RU2008001C1 - Method for prophylaxis and treatment of cancer of various localizations - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves the use of biguamides in combination with preparations of thyroid gland, cholagogues and vitamin C against the background of diet No. 9. EFFECT: restoration of immunity of organism tissues to cancer cells.

Description

 The invention relates to medicine, namely to oncology.

 About 40 drugs are used as drug therapy for cancer of various localization.

 The disadvantage of using these drugs is severe complications from normal organs and tissues. Of these, leukopenia most often occurs, up to agranulocytosis, enterocolitis, dystrophic changes in parenchymal organs.

 The aim of the proposed method is to restore anti-cancer immunity, which contributes to the destruction of cancer cells in any location without harming healthy tissues of the body, with a large cancerous tumor, localize it, prevent the development of metastases.

 The essence of the method consists in the appointment of biguanides in combination with thyroid preparations, choleretic and vitamin C in conventional therapeutic doses to patients with cancer, which helps to restore the immunity of body tissues to cancer cells, since the function of phagocytic lymphocytes improves due to improved regulation of cholesterol metabolism . Oxygen starvation of healthy tissues is reduced (oxygen deficiency is favorable for the development of the cancer process).

 The decision on the appropriateness of using the proposed method for various localization of cancer was made based on the following study.

 Monitoring of 2 groups of patients aged 50-80 years for 6 years showed that in 80 patients treated with diet No. 9 in combination with biguanides, thyroid preparations, choleretic and vitamin C in usual therapeutic doses, there was no development of cancerous tumors. In the control group of 180 people who did not use this complex of treatment, 27 developed cancer of various localization.

 Based on this, it was concluded that the proposed method has the ability to restore anti-cancer immunity, which can be used in the prevention and treatment of cancer of various localization.

 Contraindications - common for the use of drugs specified in the method.

 The method has ease of reproduction, allows for therapeutic and prophylactic purposes to cover a wide range of patients.

 Medicines are used approved by the pharmacological committee in authorized doses.

 The method is not effective for cachexia and obstructive jaundice due to liver metastases.

 PRI me R. Patient G., 80 years old, was admitted 06.06. 82 to the hospital due to persistent epigastric pain during the year, decreasing from drugs, vomiting, weakness, weight loss by 12 kg over the past year. With fibrogastroscopy on July 11, 81, gastric cancer was detected that was localized in the middle third of the stomach to the pylorus. They abstained from surgical treatment in connection with coronary heart disease. Objectively: a serious condition. The skin is pale. Peripheral lymph nodes are not enlarged. The boundaries of the lungs are normal. The vesicular breathing, the heart - the borders are normal, the tones are muffled. Tongue dry with a gray coating. The abdomen is soft, painful in the epigastrium. The liver and spleen are not enlarged.

 Upon admission to the an. red blood cells - 2,000,000, hemoglobin - 130, color indicator - 0.9, white blood cells - 3900, segments - 39, lymphocytes - 60, monocytes - 1, ESR - 53 mm / hour. Blood sugar - 8 mmol / l, cholesterol - 8.

 On 9.06.82, diformin retard 2000 mg per day, thyroidcomb 1 ton in the morning, vitamin C at 0.05 3 r / d, tyubage with magnesium sulfate 33% 100 ml 1 time per month were prescribed. After 7 days, the pain in the epigastrium disappeared, nausea, vomiting, weakness, appetite appeared, increased in body weight.

 06/16/82 drugs are canceled.

 07/23/82 in an. erythrocytes - 3500000, hemoglobin - 120, color indicator - 1, leukocytes - 3500, eosinophils - 2, segments - 58, lymphocytes - 36, monocytes - 7, ESR - 11, blood sugar - 7 mmol / l, cholesterol - 5.

 Discharged with improvement.

 Patient M., 53 years old, 09/13/91, was admitted with complaints of weakness, dry mouth, weight loss.

 In August 1991, malignant corticoandrosteroma of the left adrenal gland with metastases to the retroperitoneal lymph nodes, lungs, and skeleton bones was revealed. 08/27/91 surgical treatment was performed - left-sided adrenalectomy, but the condition continued to deteriorate. Due to bone pain, drugs are prescribed.

 Objectively: a serious condition. Male type hair. Percussion pulmonary sound above the lungs, vesicular breathing. Pulse - 70 beats in one minute, rhythmic. AD-130/80 mm RT. Art. Heart - borders are normal, tones are muffled. The tongue is wet with a gray coating. The abdomen is soft, painful in the right hypochondrium. The liver and spleen are not enlarged. The kidneys are not palpable.

Research conducted:
An. blood September 14, 91 g - hemoglobin - 109, red blood cells - 3.5, color indicator - 0.89, white blood cells - 7.3, p - 4%, s - 69%, lymphocytes - 23%, monocytes - 4%, ESR - 48 mm / h. Cholesterol - 8. Sugar - 9 mmol / l. After the appointment of glibutide 2 t x 2 times a day, thyrocomb 1 t in the morning, vitamin C at 0.05 3 r / d, tubas with magnesium sulfate 33% 100 ml once a month, the condition began to improve progressively. Bone pains subsided, drugs were canceled, body weight increased by 3 kg. Blood counts improved. 09/23/91 - hemoglobin 121, red blood cells 3.8, color indicator 0.96, white blood cells 7.0, s - 60%, lymphocytes 24%, ESR - 40 mm / h. Cholesterol 7, sugar 7 mmol / L.

