UY32042A - Compuestos de 2-aminopirimidina como potentes inhibidores de hsp-90 - Google Patents
Compuestos de 2-aminopirimidina como potentes inhibidores de hsp-90Info
- Publication number
- UY32042A UY32042A UY0001032042A UY32042A UY32042A UY 32042 A UY32042 A UY 32042A UY 0001032042 A UY0001032042 A UY 0001032042A UY 32042 A UY32042 A UY 32042A UY 32042 A UY32042 A UY 32042A
- Authority
- UY
- Uruguay
- Prior art keywords
- hsp
- compounds
- aminopirimidine
- powerful inhibitors
- inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102100032510 Heat shock protein HSP 90-beta Human genes 0.000 title 1
- 101001016856 Homo sapiens Heat shock protein HSP 90-beta Proteins 0.000 title 1
- 101000988090 Leishmania donovani Heat shock protein 83 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003481 heat shock protein 90 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula (I), o sales farmacéuticamente aceptables del mismo, a su síntesis y a su uso como inhibidores de HSP-90
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8859908P | 2008-08-13 | 2008-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY32042A true UY32042A (es) | 2010-03-26 |
Family
ID=41151854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001032042A UY32042A (es) | 2008-08-13 | 2009-08-11 | Compuestos de 2-aminopirimidina como potentes inhibidores de hsp-90 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8080556B2 (es) |
| EP (1) | EP2331544A1 (es) |
| JP (1) | JP2011530580A (es) |
| AR (1) | AR073008A1 (es) |
| CA (1) | CA2732922A1 (es) |
| HN (1) | HN2009001441A (es) |
| TW (1) | TW201010705A (es) |
| UY (1) | UY32042A (es) |
| WO (1) | WO2010018481A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153558B (zh) * | 2011-02-23 | 2012-11-21 | 扬州永济医药新技术有限公司 | 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法 |
| WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| CN104884449A (zh) | 2012-10-31 | 2015-09-02 | 拜尔农作物科学股份公司 | 作为害虫防治剂的新的杂环化合物 |
| EP3172210B1 (en) | 2014-07-24 | 2020-01-15 | Pfizer Inc | Pyrazolopyrimidine compounds |
| CN105985289B (zh) * | 2015-02-15 | 2018-12-21 | 正大天晴药业集团股份有限公司 | 一种乐伐替尼的制备方法 |
| PL425123A1 (pl) * | 2018-04-04 | 2019-10-07 | Politechnika Śląska | Regioselektywny sposób otrzymywania halogenopochodnych związków aromatycznych i heteroaromatycznych |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4469179B2 (ja) | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体 |
| US7312330B2 (en) | 2003-12-24 | 2007-12-25 | Renovis, Inc. | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| JP2008534609A (ja) | 2005-03-30 | 2008-08-28 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害剤としてのアルキニルピロロピリミジンおよび関連類似体 |
| JP2008540395A (ja) * | 2005-05-03 | 2008-11-20 | ファイザー・インク | アミドレソルシノール化合物 |
| US8277807B2 (en) * | 2006-10-12 | 2012-10-02 | Astex Therapeutics Limited | Pharmaceutical combinations |
| ATE502944T1 (de) * | 2007-02-06 | 2011-04-15 | Pfizer | 2-amino-5,7-dihydro-6h-pyrroloä3,4- düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs |
-
2009
- 2009-07-28 EP EP09786733A patent/EP2331544A1/en not_active Withdrawn
- 2009-07-28 WO PCT/IB2009/053277 patent/WO2010018481A1/en not_active Ceased
- 2009-07-28 JP JP2011522573A patent/JP2011530580A/ja not_active Withdrawn
- 2009-07-28 CA CA2732922A patent/CA2732922A1/en not_active Abandoned
- 2009-08-04 US US12/535,468 patent/US8080556B2/en not_active Expired - Fee Related
- 2009-08-05 HN HN2009001441A patent/HN2009001441A/es unknown
- 2009-08-11 AR ARP090103086A patent/AR073008A1/es not_active Application Discontinuation
- 2009-08-11 UY UY0001032042A patent/UY32042A/es not_active Application Discontinuation
- 2009-08-12 TW TW098127168A patent/TW201010705A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010018481A1 (en) | 2010-02-18 |
| AR073008A1 (es) | 2010-10-06 |
| US20100041681A1 (en) | 2010-02-18 |
| JP2011530580A (ja) | 2011-12-22 |
| EP2331544A1 (en) | 2011-06-15 |
| US8080556B2 (en) | 2011-12-20 |
| TW201010705A (en) | 2010-03-16 |
| HN2009001441A (es) | 2011-09-05 |
| CA2732922A1 (en) | 2010-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20181112 |