WO2018034595A1 - Method for treating atrophic scars - Google Patents
Method for treating atrophic scars Download PDFInfo
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- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- the invention relates to medicine, namely to dermatology and cosmetology, and can be used to treat atrophic skin scars that have arisen due to various reasons.
- a known method of eliminating scars (RU 2030923 C1, 03/20/1995), which consists in exposing the scar tissue to laser radiation.
- Laser exposure is carried out by a focused beam of a holmium laser with a wavelength of 1.96 - 2.15 ⁇ m in a pulse-periodic mode with a pulse duration of 200 - 500 ⁇ s, an energy of 0.1 - 2.0 J.
- Its disadvantage is that it is very difficult to dose the penetration depth laser beam, subsequently, a demarcation line remains at the border of the treated and untreated sections, in addition, the implementation of this method requires the use of expensive equipment.
- a known method of treating hypotrophic skin scars which also includes the use of laser radiation (RU 2323021 C1, 04/27/2008). Scar tissue is subjected to a single exposure to laser radiation with a wavelength of 540 nm, a pulse energy of 50-150 mJ, a pulse repetition rate of 1-4 Hz, a pulse duration of 1-2 ns. This method also requires the use of expensive equipment.
- a known method of treating normo-atrophic scars with mechanical dermabrasion using a combined collagen coating with an antimicrobial agent (RU 2230554 C2, 06/20/2004).
- a complex of preoperative measures and dermabrasion is carried out, while the area is exposed on an outpatient basis in sterile conditions of a small operating room operations, the skin surface is treated twice with 10 ml butol using a gauze cloth, capturing more than 2-3 cm of the area of the operating area, and anesthesia is performed topically with lidocaine, then dermabrasion is performed using a rotary apparatus and the skin surfaces are applied, applying a gauze cloth moistened pre-butol, the surgical wound is treated with butol twice 10-15 ml from a plastic syringe without a needle, and 3-5 minutes after the patient has a burning sensation, the gauze is removed with a forceps, after dermabrasion on the operating surface impose a collagen coating that exceeds the operating area by 1-2 cm, and the surgical wound is treated twice without interruption
- the objective of the invention is to provide a simpler highly effective method for the treatment of atrophic scars, which allows to obtain a pronounced effect in a short time.
- the technical result is to reduce the complexity and cost, as well as to shorten the treatment time and improve functional results.
- the technical result is achieved by a method of treating atrophic skin scars using fully straightened filtered high-frequency radio waves and autologous platelet-rich plasma, characterized in that from the patient’s peripheral vein take blood in vacuum tubes, mix blood with an anticoagulant, centrifuge the blood mixture with an anticoagulant for 4-6 minutes with a centrifuge speed of 700-900 rpm, remove the upper layer of platelet-rich plasma from a tube into a separate tube, activate platelet-rich plasma plasma with calcium ions by adding calcium gluconate and mixing with it, activated platelet-rich plasma is collected in a syringe and injected intradermally into the scar, the injected is heated region using the Surgitron ® radio wave apparatus with Pelleve ® GlideSafe or PelleFirm electrodes up to 41-43 ° C for at least 4 minutes.
- blood is collected from a patient’s peripheral vein into 3-9 ml vacuum tubes; 3.8% sodium citrate solution is used as an anticoagulant; to mix blood with sodium citrate, the tubes are inverted 4-5 times; the upper layer of the resulting platelet-rich plasma is removed into a separate tube using a laboratory dispenser; calcium gluconate in platelet rich plasma is added at the rate of 50 ⁇ l of calcium gluconate per 1 ml of plasma; for injection use insulin syringes with a volume of 1 ml; 0.1-0.2 ml of platelet-rich plasma per 1 cm of the rumen is injected into the rumen; heating is carried out using a radio wave apparatus
- the proposed method is as follows. From the patient's peripheral vein, blood is drawn into vacuum tubes of 3–9 ml in volume (depending on the required plasma volume). Blood is mixed with an anticoagulant, which is used as a 3.8% solution of sodium citrate. To mix blood with citrate, the tubes are inverted 4-5 times.
