[go: up one dir, main page]

WO2016051999A1 - Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux - Google Patents

Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux Download PDF

Info

Publication number
WO2016051999A1
WO2016051999A1 PCT/JP2015/073673 JP2015073673W WO2016051999A1 WO 2016051999 A1 WO2016051999 A1 WO 2016051999A1 JP 2015073673 W JP2015073673 W JP 2015073673W WO 2016051999 A1 WO2016051999 A1 WO 2016051999A1
Authority
WO
WIPO (PCT)
Prior art keywords
storage cylinder
pusher
storage
chemical
chemical solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2015/073673
Other languages
English (en)
Japanese (ja)
Inventor
内山　城司
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of WO2016051999A1 publication Critical patent/WO2016051999A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons

Definitions

  • the present invention relates to a drug solution storage device and a drug solution administration device, and more particularly to a portable drug solution storage device and a drug solution administration device such as an insulin pump.
  • a drug solution is continuously administered into a patient's body by subcutaneous injection or intravenous injection.
  • a treatment in which a minute amount of insulin is continuously infused into the body of the patient is performed.
  • a portable drug solution administration device that can be fixedly carried on the patient's body or clothes is used.
  • the device includes a storage container configured as a cylindrical canister and a piston plunger that moves within the storage container to change the volume of the fluid-containing portion within the storage container.
  • the storage container includes a partition wall through which the hollow needle can be pierced, and the injection medium in the storage container is discharged from the hollow needle in accordance with the force applied by the piston plunger.
  • the storage tube is not pre-filled with the chemical solution. Therefore, when using the chemical solution administration device, the user needs to transfer the chemical solution from a chemical solution container (for example, a vial) in which the chemical solution is separately stored into the storage cylinder and to fill the storage cylinder with the chemical solution. is there. Then, the fluid transfer device described in the following patent document 2, for example as a filling device for filling a chemical
  • a chemical solution container for example, a vial
  • the above-described filling device (fluid transfer device) is separate from the chemical solution administration device. For this reason, when the user of the chemical solution administration device misplaces the filling device, the chemical solution cannot be filled into the storage container of the chemical solution administration device.
  • an object of the present invention is to provide a chemical solution storage device that can be manually filled with a chemical solution, and to provide a chemical solution administration device that includes this chemical solution storage device.
  • the medical solution storage device of the present invention for achieving the above-described object includes a storage cylinder whose one end is closed and whose other end is an open end, a liquid supply port provided in communication with the storage cylinder, A pusher slidable in the storage cylinder with the insertion end inserted from the opening end of the storage cylinder in liquid-tight contact with the inner wall of the storage cylinder, and the storage cylinder via the liquid feeding port
  • a manual filling member that is used by being engaged with the pusher when filling the chemical solution, and the pusher extends from the insertion end to the extended end of the storage cylinder
  • the manual filling member has an engagement portion that is freely engaged, and the manual filling member is engaged with the pusher engagement portion via the manual filling member. It has a knob for operating the movement of the pusher.
  • the medicinal solution administration device of the present invention is a medicinal solution administration device having a medicinal solution storage unit filled with a medicinal solution and a drive unit for controlling administration of the medicinal solution from the medicinal solution storage unit, wherein the medicinal solution storage unit stores the storage It has a cylinder, the liquid feeding port, and the pusher.
  • the medicinal solution storage device of the present invention is preferably used for storing a very small amount of medicinal solution
  • the medicinal solution administration apparatus using the medicinal solution storage device includes a patch type insulin pump, a tube type insulin pump, and other types.
  • the present invention is widely applied to a portable drug solution administration device for continuously administering a drug solution into a patient's body, such as a portable drug solution administration device.
  • FIG. 1 is an exploded perspective view for explaining the overall configuration of the chemical storage device 1 according to the embodiment.
  • FIG. 2 is a principal part top view of the chemical
  • the chemical solution storage device 1 shown in these drawings includes a storage device body 2, manual filling members 3, 3 ′ used in combination with the storage device body 2, and an adapter 4.
  • the storage device main body 2 includes a housing 21, a chemical solution storage container 10 housed in the housing 21, and a drive unit 23.
  • casing 21 has the concave storage part 21a which opened large the one main surface side of flat box shape. Further, the housing 21 has a small-capacity concave back surface storage portion 21b having an open corner on the other main surface side of a flat box shape, and the bottom surface of the back surface storage portion 21b is convex toward the storage portion 21a side. Yes.
  • the storage portion 21a and the back surface storage portion 21b communicate with each other through an opening 21c provided on a wall surface that separates the storage portion 21a and the back surface storage portion 21b.
