TN2010000070A1 - Fused bicyclic pyrimidines - Google Patents

Fused bicyclic pyrimidines

Info

Publication number: TN2010000070A1
Authority: TN; Tunisia
Prior art keywords: fused bicyclic; bicyclic pyrimidines; pyrimidines; fused; pi3k
Prior art date: 2007-08-14

Application number

TNP2010000070A

Other languages

English (en)

Inventor

Swen Holder

Matthias Vennemann

Gerrit Beneke

Armin Zülch

Volker Gekeler

Thomas Beckers

Astrid Zimmermann

Hemant Joshi

Original Assignee

Bayer Ip Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-14

Filing date

2010-02-12

Publication date

2011-09-26

2007-10-18 Priority claimed from EP07118736A external-priority patent/EP2050748A1/fr

2010-02-12 Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh

2011-09-26 Publication of TN2010000070A1 publication Critical patent/TN2010000070A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

TNP2010000070A 2007-08-14 2010-02-12 Fused bicyclic pyrimidines TN2010000070A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN1572MU2007		2007-08-14
EP07118736A EP2050748A1 (fr)	2007-10-18	2007-10-18	Nouveau pyrimidines fusionnés
PCT/EP2008/060690 WO2009021992A2 (fr)	2007-08-14	2008-08-14	Pyrimidines bicycliques condensées

Publications (1)

Publication Number	Publication Date
TN2010000070A1 true TN2010000070A1 (en)	2011-09-26

Family

ID=40153211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2010000070A TN2010000070A1 (en)	2007-08-14	2010-02-12	Fused bicyclic pyrimidines

Country Status (37)

Country	Link
US (2)	US7776864B2 (fr)
EP (1)	EP2188291B1 (fr)
JP (1)	JP5344637B2 (fr)
KR (1)	KR20100053556A (fr)
CN (1)	CN101778851B (fr)
AR (1)	AR067945A1 (fr)
AU (1)	AU2008288392B2 (fr)
BR (1)	BRPI0815207A2 (fr)
CA (1)	CA2694058C (fr)
CL (1)	CL2008002398A1 (fr)
CO (1)	CO6260077A2 (fr)
CR (1)	CR11270A (fr)
CY (1)	CY1113486T1 (fr)
DK (1)	DK2188291T3 (fr)
DO (1)	DOP2010000058A (fr)
EA (1)	EA020996B1 (fr)
EC (1)	ECSP109964A (fr)
ES (1)	ES2396177T3 (fr)
HN (1)	HN2010000313A (fr)
HR (1)	HRP20121022T1 (fr)
IL (1)	IL203163A (fr)
MA (1)	MA31608B1 (fr)
MX (1)	MX2010001746A (fr)
MY (1)	MY169738A (fr)
NZ (1)	NZ583267A (fr)
PA (1)	PA8793201A1 (fr)
PE (1)	PE20090944A1 (fr)
PL (1)	PL2188291T3 (fr)
PT (1)	PT2188291E (fr)
RS (1)	RS52559B (fr)
SI (1)	SI2188291T1 (fr)
SV (1)	SV2010003483A (fr)
TN (1)	TN2010000070A1 (fr)
TW (1)	TWI439272B (fr)
UA (1)	UA99735C2 (fr)
UY (1)	UY31293A1 (fr)
WO (1)	WO2009021992A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA97257C2 (en) *	2006-10-19	2012-01-25	Такеда Фармасьютикал Компани Лимитед	Indole derivatives
CA2694058C (fr)	2007-08-14	2016-06-07	Bayer Schering Pharma Aktiengesellschaft	Pyrimidines bicycliques condensees
MX315904B (es)	2008-05-30	2013-11-29	Amgen Inc	Inhibidores de fosfoinosituro-3 cinasa.
EP2396331B1 (fr) *	2009-02-13	2013-10-16	Bayer Intellectual Property GmbH	Pyrimidines condensées en tant qu'inhibiteurs d'akt
AU2010213192A1 (en)	2009-02-13	2011-08-04	Bayer Intellectual Property Gmbh	Fused pyrimidines
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
JPWO2010125799A1 (ja)	2009-04-27	2012-10-25	塩野義製薬株式会社	Ｐｉ３ｋ阻害活性を有するウレア誘導体
CN103189379A (zh) *	2010-07-13	2013-07-03	拜耳知识产权有限责任公司	双环嘧啶
ES2539257T3 (es)	2010-07-28	2015-06-29	Bayer Intellectual Property Gmbh	Imidazo[1,2-b]piridazinas sustituidas
PH12013502073A1 (en)	2011-04-07	2014-01-13	Bayer Ip Gmbh	Imidazopyridazines as akt kinase inhibitors
CA2897279C (fr)	2013-01-23	2020-12-29	Astrazeneca Ab	Derives d'aminopyrazine et compositions pharmaceutiques de ceux-ci pour utilisation dans le traitement du cancer
US20140274685A1 (en)	2013-03-15	2014-09-18	Bayer Cropscience Lp	Compositions, additives, and methods for mitigating or controlling seed dust
AU2014232160A1 (en) *	2013-03-15	2015-09-10	Bayer Cropscience Lp	Compositions, additives, and methods for mitigating or controlling seed dust
BR112020003676A2 (pt)	2017-09-15	2020-09-01	Aduro Biotech, Inc.	compostos de pirazolopirimidinona e usos dos mesmos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7306201A (en)	2000-06-30	2002-01-14	American Home Prod	Substituted-triazolopyrimidines as anticancer agents
US7449488B2 (en) *	2002-06-04	2008-11-11	Schering Corporation	Pyrazolopyrimidines as protein kinase inhibitors
AU2004233828B2 (en)	2003-04-24	2009-05-28	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity
AU2005233584B2 (en) *	2004-04-09	2010-12-09	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity
AR050188A1 (es) *	2004-08-03	2006-10-04	Uriach Y Compania S A J	Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
AU2005290081B2 (en) *	2004-08-23	2010-12-02	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity
AU2005316826A1 (en)	2004-12-15	2006-06-22	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity
JP5274842B2 (ja) *	2004-12-28	2013-08-28	エグゼリクシス，インコーポレイテッド	免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
EP1850843A4 (fr)	2005-02-14	2012-02-15	Merck Sharp & Dohme	Inhibiteurs d'activite d'akt
ES2409168T3 (es)	2005-06-10	2013-06-25	Merck Sharp & Dohme Corp.	Inhibidores de la actividad Akt
CA2694058C (fr)	2007-08-14	2016-06-07	Bayer Schering Pharma Aktiengesellschaft	Pyrimidines bicycliques condensees
AU2010213192A1 (en) *	2009-02-13	2011-08-04	Bayer Intellectual Property Gmbh	Fused pyrimidines