- the blood in the test tubes is divided into three layers: the lower is red blood cells, the middle is a thin layer of white blood cells, and the upper is plasma enriched with platelets.
- platelet-rich plasma (BTP) is removed into a separate tube. After this, platelet-rich plasma (BTP) is activated with calcium ions: 50 ⁇ l of calcium gluconate per 1 ml of plasma.
- BoTP BoTP is ready for use and should be used within 5-10 minutes.
- the plasma volume required for the procedure depends on the size of the skin defect.
- BTP All obtained BTP are collected in 1 ml insulin syringes. BOTP is injected intradermally into the scar at 0.1-0.2 ml per cm.
- the procedure is carried out 1 time per week 5-7 times.
- the method was applied in clinical conditions in 22 patients with atrophic skin scars aged 20 to 50 years. All patients were female. 12 patients with post-acne without signs of inflammation (atrophic scars resulting from acne). 10 patients with striae (atrophic scars). The disease is over 2 years old. The procedure was performed 1 time per week.
- Example 1 Patient T., 37 years old.
- the patient was treated by the proposed method. 12 ml of blood were taken from peripheral blood (in 4 vacuum tubes of 3 ml each). 3.8% sodium citrate solution was used as an anticoagulant. Further, the blood was centrifuged for 5 min with a centrifuge rotation speed of 800 rpm. During rotation, the blood in the test tubes was divided into three layers: the lower — red blood cells, the middle — a thin layer of leukocytes, and the upper — plasma enriched with platelets. Then, using the laboratory dispenser, the upper layer (BOT) was removed into a separate tube.
- BOTP was activated with calcium ions: 50 ⁇ l of calcium gluconate per 1 ml of plasma. The liquid was mixed by carefully turning the tubes. Received 5 ml of BOTP. All obtained BTPs were collected in 1 ml insulin syringes. BOTP was injected intradermally into the scar at 0.1-0.2 ml per cm. After BOTP injection into the scar, this area was heated using a Surgitron S5 radio wave apparatus with a PelleFirm TM electrode to 42 ° C for 5 minutes (the temperature was measured with an infrared pyrometer on the skin above the scar) to resume regeneration processes. The procedure was carried out 1 time per week 5 times. After 6 months there was a complete regression of striae. By the end of 2 months, a significant densification of scar tissue and alignment of the relief with the surrounding skin were noted. No adverse effects have been reported.
- platelets due to short-term centrifugation for 4-6 minutes, platelets do not have time to sink to the bottom of the tube and mix with the layer of leukocytes and red blood cells, but remain suspended in the upper part of the tube, evenly distributed in the plasma, which does not require separation of the plasma into layers or repeated centrifugation.
- the short time required for the manufacture of platelet-rich plasma, and the simplicity of its preparation make it possible to use this technique in routine medical practice in institutions of any profile.
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Abstract
Description
Способ лечения атрофических рубцов кожи A method for the treatment of atrophic skin scars
Изобретение относится к медицине, а именно к дерматологии и косметологии, и может быть использовано для лечения атрофических рубцов кожи, возникших вследствие различных причин. The invention relates to medicine, namely to dermatology and cosmetology, and can be used to treat atrophic skin scars that have arisen due to various reasons.
Известен способ устранения рубцов (RU 2030923 С1, 20.03.1995), заключающийся в воздействии на рубцовую ткань лазерным излучением. Лазерное воздействие осуществляют сфокусированным лучом гольмиевого лазера длиной волны 1,96 - 2,15 мкм в импульсно-периодическом режиме длительностью импульса 200 - 500 мкс, энергией 0,1 - 2,0 Дж. Недостатком его является то, что очень сложно дозировать глубину проникновения лазерного луча, впоследствии на границе обработанных и необработанных участков остается линия демаркации, кроме того, реализация этого способа требует применения дорогостоящего оборудования. A known method of eliminating scars (RU 2030923 C1, 03/20/1995), which consists in exposing the scar tissue to laser radiation. Laser exposure is carried out by a focused beam of a holmium laser with a wavelength of 1.96 - 2.15 μm in a pulse-periodic mode with a pulse duration of 200 - 500 μs, an energy of 0.1 - 2.0 J. Its disadvantage is that it is very difficult to dose the penetration depth laser beam, subsequently, a demarcation line remains at the border of the treated and untreated sections, in addition, the implementation of this method requires the use of expensive equipment.