  • the storage portion 21a is provided with a bearing 21d for supporting the rotation shaft of the spur gear 23a in the drive portion 23 described below and a bearing 21e for supporting the feed screw 23b in the drive portion 23.
  • the chemical liquid storage container 10 has a cylindrical storage cylinder 11 closed on one side, a discharge port 13 and a filling port 15 as liquid supply ports provided in the storage cylinder 11, and one end side inside the storage cylinder 11. It has a pusher 17.
  • the chemical storage container 10 is stored in the storage portion 21a of the housing 21 with the discharge port 13 facing the back surface storage portion 21b. Details of each component in the chemical solution storage container 10 are as follows.
  • the storage cylinder 11 has a cylindrical body 11a and a conical head portion 11b provided in a state of closing one end side thereof, and the other end side of the cylindrical body 11a is configured as an open end 11c. .
  • the cylindrical body 11a has a cylindrical body, and it is sufficient that a constant diameter is maintained in the cylindrical extending direction (that is, the axial direction). It may be a shape.
  • the cone-shaped head portion 11b is provided in a state of being convex on the outside of the cylindrical body 11a, that is, on one end side in the axial direction of the cylindrical body 11a.
  • a head portion 11b has a conical shape having a bottom surface that coincides with the diameter (opening shape) of the cylindrical body 11a. If the cylindrical body 11a is cylindrical, a conical shape, and the cylindrical body 11a has an elliptical cylinder. If it is a shape, it is an elliptical cone. Further, the inner diameter of the head portion 11b is narrowed from the bottom surface corresponding to the diameter of the cylindrical body 11a toward the top of the cone.
  • the top part in the cone-shaped head part 11b is located on the centerline of a cone-shaped bottom face as an example.
  • the top of the cone shape in the head 11b May be a position off the center line of the bottom surface of the cone.
  • the opening end 11c only needs to have a shape that does not hinder sliding of the pusher 17 described later in the storage cylinder 11. For this reason, the opening shape of the opening end 11c does not need to correspond with the aperture (opening shape) of the cylindrical body 11a.
  • the storage cylinder 11 having the above-described configuration is disposed with the cone-shaped head portion 11b facing upward when the chemical solution storage container 10 is filled with the chemical solution.
  • the discharge port 13 is provided in communication with the storage cylinder 11 at, for example, a conical top portion of the head portion 11b.
  • the discharge port 13 has a tubular shape, and when the chemical solution storage container 10 is filled with the chemical solution, the gas in the chemical solution storage vessel 10 is exhausted while the chemical solution filled in the chemical solution storage container 10 is administered. When it does, it becomes a channel for making the chemical solution in chemical solution storage container 10 flow out.
  • Such a tube-shaped discharge port 13 may be extended in a direction according to the layout in the chemical solution administration apparatus in which the chemical solution storage container 10 is installed. For this reason, from the viewpoint of downsizing the drug solution administration device, it is preferable to make the storage cylinder 11 compact by extending the discharge port 13 in a direction perpendicular to the axis of the cylindrical body 11a.
  • the storage cylinder 11 when the chemical solution is filled into the chemical solution storage container 10, the storage cylinder 11 is arranged with the conical head portion 11b facing upward. For this reason, from the viewpoint of raising the gas in the storage cylinder 11 and exhausting it from the discharge port 13 when filling the chemical liquid storage container 10 with the chemical liquid, the discharge port 13 has an obtuse angle with respect to the cylindrical body 11a. Preferably they are arranged. That is, when the storage cylinder 11 is disposed with the head portion 11b facing upward, the discharge port 13 is preferably extended from the top of the cone shape in the head portion 11b toward the upper side in the horizontal direction. .
  • the discharge port 13 is most preferably provided with the axial direction parallel to the axis of the cylindrical body 11 a in the storage cylinder 11. Thereby, the gas which rose to the top of the cone shape in the head portion 11 b is discharged without stagnation in the discharge port 13 at the time of the above-described chemical solution filling.
  • the discharge port 13 is provided with a sealing member inside the tube shape.
  • This sealing member is, for example, rubber packing, and the hollow tube P1 is punctured.
  • the hollow tube P1 is connected to a suction mechanism for sucking the gas in the chemical solution storage container 10 when the chemical solution storage container 10 is filled with the chemical solution, and is filled in the chemical solution storage container 10.
  • An administration port is connected when a drug solution is administered.
  • the filling port 15 is provided in communication with the storage cylinder 11 on the opening end 11 c side of the storage cylinder 11 with respect to the discharge port 13.
  • the filling port 15 has a tubular shape, and serves as a flow path for allowing the chemical solution to flow from the chemical solution container when the chemical solution storage container 10 is filled with the chemical solution.
  • Such a filling port 15 has at least a part of its inner wall provided continuously from the inner wall of the cylindrical body 11 a in the storage cylinder 11. In the portion where the filling port 15 and the inner wall of the cylindrical body 11a are continuous, the inner wall of the conical head portion 11b is not interposed between the inner wall of the filling port 15 and the inner wall of the cylindrical body 11a. The inner wall is directly connected to the inner wall of the cylindrical body 11a.
