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WO2002031161A3 - Regulation of human phospholipase-like enzyme - Google Patents

Regulation of human phospholipase-like enzyme Download PDF

Info

Publication number
WO2002031161A3
WO2002031161A3 PCT/EP2001/011641 EP0111641W WO0231161A3 WO 2002031161 A3 WO2002031161 A3 WO 2002031161A3 EP 0111641 W EP0111641 W EP 0111641W WO 0231161 A3 WO0231161 A3 WO 0231161A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
human phospholipase
regulation
reagents
phospholipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/011641
Other languages
French (fr)
Other versions
WO2002031161A2 (en
Inventor
Zhimin Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002210525A priority Critical patent/AU2002210525A1/en
Publication of WO2002031161A2 publication Critical patent/WO2002031161A2/en
Publication of WO2002031161A3 publication Critical patent/WO2002031161A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human phospholipase-like enzyme and reagents which bind to human phospholipase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, inflammation, CNS disorders, cardiovascular disorders, chronic obstructive pulmonary disease, diabetes, and obesity.
PCT/EP2001/011641 2000-10-10 2001-10-09 Regulation of human phospholipase-like enzyme Ceased WO2002031161A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002210525A AU2002210525A1 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase-like enzyme

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23844500P 2000-10-10 2000-10-10
US60/238,445 2000-10-10
US25729300P 2000-12-26 2000-12-26
US60/257,293 2000-12-26

Publications (2)

Publication Number Publication Date
WO2002031161A2 WO2002031161A2 (en) 2002-04-18
WO2002031161A3 true WO2002031161A3 (en) 2003-02-27

Family

ID=26931681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011641 Ceased WO2002031161A2 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase-like enzyme

Country Status (2)

Country Link
AU (1) AU2002210525A1 (en)
WO (1) WO2002031161A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2434897A1 (en) * 2001-01-24 2002-08-01 Lexicon Genetics Incorporated Human lipase and polynucleotides encoding the same
US6943003B2 (en) 2001-02-08 2005-09-13 Applera Corporation Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09248190A (en) * 1996-03-15 1997-09-22 Hiromasa Tojo Novel phospholipase and DNA encoding the same
US5840511A (en) * 1994-07-27 1998-11-24 Genetics Institute, Inc. Methods comprising calcium independent cytosolic phospholipase A/B enzymes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840511A (en) * 1994-07-27 1998-11-24 Genetics Institute, Inc. Methods comprising calcium independent cytosolic phospholipase A/B enzymes
JPH09248190A (en) * 1996-03-15 1997-09-22 Hiromasa Tojo Novel phospholipase and DNA encoding the same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] XP002222280, retrieved from EBI Database accession no. Z12841 *
DATABASE EMBL [online] XP002222281, retrieved from EBI Database accession no. Q05017 *
DATABASE EMBL [online] XP002222282, retrieved from EBI Database accession no. AF045454 *
DATABASE EMBL [online] XP002222283, retrieved from EBI Database accession no. O70320 *
DATABASE EMBL [online] XP002222284, retrieved from EBI Database accession no. D63648 *
DATABASE EMBL [online] XP002222285, retrieved from EBI Database accession no. O54728 *
DATABASE EMBL [online] XP002222286, retrieved from EBI Database accession no. E13935 *
PATENT ABSTRACTS OF JAPAN vol. 199, no. 801 E13935 30 January 1998 (1998-01-30) *
TAKEMORI HIROSHI ET AL: "Identification of functional domains of rat intestinal phospholipase B/lipase. Its cDNA cloning, expression, and tissue distribution.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 4, D63648, 23 January 1998 (1998-01-23), pages 2222 - 2231, XP002222279, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *

Also Published As

Publication number Publication date
WO2002031161A2 (en) 2002-04-18
AU2002210525A1 (en) 2002-04-22

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