Известен способ лечения гипотрофических рубцов кожи, также включающий применение лазерного излучения (RU 2323021 С1, 27.04.2008). Рубцовую ткань подвергают однократному воздействию лазерного излучения длиной волны 540 нм, энергией импульса 50-150 мДж, частотой следования импульсов 1-4 Гц, длительностью импульса 1-2 не. Данный способ также требует применения дорогостоящего оборудования. A known method of treating hypotrophic skin scars, which also includes the use of laser radiation (RU 2323021 C1, 04/27/2008). Scar tissue is subjected to a single exposure to laser radiation with a wavelength of 540 nm, a pulse energy of 50-150 mJ, a pulse repetition rate of 1-4 Hz, a pulse duration of 1-2 ns. This method also requires the use of expensive equipment.
Известен способ лечения нормо-атрофических рубцов механической дермабразией с применением комбинированного коллагенового покрытия с антимикробным средством (RU 2230554 С2, 20.06.2004). Проводят комплекс предоперационных мероприятий и дермабразии, при этом амбулаторно в стерильных условиях малой операционной обнажают зону операции, кожную поверхность дважды обрабатывают бутолом по 10 мл с помощью марлевой салфетки, захватывая более чем на 2-3 см области операционной зоны, а анастезию производят местно лидокаином, затем с помощью ротационного аппарата производят дермабразию и обрабатывают поверхности кожи, накладывая марлевую салфетку, смоченную предварительно бутолом, операционную рану обрабатывают бутолом дважды 10-15 мл из пластикового шприца без иглы, а через 3-5 минут после исчезновения у пациента чувства жжения удаляют корцангом марлевую салфетку, после дермабразии на операционную поверхность накладывают коллагеновое покрытие, которое превышает операционную зону на 1-2 см, и операционную рану дважды без перерыва обрабатывают бутолом по 10-15 мл из пластикового шприца без иглы и операционную поверхность облучают инфракрасным излучением слабой мощности 5-8 раз в день, а в послеоперационный период в течение 7-10 дней спринцуют несколько раз в день марлевые повязки бутолом, вплоть до заживления эпидермиса и самопроизвольного снятия струпа. Данный способ является относительно трудоемким. A known method of treating normo-atrophic scars with mechanical dermabrasion using a combined collagen coating with an antimicrobial agent (RU 2230554 C2, 06/20/2004). A complex of preoperative measures and dermabrasion is carried out, while the area is exposed on an outpatient basis in sterile conditions of a small operating room operations, the skin surface is treated twice with 10 ml butol using a gauze cloth, capturing more than 2-3 cm of the area of the operating area, and anesthesia is performed topically with lidocaine, then dermabrasion is performed using a rotary apparatus and the skin surfaces are applied, applying a gauze cloth moistened pre-butol, the surgical wound is treated with butol twice 10-15 ml from a plastic syringe without a needle, and 3-5 minutes after the patient has a burning sensation, the gauze is removed with a forceps, after dermabrasion on the operating surface impose a collagen coating that exceeds the operating area by 1-2 cm, and the surgical wound is treated twice without interruption with 10-15 ml butol from a plastic syringe without a needle and the operating surface is irradiated with low-power infrared radiation 5-8 times a day and in the postoperative period for 7-10 days they will douche gauze dressings with butanol several times a day, up to the healing of the epidermis and spontaneous removal of the scab. This method is relatively time consuming.
Задачей изобретения является создание более простого высокоэффективного способа лечения атрофических рубцов, позволяющего получить в короткие сроки выраженный эффект. The objective of the invention is to provide a simpler highly effective method for the treatment of atrophic scars, which allows to obtain a pronounced effect in a short time.
Технический результат заключается в снижении трудоемкости и себестоимости, а также в сокращении сроков лечения и улучшении функциональных результатов. The technical result is to reduce the complexity and cost, as well as to shorten the treatment time and improve functional results.