  • the filling port 15 is shown extending from the end of the cylindrical body 11a on the conical head 11b side.
  • a part of the peripheral wall of the filling port 15 extends from the cylindrical body 11a in the storage cylinder 11, and communicates with the storage cylinder 11 at the conical head portion 11b.
  • the communication position of the filling port 15 with respect to the storage cylinder 11 is not limited to the illustrated configuration, and the peripheral wall of the cylindrical body 11a of the storage cylinder 11 may be the communication position of the filling port 15.
  • the portion where the inner wall of the filling port 15 and the inner wall of the cylindrical body 11a are continuous has continuity such that the inner wall of the filling port 15 does not protrude inside the cylindrical body 11a.
  • the inner walls are preferably flush with each other.
  • the filling port 15 as described above may be extended in a direction according to the layout in the apparatus in which the chemical solution storage container 10 is installed. Furthermore, the position of the filling port 15 with respect to the extending direction of the discharge port 13 when the storage cylinder 11 is viewed from the cone-shaped head portion 11b side is also a position corresponding to the layout in the apparatus in which the chemical solution storage container 10 is installed. If it is.
  • the filling port 15 is provided with a sealing member inside the tube shape.
  • This sealing member is, for example, a rubber packing, and when the chemical solution storage container 10 is filled with the chemical solution, the liquid feeding pipe P2 communicating with the chemical solution container is punctured.
  • the pusher 17 is inserted into the storage cylinder 11 from the open end 11 c of the storage cylinder 11.
  • the pusher 17 is configured as a gasket 17 a that can slide in the storage cylinder 11 in a state where the insertion end accommodated in the storage cylinder 11 is in liquid-tight contact with the inner wall of the storage cylinder 11.
  • the gasket 17a has a shape that fits into the head 11b of the storage cylinder 11, for example. That is, the shape of the gasket 17 a is a shape obtained by transferring the inner wall of the conical head portion 11 b in the storage cylinder 11.
  • medical solution storage container 10 becomes a structure by which the chemical
  • the pusher 17 has a shaft 17b extending from the gasket 17a as an insertion end to the outside of the storage cylinder 11.
  • the shaft 17b in the present embodiment is composed of a pair arranged with a feed screw 23b of the drive unit 23 described below interposed therebetween, and the pair of shafts 17b extends from the gasket 17a. It is installed.
  • the extended end extended from the gasket 17a that is, the extended end of the pusher 17 is freely engaged with a manual filling member 3, 3 'described below.
  • a coupling portion 17c and a connecting portion 17d with the driving portion 23 are formed.
  • the engaging portion 17c is formed in a hole shape, for example, and as shown in FIGS. 3 and 4, the manual filling member 3 described below from a direction perpendicular to the extending direction of the shaft 17b.
  • 3 ′ leg 303 is formed in a hole shape.
  • the hole shape of the engaging portion 17c is, for example, a shape opened in a direction perpendicular to the extending direction of the storage cylinder 11 that is the moving direction of the pusher 17 as illustrated.
  • the engagement portion 17c may be a hole with a closed circumference.
  • Such an engaging portion 17c is provided with a pair of pins arranged with the feed screw 23b interposed therebetween in order to facilitate the movement of the pusher 17 by the manual filling members 3, 3 'in the extending direction of the storage cylinder 11. It is provided on both shafts 17b. Moreover, it is preferable that the engaging part 17c has a certain depth d (refer FIG. 1) toward the intrusion direction of the leg part 303. FIG. However, here, for the convenience of arranging the connecting portion 17d, each engaging portion 17c provided on the pair of shafts 17b is divided into two in the direction of the depth d.
  • the connecting portion 17d is provided between the extended engagement ends of the pair of shafts 17b and between the hole-shaped engaging portions 17c divided into two in the depth direction. 17d is arranged with the feed screw 23b interposed therebetween.
  • the connecting portion 17d extends along the pusher 17 as a leaf spring that bends toward the feed screw 23b while being independent of the engaging portion 17c.
  • the tip of the leaf spring extending along the pusher 17 is formed in a crochet shape that is convex on the opposite side to the feed screw 23b. In the crochet shape, the tip (top) in the direction extending along the pusher 17 is located on the feed screw 23b side.
  • the pusher 17 as described above has a configuration in which the rotation with respect to the storage cylinder 11 is restricted in a state where the pusher 17 is housed in the housing 21.
  • the pusher 17 is connected to the pusher 17 in a state where the connecting member 23c of the drive unit 23 is connected to the connecting portion 17d as described below.
  • the stopper part which regulates the movement of the member 23c is provided.
  • the drive unit 23 is provided on the extending end side of the pusher 17.
  • the drive unit 23 includes a spur gear 23a, a feed screw 23b erected on the shaft of the spur gear 23a, and a connecting member 23c screwed to the feed screw 23b. It is stored in a fixed state.
  • the spur gear 23 a is arranged in a state where its rotation shaft is supported with respect to a bearing 21 d fixed to the storage portion 21 a of the housing 21.
  • the feed screw 23b is fixed to the shaft 17b in a state where one end is fixed on a rotating shaft of the spur gear 23a and the other end is supported by a bearing 21e fixed to the housing portion 21a of the housing 21. It is provided in parallel to.
