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ECSP109964A - Pirimidinas bicíclicas fusionadas - Google Patents

Pirimidinas bicíclicas fusionadas

Info

Publication number
ECSP109964A
ECSP109964A EC2010009964A ECSP109964A ECSP109964A EC SP109964 A ECSP109964 A EC SP109964A EC 2010009964 A EC2010009964 A EC 2010009964A EC SP109964 A ECSP109964 A EC SP109964A EC SP109964 A ECSP109964 A EC SP109964A
Authority
EC
Ecuador
Prior art keywords
fusioned
pyrimidins
bicyclic
pi3k
tautomers
Prior art date
Application number
EC2010009964A
Other languages
English (en)
Inventor
Swen Hoelder
Matthias Vennemann
Gerrit Beneke
Armin Zuelch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ECSP109964A publication Critical patent/ECSP109964A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula (I), los tautómeros o los estereoisómeros de éstos, o las sales de éstos, donde el anillo B y la pirimidina a la que está fusionado, R4, R5, R6, y R7 tienen los valores indicados en la descripción y las reivindicaciones, y son inhibidores eficaces de la vía Pi3K/Akt.
EC2010009964A 2007-08-14 2010-02-12 Pirimidinas bicíclicas fusionadas ECSP109964A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines

Publications (1)

Publication Number Publication Date
ECSP109964A true ECSP109964A (es) 2010-03-31

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010009964A ECSP109964A (es) 2007-08-14 2010-02-12 Pirimidinas bicíclicas fusionadas

Country Status (37)

Country Link
US (2) US7776864B2 (es)
EP (1) EP2188291B1 (es)
JP (1) JP5344637B2 (es)
KR (1) KR20100053556A (es)
CN (1) CN101778851B (es)
AR (1) AR067945A1 (es)
AU (1) AU2008288392B2 (es)
BR (1) BRPI0815207A2 (es)
CA (1) CA2694058C (es)
CL (1) CL2008002398A1 (es)
CO (1) CO6260077A2 (es)
CR (1) CR11270A (es)
CY (1) CY1113486T1 (es)
DK (1) DK2188291T3 (es)
DO (1) DOP2010000058A (es)
EA (1) EA020996B1 (es)
EC (1) ECSP109964A (es)
ES (1) ES2396177T3 (es)
HN (1) HN2010000313A (es)
HR (1) HRP20121022T1 (es)
IL (1) IL203163A (es)
MA (1) MA31608B1 (es)
MX (1) MX2010001746A (es)
MY (1) MY169738A (es)
NZ (1) NZ583267A (es)
PA (1) PA8793201A1 (es)
PE (1) PE20090944A1 (es)
PL (1) PL2188291T3 (es)
PT (1) PT2188291E (es)
RS (1) RS52559B (es)
SI (1) SI2188291T1 (es)
SV (1) SV2010003483A (es)
TN (1) TN2010000070A1 (es)
TW (1) TWI439272B (es)
UA (1) UA99735C2 (es)
UY (1) UY31293A1 (es)
WO (1) WO2009021992A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY158052A (en) * 2006-10-19 2016-08-30 Takeda Pharmaceutical Indole compound
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
CA2725014C (en) 2008-05-30 2014-06-17 Amgen Inc. Inhibitors of pi3 kinase
ES2435804T3 (es) * 2009-02-13 2013-12-23 Bayer Intellectual Property Gmbh Pirimidinas condensadas como inhibidores de Akt
MX2011008583A (es) * 2009-02-13 2011-12-12 Bayer Pharma AG Pirimidinas fusionadas.
EP2413932A4 (en) * 2009-04-01 2012-09-19 Merck Sharp & Dohme HAMMER OF ACT ACTIVITY
US20120071475A1 (en) 2009-04-27 2012-03-22 Shionogi & Co., Ltd. Urea derivatives having pi3k-inhibiting activity
CA2805015A1 (en) * 2010-07-13 2012-01-19 Stuart Ince Bicyclic pyrimidines
CA2806655A1 (en) 2010-07-28 2012-02-02 Bayer Intellectual Property Gmbh Substituted imidazo[1,2-b]pyridazines
SI2694510T1 (sl) 2011-04-07 2016-02-29 Bayer Intellectual Property Gmbh Imidazopiridazini kot inhibitorji AKT kinaze
EP2948447B1 (en) 2013-01-23 2016-09-21 Astrazeneca AB Chemical compounds
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
WO2014146144A2 (en) * 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
JP2020533376A (ja) 2017-09-15 2020-11-19 アドゥロ バイオテック，インク． ピラゾロピリミジノン化合物およびその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112038A (pt) 2000-06-30 2003-04-01 Wyeth Corp Triazolopirimidinas substituìdas como agentes anticâncer
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
CN1809354A (zh) 2003-04-24 2006-07-26 麦克公司 Akt活性抑制剂
US7655649B2 (en) * 2004-04-09 2010-02-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
AU2005290081B2 (en) * 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
WO2006065601A2 (en) 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibitors of akt activity
ATE543821T1 (de) * 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
CA2597456A1 (en) 2005-02-14 2006-08-31 Merck & Co., Inc. Inhibitors of akt activity
HRP20130429T1 (en) 2005-06-10 2013-06-30 Merck Sharp & Dohme Corp. Inhibitors of akt activity
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
MX2011008583A (es) * 2009-02-13 2011-12-12 Bayer Pharma AG Pirimidinas fusionadas.

