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WO2004031375A3 - Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c - Google Patents

Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c Download PDF

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Publication number
WO2004031375A3
WO2004031375A3 PCT/EP2003/010833 EP0310833W WO2004031375A3 WO 2004031375 A3 WO2004031375 A3 WO 2004031375A3 EP 0310833 W EP0310833 W EP 0310833W WO 2004031375 A3 WO2004031375 A3 WO 2004031375A3
Authority
WO
WIPO (PCT)
Prior art keywords
pde1c
human
regulation
cyclic nucleotide
nucleotide phosphodiesterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/010833
Other languages
French (fr)
Other versions
WO2004031375A2 (en
Inventor
Jiing-Ren Liou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2003276009A priority Critical patent/AU2003276009A1/en
Publication of WO2004031375A2 publication Critical patent/WO2004031375A2/en
Publication of WO2004031375A3 publication Critical patent/WO2004031375A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents that regulate human PDE1C and reagents which bind to human PDE1C gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, diabetes, neurological disorders, asthma, obesity, and cardiovascular disorders.
PCT/EP2003/010833 2002-10-01 2003-09-30 Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c Ceased WO2004031375A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003276009A AU2003276009A1 (en) 2002-10-01 2003-09-30 Regulation of human 3', 5' cyclic nucleotide phosphodiesterase pde1c

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41463402P 2002-10-01 2002-10-01
US60/414,634 2002-10-01
US43444402P 2002-12-19 2002-12-19
US60/434,444 2002-12-19

Publications (2)

Publication Number Publication Date
WO2004031375A2 WO2004031375A2 (en) 2004-04-15
WO2004031375A3 true WO2004031375A3 (en) 2004-07-15

Family

ID=32073336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/010833 Ceased WO2004031375A2 (en) 2002-10-01 2003-09-30 Regulation of human 3’, 5’ cyclic nucleotide phosphodiesterase pde1c

Country Status (2)

Country Link
AU (1) AU2003276009A1 (en)
WO (1) WO2004031375A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060188882A1 (en) * 2003-03-13 2006-08-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with phosphodi-esterase 1c (pde1c)
EP1901725A2 (en) * 2005-06-17 2008-03-26 Nycomed GmbH Use of pde1c and inhibitors thereof
US20120070443A1 (en) * 2008-12-02 2012-03-22 University Of Utah Research Foundation Pde1 as a target therapeutic in heart disease
ES2717688T3 (en) 2013-03-15 2019-06-24 Intra Cellular Therapies Inc PDE1 inhibitors for use in the treatment and / or prevention of CNS lesions, and diseases, disorders or injuries of SNP
JP2019510039A (en) 2016-03-28 2019-04-11 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． Novel compositions and methods
JP7134168B6 (en) 2016-09-12 2024-02-02 イントラ－セルラー・セラピーズ・インコーポレイテッド new use
US12364695B2 (en) 2020-06-02 2025-07-22 Intra-Cellular Therapies, Inc. Methods of treating inflammatory disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800987A (en) * 1991-04-19 1998-09-01 The Board Of Regents Of The University Of Washington Assay methods using DNA encoding mammalian phosphodiesterases
EP1308459A2 (en) * 2001-11-05 2003-05-07 Helix Research Institute Full-length cDNA sequences

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800987A (en) * 1991-04-19 1998-09-01 The Board Of Regents Of The University Of Washington Assay methods using DNA encoding mammalian phosphodiesterases
EP1308459A2 (en) * 2001-11-05 2003-05-07 Helix Research Institute Full-length cDNA sequences

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEAVO J A: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS", PHYSIOLOGICAL REVIEWS, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 75, no. 4, 1 October 1995 (1995-10-01), pages 725 - 748, XP002034532, ISSN: 0031-9333 *
CHEN YAN ET AL: "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, no. 21, 10 October 1995 (1995-10-10), pages 9677 - 9681, XP002139647, ISSN: 0027-8424 *
DATABASE EMBL SEQUENCE LIBRARY [online] 16 July 2002 (2002-07-16), ISOGAI T., YAMAMOTO J.: "Homo sapiens cDNA FLJ34415 fis, clone HEART2004764, highly similar to CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17)", XP002280868, retrieved from HTTP://SRS.EBI.AC.UK Database accession no. AK091734 *
LOUGHNEY KATE ET AL: "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 2, 1996, pages 796 - 806, XP002280866, ISSN: 0021-9258 *
YAN CHEN ET AL: "The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functional different splice variants in a tissue-specific manner", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 41, 1996, pages 25699 - 25706, XP002280867, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2004031375A2 (en) 2004-04-15
AU2003276009A8 (en) 2004-04-23
AU2003276009A1 (en) 2004-04-23

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