  • the connecting member 23c is plate-shaped and is screwed to a feed screw 23b penetrating between the plate-shaped main surfaces.
  • a connecting member 23c is provided at a position close to the spur gear 23a side of the feed screw 23b.
  • the connecting member 23c is formed with two connecting holes 23d across a position where the connecting member 23c is screwed to the feed screw 23b.
  • These connecting holes 23d have a shape into which the distal end portion of the connecting portion 17d of the pusher 17 described above is inserted, and are located slightly closer to the feed screw 23b side than the crochet-shaped distal end of the connecting portion 17d. Is provided.
  • the connecting member 23c as described above is configured to be restricted from rotating with respect to the storage cylinder 11 in the state of being housed in the casing 21.
  • the connecting member 23c screwed to the feed screw 23b moves in the direction along the feed screw 23b without rotating.
  • the connecting member 23c is moved to the storage cylinder 11 side, when the connecting member 23c reaches the extending end of the pusher 17, the crochet-shaped tip of the connecting portion 17d of the pusher 17 is connected. It is inserted into the connecting hole 23d of the member 23c.
  • the connecting hole 23d of the connecting member 23c is provided slightly closer to the feed screw 23b side than the tip of the crochet shape in the connecting portion 17d of the pusher 17. For this reason, the leaf spring-like connecting portion 17d bends toward the feed screw 23b in accordance with the arrangement of the connecting hole 23d, and the connecting member 23c further moves in a direction along the feed screw 23b.
  • the crochet shape in the connecting portion 17d of the pusher 17 is convex on the opposite side to the feed screw 23b.
  • the connecting member 23c further moves and passes the crochet shape in the connecting portion 17d of the pusher 17
  • the bending of the connecting portion 17d configured as a leaf spring is released,
  • the crochet-shaped convex portion of the connecting portion 17d protrudes outside the connecting hole 23d of the connecting member 23c, and the connecting member 23c is connected to the pusher 17.
  • movement of the connecting member 23 c relative to the pusher 17 is restricted by a stopper portion (not shown) provided on the pusher 17.
  • a stopper portion not shown
  • Manual filling member 3, 3 '> 1, 3 and 4 show two types of manual filling members 3 and manual filling members 3 ′.
  • the medicinal solution storage device 1 may be provided with any one of the manual filling member 3 and the manual filling member 3 ′.
  • the manual filling member 3 has a configuration in which two leg portions 303 are provided on a plate-shaped knob portion 301.
  • the knob portion 301 is configured as a plate-like portion having a size that can be easily picked with a human finger.
  • leg portions 303 are extended in the same direction in parallel with the plate surface of the knob portion 301. These leg portions 303 are portions inserted into the hole-shaped engaging portions 17c of the pusher 17 described above, and coincide with the two engaging portions 17c arranged with the feed screw 23b interposed therebetween. It shall be provided at intervals.
  • the height h of the leg portion 303 is approximately the same as the depth d of the hole-shaped engaging portion 17c.
  • the manual filling member 3 ′ is characterized by having a stopper 305.
  • a stopper 305 for example, a tab 301 ′ is provided at one end of the plate-shaped main body 300, a leg 303 is provided at the other end, and a knob 301 is provided.
  • a stopper 305 is provided between 'and the leg portion 303.
  • the knob portion 301 ′ is provided in a flange shape at one end of the plate-like main body portion 300 in order to facilitate the operation of the manual filling member 3 ′.
  • This is a configuration in which another plate-like member is fixed perpendicularly to the plate surface of the portion 300.
  • the leg portion 303 is provided perpendicular to the plate surface of the main body 300 at the other end of the main body 300.
  • This leg 303 may be similar to that of the manual filling member 3. That is, the leg portion 303 is a portion that is inserted into the hole-shaped engaging portion 17c of the pusher 17 described above, and is made to coincide with the two engaging portions 17c arranged with the feed screw 23b interposed therebetween. It shall be provided at intervals.
  • the height h of the leg portion 303 is approximately the same as the depth d of the hole-shaped engaging portion 17c.
  • the stopper 305 is a portion for restricting the movement of the pusher 17 by the operation of the manual filling member 3 ′, and is provided at a predetermined interval w from the two legs 303.
  • two stoppers 305 are provided in parallel to the two leg portions 303 between the leg portion 303 and the knob portion 301 ′.
  • Such a stopper 305 abuts on the inner wall of the housing 21 or a member fixed to the housing 21, thereby moving the pusher 17 to the outside of the storage cylinder 11 by operating the manual filling member 3 ′. It is something to regulate.
  • the manual filling member 3 ′ with a stopper is engaged with the pusher 17, and in the operation of pulling out the pusher 17 from the storage cylinder 11, the stopper 305 is driven by the drive unit 23. Of the connecting member 23c. Thereby, the volume in the storage cylinder 11 can be set to a set value.
  • the distance w between the leg 303 and the stopper 305 is smaller as the filling amount of the chemical solution into the chemical solution storage container 10 is larger. The less it is, the bigger it is.
  • the leg portion 303 in the case where 1 ml of the chemical solution is filled with respect to the distance w between the leg portion 303 and the stopper 305 in the case where the chemical solution storage container 10 having the maximum capacity of 2 ml is filled with 2 ml of the chemical solution is illustrated in FIG.
