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UY31293A1 - Pirimidinas biciclicas fusionadas - Google Patents

Pirimidinas biciclicas fusionadas

Info

Publication number
UY31293A1
UY31293A1 UY31293A UY31293A UY31293A1 UY 31293 A1 UY31293 A1 UY 31293A1 UY 31293 A UY31293 A UY 31293A UY 31293 A UY31293 A UY 31293A UY 31293 A1 UY31293 A1 UY 31293A1
Authority
UY
Uruguay
Prior art keywords
fusioned
pyrimidins
bicycle
pi3k
tautomers
Prior art date
Application number
UY31293A
Other languages
English (en)
Inventor
Dr Hemant Joshi
Dr Astrid Zimmermann
Dr Thomas Beckers
Dr Volker Gekeler
Dr Armin Zoelch
Gerrit Beneke
Dr Matthias Vennemann
Dr Swen Holder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed filed Critical
Publication of UY31293A1 publication Critical patent/UY31293A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos de formula (I) los tautomeros o los estereoisomeros de éstos, o las sales de éstos, donde el anillo B y la pirimidina a la que está fusionado, R4, R5, R6, y R7 tienen los valores indicados en la descripcion y las reivindicaciones, y son inhibidores eficaces de la vía Pi3K/AKT
UY31293A 2007-08-14 2008-08-14 Pirimidinas biciclicas fusionadas UY31293A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines

Publications (1)

Publication Number Publication Date
UY31293A1 true UY31293A1 (es) 2009-03-31

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31293A UY31293A1 (es) 2007-08-14 2008-08-14 Pirimidinas biciclicas fusionadas

Country Status (37)

Country Link
US (2) US7776864B2 (es)
EP (1) EP2188291B1 (es)
JP (1) JP5344637B2 (es)
KR (1) KR20100053556A (es)
CN (1) CN101778851B (es)
AR (1) AR067945A1 (es)
AU (1) AU2008288392B2 (es)
BR (1) BRPI0815207A2 (es)
CA (1) CA2694058C (es)
CL (1) CL2008002398A1 (es)
CO (1) CO6260077A2 (es)
CR (1) CR11270A (es)
CY (1) CY1113486T1 (es)
DK (1) DK2188291T3 (es)
DO (1) DOP2010000058A (es)
EA (1) EA020996B1 (es)
EC (1) ECSP109964A (es)
ES (1) ES2396177T3 (es)
HN (1) HN2010000313A (es)
HR (1) HRP20121022T1 (es)
IL (1) IL203163A (es)
MA (1) MA31608B1 (es)
MX (1) MX2010001746A (es)
MY (1) MY169738A (es)
NZ (1) NZ583267A (es)
PA (1) PA8793201A1 (es)
PE (1) PE20090944A1 (es)
PL (1) PL2188291T3 (es)
PT (1) PT2188291E (es)
RS (1) RS52559B (es)
SI (1) SI2188291T1 (es)
SV (1) SV2010003483A (es)
TN (1) TN2010000070A1 (es)
TW (1) TWI439272B (es)
UA (1) UA99735C2 (es)
UY (1) UY31293A1 (es)
WO (1) WO2009021992A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2666973C (en) * 2006-10-19 2015-03-31 Takeda Pharmaceutical Company Limited Indole compound having a glucokinase activating action
MY169738A (en) 2007-08-14 2019-05-14 Bayer Ip Gmbh Fused bicyclic pyrimidines
US8415376B2 (en) 2008-05-30 2013-04-09 Amgen Inc. Inhibitors of PI3 kinase
WO2010091808A1 (en) * 2009-02-13 2010-08-19 Bayer Schering Pharma Aktiengesellschaft Fused pyrimidines
ES2435804T3 (es) * 2009-02-13 2013-12-23 Bayer Intellectual Property Gmbh Pirimidinas condensadas como inhibidores de Akt
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
TW201103943A (en) 2009-04-27 2011-02-01 Shionogi & Co Urea derivative having pi3k inhibitory activity
CN103189379A (zh) * 2010-07-13 2013-07-03 拜耳知识产权有限责任公司 双环嘧啶
WO2012013713A2 (en) 2010-07-28 2012-02-02 Bayer Pharma Aktiengesellschaft Substituted imidazo[1,2-b]pyridazines
PT2694510E (pt) 2011-04-07 2016-02-08 Bayer Pharma AG Imidazopiridazinas como inibidores da akt quinase
PE20151979A1 (es) 2013-01-23 2016-01-15 Astrazeneca Ab Compuestos quimicos
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
UA121297C2 (uk) * 2013-03-15 2020-05-12 Байєр Кропсайєнс Лп Композиції, добавки та способи зменшення або контролювання пилу насіння
KR20200032751A (ko) 2017-09-15 2020-03-26 아두로 바이오테크, 인코포레이티드 피라졸로피리미디논 화합물 및 그의 용도

