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MA31608B1 - Pyrimidines bicycliques condensees - Google Patents

Pyrimidines bicycliques condensees

Info

Publication number
MA31608B1
MA31608B1 MA32617A MA32617A MA31608B1 MA 31608 B1 MA31608 B1 MA 31608B1 MA 32617 A MA32617 A MA 32617A MA 32617 A MA32617 A MA 32617A MA 31608 B1 MA31608 B1 MA 31608B1
Authority
MA
Morocco
Prior art keywords
condensed bicyclic
bicyclic pyrimidines
pyrimidines
condensed
compounds
Prior art date
Application number
MA32617A
Other languages
English (en)
Inventor
Swen Hoelder
Matthias Vennemann
Gerrit Beneke
Armin Zuelch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/fr
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA31608B1 publication Critical patent/MA31608B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION PORTE SUR DES COMPOSÉS DE LA FORMULE (I), SUR UN TAUTOMÈRE OU UN STÉRÉOISOMÈRE DE CES DERNIERS, OU SUR UN SEL DE CES DERNIERS, DANS LAQUELLE LE CYCLE B ET LA PYRIMIDINE AVEC LAQUELLE IL EST CONDENSÉ, R4, R5, R6 ET R7 SONT TELS QUE DÉFINIS DANS LA DESCRIPTION ET LES REVENDICATIONS, LESQUELS COMPOSÉS SONT DES INHIBITEURS EFFICACES DE LA VOIE PI3K/AKT.
MA32617A 2007-08-14 2010-02-12 Pyrimidines bicycliques condensees MA31608B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (fr) 2007-10-18 2007-10-18 Nouveau pyrimidines fusionnés

Publications (1)

Publication Number Publication Date
MA31608B1 true MA31608B1 (fr) 2010-08-02

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32617A MA31608B1 (fr) 2007-08-14 2010-02-12 Pyrimidines bicycliques condensees

Country Status (37)

Country Link
US (2) US7776864B2 (fr)
EP (1) EP2188291B1 (fr)
JP (1) JP5344637B2 (fr)
KR (1) KR20100053556A (fr)
CN (1) CN101778851B (fr)
AR (1) AR067945A1 (fr)
AU (1) AU2008288392B2 (fr)
BR (1) BRPI0815207A2 (fr)
CA (1) CA2694058C (fr)
CL (1) CL2008002398A1 (fr)
CO (1) CO6260077A2 (fr)
CR (1) CR11270A (fr)
CY (1) CY1113486T1 (fr)
DK (1) DK2188291T3 (fr)
DO (1) DOP2010000058A (fr)
EA (1) EA020996B1 (fr)
EC (1) ECSP109964A (fr)
ES (1) ES2396177T3 (fr)
HN (1) HN2010000313A (fr)
HR (1) HRP20121022T1 (fr)
IL (1) IL203163A (fr)
MA (1) MA31608B1 (fr)
MX (1) MX2010001746A (fr)
MY (1) MY169738A (fr)
NZ (1) NZ583267A (fr)
PA (1) PA8793201A1 (fr)
PE (1) PE20090944A1 (fr)
PL (1) PL2188291T3 (fr)
PT (1) PT2188291E (fr)
RS (1) RS52559B (fr)
SI (1) SI2188291T1 (fr)
SV (1) SV2010003483A (fr)
TN (1) TN2010000070A1 (fr)
TW (1) TWI439272B (fr)
UA (1) UA99735C2 (fr)
UY (1) UY31293A1 (fr)
WO (1) WO2009021992A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY158052A (en) * 2006-10-19 2016-08-30 Takeda Pharmaceutical Indole compound
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
CA2725014C (fr) 2008-05-30 2014-06-17 Amgen Inc. Inhibiteurs de la pi3 kinase
ES2435804T3 (es) * 2009-02-13 2013-12-23 Bayer Intellectual Property Gmbh Pirimidinas condensadas como inhibidores de Akt
MX2011008583A (es) * 2009-02-13 2011-12-12 Bayer Pharma AG Pirimidinas fusionadas.
EP2413932A4 (fr) * 2009-04-01 2012-09-19 Merck Sharp & Dohme Inhibiteurs de l'activité akt
US20120071475A1 (en) 2009-04-27 2012-03-22 Shionogi & Co., Ltd. Urea derivatives having pi3k-inhibiting activity
CA2805015A1 (fr) * 2010-07-13 2012-01-19 Stuart Ince Pyrimidines bicycliques
CA2806655A1 (fr) 2010-07-28 2012-02-02 Bayer Intellectual Property Gmbh Imidazo[1,2-b]pyridazines substituees
SI2694510T1 (sl) 2011-04-07 2016-02-29 Bayer Intellectual Property Gmbh Imidazopiridazini kot inhibitorji AKT kinaze
EP2948447B1 (fr) 2013-01-23 2016-09-21 Astrazeneca AB Composés chimiques
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
WO2014146144A2 (fr) * 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additifs, et procédés pour atténuer ou contrôler la poussière des semences
JP2020533376A (ja) 2017-09-15 2020-11-19 アドゥロ バイオテック，インク． ピラゾロピリミジノン化合物およびその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112038A (pt) 2000-06-30 2003-04-01 Wyeth Corp Triazolopirimidinas substituìdas como agentes anticâncer
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
CN1809354A (zh) 2003-04-24 2006-07-26 麦克公司 Akt活性抑制剂
US7655649B2 (en) * 2004-04-09 2010-02-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
AU2005290081B2 (en) * 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
WO2006065601A2 (fr) 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibiteurs d'activite akt
ATE543821T1 (de) * 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
CA2597456A1 (fr) 2005-02-14 2006-08-31 Merck & Co., Inc. Inhibiteurs d'activite d'akt
HRP20130429T1 (en) 2005-06-10 2013-06-30 Merck Sharp & Dohme Corp. Inhibitors of akt activity
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
MX2011008583A (es) * 2009-02-13 2011-12-12 Bayer Pharma AG Pirimidinas fusionadas.