  • the distance w from the stopper 305 indicated by the middle broken line is set to a larger value.
  • the adapter 4 is attached to the casing 21, and is connected to the chemical solution storage container 10 housed in the casing 21 in a state of being attached to the casing 21.
  • the adapter 4 has an adapter main body 401 that is mounted on the peripheral wall of the casing 21 on the side where the discharge port 13 and the filling port 15 of the chemical solution storage container 10 are arranged.
  • FIG. 6 is a diagram for explaining a connection state between the chemical solution storage container 10 and the adapter 4 and shows a plan view in which the casing is not shown.
  • a fixing member 403 for holding the peripheral wall of the housing 21 from both sides is extended from the adapter main body 401, so that the adapter 4 attached to the housing 21 is securely fixed.
  • the adapter main body 401 is provided with a connection portion 405 for connecting the chemical solution container S.
  • the chemical solution container S is a vial whose opening is sealed with a rubber stopper.
  • the connection part 405 holds the opening part sealed with a rubber stopper in such a chemical liquid container S from the outer peripheral side.
  • the connection portion 405 holds a liquid feeding pipe P ⁇ b> 2 having one end inserted into the filling port 15 of the chemical liquid storage container 10 housed in the housing 21.
  • the connecting portion 405 holds the vent pipe P3 in parallel with the liquid feeding pipe P2. One end of the vent pipe P3 is in an air released state.
  • connection port 407 is for connecting the hollow tube P1 extending from the discharge port 13 of the chemical solution storage container 10 to a suction-type filling device not shown here.
  • a ventilation filter 409 that allows only gas to pass without passing liquid is provided.
  • Such an adapter 4 is used for filling the chemical solution storage device 1 with a chemical solution using a filling device, and a suction-type filling device is connected to the connection port 407.
  • a suction-type filling device is connected to the connection port 407.
  • the pusher 17 is pulled out from the storage cylinder 11 in accordance with the filling amount of the chemical solution L before the chemical solution container S is connected.
  • the chemical container S is held with respect to the connection portion 405 of the adapter 4, and the inside of the storage cylinder 11 is stored by a suction-type filler connected to the connection port 407 with the head portion 11 b of the storage cylinder 11 facing upward. Aspirate the air.
  • the inside of the storage cylinder 11 becomes a negative pressure, and the chemical liquid L is fed into the storage cylinder 11 from the liquid feeding pipe P2. At this time, the air in the storage cylinder 11 rises to the head of the storage cylinder 11 and is exhausted from the hollow tube P1.
  • ⁇ Manual filling of chemical solution in chemical solution storage device 1> 7 to 10 are schematic diagrams for explaining manual filling of the chemical solution into the chemical solution storage device 1 having the above-described configuration.
  • the procedure for performing the manual filling in the case where the above-described chemical liquid filling cannot be performed will be described.
  • FIG. 6 according to FIGS. 4 and 7 to 10 the operation of manually filling the chemical solution in the chemical solution storage device 1 will be described by exemplifying the case where the manual filling member 3 is used.
  • the user of the drug solution storage device 1 attaches the adapter 4 to the storage device body 2.
  • the leg portion 303 of the manual filling member 3 is inserted and engaged with the engaging portion 17 c of the pusher 17 in the chemical solution storage container 10.
  • the chemical solution container S is set in a vertically upward state, the knob 301 of the manual filling member 3 is picked, and the manual filling member 3 is pulled down to a predetermined position. If the manual filling member 3 ′ with a stopper shown in FIG. 1 is used, the stopper 305 of the manual filling member 3 ′ is in contact with the connecting member 23c fixed to the housing. The manual filling member 3 'is pulled down.
  • the pusher 17 is pulled out from the inside of the storage cylinder 11, and the chemical liquid L is filled into the storage cylinder 11 from the chemical liquid container S via the liquid feeding pipe P2.
  • the air in the storage cylinder 11 rises to the head of the storage cylinder 11 and is exhausted from the connection port 407 through the hollow pipe P1. Further, outside air is taken into the chemical liquid container S from the vent pipe P3, and the chemical liquid container S is maintained at atmospheric pressure (see FIG. 6).
  • the storage device main body 2 is arranged with the head portion 11 b of the storage cylinder 11 facing upward in the vertical direction.
  • the manual filling member 3 engaged with the pusher 17 is operated to push the pusher 17 into the storage cylinder 11, and bubbles in the storage cylinder 11 are discharged from the discharge port 13 through the hollow pipe P1. Let it drain.
  • the hollow tube P1 is filled with the chemical solution L and the exhaust is finished, the manual filling member 3 is removed, and the manual filling operation is finished.
  • the chemical liquid storage device 1 having the above-described configuration includes the manual filling members 3 and 3 ′, and the engaging portion 17 c for engaging the manual filling members 3 and 3 ′ is formed at the end of the pusher 17. It is a configuration. Thereby, even if it is the structure where the pusher 17 and the storage cylinder 11 were accommodated in the housing
  • FIG. 11 is an exploded perspective view showing the overall configuration of the drug solution administration device 5 according to the embodiment.
  • FIG. 12 is a principal part top view of the chemical
  • the configuration of the drug solution administration device 5 will be described based on these drawings.