Технический результат достигается способом лечения атрофических рубцов кожи при помощи полностью выпрямленных фильтрованных радиоволн высокой частоты и аутологичной богатой тромбоцитами плазмы, характеризующимся тем, что из периферической вены пациента производят взятие крови в вакуумные пробирки, смешивают кровь с антикоагулянтом, центрифугируют смесь крови с антикоагулянтом в течение 4-6 мин со скоростью вращения центрифуги 700-900 оборотов в мин, извлекают из пробирки верхний слой образовавшейся богатой тромбоцитами плазмы в отдельную пробирку, активируют богатую тромбоцитами плазму ионами кальция посредством добавления глюконата кальция и перемешивания с ним, активированную богатую тромбоцитами плазму набирают в шприц и инъецируют внутридермально в рубец, прогревают инъецированную область с помощью радиоволнового аппарата Сургитрон® электродами Pelleve®GlideSafe или PelleFirm до 41-43 °С на протяжении по меньшей мере 4 минут. The technical result is achieved by a method of treating atrophic skin scars using fully straightened filtered high-frequency radio waves and autologous platelet-rich plasma, characterized in that from the patient’s peripheral vein take blood in vacuum tubes, mix blood with an anticoagulant, centrifuge the blood mixture with an anticoagulant for 4-6 minutes with a centrifuge speed of 700-900 rpm, remove the upper layer of platelet-rich plasma from a tube into a separate tube, activate platelet-rich plasma plasma with calcium ions by adding calcium gluconate and mixing with it, activated platelet-rich plasma is collected in a syringe and injected intradermally into the scar, the injected is heated region using the Surgitron ® radio wave apparatus with Pelleve ® GlideSafe or PelleFirm electrodes up to 41-43 ° C for at least 4 minutes.
В отдельных вариантах осуществления данного способа кровь из периферической вены пациента забирают в вакуумные пробирки объемом 3-9 мл; в качестве антикоагулянта используют 3,8% раствор цитрата натрия; для смешивания крови с цитратом натрия пробирки переворачивают 4-5 раз; верхний слой образовавшейся богатой тромбоцитами плазмы извлекают в отдельную пробирку с помощью лабораторного дозатора; глюконат кальция в богатую тромбоцитами плазму добавляют из расчета 50 мкл глюконата кальция на 1 мл плазмы; для инъекций используют инсулиновые шприцы объемом по 1 мл; в рубец инъецируют по 0,1-0,2 мл богатой тромбоцитами плазмы на 1 см рубца; прогревание производят при помощи радиоволнового аппарата In certain embodiments of this method, blood is collected from a patient’s peripheral vein into 3-9 ml vacuum tubes; 3.8% sodium citrate solution is used as an anticoagulant; to mix blood with sodium citrate, the tubes are inverted 4-5 times; the upper layer of the resulting platelet-rich plasma is removed into a separate tube using a laboratory dispenser; calcium gluconate in platelet rich plasma is added at the rate of 50 μl of calcium gluconate per 1 ml of plasma; for injection use insulin syringes with a volume of 1 ml; 0.1-0.2 ml of platelet-rich plasma per 1 cm of the rumen is injected into the rumen; heating is carried out using a radio wave apparatus
Сургитрон модели Surgitron S5; при прогревании температура кожи прогреваемой области измеряется инфракрасным пирометром; процедуру повторяют 5-7 раз, по 1 разу в неделю. Surgitron Surgitron S5; when warming, the skin temperature of the heated area is measured by an infrared pyrometer; the procedure is repeated 5-7 times, 1 time per week.
Предложенный способ осуществляется следующим образом. Из периферической вены пациента производят взятие крови в вакуумные пробирки объемом 3-9 мл (в зависимости от необходимого объема плазмы). Кровь смешивают с антикоагулянтом, в качестве которого используют 3,8% раствор цитрата натрия. Для смешивания крови с цитратом пробирки переворачивают 4-5 раз. The proposed method is as follows. From the patient's peripheral vein, blood is drawn into vacuum tubes of 3–9 ml in volume (depending on the required plasma volume). Blood is mixed with an anticoagulant, which is used as a 3.8% solution of sodium citrate. To mix blood with citrate, the tubes are inverted 4-5 times.
