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PA8660401A1 - Derivados de triazol sustituidos como antagonistas de oxitocina - Google Patents

Derivados de triazol sustituidos como antagonistas de oxitocina

Info

Publication number
PA8660401A1
PA8660401A1 PA20068660401A PA8660401A PA8660401A1 PA 8660401 A1 PA8660401 A1 PA 8660401A1 PA 20068660401 A PA20068660401 A PA 20068660401A PA 8660401 A PA8660401 A PA 8660401A PA 8660401 A1 PA8660401 A1 PA 8660401A1
Authority
PA
Panama
Prior art keywords
oxitocine
antagonists
derivatives replaced
triazol derivatives
triazol
Prior art date
Application number
PA20068660401A
Other languages
English (en)
Inventor
David Ellis
Alan Daniel Brown
Andrew Antony Calabrese
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of PA8660401A1 publication Critical patent/PA8660401A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A TRIAZOLES SUSTITUIDOS DE FORMULA (I), A SUS USOS, A PROCEDIMINETOS PARA SU PREPARACION Y A COMPOSICIONES QUE CONTIENEN DICHOS COMPUESTOS. ESTOS INHIBIDORES TIENEN UTILIDAD EN DIVERSAS AREAS TERAPEUTICAS INCLUYENDO DISFUNCION SXUAL.
PA20068660401A 2005-01-20 2006-01-20 Derivados de triazol sustituidos como antagonistas de oxitocina PA8660401A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0501190.3A GB0501190D0 (en) 2005-01-20 2005-01-20 Novel pharmaceuticals

Publications (1)

Publication Number Publication Date
PA8660401A1 true PA8660401A1 (es) 2006-09-08

Family

ID=34259404

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20068660401A PA8660401A1 (es) 2005-01-20 2006-01-20 Derivados de triazol sustituidos como antagonistas de oxitocina

Country Status (31)

Country Link
US (5) US7557131B2 (es)
EP (1) EP1841758B1 (es)
JP (1) JP4124805B1 (es)
KR (1) KR100936854B1 (es)
CN (1) CN101107243B (es)
AP (1) AP2007004047A0 (es)
AR (1) AR055303A1 (es)
AT (1) ATE449091T1 (es)
AU (1) AU2006207300B2 (es)
BR (1) BRPI0606463A2 (es)
CA (1) CA2595569C (es)
CR (1) CR9219A (es)
DE (1) DE602006010508D1 (es)
DK (1) DK1841758T3 (es)
DO (1) DOP2006000014A (es)
EA (1) EA200701328A1 (es)
ES (1) ES2334517T3 (es)
GB (1) GB0501190D0 (es)
GT (1) GT200600024A (es)
IL (1) IL184148A (es)
MA (1) MA29160B1 (es)
MX (1) MX2007008757A (es)
NL (1) NL1030961C2 (es)
NO (1) NO338420B1 (es)
PA (1) PA8660401A1 (es)
PE (1) PE20060875A1 (es)
TN (1) TNSN07275A1 (es)
TW (1) TW200637847A (es)
UY (1) UY29339A1 (es)
WO (1) WO2006077496A1 (es)
ZA (1) ZA200705718B (es)