  • the same components as those described with reference to FIGS. 1 to 10 are denoted by the same reference numerals, and redundant description is omitted.
  • the medicinal solution administration device 5 shown in FIGS. 10 and 11 is provided with the storage device body 2 of the medicinal solution storage device 1 described with reference to FIGS. 1 to 10 as a medicinal solution storage unit, and is used as an insulin pump, for example. .
  • a chemical solution administration device 5 includes a disposable unit 20 configured using the storage device body 2, a reuse unit 30 used in combination with the disposable unit 20, and a cradle 40.
  • the detailed configuration of the drug solution administration device 5 will be described in the order of the disposable unit 20, the reuse unit 30, and the cradle 40.
  • the disposable unit 20 is a chemical solution storage unit configured using the storage device main body 2 described above, and the battery unit 25 is housed in the housing 21 together with the chemical solution storage container 10 and the drive unit 23. It is.
  • the casing 21, the chemical solution storage container 10, and the drive unit 23 are the same as those described above, and a battery box 25 is added.
  • the battery box 25 stores a battery serving as a power source for the motor 33 described below, and includes an electrode for connecting the motor 33 and the battery.
  • the battery box 25 is housed in a fixed state with respect to the housing portion 21 a of the housing 21.
  • the battery box 25 may be provided as a component of the reuse unit 30.
  • the reuse unit 30 includes a lid 31 for the casing 21 of the disposable unit 20, a motor 33 housed in the lid 31, and a gear unit 35.
  • the lid 31 is configured to cover and close the housing portion 21 a side in the housing 21 of the disposable portion 20, and the motor 33 and the gear portion 35 described above are fixed to the main surface side facing the housing 21. It has a configuration.
  • the motor 33 is driven by a battery and has a rotating shaft that rotates.
  • the motor 33 is assumed to be a pulsed stepping motor, for example.
  • the motor 33 is configured to be connected to the electrode of the battery box 25 housed in the casing 21 of the disposable unit 20 in a state where the casing 21 of the disposable unit 20 is closed with the lid 31.
  • Such a motor 33 constitutes a drive unit that controls the administration of the chemical liquid L from the chemical liquid storage container 10.
  • the gear portion 35 is composed of a plurality of gears that rotate in conjunction with the drive of the motor 33. As shown in FIG. 12, the first stage gear 35 a among the plurality of stages constituting the gear unit 35 is fixed coaxially with the rotation shaft of the motor 33. Further, in a state where the lid 31 is put on the casing 21 of the disposable part 20 and the disposable part 20 and the reuse part 30 are combined, the final stage gear 35b among the plural stages of gears constituting the gear part 35 is The spur gear 23a constituting the drive unit 23 of the disposable unit 20 is provided in mesh with the spur gear 23a.
  • the gear unit 35 constitutes a drive unit that controls the administration of the chemical liquid L from the chemical liquid storage container 10.
  • the cradle 40 includes a main body 41, a catheter port 43 provided in the main body 41, and an administration port 45.
  • the main body 41 is detachably attached to the housing 21 of the disposable unit 20 from the side opposite to the lid 31 of the reuse unit 30. Moreover, in the main-body part 41, the surface on the opposite side to the surface which faces the disposable part 20 is a bonding surface with respect to skin.
  • the catheter port 43 is a surface directed toward the disposable part 20 in the main body part 41, and is provided at a position where the catheter port 43 is overlapped with the rear surface storage part 21 b of the casing 21 of the disposable part 20.
  • the catheter port 43 is a portion for holding an administration port 45 to be described below.
  • the main body portion 41 is provided with a through hole not shown here.
  • the administration port 45 holds the injection needle 45a and is arranged in a state of being fitted to the catheter port 43. In a state where the administration port 45 is fitted to the catheter port 43, the injection needle 45 a held by the administration port 45 protrudes from the through hole provided in the main body portion 41 of the cradle 40 to the opposite side to the disposable portion 20. .
  • the administration port 45 fitted to the catheter port 43 is accommodated in the back surface accommodating part 21b of the casing 21 in the disposable part 20. Further, in this state, the administration port 45 is connected to the hollow tube P1 drawn from the discharge port 13 of the drug solution storage container 10 through the opening 21c that connects the storage portion 21a and the back surface storage portion 21b. The held injection needle 45a is communicated with the hollow tube P1.
  • the administration port 45 is freely connectable to the hollow tube P1, and when the chemical solution is filled into the chemical solution storage container 10, a ventilation filter is used instead of the administration port 45 for the hollow tube P1. It becomes the structure to which a suction mechanism is connected via.
  • the chemical solution administration by the chemical solution administration device 5 configured as described above is performed as follows. First, the chemical solution storage container 10 is filled with a predetermined amount of the chemical solution L by manual filling described with reference to FIGS. 7 to 10 or filling using a suction type filling device. In this state, the drive unit 23 and the pusher 17 of the chemical solution storage container 10 are not connected.
  • the disposable unit 20 and the reuse unit 30 are combined by covering the casing 31 of the disposable unit 20 with the lid 31 of the reuse unit 30 in which the motor 33 and the gear unit 35 are housed.
