ZA200705718B - Substituted triazole derivatives as oxytocin antagnists - Google Patents

Substituted triazole derivatives as oxytocin antagnists

Info

Publication number: ZA200705718B
Authority: ZA; South Africa
Prior art keywords: antagnists; oxytocin; triazole derivatives; substituted triazole; substituted
Prior art date: 2005-01-20

Application number

ZA200705718A

Other languages

English (en)

Inventor

Brown Alan Daniel

Ellis David

Calabrese Andew Antony

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-20

Filing date

2007-07-11

Publication date

2008-08-27

2007-07-11 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2008-08-27 Publication of ZA200705718B publication Critical patent/ZA200705718B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200705718A 2005-01-20 2007-07-11 Substituted triazole derivatives as oxytocin antagnists ZA200705718B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0501190.3A GB0501190D0 (en)	2005-01-20	2005-01-20	Novel pharmaceuticals

Publications (1)

Publication Number	Publication Date
ZA200705718B true ZA200705718B (en)	2008-08-27

Family

ID=34259404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200705718A ZA200705718B (en)	2005-01-20	2007-07-11	Substituted triazole derivatives as oxytocin antagnists

Country Status (31)

Country	Link
US (5)	US7557131B2 (xx)
EP (1)	EP1841758B1 (xx)
JP (1)	JP4124805B1 (xx)
KR (1)	KR100936854B1 (xx)
CN (1)	CN101107243B (xx)
AP (1)	AP2007004047A0 (xx)
AR (1)	AR055303A1 (xx)
AT (1)	ATE449091T1 (xx)
AU (1)	AU2006207300B2 (xx)
BR (1)	BRPI0606463A2 (xx)
CA (1)	CA2595569C (xx)
CR (1)	CR9219A (xx)
DE (1)	DE602006010508D1 (xx)
DK (1)	DK1841758T3 (xx)
DO (1)	DOP2006000014A (xx)
EA (1)	EA200701328A1 (xx)
ES (1)	ES2334517T3 (xx)
GB (1)	GB0501190D0 (xx)
GT (1)	GT200600024A (xx)
IL (1)	IL184148A (xx)
MA (1)	MA29160B1 (xx)
MX (1)	MX2007008757A (xx)
NL (1)	NL1030961C2 (xx)
NO (1)	NO338420B1 (xx)
PA (1)	PA8660401A1 (xx)
PE (1)	PE20060875A1 (xx)
TN (1)	TNSN07275A1 (xx)
TW (1)	TW200637847A (xx)
UY (1)	UY29339A1 (xx)
WO (1)	WO2006077496A1 (xx)
ZA (1)	ZA200705718B (xx)

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AP2007004047A0 (en)	2005-01-20	2007-06-30	Pfizer Ltd	Substituted triazole derivatives as oxtocin antagonists
GB0504556D0 (en) *	2005-03-04	2005-04-13	Pfizer Ltd	Novel pharmaceuticals
EP1902051A1 (en) *	2005-06-09	2008-03-26	Merck Frosst Canada Ltd.	Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
GB0607196D0 (en) *	2006-04-11	2006-05-17	Prosidion Ltd	G-protein coupled receptor agonists
CA2654792A1 (en) *	2006-06-12	2007-12-21	Merck Frosst Canada Ltd.	Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
JP2009539885A (ja) *	2006-06-13	2009-11-19	メルクフロストカナダリミテツド	ステアロイルコエンザイムａデルタ−９デサチュラーゼの阻害剤としてのアザシクロペンタン誘導体
EP2141994A4 (en) *	2007-04-26	2011-05-18	Avalon Pharmaceuticals	POLYCYCLIC COMPOUNDS AND USES THEREOF
MX2010007661A (es)	2008-01-31	2010-08-03	Sanofi Aventis	Azaindol-3-carboxamidas ciclicas, su preparacion y su uso como productos farmaceuticos.
EP2247575B1 (en)	2008-01-31	2016-03-23	Sanofi	Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
CN103435546B (zh) *	2012-07-16	2016-08-10	菲布罗根有限公司	制备异喹啉化合物的方法
WO2016014975A2 (en)	2014-07-25	2016-01-28	Northeastern University	Urea/carbamates faah magl or dual faah/magl inhibitors and uses thereof
JOP20190072A1 (ar) *	2016-10-13	2019-04-07	Glaxosmithkline Ip Dev Ltd	مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
FI3541784T3 (fi)	2016-11-18	2023-10-02	Integrative Res Laboratories Sweden Ab	Uudet atsetidiinijohdannaiset, jotka ovat hyödyllisiä kortikaalisen katekoliamiini-neurotransmission modulaattoreina
KR20190094187A (ko) *	2016-12-21	2019-08-12	지앙수 헨그루이 메디슨 컴퍼니 리미티드	축합 고리기 아자시클로부틸 트리아졸 유도체, 이의 제조 방법 및 의약에서의 이의 용도
MX2019007360A (es) *	2016-12-28	2019-08-16	Jiangsu Hengrui Medicine Co	Derivado de triazol azabiciclo-sustituido, preparacion, metodo del mismo, y aplicacion de la misma en medicina.
CN111094273B (zh) *	2018-06-20	2022-04-12	江苏恒瑞医药股份有限公司	催产素受体抑制剂的晶型及其制备方法
TW202016091A (zh) *	2018-06-20	2020-05-01	大陸商江蘇恆瑞醫藥股份有限公司	一種ｏｔｒ抑制劑的可藥用鹽、晶型及製備方法
WO2020001460A1 (zh) *	2018-06-27	2020-01-02	江苏恒瑞医药股份有限公司	氮杂双环基取代的三唑类衍生物的可药用盐、晶型及制备方法
CN113004250B (zh) *	2019-12-19	2022-07-26	上海森辉医药有限公司	一种制备取代的三唑衍生物的方法
CN113582818B (zh) *	2021-08-30	2023-08-01	上海日异生物科技有限公司	一种3-卤-2-烷基苯酚的合成方法
EP4444305A2 (en) *	2022-02-16	2024-10-16	Duke Street Bio Limited	Pharmaceutical compound
CN114805161B (zh) *	2022-06-14	2023-08-25	南通华祥医药科技有限公司	一种3-氟丫丁啶盐酸盐的制备方法

