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WO2008117773A1 - 不斉四置換キノロンカルボン酸の製造方法およびその製造中間体 - Google Patents

不斉四置換キノロンカルボン酸の製造方法およびその製造中間体 Download PDF

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Publication number
WO2008117773A1
WO2008117773A1 PCT/JP2008/055424 JP2008055424W WO2008117773A1 WO 2008117773 A1 WO2008117773 A1 WO 2008117773A1 JP 2008055424 W JP2008055424 W JP 2008055424W WO 2008117773 A1 WO2008117773 A1 WO 2008117773A1
Authority
WO
WIPO (PCT)
Prior art keywords
production
aryl
alkyl
intermediates
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/055424
Other languages
English (en)
French (fr)
Inventor
Koji Sato
Tsutomu Yagi
Yuichi Kodaira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Priority to JP2009506331A priority Critical patent/JP5236627B2/ja
Publication of WO2008117773A1 publication Critical patent/WO2008117773A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

　抗菌活性および安全性の高いキノロンカルボン酸について、その製造に使用する置換基構築用の光学活性化合物を簡便に工業的に製造することを可能ならしめる。 式（３）で示される化合物を金属触媒及び水素源の存在下で処理し、式（５）で示される中間体化合物を製造する（ｎは２～５、Ｒ１はアルキル又はアリール、Ｒ６はアルキル、アリール又は水素、Ｒ７１及びＲ７２の一方はアリール、他方はアリール、アルキル、アルケニル、アラルキル又は水素を示す。）。
PCT/JP2008/055424 2007-03-26 2008-03-24 不斉四置換キノロンカルボン酸の製造方法およびその製造中間体 Ceased WO2008117773A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009506331A JP5236627B2 (ja) 2007-03-26 2008-03-24 不斉四置換キノロンカルボン酸の製造方法およびその製造中間体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-078651 2007-03-26
JP2007078651 2007-03-26

Publications (1)

Publication Number Publication Date
WO2008117773A1 true WO2008117773A1 (ja) 2008-10-02

Family

ID=39788508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055424 Ceased WO2008117773A1 (ja) 2007-03-26 2008-03-24 不斉四置換キノロンカルボン酸の製造方法およびその製造中間体

Country Status (3)

Country Link
JP (1) JP5236627B2 (ja)
TW (1) TW200846336A (ja)
WO (1) WO2008117773A1 (ja)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09208561A (ja) * 1995-05-26 1997-08-12 Dai Ichi Seiyaku Co Ltd 環式化合物の製法
JP2003306475A (ja) * 2002-02-13 2003-10-28 Dai Ichi Seiyaku Co Ltd 光学活性化合物の製法
WO2006123767A1 (ja) * 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited 不斉四置換炭素原子含有化合物の製法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09208561A (ja) * 1995-05-26 1997-08-12 Dai Ichi Seiyaku Co Ltd 環式化合物の製法
JP2003306475A (ja) * 2002-02-13 2003-10-28 Dai Ichi Seiyaku Co Ltd 光学活性化合物の製法
WO2006123767A1 (ja) * 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited 不斉四置換炭素原子含有化合物の製法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MACDONALD S.J. ET AL.: "A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-translactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 14, 1999, pages 5166 - 5175 *
MOSS N. ET AL.: "An enantioselective synthesis of cyclopentyl-L-aspartic acid amenable to large scale", SYNTHESIS, no. 1, 1997, pages 32 - 34 *

Also Published As

Publication number Publication date
JPWO2008117773A1 (ja) 2010-07-15
JP5236627B2 (ja) 2013-07-17
TW200846336A (en) 2008-12-01

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