can be moved in the axial direction A via the engaging portion 202 by operating the operating portion 203 .
  • the operating lever 207 of the operating portion 203 protrudes outward from one side cover plate portion 210d of the housing body 210, and moves toward and away from the one side cover plate portion 210d.
  • a working configuration is preferred. By doing so, the operation lever 207 can be easily operated by gripping the operation lever 207 and the other side cover plate portion 210d with one hand so as to sandwich the operation lever 207 therebetween. Therefore, operability for the user can be improved.
  • the operating portion 203 may further include a coil spring 208a as a biasing member 208 that biases the operating lever 207 to one side in the rotation direction.
  • the adapter 4 can be attached to the cartridge 2 .
  • the adapter 4 of this embodiment includes a housing portion 211 that houses the cartridge 2 .
  • the housing portion 211 is defined by a back plate portion 230 , a pair of opposing side plate portions 231 , and a front plate portion 232 opposing the back plate portion 230 .
  • At least part of the cartridge 2 is accommodated in the accommodating portion 211 .
  • the lower surface of the cartridge 2 (the lower surface of the base plate portion 32a) is accommodated in the accommodating portion 211 toward one side (lower side in FIG. 3) in the axial direction A along the back plate portion 230 of the accommodating portion 211.
  • the side plate portions 231 are a pair of opposing walls rising in the device thickness direction C from the back plate portion 230 .
  • the side plate portion 231 is formed along the side wall portion 32 b of the cartridge 2 , and the one-directional surface defines the accommodating portion 211 .
  • the front plate portion 232 is provided to face the back plate portion 230 and partially covers the cartridge 2 .
  • the front plate portion 232 rises from the side plate portion 231 in the device width direction D and faces the back plate portion 230 .
  • the front plate portion 232 may be provided so as to rise from the pair of side plate portions 231 respectively, but it does not cover the plunger 38 and the cylindrical body 36 .
  • the cartridge 2 is accommodated in the accommodation portion 211 of the adapter 4 by being slid into the accommodation portion 211 from a predetermined direction (inserted from top to bottom in FIG. 2A).
  • the adapter 4 also includes a tube portion 212 that fluidly connects the inside of the drug solution container 300 and the inside of the cylindrical body 36 of the cartridge 2 .
  • one end of the tube portion 212 of the adapter 4 is inserted into the drug solution flow path of the cartridge 2 . It communicates with the connection port 37a of 37 in a liquid-tight manner.
  • connection port 37a of the drug solution flow path 37 of the cartridge 2 communicates with the interior of the cylinder 36 through the filling port 36a.
  • the mounting of the adapter 4 to the cartridge 2 is completed in a state in which the cartridge 2 is housed in the housing portion 211 of the adapter 4 and the connection port 37a of the cartridge 2 is in liquid-tight communication with the pipe portion 212 of the adapter 4. do.
  • the back plate portion 230 and the front plate portion 232 may be provided with engagement portions for the cartridge 2 .
  • the rear plate portion 230 is provided with a protrusion 234 to hold the cartridge 2 in the axial direction A. As shown in FIG. As a result, even during the filling operation, a good connection between the connection port 37a and the tube portion 212 can be maintained.
  • the adapter 4 also includes a container connecting portion 213 to which a drug solution container 300 such as a vial in which a drug solution is hermetically stored by a plug member 301 can be connected.
  • a drug solution container 300 such as a vial in which a drug solution is hermetically stored by a plug member 301 can be connected.
  • the other end of the tube portion 212 is arranged in the container connection portion 213 .
  • the drug solution container 300 is connected to the container connecting portion 213 so that the other end of the tube portion 212 passes through the plug member 301 .
  • the container connecting portion 213 is located on the opposite side of the cartridge 2 with the back plate portion 230 interposed therebetween.
  • the positional relationship between the cylinder 36 and the chemical container 300 is properly maintained in the chemical solution filling device 100 during the filling operation, and the chemical solution container 300 is less likely to topple over. Also, even if the cartridge 2 and the adapter 4 are assembled and distributed, the size can be reduced.