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WO2005082866A2 (en) *	2004-02-20	2005-09-09	Pfizer Limited	Substituted 1, 2, 4- triazole derivatives as oxytocin antagonists
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2005
- 2005-01-11 AP AP2007004047A patent/AP2007004047A0/xx unknown
- 2005-01-20 GB GBGB0501190.3A patent/GB0501190D0/en not_active Ceased
2006
- 2006-01-11 DK DK06710261.6T patent/DK1841758T3/da active
- 2006-01-11 MX MX2007008757A patent/MX2007008757A/es active IP Right Grant
- 2006-01-11 EP EP06710261A patent/EP1841758B1/en active Active
- 2006-01-11 EA EA200701328A patent/EA200701328A1/ru unknown
- 2006-01-11 CN CN2006800028617A patent/CN101107243B/zh not_active Expired - Fee Related
- 2006-01-11 BR BRPI0606463-9A patent/BRPI0606463A2/pt not_active IP Right Cessation
- 2006-01-11 KR KR1020077016553A patent/KR100936854B1/ko not_active Expired - Fee Related
- 2006-01-11 AU AU2006207300A patent/AU2006207300B2/en not_active Ceased
- 2006-01-11 AT AT06710261T patent/ATE449091T1/de not_active IP Right Cessation
- 2006-01-11 ES ES06710261T patent/ES2334517T3/es active Active
- 2006-01-11 DE DE602006010508T patent/DE602006010508D1/de active Active
- 2006-01-11 CA CA2595569A patent/CA2595569C/en active Active
- 2006-01-11 WO PCT/IB2006/000118 patent/WO2006077496A1/en not_active Ceased
- 2006-01-11 JP JP2007551766A patent/JP4124805B1/ja not_active Expired - Fee Related
- 2006-01-17 PE PE2006000072A patent/PE20060875A1/es not_active Application Discontinuation
- 2006-01-17 DO DO2006000014A patent/DOP2006000014A/es unknown
- 2006-01-18 AR ARP060100188A patent/AR055303A1/es unknown
- 2006-01-18 UY UY29339A patent/UY29339A1/es active IP Right Grant
- 2006-01-19 TW TW095102071A patent/TW200637847A/zh unknown
- 2006-01-19 NL NL1030961A patent/NL1030961C2/nl not_active IP Right Cessation
- 2006-01-19 GT GT200600024A patent/GT200600024A/es unknown
- 2006-01-20 US US11/335,940 patent/US7557131B2/en active Active
- 2006-01-20 PA PA20068660401A patent/PA8660401A1/es unknown
2007
- 2007-06-21 IL IL184148A patent/IL184148A/en active IP Right Grant
- 2007-07-02 CR CR9219A patent/CR9219A/es not_active Application Discontinuation
- 2007-07-11 ZA ZA200705718A patent/ZA200705718B/xx unknown
- 2007-07-19 TN TNP2007000275A patent/TNSN07275A1/fr unknown
- 2007-07-20 MA MA30089A patent/MA29160B1/fr unknown
- 2007-08-14 NO NO20074177A patent/NO338420B1/no unknown
2009
- 2009-05-15 US US12/466,785 patent/US8207198B2/en not_active Expired - Fee Related
2012
- 2012-05-23 US US13/478,384 patent/US9023872B2/en active Active
2015
- 2015-04-20 US US14/691,319 patent/US9394278B2/en not_active Expired - Fee Related
2016
- 2016-06-28 US US15/195,480 patent/US10150752B2/en active Active