Затем кровь центрифугируют в течение 4-6 мин со скоростью вращения центрифуги 600-800 оборотов в мин. При вращении кровь в пробирках разделяется на три слоя: нижний - эритроциты, средний - тонкая прослойка лейкоцитов, верхний — плазма, обогащенная тромбоцитами. Then the blood is centrifuged for 4-6 minutes with a centrifuge rotation speed of 600-800 rpm. During rotation, the blood in the test tubes is divided into three layers: the lower is red blood cells, the middle is a thin layer of white blood cells, and the upper is plasma enriched with platelets.
С помощью лабораторного дозатора извлекают верхний слой богатой тромбоцитами плазмы (БоТП) в отдельную пробирку. После этого активируют богатую тромбоцитами плазму (БоТП) ионами кальция: на 1 мл плазмы - 50 мкл глюконата кальция. Using a laboratory dispenser, the top layer of platelet-rich plasma (BTP) is removed into a separate tube. After this, platelet-rich plasma (BTP) is activated with calcium ions: 50 μl of calcium gluconate per 1 ml of plasma.
Жидкость смешивают, осторожно переворачивая пробирки. Таким образом, БоТП готова к применению и должна быть использована в течение 5-10 мин. Объем плазмы, необходимый для проведения процедуры, зависит от размера дефекта кожи. The fluid is mixed by carefully turning the tubes. Thus, BoTP is ready for use and should be used within 5-10 minutes. The plasma volume required for the procedure depends on the size of the skin defect.
Всю полученную БоТП набирают в инсулиновые шприцы объемом по 1 мл. БоТП инъецируют внутридермально в рубец по 0,1-0,2 мл на см . All obtained BTP are collected in 1 ml insulin syringes. BOTP is injected intradermally into the scar at 0.1-0.2 ml per cm.
После инъецирования БоТП в рубец, необходимо прогреть данную область с помощью радиоволнового аппарата Surgitron S электродами марки Pelleve® моделей GlideSafe или PelleFirm (в зависимости от площади After BOTP is injected into the scar, it is necessary to warm this area with the Surgitron S radio wave apparatus using Pelleve ® brand electrodes of GlideSafe or PelleFirm models (depending on the area
о about
рубца) до 41-43 С на протяжении 5 минут (при этом температура измеряется инфракрасным пирометром на коже над рубцом) для возобновления процессов регенерации. Процедуру проводят 1 раз в неделю 5-7 раз. Способ применен в клинических условиях у 22 пациентов с атрофическими рубцами кожи в возрасте от 20 до 50 лет. Все пациенты были женского пола. 12 пациенток с постакне без признаков воспаления (атрофические рубцы, возникшие вследствие акне). 10 пациенток со стриями (атрофические рубцы). Давность заболевания более 2 лет. Процедуру выполняли 1 раз в неделю. scar) to 41-43 C for 5 minutes (the temperature is measured by an infrared pyrometer on the skin above the scar) to resume regeneration processes. The procedure is carried out 1 time per week 5-7 times. The method was applied in clinical conditions in 22 patients with atrophic skin scars aged 20 to 50 years. All patients were female. 12 patients with post-acne without signs of inflammation (atrophic scars resulting from acne). 10 patients with striae (atrophic scars). The disease is over 2 years old. The procedure was performed 1 time per week.
Полный регресс наблюдался у 20 из 22 пациенток к 6 месяцу после начала процедур. К концу 2 месяца отмечалось значительное уплотнение рубцовой ткани и выравнивание рельефа с окружающей кожей. Нежелательных эффектов зарегистрировано не было. Complete regression was observed in 20 of 22 patients by 6 months after the start of the procedures. By the end of 2 months, a significant densification of scar tissue and alignment of the relief with the surrounding skin were noted. No adverse effects have been reported.
Пример 1. Больная Т., 37 лет. Example 1. Patient T., 37 years old.
