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WO2002020731A3 - Regulation of human protein disulfide isomerase-like enzyme - Google Patents

Regulation of human protein disulfide isomerase-like enzyme Download PDF

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Publication number
WO2002020731A3
WO2002020731A3 PCT/EP2001/010125 EP0110125W WO0220731A3 WO 2002020731 A3 WO2002020731 A3 WO 2002020731A3 EP 0110125 W EP0110125 W EP 0110125W WO 0220731 A3 WO0220731 A3 WO 0220731A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
human protein
protein disulfide
disulfide isomerase
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/010125
Other languages
French (fr)
Other versions
WO2002020731A2 (en
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001289864A priority Critical patent/AU2001289864A1/en
Publication of WO2002020731A2 publication Critical patent/WO2002020731A2/en
Publication of WO2002020731A3 publication Critical patent/WO2002020731A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents which regulate human protein disulfide isomerase-like enzyme and reagents which bind to human protein disulfide isomerase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or disorders including, but not limited to, cancer, diabetes, and obesity.
PCT/EP2001/010125 2000-09-08 2001-09-03 Regulation of human protein disulfide isomerase-like enzyme Ceased WO2002020731A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289864A AU2001289864A1 (en) 2000-09-08 2001-09-03 Regulation of human protein disulfide isomerase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23129700P 2000-09-08 2000-09-08
US60/231,297 2000-09-08

Publications (2)

Publication Number Publication Date
WO2002020731A2 WO2002020731A2 (en) 2002-03-14
WO2002020731A3 true WO2002020731A3 (en) 2002-07-25

Family

ID=22868615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010125 Ceased WO2002020731A2 (en) 2000-09-08 2001-09-03 Regulation of human protein disulfide isomerase-like enzyme

Country Status (2)

Country Link
AU (1) AU2001289864A1 (en)
WO (1) WO2002020731A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE422540T1 (en) * 2001-04-02 2009-02-15 Develogen Ag PROTEIN DISULFID ISOMERASE AND ABC TRANSPORTER- HOMOLOGUE PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS
DE10217254A1 (en) * 2002-04-15 2003-10-23 Proteosys Ag Prevention or treatment of tumors comprises treating eukaryotic cells with an agent that modulates the expression and/or function of proteins synthesized and/or secreted by tumors
US20040203132A1 (en) 2003-02-28 2004-10-14 Cognetix, Inc. Conus protein disulfide isomerase
CA2693098C (en) 2007-07-19 2019-06-18 Yasemin Ataman-Onal Dosage method for the carcino-embryonic antigen and the carbohydrate 19-9 antigen to hepatic fatty acid-binding protein for the diagnosis of colorectal cancer
FR2919063B1 (en) 2007-07-19 2009-10-02 Biomerieux Sa METHOD OF DETERMINING LEUCOCYTE ELASTASE INHIBITOR FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER.
FR2919062B1 (en) 2007-07-19 2009-10-02 Biomerieux Sa METHOD OF DETERMINING AMINOACYLASE 1 FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER.
FR2919060B1 (en) 2007-07-19 2012-11-30 Biomerieux Sa METHOD OF DETERMINING EZRINE FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER
FR2919065B1 (en) 2007-07-19 2009-10-02 Biomerieux Sa METHOD FOR DETERMINING APOLIPOPROTEIN AI FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER
FR2919064B1 (en) 2007-07-19 2009-10-02 Biomerieux Sa METHOD OF ASSAYING APOLIPOPROTEIN ALL FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER
FR2919061B1 (en) 2007-07-19 2009-10-02 Biomerieux Sa METHOD OF DOSING PLASTINE-I FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER.
FR2933773B1 (en) * 2008-07-10 2013-02-15 Biomerieux Sa METHOD FOR DETERMINING THE ISOMERASE DISULFIDE PROTEIN FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001632A (en) * 1996-05-15 1999-12-14 Incyte Pharmaceuticals, Inc. Human protein disulfide isomerase
WO2001012790A2 (en) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Isomerase proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001632A (en) * 1996-05-15 1999-12-14 Incyte Pharmaceuticals, Inc. Human protein disulfide isomerase
WO2001012790A2 (en) * 1999-08-17 2001-02-22 Incyte Genomics, Inc. Isomerase proteins

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANAL BIOCHEM, vol. 236, 1996, pages 107 - 113, XP000857646 *
DATABASE EM_EST [online] EMBL; 13 March 1999 (1999-03-13), OTTENWALD ET AL.: "EST", XP002198789, retrieved from EBI accession no. HSM006372 Database accession no. AL048830 *
DATABASE EM_EST [online] EMBL; 8 June 2000 (2000-06-08), HEGDE ET AL.: "EST", XP002198788, retrieved from EBI accession no. AW959209 Database accession no. AW959209 *
DATABASE EM_HUM [online] EMBL; 15 March 1999 (1999-03-15), ANDERSSON ET AL.: "Homo sapiens clone 25100 mRNA sequence, complete cds.", XP002198786, retrieved from EBI accession no. AF131780 Database accession no. AF131780 *
DATABASE EM_HUM [online] EMBL; 15 May 2001 (2001-05-15), ISOGAI ET AL.: "Homo sapiens cDNA FLJ14558 fis ....", XP002198790, retrieved from EBI accession no. AK027464 Database accession no. AK027464 *
DATABASE SWALL [online] 1 December 2001 (2001-12-01), ISOGAI ET AL.: "cDNA FLJ14558 fis ....", XP002198791, retrieved from EBI accession no. Q96K53 Database accession no. Q96K53 *
DATABASE SWALL [online] 1 May 1999 (1999-05-01), NDERSSON ET AL.: "Hypothetical 37.7 kDa protein", XP002198787, retrieved from EBI accession no. O95887 Database accession no. O95887 *
GENOME RES, vol. 7, no. 4, 1997, pages 353 - 358, XP000867830 *
TASANEN ET AL.: "Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 16, 5 June 1992 (1992-06-05), pages 11513 - 11519, XP002198785 *

Also Published As

Publication number Publication date
AU2001289864A1 (en) 2002-03-22
WO2002020731A2 (en) 2002-03-14

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