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SI2899191T1 - Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji - Google Patents

Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji

Info

Publication number
SI2899191T1
SI2899191T1 SI201031548T SI201031548T SI2899191T1 SI 2899191 T1 SI2899191 T1 SI 2899191T1 SI 201031548 T SI201031548 T SI 201031548T SI 201031548 T SI201031548 T SI 201031548T SI 2899191 T1 SI2899191 T1 SI 2899191T1
Authority
SI
Slovenia
Prior art keywords
kinase inhibitors
substituted indazoles
oxazole substituted
oxazole
indazoles
Prior art date
Application number
SI201031548T
Other languages
English (en)
Inventor
Julie Nicole Hamblin
Paul Spencer Jones
Suzanne Elaine Keeling
Joelle Le
Charlotte Jane Mitchell
Nigel James Parr
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of SI2899191T1 publication Critical patent/SI2899191T1/sl

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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SI201031548T 2009-04-30 2010-04-28 Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji SI2899191T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17403309P 2009-04-30 2009-04-30
EP14194866.1A EP2899191B1 (en) 2009-04-30 2010-04-28 Oxazole substituted indazoles as pi3-kinase inhibitors

Publications (1)

Publication Number Publication Date
SI2899191T1 true SI2899191T1 (sl) 2017-11-30

Family

ID=42225106

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201031548T SI2899191T1 (sl) 2009-04-30 2010-04-28 Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji
SI201030873T SI2424864T1 (sl) 2009-04-30 2010-04-28 Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201030873T SI2424864T1 (sl) 2009-04-30 2010-04-28 Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji

Country Status (39)

Country Link
US (14) US20120046286A1 (sl)
EP (3) EP3260453B1 (sl)
JP (1) JP5570589B2 (sl)
KR (2) KR101771193B1 (sl)
CN (1) CN102459253B (sl)
AR (2) AR076435A1 (sl)
AU (1) AU2010243613B2 (sl)
BR (1) BRPI1016219B8 (sl)
CA (1) CA2759476C (sl)
CL (1) CL2011002706A1 (sl)
CO (1) CO6390057A2 (sl)
CR (1) CR20110603A (sl)
CY (1) CY1119515T1 (sl)
DK (2) DK2899191T3 (sl)
DO (1) DOP2011000328A (sl)
EA (1) EA021056B1 (sl)
ES (3) ES2644724T3 (sl)
HR (2) HRP20150173T1 (sl)
HU (1) HUE034724T2 (sl)
IL (1) IL215803A (sl)
JO (1) JO3025B1 (sl)
LT (1) LT2899191T (sl)
MA (1) MA33304B1 (sl)
ME (2) ME02053B (sl)
MX (1) MX2011011534A (sl)
MY (1) MY160454A (sl)
NZ (1) NZ596071A (sl)
PE (1) PE20120321A1 (sl)
PL (2) PL2899191T3 (sl)
PT (2) PT2424864E (sl)
RS (2) RS56433B1 (sl)
SG (2) SG10201401881QA (sl)
SI (2) SI2899191T1 (sl)
SM (2) SMT201700481T1 (sl)
TW (3) TWI466884B (sl)
UA (1) UA101098C2 (sl)
UY (1) UY32585A (sl)
WO (1) WO2010125082A1 (sl)
ZA (1) ZA201107878B (sl)

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EP2280705B1 (en) 2008-06-05 2014-10-08 Glaxo Group Limited Novel compounds
ES2445199T3 (es) * 2008-06-05 2014-02-28 Glaxo Group Limited Derivados de benzpirazol como inhibidores de PI3-quinasas
JP5502077B2 (ja) * 2008-06-05 2014-05-28 グラクソ グループ リミテッド 新規な化合物
US8524751B2 (en) 2009-03-09 2013-09-03 GlaxoSmithKline Intellecutual Property Development 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases
ES2644724T3 (es) 2009-04-30 2017-11-30 Glaxo Group Limited Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas
CN102372675B (zh) * 2010-08-14 2013-12-18 王娜 6-氯-4-碘吲唑及其制备方法与应用
US9102668B2 (en) 2010-09-08 2015-08-11 Glaxo Group Limited Polymorphs and salts
JP5876051B2 (ja) * 2010-09-08 2016-03-02 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ インフルエンザウィルス感染の治療に使用するためのインダゾール誘導体
HUE026059T2 (en) 2010-09-08 2016-05-30 Glaxosmithkline Ip Dev Ltd N- [5- [4- (5 - {[(2R, 6S) -2,6-dimethyl-4-morpholinyl] methyl} -1,3-oxazol-2-yl) -1H-indazol-6-yl ] Polymorphs and salts of 2 - (methyloxy) -3-pyridinyl] methanesulfonamide
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
AU2011326071A1 (en) * 2010-11-08 2013-05-23 Lycera Corporation N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of RORy activity and the treatment of diseases
DK2790705T3 (en) 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
MX367341B (es) 2012-05-08 2019-08-14 Merck Sharp & Dohme Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades.
US9394315B2 (en) 2012-05-08 2016-07-19 Lycera Corporation Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
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