  • the cradle 40 is affixed to the drug solution administration site. At this time, the cradle 40 is attached so that the catheter port 43 provided in the cradle 40 coincides with the administration site. Next, by fitting the administration port 45 to the catheter port 43, the injection needle 45a held by the administration port 45 is punctured into the administration site.
  • the disposable part 20 combined with the reuse part 30 is attached to the cradle 40 attached to the administration site of the chemical solution.
  • the administration port 45 is stored in the back surface storage portion 21b of the housing 21 in the disposable portion 20, and the administration port 45 is further connected to the storage portion 21a and the back surface storage portion 21b in the housing 21 of the disposable portion 20.
  • the hollow tube P1 are connected.
  • the motor 33 is driven by wireless remote operation from a controller (not shown).
  • the spur gear 23a which comprises the drive part 23 of the disposable part 20 rotates.
  • the connecting member 23c moves to the storage cylinder 11 side along the feed screw 23b without rotating, passes through the crochet shape in the connecting portion 17d of the pusher 17 (see FIG. 5), and moves to the pusher 17. Connected.
  • the pusher 17 connected to the connecting member 23c moves to the storage cylinder 11 side along the feed screw 23b.
  • medical solution storage container 10 was filled is administered to an administration site
  • the pusher 17 is pushed to the deepest part of the storage cylinder 11, the administration of the drug solution L is completed.
  • the chemical solution administration device 5 described above includes a drive unit that drives the pusher 17 of the chemical solution storage container 10 provided in the storage device body 2 together with the storage device body 2 in the medical solution storage device 1 of the embodiment described above. It is provided. Thereby, although the pusher 17 and the storage cylinder 11 are housed in the housing 21 for the purpose of connecting the filling device, the medicinal solution L filled manually can be administered.
  • FIG. 13 is a principal part top view for demonstrating the chemical
  • the chemical solution storage device described with reference to this figure is different from the chemical solution storage device described above with reference to FIGS. 1 to 6 in that the connecting portion 17d ′ provided on the pusher 17 ′ is configured as a half nut. It is in.
  • the configuration of the drive unit 23 ′ is also changed, but the other components are the same as the chemical solution storage device described with reference to FIGS. 1 to 6, and the same components are the same.
  • the reference numerals are attached, and duplicate descriptions are omitted.
  • 13A is a plan view showing the chemical solution storage container 10
  • FIG. 13B is a plan view in which the driving unit 23 ′ is combined with the chemical solution storage container 10.
  • the connecting portion 17 d ′ for connecting the driving portion 23 ′ is configured as a half nut that is screwed to the feed screw 23 b of the driving portion 23 ′.
  • the connecting portion 17d ′ is configured such that the feed screw 23b of the driving portion 23 ′ is fitted to the pusher 17 ′ that is housed together with the storage cylinder 11 in a housing (not shown). ing.
  • the drive unit 23 ' has a spur gear 23a and a feed screw 23b, and the feed screw 23b itself is a connecting member connected to the connecting portion 17d'. Therefore, it is not necessary to provide a connecting member as a separate body.
  • the drive unit 23 ′ is not necessarily a component of the drug solution storage device, and may be a component of the reuse unit of the drug solution administration device together with the motor 33 and the gear unit 35 for driving the drive unit 23 ′. .
  • the chemical solution storage device having such a connecting portion 17d ′ can perform manual filling of the chemical solution by the same operation as the chemical solution storage device described above with reference to FIGS. 1 to 6, and obtains the same effect. be able to.
  • the drive unit 23 ′ is not disposed in the housing, and thus the manual filling member.
  • the 3 ′ stopper 305 abuts against the inner wall of the housing to restrict the movement of the pusher 17.
  • the chemical solution storage device is not limited to one that performs chemical solution filling with a suction-type filling device.
  • the storage cylinder is configured to include both the discharge port and the filling port, it may be configured to include only one liquid feeding port and to fill the chemical liquid from this liquid feeding port.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif de stockage de liquides médicamenteux, comprenant : un cylindre de stockage ayant une extrémité fermée et l'autre extrémité ouverte ; un orifice de distribution de liquide, disposé en communication avec le cylindre de stockage ; un poussoir capable de coulisser à l'intérieur du cylindre de stockage, tandis que l'extrémité d'insertion du poussoir, qui est insérée à partir de l'extrémité ouverte du cylindre de stockage, est en contact étroit, étanche aux liquides, avec la paroi intérieure du cylindre de stockage ; et un élément de remplissage manuel qui, lors du remplissage du cylindre de stockage avec un liquide médicamenteux par l'orifice de distribution de liquide, est utilisé en étant en prise avec le poussoir. Le poussoir possède une section de mise en prise au niveau de son extrémité étendue, qui est étendue de l'extrémité d'insertion à la face extérieure du cylindre de stockage, la section de mise en prise permettant à l'élément de remplissage manuel de se mettre librement en prise avec lui. L'élément de remplissage manuel possède une poignée, destinée à manœuvrer, par l'intermédiaire de l'élément de remplissage manuel, le déplacement du poussoir, la poignée entrant en prise avec la section de mise en prise du poussoir.
PCT/JP2015/073673 2014-09-29 2015-08-24 Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux Ceased WO2016051999A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014-198434 2014-09-29
JP2014198434 2014-09-29

