[go: up one dir, main page]

WO2000047584A3 - Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung - Google Patents

Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung Download PDF

Info

Publication number
WO2000047584A3
WO2000047584A3 PCT/EP2000/001104 EP0001104W WO0047584A3 WO 2000047584 A3 WO2000047584 A3 WO 2000047584A3 EP 0001104 W EP0001104 W EP 0001104W WO 0047584 A3 WO0047584 A3 WO 0047584A3
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
residue
pyridyl
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/001104
Other languages
English (en)
French (fr)
Other versions
WO2000047584A2 (de
Inventor
Ulrich Klar
Werner Skuballa
Bernd Buchmann
Wolfgang Schwede
Michael Schirner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107480 external-priority patent/DE19907480A1/de
Priority claimed from DE19954229A external-priority patent/DE19954229A1/de
Priority to EP00920433A priority Critical patent/EP1161430A2/de
Priority to MXPA01008148A priority patent/MXPA01008148A/es
Priority to HK02106492.8A priority patent/HK1044946A1/zh
Priority to AU41018/00A priority patent/AU4101800A/en
Priority to IL14437000A priority patent/IL144370A0/xx
Priority to BR0008206-6A priority patent/BR0008206A/pt
Priority to EA200100833A priority patent/EA200100833A1/ru
Priority to EEP200100422A priority patent/EE200100422A/xx
Application filed by Schering AG filed Critical Schering AG
Priority to JP2000598504A priority patent/JP2002536450A/ja
Priority to KR1020017010109A priority patent/KR20010094763A/ko
Priority to SK1145-2001A priority patent/SK11452001A3/sk
Priority to US09/913,163 priority patent/US7001916B1/en
Priority to CA002360952A priority patent/CA2360952A1/en
Publication of WO2000047584A2 publication Critical patent/WO2000047584A2/de
Publication of WO2000047584A3 publication Critical patent/WO2000047584A3/de
Priority to BG105803A priority patent/BG105803A/xx
Priority to NO20013900A priority patent/NO20013900L/no
Anticipated expiration legal-status Critical
Priority to US11/189,787 priority patent/US20060040990A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Die vorliegende Erfindung beschreibt die neuen Epothilon-Derivate der allgemeinen Formel (I), worin R4 Wasserstoff, C¿1?-C10-Alkyl, Aryl, C7-C20-Aralkyl, R?5¿ Wasserstoff, C¿1?-C10-Alkyl, Aryl, C7-C20-Aralkyl, R?6, R7¿ je ein Wasserstoffatom, gemeinsam eine zusätzliche Bindung oder ein Sauerstoffatom, R8 eine Methylgruppe oder Wasserstoff, bedeuten, sowie gleichzeitig R?1a und R1b¿ gemeinsam für eine Trimethylengruppe sowie X für einen 2-Pyridyl-, 2-Methyl-4-thiazolyl- oder 2-Methyl-4-oxazolylrest oder gleichzeitig R?1a und R1b¿ gemeinsam für eine Trimethylengruppe, R2 für eine Methyl-, Ethyl- oder Propylgruppe sowie X für einen 2-Pyridyl-, 2-Methyl-4-thiazolyl- oder 2-Methyl-4-oxazolylrest oder gleichzeitig R?1a und R1b¿ jeweils für eine Methylgruppe, R2 für einen Methyl-, Ethyl- oder Propyl- und X für einen 2-Pyridyl-, 2-Methyl-4-thiazolyl- oder 2-Methyl-4-oxazolylrest, wobei das Stickstoff- und/oder Schwefelatom in X in oxidierter Form vorliegen kann und wobei, wenn R?2 und R8¿ jeweils einen Methylrest bedeuten, X nur ein, gegebenenfalls am Stickstoffatom oxidierter, 2-Pyridylrest sein kann, stehen, einschliesslich aller möglichen Stereoisomeren sowie deren Gemische. Die neuen Verbindungen sind zur Herstellung von Arzneimitteln geeignet.
PCT/EP2000/001104 1999-02-11 2000-02-11 Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung Ceased WO2000047584A2 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
US09/913,163 US7001916B1 (en) 1999-02-11 2000-02-11 Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
CA002360952A CA2360952A1 (en) 1999-02-11 2000-02-11 Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
SK1145-2001A SK11452001A3 (sk) 1999-02-11 2000-02-11 Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie
HK02106492.8A HK1044946A1 (zh) 1999-02-11 2000-02-11 依泊昔酮衍生物、其製備方法及藥物用途
AU41018/00A AU4101800A (en) 1999-02-11 2000-02-11 Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
IL14437000A IL144370A0 (en) 1999-02-11 2000-02-11 Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
BR0008206-6A BR0008206A (pt) 1999-02-11 2000-02-11 Derivados de epotilon, processos para a sua preparação e sua aplicação farmacêutica
EA200100833A EA200100833A1 (ru) 1999-02-11 2000-02-11 Производные эпотилона, способ их получения и их применение в фармацевтике
EEP200100422A EE200100422A (et) 1999-02-11 2000-02-11 Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine
EP00920433A EP1161430A2 (de) 1999-02-11 2000-02-11 Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
JP2000598504A JP2002536450A (ja) 1999-02-11 2000-02-11 エポチロン誘導体、それらの製造方法、及びそれらの医薬としての使用
KR1020017010109A KR20010094763A (ko) 1999-02-11 2000-02-11 에포틸론 유도체, 그 제조방법 및 제약적 용도
MXPA01008148A MXPA01008148A (es) 1999-02-11 2000-02-11 Derivados de epotilona, metodo para su produccion y su uso farmaceutico.
BG105803A BG105803A (en) 1999-02-11 2001-08-09 Epotylon derivatives, method for their production and pharmaceutical use thereof
NO20013900A NO20013900L (no) 1999-02-11 2001-08-10 Epotilonderivater, fremgangsmåter for fremstilling av disse og farmasöytisk anvendelse av dem
US11/189,787 US20060040990A1 (en) 1999-02-11 2005-07-27 Epothilone derivatives, process for their production, and their pharmaceutical use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19907480.1 1999-02-11
DE1999107480 DE19907480A1 (de) 1999-02-11 1999-02-11 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954229A DE19954229A1 (de) 1999-11-04 1999-11-04 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954229.5 1999-11-04

