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WO2002031160A3 - Regulation of human phospholipase a2-like enzyme - Google Patents

Regulation of human phospholipase a2-like enzyme Download PDF

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Publication number
WO2002031160A3
WO2002031160A3 PCT/EP2001/011640 EP0111640W WO0231160A3 WO 2002031160 A3 WO2002031160 A3 WO 2002031160A3 EP 0111640 W EP0111640 W EP 0111640W WO 0231160 A3 WO0231160 A3 WO 0231160A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
human phospholipase
regulation
reagents
phospholipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/011640
Other languages
French (fr)
Other versions
WO2002031160A2 (en
Inventor
Zhimin Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001295602A priority Critical patent/AU2001295602A1/en
Publication of WO2002031160A2 publication Critical patent/WO2002031160A2/en
Anticipated expiration legal-status Critical
Publication of WO2002031160A3 publication Critical patent/WO2002031160A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human phospholipase A2-like enzyme and reagents which bind to human phospholipase A2-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, asthma, cancer, inflammation, CNS disorders, cardiovascular disorders, chronic obstructive pulmonary disease, diabetes, and obesity.
PCT/EP2001/011640 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme Ceased WO2002031160A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001295602A AU2001295602A1 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23843200P 2000-10-10 2000-10-10
US60/238,432 2000-10-10
US25805300P 2000-12-27 2000-12-27
US60/258,053 2000-12-27
US31796401P 2001-09-10 2001-09-10
US60/317,964 2001-09-10

Publications (2)

Publication Number Publication Date
WO2002031160A2 WO2002031160A2 (en) 2002-04-18
WO2002031160A3 true WO2002031160A3 (en) 2003-10-09

Family

ID=27399096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011640 Ceased WO2002031160A2 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme

Country Status (2)

Country Link
AU (1) AU2001295602A1 (en)
WO (1) WO2002031160A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002224774A1 (en) * 2000-10-10 2002-04-22 Bayer Aktiengesellschaft Human phospholipase a2-like enzyme
CA2437497A1 (en) * 2001-02-06 2002-08-15 Incyte Genomics, Inc. Lipid-associated molecules
FR2847267B1 (en) * 2002-11-19 2006-07-28 Coletica METHOD FOR TESTING THE ACTIVITY OF A POTENTIALLY ACTIVE SUBSTANCE FOR INHIBITING THE ENZYMATIC ACTIVITY OF A2 PHOSPHOLIPASE
EP3993871A1 (en) * 2019-07-02 2022-05-11 Fundacion para la Investigacion Medica Aplicada Cpla2e inducing agents and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 May 1999 (1999-05-01), XP002225010, retrieved from EBI Database accession no. O95712 *
DATABASE EMBL [online] Database accession no. Q9UKV7 *
SONG CHUANZHENG ET AL: "Molecular characterization of cytosolic phospholipase A2-beta.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 24, Q9ukv7, 11 June 1999 (1999-06-11), pages 17063 - 17067, XP002212884, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *
TODD PICKARD R ET AL: "Molecular cloning of two new human paralogs of 85-KDa cytosolic phospholipase A2", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 13, O95712, 26 March 1999 (1999-03-26), pages 8823 - 8831, XP002143988, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *

Also Published As

Publication number Publication date
WO2002031160A2 (en) 2002-04-18
AU2001295602A1 (en) 2002-04-22

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