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TNSN07275A1 - Derives de triazole substitues, servant d'antagonistes d'ocytocine - Google Patents

Derives de triazole substitues, servant d'antagonistes d'ocytocine

Info

Publication number
TNSN07275A1
TNSN07275A1 TNP2007000275A TNSN07275A TNSN07275A1 TN SN07275 A1 TNSN07275 A1 TN SN07275A1 TN P2007000275 A TNP2007000275 A TN P2007000275A TN SN07275 A TNSN07275 A TN SN07275A TN SN07275 A1 TNSN07275 A1 TN SN07275A1
Authority
TN
Tunisia
Prior art keywords
ocytocin
antagonists
triazole derivatives
substituted triazole
substituted
Prior art date
Application number
TNP2007000275A
Other languages
English (en)
Inventor
Alan Daniel Brown
Andrew Antony Calabrese
David Ellis
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of TNSN07275A1 publication Critical patent/TNSN07275A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des triazoles substitués de formule (I), leurs utilisations, des procédés pour leur préparation et des compositions contenant lesdits composés. Ces inhibiteurs sont utiles dans divers domaines thérapeutiques, y compris un dysfonctionnement sexuel.
TNP2007000275A 2005-01-20 2007-07-19 Derives de triazole substitues, servant d'antagonistes d'ocytocine TNSN07275A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0501190.3A GB0501190D0 (en) 2005-01-20 2005-01-20 Novel pharmaceuticals
PCT/IB2006/000118 WO2006077496A1 (fr) 2005-01-20 2006-01-11 Utilisation de derives de triazole substitues comme antagonistes de l'oxytocine

Publications (1)

Publication Number Publication Date
TNSN07275A1 true TNSN07275A1 (fr) 2008-12-31

Family

ID=34259404

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000275A TNSN07275A1 (fr) 2005-01-20 2007-07-19 Derives de triazole substitues, servant d'antagonistes d'ocytocine

Country Status (31)

Country Link
US (5) US7557131B2 (fr)
EP (1) EP1841758B1 (fr)
JP (1) JP4124805B1 (fr)
KR (1) KR100936854B1 (fr)
CN (1) CN101107243B (fr)
AP (1) AP2007004047A0 (fr)
AR (1) AR055303A1 (fr)
AT (1) ATE449091T1 (fr)
AU (1) AU2006207300B2 (fr)
BR (1) BRPI0606463A2 (fr)
CA (1) CA2595569C (fr)
CR (1) CR9219A (fr)
DE (1) DE602006010508D1 (fr)
DK (1) DK1841758T3 (fr)
DO (1) DOP2006000014A (fr)
EA (1) EA200701328A1 (fr)
ES (1) ES2334517T3 (fr)
GB (1) GB0501190D0 (fr)
GT (1) GT200600024A (fr)
IL (1) IL184148A (fr)
MA (1) MA29160B1 (fr)
MX (1) MX2007008757A (fr)
NL (1) NL1030961C2 (fr)
NO (1) NO338420B1 (fr)
PA (1) PA8660401A1 (fr)
PE (1) PE20060875A1 (fr)
TN (1) TNSN07275A1 (fr)
TW (1) TW200637847A (fr)
UY (1) UY29339A1 (fr)
WO (1) WO2006077496A1 (fr)
ZA (1) ZA200705718B (fr)

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JPH06284516A (ja) * 1993-03-31 1994-10-07 Mitsubishi Electric Corp 電気車制御装置
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
GB0504556D0 (en) * 2005-03-04 2005-04-13 Pfizer Ltd Novel pharmaceuticals
EP1902051A1 (fr) * 2005-06-09 2008-03-26 Merck Frosst Canada Ltd. Derives d'azacyclohexane comme inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
GB0607196D0 (en) * 2006-04-11 2006-05-17 Prosidion Ltd G-protein coupled receptor agonists
WO2007143823A1 (fr) * 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Dérivés d'azétidine comme inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
CA2654098A1 (fr) * 2006-06-13 2007-12-21 Merck Frosst Canada Ltd. Derives de l'azacyclopentane utilises en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
WO2008133975A1 (fr) * 2007-04-26 2008-11-06 Avalon Pharmaceuticals Composés polycycliques et leurs utilisations
AU2009210296B2 (en) 2008-01-31 2013-11-14 Sanofi Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
EP2247575B1 (fr) 2008-01-31 2016-03-23 Sanofi Indole-3-carboxamides cycliques, leur preparation et leur utilisation comme produits pharmaceutiques
MX350922B (es) * 2012-07-16 2017-09-25 Fibrogen Inc Proceso para elaborar compuestos de isoquinolina.
US10570146B2 (en) 2014-07-25 2020-02-25 Northeastern University Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
JOP20190072A1 (ar) 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
US10875829B1 (en) 2016-11-18 2020-12-29 Integrative Research Laboratories Sweden Ab Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
CN108884071B (zh) * 2016-12-21 2021-05-14 江苏恒瑞医药股份有限公司 稠环基氮杂环丁基三唑类衍生物、其制备方法及其在医药上的应用
EP3564231A4 (fr) * 2016-12-28 2020-08-12 Jiangsu Hengrui Medicine Co., Ltd. Dérivé de triazole azabicyclo-substitué, sa méthode de préparation et son application en médecine
CN111094272B (zh) * 2018-06-20 2022-05-27 江苏恒瑞医药股份有限公司 一种otr抑制剂的可药用盐、晶型及制备方法
TW202016092A (zh) * 2018-06-20 2020-05-01 大陸商江蘇恆瑞醫藥股份有限公司 Otr抑制劑的晶型及其製備方法
WO2020001460A1 (fr) * 2018-06-27 2020-01-02 江苏恒瑞医药股份有限公司 Sel pharmaceutiquement acceptable, forme cristalline d'un dérivé de triazole substitué par azabicyclo et procédé de préparation
CN113004250B (zh) * 2019-12-19 2022-07-26 上海森辉医药有限公司 一种制备取代的三唑衍生物的方法
CN113582818B (zh) * 2021-08-30 2023-08-01 上海日异生物科技有限公司 一种3-卤-2-烷基苯酚的合成方法
US20250152585A1 (en) * 2022-02-16 2025-05-15 Duke Street Bio Limited Pharmaceutical compound
CN114805161B (zh) * 2022-06-14 2023-08-25 南通华祥医药科技有限公司 一种3-氟丫丁啶盐酸盐的制备方法