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JPH06284516A (ja) * 1993-03-31 1994-10-07 Mitsubishi Electric Corp 電気車制御装置
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
GB0504556D0 (en) * 2005-03-04 2005-04-13 Pfizer Ltd Novel pharmaceuticals
US20090099200A1 (en) * 2005-06-09 2009-04-16 Chun Sing Li Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
GB0607196D0 (en) * 2006-04-11 2006-05-17 Prosidion Ltd G-protein coupled receptor agonists
WO2007143823A1 (en) * 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
AU2007260528A1 (en) * 2006-06-13 2007-12-21 Merck Frosst Canada Ltd. Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2008133975A1 (en) * 2007-04-26 2008-11-06 Avalon Pharmaceuticals Multi-ring compounds and uses thereof
CA2712701A1 (en) * 2008-01-31 2009-08-06 Henning Steinhagen Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
MX2010007660A (es) 2008-01-31 2010-08-10 Sanofi Aventis Indol-3-carboxamidas ciclicas, su preparacion y su uso como productos farmaceuticos.
CN103435546B (zh) * 2012-07-16 2016-08-10 菲布罗根有限公司 制备异喹啉化合物的方法
US10570146B2 (en) * 2014-07-25 2020-02-25 Northeastern University Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
JP6990702B2 (ja) 2016-11-18 2022-01-13 インテグレーティブ リサーチ ラボラトリーズ スウェーデン アーベー 皮質カテコールアミン作動性神経伝達のモジュレーターとして有用な新規アゼチジン誘導体
CA3047643A1 (en) * 2016-12-21 2018-06-28 Jiangsu Hengrui Medicine Co., Ltd. Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
CN109071492B (zh) * 2016-12-28 2021-02-26 江苏恒瑞医药股份有限公司 氮杂双环基取代的三唑类衍生物、其制备方法及其在医药上的应用
WO2019242646A1 (zh) * 2018-06-20 2019-12-26 江苏恒瑞医药股份有限公司 催产素受体抑制剂的晶型及其制备方法
WO2019242642A1 (zh) * 2018-06-20 2019-12-26 江苏恒瑞医药股份有限公司 一种otr抑制剂的可药用盐、晶型及制备方法
TWI711612B (zh) * 2018-06-27 2020-12-01 大陸商江蘇恒瑞醫藥股份有限公司 氮雜雙環基取代的三唑類衍生物的可藥用鹽、晶型及製備方法
CN113004250B (zh) * 2019-12-19 2022-07-26 上海森辉医药有限公司 一种制备取代的三唑衍生物的方法
CN113582818B (zh) * 2021-08-30 2023-08-01 上海日异生物科技有限公司 一种3-卤-2-烷基苯酚的合成方法
MX2024010096A (es) * 2022-02-16 2024-08-28 Duke Street Bio Ltd Compuesto farmaceutico.
CN114805161B (zh) * 2022-06-14 2023-08-25 南通华祥医药科技有限公司 一种3-氟丫丁啶盐酸盐的制备方法

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Also Published As

Publication number Publication date
NO338420B1 (no) 2016-08-15
JP2008528476A (ja) 2008-07-31
US8207198B2 (en) 2012-06-26
AR055303A1 (es) 2007-08-15
US9023872B2 (en) 2015-05-05
AU2006207300A1 (en) 2006-07-27
DE602006010508D1 (de) 2009-12-31
CR9219A (es) 2007-07-24
BRPI0606463A2 (pt) 2009-06-30
EP1841758B1 (en) 2009-11-18
ES2334517T3 (es) 2010-03-11
IL184148A (en) 2013-06-27
DK1841758T3 (da) 2010-01-18
AU2006207300B2 (en) 2011-03-03
PE20060875A1 (es) 2006-09-04
TNSN07275A1 (fr) 2008-12-31
NO20074177L (no) 2007-10-16
MX2007008757A (es) 2008-03-10
ZA200705718B (en) 2008-08-27
CA2595569C (en) 2010-07-20
US10150752B2 (en) 2018-12-11
GT200600024A (es) 2006-08-23
KR100936854B1 (ko) 2010-01-14
US20060160786A1 (en) 2006-07-20
EP1841758A1 (en) 2007-10-10
GB0501190D0 (en) 2005-03-02
US9394278B2 (en) 2016-07-19
KR20070091023A (ko) 2007-09-06
US20150322042A1 (en) 2015-11-12
UY29339A1 (es) 2006-08-31
WO2006077496A1 (en) 2006-07-27
CN101107243A (zh) 2008-01-16
US20170114040A1 (en) 2017-04-27
HK1113927A1 (en) 2008-10-17
CA2595569A1 (en) 2006-07-27
US20130137671A1 (en) 2013-05-30
JP4124805B1 (ja) 2008-07-23
TW200637847A (en) 2006-11-01
NL1030961A1 (nl) 2006-07-21
MA29160B1 (fr) 2008-01-02
US7557131B2 (en) 2009-07-07
US20090253674A1 (en) 2009-10-08
AP2007004047A0 (en) 2007-06-30
ATE449091T1 (de) 2009-12-15
NL1030961C2 (nl) 2007-01-12
EA200701328A1 (ru) 2007-12-28
DOP2006000014A (es) 2006-07-31
IL184148A0 (en) 2007-10-31
CN101107243B (zh) 2010-11-24

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