SU1264947A1 - Method of treatment of nonspecific ulcerative colitis with total injure of large intestine - Google Patents

Abstract

This invention relates to the field of medicine. The purpose of the invention is to reduce the time of treatment and lengthen the time of remission of nonspecific ulcerative colitis. To this end, patients suffering from nonspecific ulcerative colitis with a total lesion of the large intestine are prescribed one of the corticosteroids, for example, prednisone 50 mg, and salicylazosulfanilamide 5 g for two weeks. The treatment is carried out according to a regimen with a gradual decrease in prednisolone every 5 days. 5 mg to cancel. At the same time, a dose of 1.5 g is added to the treatment. After discontinuation of prednisolone, the dose of sulfasalazine is reduced to .2.5 g, and the dose of proectin is 0.75 g. These drugs are administered in average daily doses before the onset of clinical effect. th od 4a co 4 vj

Description

The invention relates to medicine.

The purpose of the invention is the reduction of treatment time and lengthening the duration of remission of ulcerative colitis.

Example 1. Patient P., 43 years old, was admitted to the Research Institute of Proctology M3 of the RSFSR with complaints of frequent loose stools up to 20 times a day, mixed with mucus and blood, false desires with bloody & licking, tenesmus, constant abdominal pain subsiding after bowel movements, weakness, dry mouth, joint pain., weight loss.

Nonspecific ulcerative colitis is sick for 7 years. The course of the process is chronically relapsing with exacerbations in the autumn-winter period requiring inpatient treatment. Real severe exacerbation for 6 months. using in the treatment of prednisone at a dose of 60 mg. The patient's condition has improved, but with. In an attempt to reduce the dose of hormones below 15 mg, the condition worsened.

Upon admission, the patient is in serious condition. Proper physique, low nutrition. Visible mucous membranes are pale, skin is clean. From the respiratory and circulatory organs, pathological changes were not detected. Pulse 92 beats / min BP = 110 / / 70 mmHg The tongue is overlaid. The abdomen is soft, painful along the colon, there are no symptoms of peritoneal irritation. The liver and spleen are not palpable. There is no dysuria ..

During the examination, the diagnosis was established: ulcerative colitis, total, chronically continuous course, severe, intestinal dysbiosis.

In connection with the serious condition of the patient, surgical treatment was offered, but in connection with a categorical refusal, it was decided to conduct conservative treatment. 50 mg prednisolone and 5 g sulfasalazine were prescribed for two weeks. Then, prodectin at a dose of 1.5 g was added to the treatment, while the dose of prednisolone was reduced to 20 mg. Then, prednisone was reduced every 5 days. 5 mg until complete withdrawal. After the withdrawal of prednisolone, the dose of sulfasalazine was reduced to 2.5 g.

and prodectin up to 0.75 g. The treatment period was 5 weeks.

After the treatment, she was discharged in a state of remission, which 5 was noted. Within 12 months.

EXAMPLE 2, A 70-year-old patient was admitted to the Research Institute of Proctology M3 of the RSFSR complaining of frequent false urges up to 15 times with mucus and blood discharge, weight loss over the past 1.5 years by 7 kg. .

I have been ill with ulcerative colitis for 10 years. In recent years, exacerbations are more severe.

Upon admission, the patient's condition is relatively satisfactory. The skin is pale. In the lungs, harsh breathing. Heart sounds are muffled, rhythmic. Pulse 95 bpm

HELL = 160/90 mm Hg The tongue is wet, coated with a white coating. The abdomen is significantly swollen, with palpation painful along the colon. The liver protrudes from under the edge of the costal arch, its edge is dense, smooth. The spleen is not palpable. There is no dysuria.

During the examination, the diagnosis was established: nonspecific ulcerative colitis, total, chronically relapsing30 infection, medium-severe form. Colon pseudopolyposis. Iron deficiency hypochromic anemia. Sigmoid colon stricture.

The treatment was carried out: prednisone 30 mg, sulfasalazine in a dose of 4 g, for 2 weeks. Then, prodectin in a dose of 1.5 was added to the treatment. g, and the dose of prednisolone was reduced to 20 mg with its subsequent decrease by 40 5 mg every 5 days until it is completely canceled. After canceling prednisolone, the dose of sulfasalazine and prodectin was halved. The duration of treatment was 5 weeks, I

Discharged in remission, which lasted 18 months.