Also Published As

Publication number	Publication date
CA2595569C (en)	2010-07-20
UY29339A1 (es)	2006-08-31
BRPI0606463A2 (pt)	2009-06-30
CR9219A (es)	2007-07-24
JP2008528476A (ja)	2008-07-31
US9394278B2 (en)	2016-07-19
AR055303A1 (es)	2007-08-15
HK1113927A1 (en)	2008-10-17
US9023872B2 (en)	2015-05-05
PE20060875A1 (es)	2006-09-04
NL1030961C2 (nl)	2007-01-12
AP2007004047A0 (en)	2007-06-30
TNSN07275A1 (fr)	2008-12-31
EP1841758A1 (en)	2007-10-10
DE602006010508D1 (de)	2009-12-31
NL1030961A1 (nl)	2006-07-21
ATE449091T1 (de)	2009-12-15
AU2006207300B2 (en)	2011-03-03
US20060160786A1 (en)	2006-07-20
US10150752B2 (en)	2018-12-11
CA2595569A1 (en)	2006-07-27
US20150322042A1 (en)	2015-11-12
DOP2006000014A (es)	2006-07-31
NO20074177L (no)	2007-10-16
WO2006077496A1 (en)	2006-07-27
US20170114040A1 (en)	2017-04-27
JP4124805B1 (ja)	2008-07-23
EP1841758B1 (en)	2009-11-18
US8207198B2 (en)	2012-06-26
GT200600024A (es)	2006-08-23
TW200637847A (en)	2006-11-01
CN101107243A (zh)	2008-01-16
DK1841758T3 (da)	2010-01-18
MA29160B1 (fr)	2008-01-02
MX2007008757A (es)	2008-03-10
PA8660401A1 (es)	2006-09-08
GB0501190D0 (en)	2005-03-02
US20090253674A1 (en)	2009-10-08
US20130137671A1 (en)	2013-05-30
KR100936854B1 (ko)	2010-01-14
AU2006207300A1 (en)	2006-07-27
CN101107243B (zh)	2010-11-24
IL184148A0 (en)	2007-10-31
KR20070091023A (ko)	2007-09-06
IL184148A (en)	2013-06-27
US7557131B2 (en)	2009-07-07
NO338420B1 (no)	2016-08-15
EA200701328A1 (ru)	2007-12-28
ES2334517T3 (es)	2010-03-11

Publication	Publication Date	Title
ZA200705718B (en)	2008-08-27	Substituted triazole derivatives as oxytocin antagnists
ZA200707911B (en)	2008-10-29	HSP90-Inhibiting triazole derivatives
EP1847531A4 (en)	2009-04-22	PYRAZOLE DERIVATIVE
IL190450A0 (en)	2008-11-03	Substituted pyrazole compounds
ZA200709994B (en)	2008-11-26	Neurotherapeutic Azole Compounds
GB0500492D0 (en)	2005-02-16	Compound
EP1942105A4 (en)	2011-06-15	AMINODIHYDROTHIAZINE DERIVATIVE
GB0513702D0 (en)	2005-08-10	Compound
IL195278A0 (en)	2009-08-03	Triazole derivatives ii
GB0506133D0 (en)	2005-05-04	Compound
ZA200806358B (en)	2009-12-30	Triazole Derivatives
IL184006A0 (en)	2007-10-31	1h-imidiazole derivatives as cannabinoid
PL1988083T3 (pl)	2014-08-29	Pochodna triazolowa
EP1871766A4 (en)	2010-07-21	TRIAZONE DERIVATIVES WITH ANTIPILY EFFECT
GB0520955D0 (en)	2005-11-23	Compound
IL184841A0 (en)	2007-12-03	Substituted aminoalkyl-and amidoalkyl-benzopyran derivatives
IL186107A0 (en)	2008-01-20	Pyridylmethylsulfone derivative
IL184559A0 (en)	2007-10-31	Imidazole derivatives
EP1951705A4 (en)	2010-12-15	NEW ANTIFUNGAL TRIAZOLE DERIVATIVES
ZA200711025B (en)	2008-12-31	N-dihydroxyalkyl-substituted 2-oxoimidazole derivative
AP2007004220A0 (en)	2007-10-31	Motilide compounds
ZA200802786B (en)	2009-03-25	Substituted pyrazole compounds
GB0525323D0 (en)	2006-01-18	Compound
GB0509829D0 (en)	2005-06-22	Compound
EP1907385A4 (en)	2009-05-06	LINKS