  • the adapter 4 of the present embodiment is housed in the housing space 209b of the housing member 209 of the filling device 3 together with the cartridge 2 while being attached to the cartridge 2 .
  • the adapter 4 attached to the cartridge 2 abuts against the housing member 209 in the housing space 209b and is positioned with respect to the housing member 209. As shown in FIG. As a result, the cartridge 2 with the adapter 4 attached is also positioned within the housing space 209b.
  • the user takes out the cartridge 2 (see FIG. 2B) with the adapter 4 attached from the packaging container.
  • the cartridge 2 and the adapter 4 are packaged separately in a packaging container (see FIG. 2A) and may be attached to each other by the user after removal.
  • the cylindrical body 36 of the cartridge 2 is not filled with the liquid medicine after being removed from the packaging container. Therefore, the nut portion 42 is in the initial position where it does not contact the plunger 38 (see FIG. 5).
  • One end of the tube portion 212 of the adapter 4 attached to the cartridge 2 is liquid-tightly communicated with the connection port 37a of the chemical flow path 37 of the cartridge 2 .
  • the user causes the filling device 3 to hold the cartridge 2 with the adapter 4 attached, in order to fill the cylinder 36 with an appropriate amount of liquid medicine.
  • the cartridge 2 with the adapter 4 attached is housed in the housing space 209b of the housing member 209 in the non-fixed posture.
  • the containing member 209 is changed to a fixed posture.
  • the convex portion 206b as the engaging portion 202 fits into the concave portion 58a formed in each extending portion 58 of the pusher 54. As shown in FIG.
  • the drug solution container 300 in which the drug solution is hermetically stored is connected to the container connecting portion 213 of the adapter 4 .
  • the other end of the tube portion 212 of the adapter 4 passes through the plug member 301 and is positioned inside the drug solution container 300 . That is, the other end of the tube portion 212 of the adapter 4 communicates with the inside of the drug solution container 300 in a liquid-tight manner. That is, the inside of the cylindrical body 36 of the cartridge 2 and the inside of the drug solution container 300 are in communication with each other through the tube portion 212 of the adapter 4 .
  • the cartridge 2 is in a vertical posture.
  • the drug solution container 300 connected to the container connecting portion 213 of the adapter 4 is arranged so that the plug member 301 faces vertically downward.
  • the nut portion 42 is at the initial position (see FIG. 5) where it does not contact the plunger 38, and is in a non-interlocked state with the driving portion 76 of the drug solution administration device 10.
  • the position of the plunger 38 can be manually changed depending on the amount.
  • FIG. 8A is an explanatory diagram showing the operation of sending the air inside the cylindrical body 36 into the drug solution container 300 by operating the operating portion 203.
  • FIG. The operating lever 207 in the state shown in FIG. 7A is rotated in the direction indicated by the bold arrow in FIG. 8A.
  • this rotating torque is transmitted to the movable body 206 .
  • the movable body 206 moves vertically upward (see the thick upward arrow in FIG. 8A).
  • the convex portion 206b of the movable body 206 as the engaging portion 202 is fitted into the concave portion 58a formed in each extending portion 58 of the pusher 54. As shown in FIG.
  • the pusher 54 also moves vertically upward together with the movable body 206 .
  • the air in the cylindrical body 36 is compressed by the plunger 38 and sent into the drug solution container 300 from the filling port 36a through the drug solution channel 37 and the tube portion 212 of the adapter 4 (the dashed arrow in FIG. 8A reference). Therefore, the pressure inside the chemical liquid container 300 can be increased.
  • FIG. 8B is an explanatory diagram showing the operation of filling the cylinder 36 with the chemical liquid in the chemical liquid container 300 by operating the operation unit 203.
  • FIG. The operating lever 207 in the state shown in FIG. 7B is rotated in the direction indicated by the thick line arrow in FIG. 8B, that is, so as to return to the unoperated state shown in FIG. 7A.