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Publication number Priority date Publication date Assignee Title
US4554276A (en) 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
US5053411A (en) 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
DE4124942A1 (de) 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4302051A1 (de) 1993-01-26 1994-07-28 Thomae Gmbh Dr K 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
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US7169797B2 (en) 2003-02-14 2007-01-30 Abbott Laboratories Protein-tyrosine phosphatase inhibitors and uses thereof
MXPA06003158A (es) * 2003-09-22 2006-06-05 Pfizer Derivados de triazol sustituidos como antagonistas de oxitocina.
GEP20084571B (en) 2003-12-22 2008-12-25 Pfizer Triazole derivatives as vasopressin antagonists
WO2005082866A2 (fr) * 2004-02-20 2005-09-09 Pfizer Limited Derives de triazole substitues utilises en tant qu'antagonistes de l'oxytocine
EP1742932A1 (fr) 2004-04-28 2007-01-17 Pfizer Limited Derives 3-heterocyclyl-4-phenyl-triazole comme inhibiteurs de la vasopressine par recepteur
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists

Also Published As

Publication number Publication date
KR100936854B1 (ko) 2010-01-14
EP1841758B1 (fr) 2009-11-18
CA2595569C (fr) 2010-07-20
US9023872B2 (en) 2015-05-05
NL1030961A1 (nl) 2006-07-21
CN101107243A (zh) 2008-01-16
US20090253674A1 (en) 2009-10-08
TW200637847A (en) 2006-11-01
US8207198B2 (en) 2012-06-26
CN101107243B (zh) 2010-11-24
AU2006207300B2 (en) 2011-03-03
AR055303A1 (es) 2007-08-15
EP1841758A1 (fr) 2007-10-10
DE602006010508D1 (de) 2009-12-31
IL184148A (en) 2013-06-27
AP2007004047A0 (en) 2007-06-30
BRPI0606463A2 (pt) 2009-06-30
US9394278B2 (en) 2016-07-19
IL184148A0 (en) 2007-10-31
US10150752B2 (en) 2018-12-11
NL1030961C2 (nl) 2007-01-12
US20150322042A1 (en) 2015-11-12
PE20060875A1 (es) 2006-09-04
DOP2006000014A (es) 2006-07-31
UY29339A1 (es) 2006-08-31
ZA200705718B (en) 2008-08-27
ES2334517T3 (es) 2010-03-11
CR9219A (es) 2007-07-24
US20170114040A1 (en) 2017-04-27
US20130137671A1 (en) 2013-05-30
MX2007008757A (es) 2008-03-10
GT200600024A (es) 2006-08-23
EA200701328A1 (ru) 2007-12-28
DK1841758T3 (da) 2010-01-18
NO20074177L (no) 2007-10-16
US7557131B2 (en) 2009-07-07
US20060160786A1 (en) 2006-07-20
ATE449091T1 (de) 2009-12-15
KR20070091023A (ko) 2007-09-06
HK1113927A1 (en) 2008-10-17
WO2006077496A1 (fr) 2006-07-27
GB0501190D0 (en) 2005-03-02
JP4124805B1 (ja) 2008-07-23
MA29160B1 (fr) 2008-01-02
AU2006207300A1 (en) 2006-07-27
CA2595569A1 (fr) 2006-07-27
NO338420B1 (no) 2016-08-15
JP2008528476A (ja) 2008-07-31
PA8660401A1 (es) 2006-09-08

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