Claims (1)

The invention relates to the medicine of the invention - reducing the time of treatment and lengthening the time of remission of nonspecific ulcerative colitis. An example. Patient P., 43 years old, was admitted to the Research Institute of Proctology of the Ministry of Health of the RSFSR with complaints of frequent loose stools up to 20 times a day, with an admixture of mucus and blood, false desires with bleeding, tenesmus, persistent abdominal pain, subsiding after stool, weakness5 dry mouth, joint pain., weight loss. Nonspecific ulcer colitis has been ill for 7 years. The course of the process is a chronic recurrence with exacerbations of the autumn-winter period, requiring inpatient treatment. The present severe exacerbation is within 6 months, with the use of prednisolone 60 mg in the therapy. The patient's condition improved, but at. an attempt to reduce the dose of hormones below 15 mg, the condition worsened. On admission, the patient's condition is severe. Proper physique, reduced nutrition. Visible mucous pale, skin is clean. No pathological changes have been identified on the part of the organs of blood flow and blood circulation. Pulse 92 beats / min / 70 mm Hg The language is overlaid. Mild abdomen 5 painful along the fat. there are no symptoms of peritoneal irritation. The liver and spleen do not palpate. Dysuria is not. The examination diagnosed; nonspecific ulcerative colitis, total, chronically continuous flow, severe, dysbacteriosis of the boder. In connection with the serious condition of the patient, surgical treatment was suggested, but due to a categorical refusal, it was decided to conduct a conservative treatment. Prednisone was administered at a dose of 50 mg and sul fasalazin at a dose of 5 g over a period of weeks. Then, prodectin in a dose of 1.5 tons was added to the treatment, at the same time, but the dose of prednisone was reduced to 20 mg. Then the prednisone was reduced every 5 days. 5 mg to cancel. After the abolition of prednisolone, the wife received a dose of sulfasalazine up to r = 472 and proectin up to Oj75 g. The treatment time was 5 weeks. After the treatment, he was discharged in the state of remission, which was observed. For 12 months. PRI me R 2, A 70-year-old patient was admitted to the Research Institute of Proctology of the Ministry of Health of the RSFSR with complaints of frequent false desires up to 15 times with mucus and cross loss over the past 1.5 years by 7 kg. Nonspecific ulcer colitis has been ill for 10 years. In recent years, sharpening flows are more severe. On admission, the patient’s condition is relatively satisfactory. Pale skin, In the lungs breathing hard. Heart sounds are dimmed, rhythmic. Pulse 95 beats./min, HELL 160/90 mm Hg Tongue moist, furred with bloom patina. The abdomen is much swollen, with palpation painful along the large intestine. The liver protrudes from under the edge of the costal arch, its edge is dense and smooth. The spleen is not palpable. There is no dysuria. The examination diagnosed; nonspecific ulcerative colitis, a total, chronically relapsing course, medium to moderate form. Pseudopolyposis of the colon, Iron deficiency g lame anemia. . Stricture of the sigmoid colon. Treatment: prednisone 30 mg, sulfasalazine at a dose of 4 g, for 2 weeks. Then, proectin at a dose of 1.5 g is added to treatment, and the dose of prednisolone is reduced to 20 mg, followed by a decrease of 5 mg every 5 days to full cancellation, After the abolition of prednisone, the dose of sulfasalazine and prodehtin was halved The treatment time was 5 weeks. Mr. Vitan in remission, which lasted 18 months. The claims of the invention; and a method for treating nonspecific ulcerative colitis with a total lesion of the colon by administering salncylase sulfanilamide and corticosteroids according to a scheme with a gradual decrease in the dose of corticosteroids until they are completely canceled, characterized in that in order to shorten the treatment time and lengthen the period of remission, these preparations You are administered in reduced to average daily doses before the onset of the clinical effect, then additionally administered with a secreta while simultaneously reducing the dose of the steroids to their prevalence. lnoy canceled, then twice lower dose salitsilazosulfanilamidov.