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EA200970575A1 - Соединения на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина и способы их применения - Google Patents

Соединения на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина и способы их применения

Info

Publication number
EA200970575A1
EA200970575A1 EA200970575A EA200970575A EA200970575A1 EA 200970575 A1 EA200970575 A1 EA 200970575A1 EA 200970575 A EA200970575 A EA 200970575A EA 200970575 A EA200970575 A EA 200970575A EA 200970575 A1 EA200970575 A1 EA 200970575A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
methods
triftor
phenyletoxi
pyrimidine
Prior art date
Application number
EA200970575A
Other languages
English (en)
Other versions
EA018150B1 (ru
Inventor
Арокиасами Девасагаярадж
Хайхун Цзинь
Чжи-цай Ши
Ашок Туноори
Ин Ван
Чэньминь Чжан
Original Assignee
Лексикон Фармасьютикалз , Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лексикон Фармасьютикалз , Инк. filed Critical Лексикон Фармасьютикалз , Инк.
Publication of EA200970575A1 publication Critical patent/EA200970575A1/ru
Publication of EA018150B1 publication Critical patent/EA018150B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone

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  • Chemical & Material Sciences (AREA)
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  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Раскрыты соединения формулы I, а также включающие их композиции и способы их использования для лечения, предотвращения и/или контроля заболевания и расстройства.
EA200970575A 2006-12-12 2007-12-11 Соединения на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина и способы их применения EA018150B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87459606P 2006-12-12 2006-12-12
PCT/US2007/087068 WO2008073933A2 (en) 2006-12-12 2007-12-11 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

Publications (2)

Publication Number Publication Date
EA200970575A1 true EA200970575A1 (ru) 2009-12-30
EA018150B1 EA018150B1 (ru) 2013-05-30

Family

ID=39432875

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970575A EA018150B1 (ru) 2006-12-12 2007-12-11 Соединения на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина и способы их применения

Country Status (25)

Country Link
US (4) US7553840B2 (ru)
EP (4) EP3176159B1 (ru)
JP (1) JP5361734B2 (ru)
KR (1) KR101464391B1 (ru)
AR (1) AR064279A1 (ru)
AU (1) AU2007333120B2 (ru)
BR (1) BRPI0720270B8 (ru)
CA (1) CA2672233C (ru)
CO (1) CO6220855A2 (ru)
DK (2) DK2091940T6 (ru)
EA (1) EA018150B1 (ru)
EC (1) ECSP099413A (ru)
ES (3) ES2856871T3 (ru)
HU (3) HUE053098T2 (ru)
IL (2) IL198806A (ru)
MX (1) MX2009006195A (ru)
NL (1) NL300929I2 (ru)
NO (2) NO345062B1 (ru)
NZ (1) NZ577004A (ru)
PL (2) PL3176159T3 (ru)
PT (2) PT2091940E (ru)
TW (1) TWI412365B (ru)
UA (1) UA99270C2 (ru)
WO (1) WO2008073933A2 (ru)
ZA (1) ZA200903367B (ru)

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KR20100033975A (ko) * 2007-06-26 2010-03-31 렉시컨 파마슈티컬스 인코퍼레이티드 트립토판 히드록실라제 억제제를 포함하는 조성물
KR20100037047A (ko) * 2007-06-26 2010-04-08 렉시컨 파마슈티컬스 인코퍼레이티드 세로토닌-매개 질환 및 장애의 치료 방법
EA201070127A1 (ru) 2007-07-11 2010-08-30 Лексикон Фармасьютикалз , Инк. Способы лечения легочной гипертензии, родственных заболеваний и нарушений и композиции для их осуществления
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TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
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JP2013510092A (ja) 2009-11-05 2013-03-21 レクシコン ファーマシューティカルズ インコーポレイテッド がんの治療のためのトリプトファンヒドロキシラーゼ阻害剤
WO2011063072A2 (en) 2009-11-19 2011-05-26 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
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JP2013519673A (ja) * 2010-02-10 2013-05-30 レクシコン ファーマシューティカルズ インコーポレイテッド 転移性骨疾患の治療のためのトリプトファンヒドロキシラーゼ阻害剤
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