Диагноз: Стрии. Diagnosis: Striae.
В анамнезе избыточная масса тела. Стрии на коже боковых поверхностей живота. Длительность существования стрий 3 года. Пациентка пролечена предложенным способом. Из периферической крови произведено взятие 12 мл крови (в 4 вакуумные пробирки по 3 мл каждая). В качестве антикоагулянта использовали 3,8 % р-р цитрата натрия. Далее кровь центрифугировали в течение 5 мин со скоростью вращения центрифуги 800 оборотов в мин. При вращении кровь в пробирках разделилась на три слоя: нижний - эритроциты, средний - тонкая прослойка лейкоцитов, верхний - плазма, обогащенная тромбоцитами. Далее с помощью лабораторного дозатора извлекали верхний слой (БоТП) в отдельную пробирку. Далее активировали БоТП ионами кальция: на 1 мл плазмы - 50 мкл глюконата кальция. Жидкость смешивали, осторожно переворачивая пробирки. Получали 5 мл БоТП. Всю полученную БоТП набирали в инсулиновые шприцы объемом по 1 мл. БоТП инъецировали внутридермально в рубец по 0,1-0,2 мл на см . После инъецирования БоТП в рубец прогревали данную область с помощью радиоволнового аппарата Surgitron S5 электродом PelleFirm™ до 42°С на протяжении 5 минут (при этом температура измерялась инфракрасным пирометром на коже над рубцом) для возобновления процессов регенерации. Процедуру проводили 1 раз в неделю 5 раз. Через 6 месяцев произошел полный регресс стрий. К концу 2 месяца отмечалось значительное уплотнение рубцовой ткани и выравнивание рельефа с окружающей кожей. Нежелательных эффектов зарегистрировано не было. A history of overweight. Striae on the skin of the lateral surfaces of the abdomen. The duration of the stretch is 3 years. The patient was treated by the proposed method. 12 ml of blood were taken from peripheral blood (in 4 vacuum tubes of 3 ml each). 3.8% sodium citrate solution was used as an anticoagulant. Further, the blood was centrifuged for 5 min with a centrifuge rotation speed of 800 rpm. During rotation, the blood in the test tubes was divided into three layers: the lower — red blood cells, the middle — a thin layer of leukocytes, and the upper — plasma enriched with platelets. Then, using the laboratory dispenser, the upper layer (BOT) was removed into a separate tube. Then, BOTP was activated with calcium ions: 50 μl of calcium gluconate per 1 ml of plasma. The liquid was mixed by carefully turning the tubes. Received 5 ml of BOTP. All obtained BTPs were collected in 1 ml insulin syringes. BOTP was injected intradermally into the scar at 0.1-0.2 ml per cm. After BOTP injection into the scar, this area was heated using a Surgitron S5 radio wave apparatus with a PelleFirm ™ electrode to 42 ° C for 5 minutes (the temperature was measured with an infrared pyrometer on the skin above the scar) to resume regeneration processes. The procedure was carried out 1 time per week 5 times. After 6 months there was a complete regression of striae. By the end of 2 months, a significant densification of scar tissue and alignment of the relief with the surrounding skin were noted. No adverse effects have been reported.
Как показала практика применения предложенного способа лечения атрофических рубцов, авторами изобретения разработана новая технологии применения аутологичной богатой тромбоцитами плазмы для лечения данного заболевания. As shown by the application of the proposed method for the treatment of atrophic scars, the inventors have developed a new technology for the use of autologous platelet-rich plasma for the treatment of this disease.
Использование режима однократного медленного центрифугирования со скоростью вращения центрифуги 700-900 оборотов в минуту в течение 4-6 минут, позволяет максимально сохранить целостность тромбоцитов, содержащих факторы роста, которые из-за очень высокой скорости центрифугирования могут механически травмироваться и/или вступать в химические взаимодействия за счет повышения температуры, а все это приводит к преждевременной дегрануляции тромбоцитов, к разрушению факторов роста и, как следствие, к отсутствию положительного эффекта. The use of a single slow centrifugation mode with a centrifuge speed of 700-900 rpm for 4-6 minutes allows you to preserve the integrity of platelets containing growth factors that can mechanically be injured and / or enter into chemical interactions due to the very high centrifugation speed due to an increase in temperature, and all this leads to premature platelet degranulation, to the destruction of growth factors and, as a result, to the absence of a positive effect.
