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UY32585A - Nuevos derivados del indazol utiles como inhibidores de la familia fosfoinositida 3´oh quinasa - Google Patents

Nuevos derivados del indazol utiles como inhibidores de la familia fosfoinositida 3´oh quinasa

Info

Publication number
UY32585A
UY32585A UY0001032585A UY32585A UY32585A UY 32585 A UY32585 A UY 32585A UY 0001032585 A UY0001032585 A UY 0001032585A UY 32585 A UY32585 A UY 32585A UY 32585 A UY32585 A UY 32585A
Authority
UY
Uruguay
Prior art keywords
inhibitors
phosfoinositida
quinasa
family
new
Prior art date
Application number
UY0001032585A
Other languages
English (en)
Inventor
Charlotte Jane Mitchell
Nigel James Parr
Julie Nicole Hamblin
Paul Spencer Jones
Suzanne Elaine Keeling
Le Joelle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of UY32585A publication Critical patent/UY32585A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07—ORGANIC CHEMISTRY
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
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  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

La invención está dirigida a ciertos compuestos nuevos. Especificamente, la invención está dirigida a compuestos de fórmula (I): y sus sales. Los compuestos de la invención son inhibidores de la actividad quinasa, en particular de la actividad de la Pl3-quinasa
UY0001032585A 2009-04-30 2010-04-28 Nuevos derivados del indazol utiles como inhibidores de la familia fosfoinositida 3´oh quinasa UY32585A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17403309P 2009-04-30 2009-04-30

Publications (1)

Publication Number Publication Date
UY32585A true UY32585A (es) 2010-11-30

Family

ID=42225106

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032585A UY32585A (es) 2009-04-30 2010-04-28 Nuevos derivados del indazol utiles como inhibidores de la familia fosfoinositida 3´oh quinasa

Country Status (39)

Country Link
US (14) US20120046286A1 (es)
EP (3) EP2424864B1 (es)
JP (1) JP5570589B2 (es)
KR (2) KR101771193B1 (es)
CN (1) CN102459253B (es)
AR (2) AR076435A1 (es)
AU (1) AU2010243613B2 (es)
BR (1) BRPI1016219B8 (es)
CA (1) CA2759476C (es)
CL (1) CL2011002706A1 (es)
CO (1) CO6390057A2 (es)
CR (1) CR20110603A (es)
CY (1) CY1119515T1 (es)
DK (2) DK2899191T3 (es)
DO (1) DOP2011000328A (es)
EA (1) EA021056B1 (es)
ES (3) ES2876933T3 (es)
HR (2) HRP20150173T1 (es)
HU (1) HUE034724T2 (es)
IL (1) IL215803A (es)
JO (1) JO3025B1 (es)
LT (1) LT2899191T (es)
MA (1) MA33304B1 (es)
ME (2) ME02053B (es)
MX (1) MX2011011534A (es)
MY (1) MY160454A (es)
NZ (1) NZ596071A (es)
PE (1) PE20120321A1 (es)
PL (2) PL2424864T3 (es)
PT (2) PT2424864E (es)
RS (2) RS53830B1 (es)
SG (2) SG10201401881QA (es)
SI (2) SI2899191T1 (es)
SM (2) SMT201700481T1 (es)
TW (3) TWI516487B (es)
UA (1) UA101098C2 (es)
UY (1) UY32585A (es)
WO (1) WO2010125082A1 (es)
ZA (1) ZA201107878B (es)

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JP5508400B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッド Ｐｉ３キナーゼの阻害剤としてのベンズピラゾール誘導体
JP5502076B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッド 新規化合物
ES2542551T3 (es) 2009-03-09 2015-08-06 Glaxo Group Limited 4-Oxadiazol-2-il-indazoles como inhibidores de PI3 cinasas
TWI516487B (zh) 2009-04-30 2016-01-11 葛蘭素集團有限公司 新穎化合物、其醫藥組合物及作為激酶活性抑制劑之用途
CN102372675B (zh) * 2010-08-14 2013-12-18 王娜 6-氯-4-碘吲唑及其制备方法与应用
PL2614058T3 (pl) 2010-09-08 2015-12-31 Glaxosmithkline Ip Dev Ltd Polimorfy i sole n-[5-[4-(5-{[(2r,6s)-2,6-dimetylo-4-morfolinylo]-metylo}-1,3-oksazol-2-ilo)-1h-indazol-6-ilo]-2-(metyloksy)-3-pirydynylo]metanosulfonamidu
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US9326987B2 (en) 2010-09-08 2016-05-03 Glaxo Group Limited Indazole derivatives for use in the treatment of influenza virus infection
GB201018124D0 (en) * 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
US9512111B2 (en) 2010-11-08 2016-12-06 Lycera Corporation N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease
EP2790705B1 (en) 2011-12-15 2017-12-06 Novartis AG Use of inhibitors of the activity or function of pi3k
WO2013169704A2 (en) 2012-05-08 2013-11-14 Merck Sharp & Dohme Corp. TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
AU2013259624B2 (en) 2012-05-08 2017-10-19 Lycera Corporation Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
KR20150031481A (ko) * 2012-07-16 2015-03-24 뉴로포레 테라피스, 인코포레이티드 단백질 응집 저해제로서의 디- 및 트리-헤테로아릴 유도체
WO2014068070A1 (en) 2012-10-31 2014-05-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
WO2014098232A1 (ja) * 2012-12-21 2014-06-26 Yamashita Chikamasa Ｐｉ３キナーゼ阻害剤を含む医薬組成物、ビタミンｄ受容体に作用する化合物を含む医薬組成物、凍結乾燥組成物、凍結乾燥組成物の製造方法、及び経肺投与用医薬組成物
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