2008
- 2008-08-14 CA CA2694058A patent/CA2694058C/fr not_active Expired - Fee Related
- 2008-08-14 UY UY31293A patent/UY31293A1/es not_active Application Discontinuation
- 2008-08-14 UA UAA201002746A patent/UA99735C2/uk unknown
- 2008-08-14 MY MYPI2010000150A patent/MY169738A/en unknown
- 2008-08-14 WO PCT/EP2008/060690 patent/WO2009021992A2/fr not_active Ceased
- 2008-08-14 PT PT87872248T patent/PT2188291E/pt unknown
- 2008-08-14 KR KR1020107003246A patent/KR20100053556A/ko not_active Abandoned
- 2008-08-14 NZ NZ583267A patent/NZ583267A/en not_active IP Right Cessation
- 2008-08-14 EP EP08787224A patent/EP2188291B1/fr active Active
- 2008-08-14 EA EA201000298A patent/EA020996B1/ru not_active IP Right Cessation
- 2008-08-14 HR HRP20121022AT patent/HRP20121022T1/hr unknown
- 2008-08-14 CL CL2008002398A patent/CL2008002398A1/es unknown
- 2008-08-14 MX MX2010001746A patent/MX2010001746A/es active IP Right Grant
- 2008-08-14 PA PA20088793201A patent/PA8793201A1/es unknown
- 2008-08-14 PL PL08787224T patent/PL2188291T3/pl unknown
- 2008-08-14 ES ES08787224T patent/ES2396177T3/es active Active
- 2008-08-14 PE PE2008001378A patent/PE20090944A1/es not_active Application Discontinuation
- 2008-08-14 JP JP2010520586A patent/JP5344637B2/ja not_active Expired - Fee Related
- 2008-08-14 TW TW097131066A patent/TWI439272B/zh not_active IP Right Cessation
- 2008-08-14 RS RS20120556A patent/RS52559B/sr unknown
- 2008-08-14 AU AU2008288392A patent/AU2008288392B2/en not_active Ceased
- 2008-08-14 US US12/191,703 patent/US7776864B2/en not_active Expired - Fee Related
- 2008-08-14 SI SI200830848T patent/SI2188291T1/sl unknown
- 2008-08-14 BR BRPI0815207A patent/BRPI0815207A2/pt not_active IP Right Cessation
- 2008-08-14 CN CN2008801031086A patent/CN101778851B/zh not_active Expired - Fee Related
- 2008-08-14 DK DK08787224.8T patent/DK2188291T3/da active
- 2008-08-15 AR ARP080103562A patent/AR067945A1/es unknown
2010
- 2010-01-06 IL IL203163A patent/IL203163A/en not_active IP Right Cessation
- 2010-02-12 HN HN2010000313A patent/HN2010000313A/es unknown
- 2010-02-12 CR CR11270A patent/CR11270A/es unknown
- 2010-02-12 EC EC2010009964A patent/ECSP109964A/es unknown
- 2010-02-12 CO CO10015919A patent/CO6260077A2/es active IP Right Grant
- 2010-02-12 SV SV2010003483A patent/SV2010003483A/es unknown
- 2010-02-12 MA MA32617A patent/MA31608B1/fr unknown
- 2010-02-12 DO DO2010000058A patent/DOP2010000058A/es unknown
- 2010-02-12 TN TNP2010000070A patent/TN2010000070A1/fr unknown
- 2010-03-25 US US12/731,880 patent/US8614218B2/en not_active Expired - Fee Related
2012
- 2012-12-13 CY CY20121101220T patent/CY1113486T1/el unknown

