SK13682003A3 - Dihydrobenzo[b][1,4]diazepin-2-ónové deriváty ako mGluR2 antagonisty II - Google Patents

Dihydrobenzo[b][1,4]diazepin-2-ónové deriváty ako mGluR2 antagonisty II Download PDF

Info

Publication number: SK13682003A3
Authority: SK; Slovakia
Prior art keywords: phenyl; butyl ester; diazepin; mmol; methyl
Prior art date: 2001-04-12

Application number

SK1368-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Geo Adam

Erwin Goetschi

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-02

Publication date

2004-07-07

2002-04-02 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2004-07-07 Publication of SK13682003A3 publication Critical patent/SK13682003A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK1368-2003A 2001-04-12 2002-04-02 Dihydrobenzo[b][1,4]diazepin-2-ónové deriváty ako mGluR2 antagonisty II SK13682003A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109125		2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number	Publication Date
SK13682003A3 true SK13682003A3 (sk)	2004-07-07

Family

ID=8177126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1368-2003A SK13682003A3 (sk)	2001-04-12	2002-04-02	Dihydrobenzo[b][1,4]diazepin-2-ónové deriváty ako mGluR2 antagonisty II

Country Status (37)

Country	Link
US (1)	US6544985B2 (es)
EP (1)	EP1379511B1 (es)
JP (1)	JP4071115B2 (es)
KR (1)	KR100566171B1 (es)
CN (1)	CN1264825C (es)
AR (1)	AR035816A1 (es)
AT (1)	ATE299868T1 (es)
AU (1)	AU2002312788B2 (es)
BG (1)	BG108254A (es)
BR (1)	BR0208891A (es)
CA (1)	CA2442557C (es)
CZ (1)	CZ20033003A3 (es)
DE (1)	DE60205100T2 (es)
DK (1)	DK1379511T3 (es)
EC (1)	ECSP034797A (es)
ES (1)	ES2246012T3 (es)
GT (1)	GT200200073A (es)
HR (1)	HRP20030792A2 (es)
HU (1)	HUP0400851A3 (es)
IL (2)	IL157873A0 (es)
JO (1)	JO2285B1 (es)
MA (1)	MA27012A1 (es)
MX (1)	MXPA03009311A (es)
MY (1)	MY140271A (es)
NO (1)	NO20034576L (es)
NZ (1)	NZ528315A (es)
PA (1)	PA8543301A1 (es)
PE (1)	PE20021041A1 (es)
PL (1)	PL367064A1 (es)
PT (1)	PT1379511E (es)
RU (1)	RU2263112C2 (es)
SI (1)	SI1379511T1 (es)
SK (1)	SK13682003A3 (es)
UY (1)	UY27258A1 (es)
WO (1)	WO2002083652A1 (es)
YU (1)	YU79003A (es)
ZA (1)	ZA200307243B (es)

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JP4708438B2 (ja)	2005-02-11	2011-06-22	エフ．ホフマン−ラロシュアーゲー	ｍＧｌｕＲ２アンタゴニストとしてのピラゾロピリミジン誘導体
AU2006226669B2 (en)	2005-03-23	2011-12-08	F. Hoffmann-La Roche Ag	Acetylenyl-pyrazolo-pvrimidine derivatives as mGluR2 antagonists
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TW200927731A (en) *	2007-09-14	2009-07-01	Ortho Mcneil Janssen Pharm	1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
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CN102232074B (zh)	2008-11-28	2014-12-03	奥梅-杨森制药有限公司	作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
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CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
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WO2014100438A1 (en)	2012-12-20	2014-06-26	The Broad Institute, Inc.	Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
RU2018138028A (ru)	2012-12-28	2019-03-21	Кристалдженомикс, Инк.	Производные 2,3-дигидро-изоиндол-1-она и способы их применения в качестве ингибиторов тирозинкиназы брутона
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
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2002
- 2002-04-02 HR HR20030792A patent/HRP20030792A2/hr not_active Application Discontinuation
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 EP EP02737911A patent/EP1379511B1/en not_active Expired - Lifetime
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 AT AT02737911T patent/ATE299868T1/de not_active IP Right Cessation
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 AU AU2002312788A patent/AU2002312788B2/en not_active Ceased
- 2002-04-02 KR KR1020037013300A patent/KR100566171B1/ko not_active Expired - Fee Related
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 CA CA002442557A patent/CA2442557C/en not_active Expired - Fee Related
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/en not_active Ceased
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 BR BR0208891-6A patent/BR0208891A/pt not_active Application Discontinuation
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-02 SK SK1368-2003A patent/SK13682003A3/sk unknown
- 2002-04-03 US US10/115,826 patent/US6544985B2/en not_active Expired - Fee Related
- 2002-04-09 PA PA20028543301A patent/PA8543301A1/es unknown
- 2002-04-09 AR ARP020101290A patent/AR035816A1/es not_active Application Discontinuation
- 2002-04-10 PE PE2002000291A patent/PE20021041A1/es not_active Application Discontinuation
- 2002-04-10 JO JO200232A patent/JO2285B1/en active
- 2002-04-11 GT GT200200073A patent/GT200200073A/es unknown
- 2002-04-11 UY UY27258A patent/UY27258A1/es not_active Application Discontinuation
- 2002-04-11 MY MYPI20021345A patent/MY140271A/en unknown
2003
- 2003-09-11 IL IL157873A patent/IL157873A/en not_active IP Right Cessation
- 2003-09-16 ZA ZA200307243A patent/ZA200307243B/en unknown
- 2003-10-08 MA MA27346A patent/MA27012A1/fr unknown
- 2003-10-08 EC EC2003004797A patent/ECSP034797A/es unknown
- 2003-10-10 BG BG108254A patent/BG108254A/bg unknown
- 2003-10-10 NO NO20034576A patent/NO20034576L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20020193367A1 (en)	2002-12-19
CA2442557A1 (en)	2002-10-24
ES2246012T3 (es)	2006-02-01
CZ20033003A3 (cs)	2004-05-12
CN1264825C (zh)	2006-07-19
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Publication	Publication Date	Title
RU2263112C2 (ru)	2005-10-27	ПРОИЗВОДНЫЕ ДИГИДРОБЕНЗО[b][1,4]ДИАЗЕПИН-2-ОНА В КАЧЕСТВЕ АНТАГОНИСТОВ MGLUR2 II
US6548495B2 (en)	2003-04-15	Dihydro-benzo [B] [1,4] diazepin-2-one derivatives
AU2002312788A1 (en)	2003-04-10	Dihydro-benzo [b] [1, 4] diazepin-2-one derivatives as mGluR2 antagonists II
US6960578B2 (en)	2005-11-01	Glutamate receptor antagonists
AU2002310912A1 (en)	2003-04-10	Dihydro-benzo[b][1,4]diazepin-2-one derivatives as mGluR2 antagonists I
CZ20021653A3 (cs)	2002-08-14	Nové deriváty benzodiazepinu
RU45093U1 (ru)	2005-04-27	Пылеуловитель