 Patient Yu., 59 years old, 08/12/91. G. entered with complaints of growing weakness, lethargy, weight loss, headache, dry mouth.

 In 1979, he underwent surgery for craniopharyngiomas, after which manifestations of hypogonadism developed. Deterioration in the last year.

 Objectively: the condition is relatively satisfactory. Nutrition lowered. There is no hair growth on the face, axillary areas, pubis. Above the lungs - percussion clear pulmonary sound, vesicular breathing. Heart - borders are normal, tones are muffled. Pulse 70 beats. in one minute, rhythmic. HELL 110/70 mm RT. Art. The tongue is wet with a gray coating. The abdomen is soft, painless. The liver and spleen are not enlarged. The kidneys are not palpable.

 Total blood test 08/13/91 - hemoglobin 113, red blood cells 3.4, color indicator 0.99, white blood cells 5.2, stab 2, segments 50, lymphocytes 40, monocytes 7, ESR 49 mm / h, cholesterol 8, sugar 7 8 mmol / L.

 X-ray of the skull and the Turkish saddle 08/14/91 - the Turkish saddle is round in shape, enlarged in vertical size with a sharply porous back and calcification fragments in the projection of the pituitary gland.

 CT scan of the brain with contrast - a pituitary tumor with retro - and superasilar growth. The patient refused the proposed surgical treatment.

 After the appointment of glibutide 2 t x 2 times a day, thyrocomb 1 t in the morning, vitamin C at 0.05 x 3 times a day, tubes with magnesium sulfate 33% - 100 ml 1 time per month. The condition began to improve, weakness and headache disappeared, gained 2.5 kg in body weight, and blood tests improved on 12.09. 91. g. - hemoglobin 130, red blood cells 4.3, color indicator 0.9, white blood cells 5.4, p-2, s-50, l-40, m-7, ESR-9. Discharged with improvement.

 Patient G., 57 years old, was admitted with complaints of severe weakness, weight loss, pain in the ribs, spine, limbs.

 In November 1983, she underwent a right-sided mastectomy for breast cancer followed by radiation therapy. However, bone metastases subsequently developed (confirmed by radiography). Prescribed drugs.

Objectively: a serious condition. Severe swelling of the face and right arm. On the chest on the right (in the area of surgery on the mammary gland) postoperative scar. Soreness when striking ribs, spine, lower legs. The temperature is 38 ^o C. The pulse is 110 per minute, rhythmic. HELL 140/80 mm RT. Art. Above the lungs - percussion clear pulmonary sound, vesicular breathing. The borders of the heart are normal, the tones are muffled. The tongue is wet with a gray coating. The abdomen is soft, painful in the right hypochondrium. The liver and spleen are not enlarged.

 An. blood upon admission: hemoglobin 86, red blood cells 2200000, col. pok. 0.75, lake. 10,000, myelocytes 10%, s-6%, n-15%, s-47%, lymph. -13, mon-9, ESR-74 mm / h. Cholesterol 9, sugar 8 mmol / L. Diet N 9, diformin retard 2000 mg per day, thyrocomb 1 ton in the morning, vitamin C at 0.05 x 3 r per day, tyubage with magnesium sulfate 33% - 100 ml once a month were prescribed. The condition has improved significantly. Weakness, pain in the limbs and ribs, spine, swelling of the face, hands decreased. Drugs canceled.

 In an. blood at discharge hemoglobin increased 96, red blood cells 2400000, col. pok. 1.4, lake. 7.0, myelocytes - 4%, s-6%, n-11, sigma. 54%, lymph. 2%, mon 15%, ESR-70. Cholesterol 7, sugar - 6 mmol / L.

 Patient G., 79 years old, was admitted 8.02.85 with complaints of progressive weakness, weight loss, bleeding from the rectum, pain in hypogastria during an act of defecation.

 In sigmoidoscopy in November 1984, rectal cancer was detected. Surgical treatment did not take place, because the course of coronary heart disease worsened.

Objectively: a serious condition. Temperature 38 ^° C. Above the lungs, percussion clear pulmonary sound. Vesicular breathing. The heart is normal. The tones are muffled. Pulse 90 rpm rhythmic. HELL 150/75 mm RT. Art. The abdomen is soft, painful in the sigmoid colon. The liver and spleen are not enlarged.

 In an. blood 9.02.85 g. erythra. 3490000, hemoglobin - 106, col. pok. 0.9, lake. 5300, segments 83%, lymph. - 7%, mon-8%, ESR-33 mm / h. Sugar-8.0 mmol / L, cholesterol 8.

02/11/85, prescribed formin retard 2000 mg / day, thyroidcomb 1 t, vitamin C 0.05 x 3 times a day, cholensim 2 t x 3 times a day. The condition has improved. Temperature 36.8 ^о С. I added 6 kg in 1 month. Abdominal pain, intestinal bleeding disappeared. 02.28.85 an. blood - red blood cells 3900000, hemoglobin 120, col. pok. 0.92, lake. -4500, e-5%, s-57%, lymph. -35%, mon-3%, ESR-20 mm / h. Sugar 6 mmol /, cholesterol 5. (56) Blokhin N.N. Clinical oncology 1971, v. 1, p. 422, 27-28.

Claims (1)

 METHOD FOR PREVENTING AND TREATING CANCER OF VARIOUS LOCALIZATION by using drugs, characterized in that, in order to restore the body's immunity to cancer cells, biguamides are used as drugs in combination with thyroid preparations, choleretic and vitamin C in therapeutic doses against a background of diet N 9.