  • the pusher 54 can be moved downward in the vertical direction (see the thick downward arrow in FIG. 8B).
  • the operating portion 203 of this embodiment includes the coil spring 208a as the biasing member 208.
  • the coil spring 208a urges the pusher 54 downward in the vertical direction via the operation lever 207.
  • the operation of the operating lever 207 shown in FIG. 8A is performed against the restoring force of the coil spring 208a.
  • the operation of the operating lever 207 shown in FIG. 8B may be performed by the restoring force of the coil spring 208a.
  • the pusher 54 moves in both directions in the axial direction A in conjunction with the pivoting operation of the operating lever 207, thereby exchanging the air in the cylinder 36 with the liquid medicine in the liquid medicine container 300. Then, the chemical solution is filled in the cylindrical body 36 . At the stage when the cylinder 36 is filled with the desired amount of the chemical, the filling of the cylinder 36 with the chemical is completed.
  • the filling device 3 can fill the liquid medicine with a simple operation even in the cartridge 2 that is downsized. In other words, it is possible to achieve both the miniaturization of the cartridge 2 and the improvement in the operability of filling the cartridge 2 with the chemical solution.
  • the engaging portion 202 of the filling device 3 is engaged with a predetermined position (recessed portion 58a in this embodiment) of the plunger 38 only by two simple operations, namely, a fixing operation of rocking and fixing the 209 to the housing body 210. be able to. Therefore, even with a small-sized cartridge 2, the switching operation between the engaged state and the disengaged state of the engaging portion 202 of the filling device 3 and the plunger 38 of the cartridge 2 is not complicated. Therefore, the operability of filling the cartridge 2 with the chemical solution is unlikely to deteriorate.
  • FIG. 9 The liquid medicine filling device 400 of the present embodiment differs from the liquid medicine filling device 100 of the first embodiment mainly in the presence or absence of an operation restricting section 504 .
  • the operation restricting unit 504 of the chemical filling device 400 will be mainly described, and the description of the configuration common to the chemical filling device 100 of the first embodiment will be omitted.
  • FIG. 9 and 10 are perspective views of the chemical filling device 400.
  • FIG. 9 shows a state in which the containing member 209 of the filling device 403 is in a fixed posture
  • FIG. 10 shows a state in which the containing member 209 of the filling device 403 is in a non-fixed posture.
  • 9 and 10 show a state in which the chemical liquid container 300 is attached to the chemical liquid filling device 400 for convenience of explanation.
  • 11A and 11B are perspective views of filler 403.
  • FIG. 11B shows the filling device 403 in a different form from the filling device 403 shown in FIG. 11A as a result of operating the operation part 203 shown in FIG. 11A.
  • 12A and 12B are diagrams showing the operation restricting portion 504 of the filling device 403.
  • FIG. 11B shows the filling device 403 in a different form from the filling device 403 shown in FIG. 11A as a result of operating the operation part 203 shown in FIG. 11A
  • 12A and 12B
  • FIG. 13A is an explanatory diagram showing an operation restriction state by the operation restriction unit 504.
  • FIG. 13B is an explanatory diagram showing an operation non-restricted state by the operation restriction unit 504.
  • FIG. 14 is a diagram showing an example of a switching mechanism between the operation restricted state shown in FIG. 13A and the operation non-restricted state shown in FIG. 13B.
  • the drug solution filling device 400 of this embodiment includes a cartridge 2, a filling device 403, and an adapter 4.
  • the cartridge 2 and the adapter 4 of the present embodiment are the same as those of the drug solution filling device 100 (see FIG. 1, etc.) of the first embodiment, and thus description thereof is omitted here.
  • the filling device 403 includes an engaging portion 202 , an operating portion 203 , a filling device housing 205 and an operation restricting portion 504 .