Publications (1)

Publication Number Publication Date
WO2016051999A1 true WO2016051999A1 (fr) 2016-04-07

Family

ID=55630045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/073673 Ceased WO2016051999A1 (fr) 2014-09-29 2015-08-24 Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux

Country Status (1)

Country Link
WO (1) WO2016051999A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3542772A4 (fr) * 2016-11-21 2020-06-03 Terumo Kabushiki Kaisha Unité de remplissage de solution médicamenteuse, ensemble de remplissage de solution médicamenteuse et adaptateur de remplissage
WO2023167044A1 (fr) * 2022-03-01 2023-09-07 テルモ株式会社 Dispositif de remplissage de médicament liquide et dispositif de remplissage
WO2023167042A1 (fr) * 2022-03-01 2023-09-07 テルモ株式会社 Dispositif de remplissage de médicament liquide et instrument de remplissage
WO2024004329A1 (fr) * 2022-06-28 2024-01-04 テルモ株式会社 Dispositif d'administration de solution medicamenteuse

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000296178A (ja) * 1999-02-08 2000-10-24 Fuji Photo Optical Co Ltd シリンジ用アダプタ装置
JP2008173459A (ja) * 2006-12-04 2008-07-31 Animas Corp シリンジアセンブリ及びこれを組み込んだ注入ポンプアセンブリ
JP3149239U (ja) * 2008-12-16 2009-03-19 株式会社メディテック ジャパン 片手で操作可能な注射器、注射器用補助具及び注射器セット
US20100084041A1 (en) * 2008-10-02 2010-04-08 Jean-Noel Fehr Manual filling aid with push button fill
JP2013521938A (ja) * 2010-03-12 2013-06-13 コントロール・メディカル・テクノロジー，エルエルシー 流量制御弁を有する注射器及び関連した方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000296178A (ja) * 1999-02-08 2000-10-24 Fuji Photo Optical Co Ltd シリンジ用アダプタ装置
JP2008173459A (ja) * 2006-12-04 2008-07-31 Animas Corp シリンジアセンブリ及びこれを組み込んだ注入ポンプアセンブリ
US20100084041A1 (en) * 2008-10-02 2010-04-08 Jean-Noel Fehr Manual filling aid with push button fill
JP3149239U (ja) * 2008-12-16 2009-03-19 株式会社メディテック ジャパン 片手で操作可能な注射器、注射器用補助具及び注射器セット
JP2013521938A (ja) * 2010-03-12 2013-06-13 コントロール・メディカル・テクノロジー，エルエルシー 流量制御弁を有する注射器及び関連した方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3542772A4 (fr) * 2016-11-21 2020-06-03 Terumo Kabushiki Kaisha Unité de remplissage de solution médicamenteuse, ensemble de remplissage de solution médicamenteuse et adaptateur de remplissage
WO2023167044A1 (fr) * 2022-03-01 2023-09-07 テルモ株式会社 Dispositif de remplissage de médicament liquide et dispositif de remplissage
WO2023167042A1 (fr) * 2022-03-01 2023-09-07 テルモ株式会社 Dispositif de remplissage de médicament liquide et instrument de remplissage
WO2024004329A1 (fr) * 2022-06-28 2024-01-04 テルモ株式会社 Dispositif d'administration de solution medicamenteuse

Similar Documents

Publication Publication Date Title
US10398831B2 (en) Positive displacement pump
US10688294B2 (en) Portable fluid delivery system
EP3100711B1 (fr) Unité de remplissage de médicament liquide, instrument à réservoir de médicament liquide, et adaptateur de remplissage
WO2016051999A1 (fr) Dispositif de stockage de liquides médicamenteux, et dispositif d'administration de liquides médicamenteux
US20190262232A1 (en) Drug solution filling unit, drug solution filling set, and filling adapter
JP2015181869A (ja) 薬液投与装置
CN219230995U (zh) 药瓶适配器
JP2015181835A (ja) 薬液投与装置
WO2016132936A1 (fr) Dispositif d'administration de médicament liquide
JP6615766B2 (ja) 薬液貯蔵容器、薬液貯蔵方法、薬液投与装置、および薬液投与方法
JP5816708B2 (ja) 薬液注入装置
CN113226404B (zh) 用于输送治疗流体的设备
JP6280376B2 (ja) 薬液充填装置
EP3544653B1 (fr) Réservoir de stockage d'un médicament liquide et procédé de production d'un réservoir
RU2828660C2 (ru) Соединитель сменного комплекта одноразового использования
JP2016064015A (ja) 充填アダプタ及び薬液充填セット
HK1225600B (zh) 药液填充单元、药液贮藏件以及填充接合器

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15846232

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: JP

122 Ep: pct application non-entry in european phase

Ref document number: 15846232

Country of ref document: EP

Kind code of ref document: A1