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09913163 Continuation-In-Part 2000-02-11
US11/189,787 Division US20060040990A1 (en) 1999-02-11 2005-07-27 Epothilone derivatives, process for their production, and their pharmaceutical use

Publications (2)

Publication Number Publication Date
WO2000047584A2 WO2000047584A2 (de) 2000-08-17
WO2000047584A3 true WO2000047584A3 (de) 2000-12-28

Family

ID=26051977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/001104 Ceased WO2000047584A2 (de) 1999-02-11 2000-02-11 Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung

Country Status (21)

Country Link
US (2) US7001916B1 (de)
EP (1) EP1161430A2 (de)
JP (1) JP2002536450A (de)
KR (1) KR20010094763A (de)
CN (1) CN1340053A (de)
AU (1) AU4101800A (de)
BG (1) BG105803A (de)
BR (1) BR0008206A (de)
CA (1) CA2360952A1 (de)
CZ (1) CZ20012886A3 (de)
EA (1) EA200100833A1 (de)
EE (1) EE200100422A (de)
HK (1) HK1044946A1 (de)
HU (1) HUP0105330A2 (de)
IL (1) IL144370A0 (de)
MX (1) MXPA01008148A (de)
NO (1) NO20013900L (de)
PL (1) PL350190A1 (de)
SK (1) SK11452001A3 (de)
WO (1) WO2000047584A2 (de)
YU (1) YU57601A (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849651B2 (en) 1996-12-03 2005-02-01 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6965034B2 (en) 1996-12-03 2005-11-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
US7125893B1 (en) * 1999-04-30 2006-10-24 Schering Ag 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
CN1511036B (zh) * 2001-02-27 2010-05-05 诺瓦提斯公司 包含信号转导抑制剂和埃坡霉素衍生物的联合形式
WO2003018002A2 (en) * 2001-08-23 2003-03-06 Novartis Ag Cyclopropyl and cyclobutyl epothilone analogs
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
ATE476995T1 (de) * 2002-06-10 2010-08-15 Novartis Pharma Gmbh Epothilone enthaltende kombinationen und deren pharmazeutische verwendungen
RU2379032C9 (ru) * 2002-06-10 2010-03-27 Новартис Аг Комбинации, включающие эпотилоны, и их фармацевтическое применение
JP4328293B2 (ja) * 2002-07-31 2009-09-09 メルシャン株式会社 新規生理活性物質
US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
EP1589011A1 (de) * 2004-04-22 2005-10-26 Schering Aktiengesellschaft Neue chirale Heptin Derivate zur Herstellung von Epothilonen und Verfahren zu deren Herstellung
JP2008536479A (ja) 2005-02-11 2008-09-11 ユニバーシティ オブ サザン カリフォルニア ジスルフィド架橋を有するタンパク質の発現法
WO2007130501A2 (en) * 2006-05-01 2007-11-15 University Of Southern California Combination therapy for treatment of cancer
US20100113128A1 (en) * 2008-11-05 2010-05-06 Snow Richard N Methods and apparatus for determining a reel strip position
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
CA2799202C (en) 2010-05-18 2016-07-05 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
AU2016340093A1 (en) 2015-10-16 2018-05-10 William Marsh Rice University Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof
WO2017096559A1 (en) * 2015-12-09 2017-06-15 Rhodia Operations Production of xylene derivatives