  • the engaging portion 202, the operating portion 203, and the filling device housing 205 of the present embodiment are different in form from the drug solution filling device 100 (see FIG. 1, etc.) of the first embodiment in, for example, the shape of the operating lever 207. However, since they have substantially the same configuration and effects, their description is omitted here.
  • the motion regulation unit 504 can regulate the motion of the operation unit 203 . Thereby, the motion restricting unit 504 can restrict the movement range of the plunger 38 interlocked with the operation of the operation unit 203 . In other words, the motion restricting portion 504 can restrict the movement range of the plunger 38 in the axial direction A with respect to the cylindrical body 36 of the cartridge 2 .
  • the motion restricting portion 504 of the present embodiment restricts the pivotal motion of the operating lever 207 with respect to the charging device housing 205 . More specifically, as shown in FIGS. 12, 13A, and 13B, the motion restricting portion 504 of the present embodiment includes a feed screw shaft portion 514 and a nut portion screwed to the feed screw shaft portion 514. 515 and a dial portion 516 connected to the feed screw shaft portion 514 .
  • the feed screw shaft portion 514 rotates relative to the nut portion 515 by rotating the dial portion 516 .
  • the dial portion 516 continues to one end of the feed screw shaft portion 514 .
  • the other end of the feed screw shaft portion 514 is engaged with the coil spring 208a as the biasing member 208 so that the coil spring 208a can be compressed and elongated. That is, the coil spring 208a can be compressed and elongated by rotating the feed screw shaft portion 514 and the nut portion 515 relative to each other.
  • the compressed state of the coil spring 208a can be manipulated.
  • the operating lever 207 is pressed by the restoring force of the coil spring 208a.
  • the air flow shown in FIG. A feed operation is performed.
  • the operation lever 207 rotates to one side (the direction in which the operation lever 207 returns to the non-operated state) with respect to the housing body 210 by the restoring force of the coil spring 208a. filling operation is performed. Therefore, after the air feeding operation shown in FIG. 8A is performed, the coil spring 208a is compressed by the operation restricting portion 504. As shown in FIG.
  • the position of the operating lever 207 does not return to the state before the air feeding operation shown in FIG. 8A is executed even if it receives the restoring force of the coil spring 208a.
  • the liquid medicine filling operation shown in FIG. 8B it is possible to limit the amount of downward movement of the plunger 38 in the vertical direction, and limit the filling amount of the liquid medicine in the cylinder 36 so that it does not exceed the desired filling amount. can be done.
  • the operation restricting portion 504 can easily prevent the cylinder 36 from being excessively filled with the chemical solution.
  • the filling device 3 can be suitably used even when the amount of liquid medicine to be filled is small.
  • the nut portion 515 of the operation restricting portion 504 of this embodiment includes a first nut 515a, a second nut 515b, and a nut lever 515c.
  • the first nut 515a and the second nut 515b can form a female threaded portion 515ab between which the feed screw shaft portion 514 can be screwed.
  • the first nut 515a and the second nut 515b are in an operation restricted state (see FIG. 13A) in which the operation restriction is performed by the operation restriction unit 504, and an operation unrestricted state in which the operation restriction is not performed by the operation restriction unit 504 (FIG. 13B). ) and can change state between.
  • the operation restricted state is a state in which the first nut 515a and the second nut 515b are in contact with each other to form a female threaded portion 515ab therebetween.
  • the operation non-restricted state is a state in which the first nut 515a and the second nut 515b are separated from each other so that the female threaded portion 515ab is not formed therebetween.
  • the state change between the operation restricted state and the operation non-restricted state is executed by operating the nut lever 515c.
  • the first nut 515a and the second nut 515b are configured to switch between an operation restricted state and an operation non-restricted state by rotating the nut lever 515c about the rotation axis O1.
  • the first nut 515a and the second nut 515b are moved from the operation restricted state shown in FIG. 13A to the state shown in FIG. 13B. It can be changed to an operation non-restricted state.