Also Published As

Publication number Publication date
ES2396177T3 (es) 2013-02-19
UY31293A1 (es) 2009-03-31
WO2009021992A3 (fr) 2009-04-16
PE20090944A1 (es) 2009-08-09
EA201000298A1 (ru) 2010-10-29
US20100184782A1 (en) 2010-07-22
SI2188291T1 (sl) 2013-01-31
RS52559B (sr) 2013-04-30
PA8793201A1 (es) 2009-04-23
US8614218B2 (en) 2013-12-24
CR11270A (es) 2010-05-19
HK1146273A1 (en) 2011-05-20
DK2188291T3 (da) 2013-01-07
HN2010000313A (es) 2013-03-18
AU2008288392A1 (en) 2009-02-19
HRP20121022T1 (hr) 2013-01-31
CA2694058C (fr) 2016-06-07
BRPI0815207A2 (pt) 2017-03-28
IL203163A (en) 2015-01-29
CY1113486T1 (el) 2016-06-22
TWI439272B (zh) 2014-06-01
JP5344637B2 (ja) 2013-11-20
CA2694058A1 (fr) 2009-02-19
EP2188291B1 (fr) 2012-09-19
CN101778851A (zh) 2010-07-14
AU2008288392B2 (en) 2013-10-24
US20090137607A1 (en) 2009-05-28
PT2188291E (pt) 2012-12-20
KR20100053556A (ko) 2010-05-20
AR067945A1 (es) 2009-10-28
CL2008002398A1 (es) 2009-07-31
EA020996B1 (ru) 2015-03-31
SV2010003483A (es) 2010-07-06
JP2010535848A (ja) 2010-11-25
DOP2010000058A (es) 2010-02-28
EP2188291A2 (fr) 2010-05-26
NZ583267A (en) 2012-03-30
WO2009021992A2 (fr) 2009-02-19
PL2188291T3 (pl) 2013-06-28
TN2010000070A1 (en) 2011-09-26
MY169738A (en) 2019-05-14
TW200922592A (en) 2009-06-01
ECSP109964A (es) 2010-03-31
MX2010001746A (es) 2010-03-10
US7776864B2 (en) 2010-08-17
UA99735C2 (uk) 2012-09-25
CO6260077A2 (es) 2011-03-22
CN101778851B (zh) 2013-05-08

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