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WO2002052016A3 - Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme - Google Patents

Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme Download PDF

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Publication number
WO2002052016A3
WO2002052016A3 PCT/EP2001/015001 EP0115001W WO02052016A3 WO 2002052016 A3 WO2002052016 A3 WO 2002052016A3 EP 0115001 W EP0115001 W EP 0115001W WO 02052016 A3 WO02052016 A3 WO 02052016A3
Authority
WO
WIPO (PCT)
Prior art keywords
isoaspartate
methyltransferase
enzyme
human protein
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/015001
Other languages
French (fr)
Other versions
WO2002052016A2 (en
Inventor
Zhimin Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002217134A priority Critical patent/AU2002217134A1/en
Publication of WO2002052016A2 publication Critical patent/WO2002052016A2/en
Publication of WO2002052016A3 publication Critical patent/WO2002052016A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Reagents that regulate human protein L-isoaspartate O-methyltransferase-like enzyme and reagents which bind to human protein L-isoaspartate O-methyltransferase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer.
PCT/EP2001/015001 2000-12-26 2001-12-19 Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme Ceased WO2002052016A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002217134A AU2002217134A1 (en) 2000-12-26 2001-12-19 Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25729200P 2000-12-26 2000-12-26
US60/257,292 2000-12-26

Publications (2)

Publication Number Publication Date
WO2002052016A2 WO2002052016A2 (en) 2002-07-04
WO2002052016A3 true WO2002052016A3 (en) 2002-11-07

Family

ID=22975669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/015001 Ceased WO2002052016A2 (en) 2000-12-26 2001-12-19 Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme

Country Status (2)

Country Link
AU (1) AU2002217134A1 (en)
WO (1) WO2002052016A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003235799A1 (en) * 2002-01-08 2003-07-24 Nordic Bioscience A/S Modulation of iamt (pimt or pcmt) in immune system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012797A1 (en) * 1994-10-19 1996-05-02 The Regents Of The University Of California Production and use of human and plant methyltransferases
WO1998015647A1 (en) * 1996-10-08 1998-04-16 Novartis Ag Modulation of apoptosis
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2002018424A2 (en) * 2000-09-01 2002-03-07 Hyseq, Inc. Nucleic acids and polypeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012797A1 (en) * 1994-10-19 1996-05-02 The Regents Of The University Of California Production and use of human and plant methyltransferases
WO1998015647A1 (en) * 1996-10-08 1998-04-16 Novartis Ag Modulation of apoptosis
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2002018424A2 (en) * 2000-09-01 2002-03-07 Hyseq, Inc. Nucleic acids and polypeptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ASWAD D W ET AL: "ISOASPARTATE IN PEPTIDES AND PROTEINS: FORMATION, SIGNIFICANCE, AND ANALYSIS", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, NEW YORK, NY, US, vol. 21, 2000, pages 1129 - 1138, XP002902282, ISSN: 0731-7085 *
DATABASE EMBL [online] 22 February 2000 (2000-02-22), ISOGAI T. ET AL.: "Homo sapiens cDNA FLJ10883 fis, clone NT2RP4001946, weakly similar to PROTEIN-L-ISOASPARTASE O-METHYLTRANSFERASE (EC 2.1.1.77)", XP002208535, Database accession no. AK001745 *
DATABASE EMBL [online] OTA T. ET AL.: "Human cDNA sequence Seq ID No 12349", XP002208537, Database accession no. AAH14668 *
DATABASE EMBL [online] OTA T. ET AL.: "Human protein sequence Seq ID No:12350", XP002208536, Database accession no. AAB93292 *
DATABASE EMBL [online] TANG Y. ET AL.: "Sequence 124 from Patent WO0218424", XP002208538, Database accession no. AX399953 *

Also Published As

Publication number Publication date
AU2002217134A1 (en) 2002-07-08
WO2002052016A2 (en) 2002-07-04

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