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025929A1 (en) * 1996-12-13 1998-06-18 Novartis Ag Epothilone analogs
WO1999001124A1 (en) * 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO1999002514A2 (en) * 1997-07-08 1999-01-21 Bristol-Myers Squibb Company Epothilone derivatives
WO1999007692A2 (de) * 1997-08-09 1999-02-18 Schering Aktiengesellschaft Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
WO1999067253A2 (en) * 1998-06-22 1999-12-29 Novartis Ag Desmethyl epothilones

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US5469145A (en) 1992-05-29 1995-11-21 Johnson; Lonnie Wet diaper detector
JP4183099B2 (ja) 1995-11-17 2008-11-19 ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） エポチロンｃおよびｄ、製造法ならびに組成物
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
JP2001500851A (ja) 1996-08-30 2001-01-23 ノバルティス アクチエンゲゼルシャフト エポシロンの製造法および製造過程中に得られる中間生産物
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
WO2001066154A2 (de) 2000-03-09 2001-09-13 Klar, Ulrich Radioaktiv markierte epothilon-derivate, verfahren zu deren herstellung und ihre biochemische und pharmazeutische verwendung
CA2359267A1 (en) 2000-10-19 2002-04-19 Manabu Takami Wavelength selecting module and wavelength selecting apparatus
EP1340498A1 (de) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Verwendung von Epothilonen zur Behandlung von mit proliferativen Prozessen assoziierten Gehirnerkrankungen
EP1524979A2 (de) * 2002-07-31 2005-04-27 Schering AG Neue effektor-konjugate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US7138279B2 (en) 2002-08-13 2006-11-21 Kosan Biosciences, Inc. Transposon-based transformation system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001124A1 (en) * 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO1998025929A1 (en) * 1996-12-13 1998-06-18 Novartis Ag Epothilone analogs
WO1999002514A2 (en) * 1997-07-08 1999-01-21 Bristol-Myers Squibb Company Epothilone derivatives
WO1999007692A2 (de) * 1997-08-09 1999-02-18 Schering Aktiengesellschaft Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
WO1999067253A2 (en) * 1998-06-22 1999-12-29 Novartis Ag Desmethyl epothilones

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K C NICOLAOU ET AL: "ANGEWANDTE CHEMIE,DE,VCH VERLAGSGESELLSCHAFT, WEINHEIM", ANGEWANDTE CHEMIE,DE,VCH VERLAGSGESELLSCHAFT, WEINHEIM, vol. 109, no. 19, 1997, pages 2181 - 2187, XP002095723, ISSN: 0044-8249 *
NICOLAOU K C ET AL: "Chemical Biology of Epothilones", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION,DE,VERLAG CHEMIE. WEINHEIM, vol. 37, no. 15, August 1998 (1998-08-01), pages 2014 - 2045, XP002131418, ISSN: 0570-0833 *
NICOLAOU K C ET AL: "DESIGNED EPOTHILONES: COMBINATORIAL SYNTHESIS, TUBULIN ASSEMBLY PROPERTIES, AND CYTOTOXIC ACTION AGAINST TAXOL.RESISTANT TUMOR CELLS", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION,DE,VERLAG CHEMIE. WEINHEIM, vol. 36, no. 19, 1997, pages 2097 - 2103, XP002064441, ISSN: 0570-0833 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849651B2 (en) 1996-12-03 2005-02-01 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6965034B2 (en) 1996-12-03 2005-11-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6972335B2 (en) 1996-12-03 2005-12-06 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
USRE41990E1 (en) 1996-12-03 2010-12-07 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Also Published As