Кроме того, за счет краткосрочного центрифугирования в течение 4- 6 минут тромбоциты не успевают опуститься на дно пробирки и смешаться с прослойкой лейкоцитов и эритроцитами, а остаются взвешенными в верхней части пробирки, равномерно распределившись в плазме, что не требует разделения плазмы на слои или повторного центрифугирования. Короткое время, необходимое для изготовления богатой тромбоцитами плазмы, и простота ее приготовления позволяют использовать эту методику в рутинной медицинской практике в учреждениях любого профиля. In addition, due to short-term centrifugation for 4-6 minutes, platelets do not have time to sink to the bottom of the tube and mix with the layer of leukocytes and red blood cells, but remain suspended in the upper part of the tube, evenly distributed in the plasma, which does not require separation of the plasma into layers or repeated centrifugation. The short time required for the manufacture of platelet-rich plasma, and the simplicity of its preparation make it possible to use this technique in routine medical practice in institutions of any profile.
За счет инъекционного введения плазмы, предложенного авторами, факторы роста надолго остаются в области рубцовой ткани, успевая таким образом реализовать свой биологический эффект, привлечь фибробласты, которые в дальнейшей синтезируют коллаген, необходимый для возобновления процессов регенерации кожи. Due to the injection of plasma proposed by the authors, growth factors remain in the area of scar tissue for a long time, thus managing to realize their biological effect, attract fibroblasts, which further synthesize collagen, necessary for the resumption of skin regeneration processes.
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| RU2016133902A RU2627468C1 (en) | 2016-08-18 | 2016-08-18 | Method for atrophic skin scars treatment |
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| RU2733576C1 (en) * | 2020-05-18 | 2020-10-05 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) | Method of treating post-traumatic scars of peri-orbital region and eyelid region |
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| US8317782B1 (en) * | 2006-10-13 | 2012-11-27 | Ellman International, Inc. | Non-ablative radio-frequency treatment of skin tissue |
| WO2013007308A1 (en) * | 2011-07-14 | 2013-01-17 | Garbin Stefania | Platelet-rich plasma composition for tissue repair and regeneration |
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| RU2230554C2 (en) * | 2002-05-07 | 2004-06-20 | Глубокова Ирина Борисовна | Method for treating normo-atrophic scars with mechanic dermabrasion by applying combined collagen covering with antimicrobial preparation |
| RU2389516C2 (en) * | 2008-06-23 | 2010-05-20 | Общество С Ограниченной Ответственностью "Новые Энергетические Технологии" | Method of radio-frequency two-step restoration of atrophic face skin and body |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8317782B1 (en) * | 2006-10-13 | 2012-11-27 | Ellman International, Inc. | Non-ablative radio-frequency treatment of skin tissue |
| WO2013007308A1 (en) * | 2011-07-14 | 2013-01-17 | Garbin Stefania | Platelet-rich plasma composition for tissue repair and regeneration |
Non-Patent Citations (3)
| Title |
|---|
| ???????????? H..B.: "??????????, ??????? ???????????? nna3Ma, B ??????? ???????? ????????? ???? ?????? ???????????", ??????????? HA ????????? ?????? ??????? ????????? ??????????? ????, M., 2014, pages 64 - 66 * |
| KIM I S ET AL.: "Efficacy of intradermal radiofrequency combined with autologous platelet-rich plasma in striae distensae: a pilot study", INT J DERMATOL., vol. 51, no. 10, October 2012 (2012-10-01), pages 1253 - 1258, XP055464615 * |
| RADIOFREQUENCY ENERGY SOURCES & ACCESSORY PRODUCTS, 2013, pages 3, 5, 6, 52, Retrieved from the Internet <URL:http://www.ellman.com/PDF/MedicalProductsCatalog2013.pdf> * |
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