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MX2010003771A - Forma cristalina 2 - de 2 ((r)-2-metilpirrolidin-2-il)-1h-benzimid azol-4-carboxamida. - Google Patents

Forma cristalina 2 - de 2 ((r)-2-metilpirrolidin-2-il)-1h-benzimid azol-4-carboxamida.

Info

Publication number
MX2010003771A
MX2010003771A MX2010003771A MX2010003771A MX2010003771A MX 2010003771 A MX2010003771 A MX 2010003771A MX 2010003771 A MX2010003771 A MX 2010003771A MX 2010003771 A MX2010003771 A MX 2010003771A MX 2010003771 A MX2010003771 A MX 2010003771A
Authority
MX
Mexico
Prior art keywords
methylpyrrolidin
benzimidazole
crystalline form
carboxamide crystalline
carboxamide
Prior art date
Application number
MX2010003771A
Other languages
English (en)
Inventor
Guidong Zhu
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2010003771A publication Critical patent/MX2010003771A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen la Forma Cristalina 2 de 2-((R)-2-metilpirroliclin-2- il)-1H-bencimidazol-4-carboxamida, formas para hacerla, composiciones que la comprenden y la usan, y m?todos para tratar pacientes con alguna enfermedad utiliz?ndola.
MX2010003771A 2007-10-12 2008-10-10 Forma cristalina 2 - de 2 ((r)-2-metilpirrolidin-2-il)-1h-benzimid azol-4-carboxamida. MX2010003771A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97965407P 2007-10-12 2007-10-12
PCT/US2008/079439 WO2009049109A1 (en) 2007-10-12 2008-10-10 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide crystalline form 2

Publications (1)

Publication Number Publication Date
MX2010003771A true MX2010003771A (es) 2010-04-21

Family

ID=40279000

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003771A MX2010003771A (es) 2007-10-12 2008-10-10 Forma cristalina 2 - de 2 ((r)-2-metilpirrolidin-2-il)-1h-benzimid azol-4-carboxamida.

Country Status (8)

Country Link
US (1) US8013168B2 (es)
EP (2) EP2727921B1 (es)
JP (3) JP2011500588A (es)
CN (2) CN104230893A (es)
CA (1) CA2696423A1 (es)
ES (1) ES2562081T3 (es)
MX (1) MX2010003771A (es)
WO (1) WO2009049109A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2722046B1 (en) * 2007-10-12 2016-12-21 AbbVie Ireland Unlimited Company 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1
NZ616227A (en) * 2011-04-11 2016-01-29 Abb Vie Inc Parp inhibitors for the treatment of cipn
CN105130961B (zh) * 2015-08-06 2018-02-16 苏州晶云药物科技有限公司 Abt‑888的晶型b及其制备方法和应用
CN106995436A (zh) * 2016-01-25 2017-08-01 重庆医药工业研究院有限责任公司 一种维利帕尼晶型a及其制备方法
US20190092756A1 (en) * 2016-03-09 2019-03-28 Crystal Pharmatech Co., Ltd. Crystalline form a of 2-[(2r)-2-methyl-2-pyrrolidyl]-1h-benzimidazole-7-carboxamide dihydrochloride and preparation method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2001117757A (ru) * 1998-11-27 2004-02-27 БАСФ Акциенгезельшафт (DE) Замещенные бензимидазолы и их применение в качестве ингибиторов поли(аденозиндифосфатрибоза)полимеразы
AU2930501A (en) * 2000-01-07 2001-07-24 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
DE10021468A1 (de) * 2000-05-04 2001-11-08 Basf Ag Verwendung von PARP-Inhibitoren in kosmetischen Zubereitungen
CN1926127A (zh) * 2003-12-29 2007-03-07 万有制药株式会社 新的2－杂芳基取代苯并咪唑衍生物
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
EP2722046B1 (en) 2007-10-12 2016-12-21 AbbVie Ireland Unlimited Company 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1

Also Published As

Publication number Publication date
EP2217603B1 (en) 2015-11-18
CN101821269A (zh) 2010-09-01
US20090099246A1 (en) 2009-04-16
EP2727921B1 (en) 2017-04-19
CN104230893A (zh) 2014-12-24
EP2727921A1 (en) 2014-05-07
EP2217603A1 (en) 2010-08-18
JP2011500588A (ja) 2011-01-06
JP2014237660A (ja) 2014-12-18
CA2696423A1 (en) 2009-04-16
ES2562081T3 (es) 2016-03-02
US8013168B2 (en) 2011-09-06
JP2017071617A (ja) 2017-04-13
WO2009049109A1 (en) 2009-04-16
CN101821269B (zh) 2014-05-28

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Legal Events

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GB Transfer or rights