Publication number Publication date
US7001916B1 (en) 2006-02-21
YU57601A (sh) 2005-06-10
WO2000047584A2 (de) 2000-08-17
NO20013900L (no) 2001-10-11
HK1044946A1 (zh) 2002-11-08
PL350190A1 (en) 2002-11-18
CZ20012886A3 (cs) 2001-11-14
JP2002536450A (ja) 2002-10-29
BR0008206A (pt) 2002-02-19
NO20013900D0 (no) 2001-08-10
SK11452001A3 (sk) 2002-04-04
EE200100422A (et) 2002-12-16
CN1340053A (zh) 2002-03-13
US20060040990A1 (en) 2006-02-23
CA2360952A1 (en) 2000-08-17
BG105803A (en) 2002-03-29
EP1161430A2 (de) 2001-12-12
MXPA01008148A (es) 2003-07-21
IL144370A0 (en) 2002-05-23
KR20010094763A (ko) 2001-11-01
EA200100833A1 (ru) 2002-02-28
HUP0105330A2 (hu) 2002-05-29
AU4101800A (en) 2000-08-29

Similar Documents

Publication Publication Date Title
WO2000047584A3 (de) Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
HUP0302380A2 (hu) Cisztein-proteázok reverzibilis inhibitoraiként alkalmazható új spiroheterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
NZ536734A (en) Spiroindolinepiperidine derivatives
TW200510381A (en) Novel 2-pyridinecarboxamide derivatives
HUP0303756A2 (hu) 1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények
WO2002059102A3 (fr) Derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et utilisation
NZ307505A (en) Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
ATE202087T1 (de) Verfahren zur herstellung von 4-substituierten azetidinon-derivaten
ATE211474T1 (de) Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente
ATE197706T1 (de) Anellierte dihydropyridine und deren verwendung für die herstellung von pharmazeutischen zubereitungen
ATE138067T1 (de) 1,2,4-triazolo(1,5-a>pyrimidinderivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung
DE60020885D1 (de) Tetrahydropyridine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE3864707D1 (de) Benzoxazin-derivate und verfahren zu ihrer herstellung.
WO2005037780A3 (de) Amidomethyl-substituierte 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromen-6-yl-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE219065T1 (de) Arylpiperidin- und arylpiperazin-derivate und sie enthaltende arzneimittel
ATE171942T1 (de) 1-piperazinyl-2-butene und 2-butyne, zwischenverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE365162T1 (de) Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
ATE92074T1 (de) Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE168371T1 (de) 5-amino-5,6,7,8-tetrahydrochinoline und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AU2002244985A1 (en) Thiazolidinedione derivatives and pharmaceutical composition comprising the same
ATE151422T1 (de) 8-azabicyclo(3.2.1>octylalkylthiazolidinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3777464D1 (de) Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
DE3671016D1 (de) Thiazolidinderivate und verfahren zu ihrer herstellung.
DE3671017D1 (de) Benzo(c)-1,5-naphthyridine, ein verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE93524T1 (de) Mitomycinanaloge, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: P-576/01

Country of ref document: YU

Ref document number: 00803717.5

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000920433

Country of ref document: EP

Ref document number: IN/PCT/2001/00825/MU

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 144370

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2360952

Country of ref document: CA

Ref document number: 2360952

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 513267

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: PV2001-2886

Country of ref document: CZ

ENP Entry into the national phase

Ref document number: 2000 105803

Country of ref document: BG

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 11452001

Country of ref document: SK

ENP Entry into the national phase

Ref document number: 2000 598504

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/008148

Country of ref document: MX

Ref document number: 1020017010109

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 200100833

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 2001/07458

Country of ref document: ZA

Ref document number: 200107458

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: P20010669A

Country of ref document: HR

WWP Wipo information: published in national office

Ref document number: 1020017010109

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: PV2001-2886

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 09913163

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2000920433

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1020017010109

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV2001-2886

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 2000920433

Country of ref document: EP