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004502691A (ja) 2000-06-30 2004-01-29 ワイス 抗癌薬としての置換トリアゾロピリミジン
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
AU2004233828B2 (en) 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
CA2561311A1 (en) 2004-04-09 2005-10-27 Merck & Co., Inc. Inhibitors of akt activity
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
AU2005290081B2 (en) 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7910561B2 (en) 2004-12-15 2011-03-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7994172B2 (en) * 2004-12-28 2011-08-09 Exelixis, Inc. [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
WO2006091395A2 (en) 2005-02-14 2006-08-31 Merck & Co., Inc. Inhibitors of akt activity
PL1898903T3 (pl) 2005-06-10 2013-08-30 Merck Sharp & Dohme Inhibitory aktywności Akt
MY169738A (en) 2007-08-14 2019-05-14 Bayer Ip Gmbh Fused bicyclic pyrimidines
WO2010091808A1 (en) * 2009-02-13 2010-08-19 Bayer Schering Pharma Aktiengesellschaft Fused pyrimidines

Also Published As

Publication number Publication date
WO2009021992A3 (en) 2009-04-16
TN2010000070A1 (en) 2011-09-26
EA201000298A1 (ru) 2010-10-29
PL2188291T3 (pl) 2013-06-28
CA2694058C (en) 2016-06-07
CR11270A (es) 2010-05-19
AU2008288392A1 (en) 2009-02-19
HRP20121022T1 (hr) 2013-01-31
NZ583267A (en) 2012-03-30
US7776864B2 (en) 2010-08-17
CN101778851B (zh) 2013-05-08
DK2188291T3 (da) 2013-01-07
PA8793201A1 (es) 2009-04-23
EA020996B1 (ru) 2015-03-31
PE20090944A1 (es) 2009-08-09
SI2188291T1 (sl) 2013-01-31
MA31608B1 (fr) 2010-08-02
TW200922592A (en) 2009-06-01
CN101778851A (zh) 2010-07-14
AR067945A1 (es) 2009-10-28
KR20100053556A (ko) 2010-05-20
WO2009021992A2 (en) 2009-02-19
ECSP109964A (es) 2010-03-31
EP2188291A2 (en) 2010-05-26
CL2008002398A1 (es) 2009-07-31
UA99735C2 (uk) 2012-09-25
US20090137607A1 (en) 2009-05-28
MX2010001746A (es) 2010-03-10
RS52559B (sr) 2013-04-30
SV2010003483A (es) 2010-07-06
US20100184782A1 (en) 2010-07-22
PT2188291E (pt) 2012-12-20
CA2694058A1 (en) 2009-02-19
MY169738A (en) 2019-05-14
CO6260077A2 (es) 2011-03-22
ES2396177T3 (es) 2013-02-19
BRPI0815207A2 (pt) 2017-03-28
DOP2010000058A (es) 2010-02-28
IL203163A (en) 2015-01-29
HK1146273A1 (en) 2011-05-20
HN2010000313A (es) 2013-03-18
US8614218B2 (en) 2013-12-24
AU2008288392B2 (en) 2013-10-24
CY1113486T1 (el) 2016-06-22
JP5344637B2 (ja) 2013-11-20
JP2010535848A (ja) 2010-11-25
TWI439272B (zh) 2014-06-01
EP2188291B1 (en) 2012-09-19

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20171011