Also Published As

Publication number Publication date
ES2396177T3 (es) 2013-02-19
UY31293A1 (es) 2009-03-31
WO2009021992A3 (en) 2009-04-16
PE20090944A1 (es) 2009-08-09
EA201000298A1 (ru) 2010-10-29
US20100184782A1 (en) 2010-07-22
SI2188291T1 (sl) 2013-01-31
RS52559B (sr) 2013-04-30
MA31608B1 (fr) 2010-08-02
PA8793201A1 (es) 2009-04-23
US8614218B2 (en) 2013-12-24
CR11270A (es) 2010-05-19
HK1146273A1 (en) 2011-05-20
DK2188291T3 (da) 2013-01-07
HN2010000313A (es) 2013-03-18
AU2008288392A1 (en) 2009-02-19
HRP20121022T1 (hr) 2013-01-31
CA2694058C (en) 2016-06-07
BRPI0815207A2 (pt) 2017-03-28
IL203163A (en) 2015-01-29
CY1113486T1 (el) 2016-06-22
TWI439272B (zh) 2014-06-01
JP5344637B2 (ja) 2013-11-20
CA2694058A1 (en) 2009-02-19
EP2188291B1 (en) 2012-09-19
CN101778851A (zh) 2010-07-14
AU2008288392B2 (en) 2013-10-24
US20090137607A1 (en) 2009-05-28
PT2188291E (pt) 2012-12-20
KR20100053556A (ko) 2010-05-20
AR067945A1 (es) 2009-10-28
CL2008002398A1 (es) 2009-07-31
EA020996B1 (ru) 2015-03-31
SV2010003483A (es) 2010-07-06
JP2010535848A (ja) 2010-11-25
DOP2010000058A (es) 2010-02-28
EP2188291A2 (en) 2010-05-26
NZ583267A (en) 2012-03-30
WO2009021992A2 (en) 2009-02-19
PL2188291T3 (pl) 2013-06-28
TN2010000070A1 (en) 2011-09-26
MY169738A (en) 2019-05-14
TW200922592A (en) 2009-06-01
MX2010001746A (es) 2010-03-10
US7776864B2 (en) 2010-08-17
UA99735C2 (uk) 2012-09-25
CO6260077A2 (es) 2011-03-22
CN101778851B (zh) 2013-05-08

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