Also Published As

Publication number	Publication date
MY169738A (en)	2019-05-14
EP2188291B1 (fr)	2012-09-19
ECSP109964A (es)	2010-03-31
US7776864B2 (en)	2010-08-17
BRPI0815207A2 (pt)	2017-03-28
RS52559B (sr)	2013-04-30
DOP2010000058A (es)	2010-02-28
JP5344637B2 (ja)	2013-11-20
SV2010003483A (es)	2010-07-06
NZ583267A (en)	2012-03-30
CL2008002398A1 (es)	2009-07-31
US20100184782A1 (en)	2010-07-22
HRP20121022T1 (hr)	2013-01-31
JP2010535848A (ja)	2010-11-25
MX2010001746A (es)	2010-03-10
CR11270A (es)	2010-05-19
US8614218B2 (en)	2013-12-24
KR20100053556A (ko)	2010-05-20
SI2188291T1 (sl)	2013-01-31
CN101778851A (zh)	2010-07-14
US20090137607A1 (en)	2009-05-28
TWI439272B (zh)	2014-06-01
TW200922592A (en)	2009-06-01
CA2694058C (fr)	2016-06-07
AU2008288392B2 (en)	2013-10-24
ES2396177T3 (es)	2013-02-19
DK2188291T3 (da)	2013-01-07
PL2188291T3 (pl)	2013-06-28
EA201000298A1 (ru)	2010-10-29
EP2188291A2 (fr)	2010-05-26
MA31608B1 (fr)	2010-08-02
WO2009021992A2 (fr)	2009-02-19
PE20090944A1 (es)	2009-08-09
CA2694058A1 (fr)	2009-02-19
PA8793201A1 (es)	2009-04-23
CO6260077A2 (es)	2011-03-22
EA020996B1 (ru)	2015-03-31
CN101778851B (zh)	2013-05-08
UA99735C2 (uk)	2012-09-25
AU2008288392A1 (en)	2009-02-19
AR067945A1 (es)	2009-10-28
HN2010000313A (es)	2013-03-18
WO2009021992A3 (fr)	2009-04-16
PT2188291E (pt)	2012-12-20
CY1113486T1 (el)	2016-06-22
HK1146273A1 (en)	2011-05-20
UY31293A1 (es)	2009-03-31
IL203163A (en)	2015-01-29

Publication	Publication Date	Title
TN2010000070A1 (en)	2011-09-26	Fused bicyclic pyrimidines
TN2011000404A1 (en)	2013-03-27	Fused pyrimidines
TN2010000071A1 (en)	2011-09-26	Fused imidazoles or cancer treatment
MX2010008040A (es)	2010-08-10	Derivados de pirimidina 5-fluoro como fungicidas.
MX2011012353A (es)	2011-12-14	Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
TN2012000142A1 (en)	2013-09-19	Pyrimidine derivatives as protein tyrosine kinase 2 inhibitors
MX2008013582A (es)	2009-01-19	Derivados de pirimidina como inhibidores de fosfatidilinositol-3-c inasa.
WO2008039359A3 (fr)	2008-05-08	Inhibiteurs de pyrimidine kinase bicyclique
MX2012009074A (es)	2012-08-23	Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa.
TW201713640A (en)	2017-04-16	Bruton's tyrosine kinase inhibitors
NZ708909A (en)	2019-11-29	Substituted reverse pyrimidine bmi-1 inhibitors
GEP20156285B (en)	2015-05-11	Compounds and compositions as trk inhibitors
WO2010120994A3 (fr)	2013-08-01	Composés d'uréido-aryl-pyrimidine et de carbamoylaryl-morpholino-pyrimidine, leur utilisation comme inhibiteurs de la kinase mtor et de la kinase pi-3, et leur synthèse
EA201290147A1 (ru)	2012-11-30	Пирроло[2,3-d]пиримидиновые соединения
MX2009010728A (es)	2009-10-26	Compuestos de imidazo[1,2-a]piridina como inhibidores de la tirosina-cinasa repectora.
MX2012002542A (es)	2012-04-02	Compuestos y composiciones como inhibidores de cinasa de proteina.
MX2010004263A (es)	2010-05-03	Inhibidores de quinasa c-fms.
MX344335B (es)	2016-12-13	Derivados de benzonitrilo como inhibidores de cinasa.
PH12014500373A1 (en)	2019-08-07	Amino quinazolines as kinase inhibitors
WO2008059368A3 (fr)	2008-10-30	Composés de 2-amino pyridine
EA201170154A1 (ru)	2011-08-30	Производные пиридинопиридинонов, способ их получения и применение в терапии
AU2012204982A8 (en)	2013-08-29	2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
EA201200891A1 (ru)	2013-01-30	Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина
NZ703381A (en)	2016-03-31	Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
MX2012005155A (es)	2012-08-31	Compuestos de quinazolina.