  • the first nut 515a and the second nut 515b are unregulated as shown in FIG. 13B. state can be changed to the operation restricted state shown in FIG. 13A.
  • the first nut 515a and the second nut 515b pivotally supported by the nut lever 515c are rotated in accordance with the rotation of the nut lever 515c, so that the above-described operation regulated state and operation non-regulated state are achieved. , but it is not limited to this configuration.
  • Another mechanism may realize switching between the above-described operation restricted state and operation non-restricted state.
  • the filling device 403 can be refilled simply by swinging the housing member 209 housing the new cartridge 2 with respect to the housing body 210 . and the plunger 38 of the cartridge 2 can be engaged. That is, it is possible to improve the operability of the filling device 403 by the user.
  • the operation of the nut lever 515c described above is preferably performed in conjunction with the swinging motion of the accommodating member 209 of the filling device housing 205 with respect to the housing body 210.
  • the nut lever 515c of this embodiment includes a locking claw 515c1 that can be locked to the projection 209c of the housing member 209. As shown in FIG.
  • the accommodating member 209 swings with respect to the housing main body 210 and changes from the non-fixed posture shown in FIG. 10 to the fixed posture shown in FIG. 209c is hooked on the locking claw 515c1 of the nut lever 515c.
  • the nut lever 515c is maintained in a posture in which the first nut 515a and the second nut 515b are restricted.
  • the movement restriction state shown in FIG. 13A and the movement non-restriction state shown in FIG. 13B are switched in conjunction with the swing movement of the housing member 209 with respect to the housing body 210 .
  • the operation non-restricted state shown in FIG. 13B is changed from the operation restricted state shown in FIG.
  • the present disclosure relates to a chemical filling device and a filling device.

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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
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Abstract

Un dispositif de remplissage de médicament liquide selon la présente divulgation comprend : une cartouche comprenant un réservoir de médicament liquide ayant un orifice de remplissage pour un médicament liquide ; et un dispositif de remplissage apte à remplir le réservoir de médicament liquide avec le médicament liquide à travers l'orifice de remplissage. Le réservoir de médicament liquide comprend un corps cylindrique ayant l'orifice de remplissage et un piston mobile dans la direction axiale à l'intérieur du corps cylindrique. Le dispositif de remplissage comprend : une unité de mise en prise qui peut venir en prise avec le piston ; une unité de fonctionnement apte à déplacer le piston dans la direction axiale par l'intermédiaire de l'unité de mise en prise ; et un boîtier de dispositif de remplissage qui comprend un élément de réception apte à recevoir la cartouche et un corps de boîtier supportant de manière oscillante l'élément de réception, et qui peut commuter l'unité de mise en prise et le piston entre un état en prise et un état libéré par oscillation de l'élément de réception par rapport au corps de boîtier.
PCT/JP2023/006073 2022-03-01 2023-02-20 Dispositif de remplissage de médicament liquide et dispositif de remplissage Ceased WO2023167044A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015115435A1 (fr) * 2014-01-30 2015-08-06 テルモ株式会社 Unité de remplissage de médicament liquide, instrument à réservoir de médicament liquide, et adaptateur de remplissage
WO2016051999A1 (fr) * 2014-09-29 2016-04-07 テルモ株式会社 Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux
WO2018092437A1 (fr) * 2016-11-21 2018-05-24 テルモ株式会社 Unité de remplissage de solution médicamenteuse, ensemble de remplissage de solution médicamenteuse et adaptateur de remplissage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015115435A1 (fr) * 2014-01-30 2015-08-06 テルモ株式会社 Unité de remplissage de médicament liquide, instrument à réservoir de médicament liquide, et adaptateur de remplissage
WO2016051999A1 (fr) * 2014-09-29 2016-04-07 テルモ株式会社 Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux
WO2018092437A1 (fr) * 2016-11-21 2018-05-24 テルモ株式会社 Unité de remplissage de solution médicamenteuse, ensemble de remplissage de solution médicamenteuse et adaptateur de remplissage

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