ATE299868T1 - Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten - Google Patents

Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten

Info

Publication number: ATE299868T1
Authority: AT; Austria
Prior art keywords: diazepine; benzo; dihydro; derivatives; mglur2 antagonists
Prior art date: 2001-04-12

Application number

AT02737911T

Other languages

English (en)

Inventor

Geo Adam

Erwin Goetschi

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-02

Publication date

2005-08-15

2002-04-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE299868T1 publication Critical patent/ATE299868T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02737911T 2001-04-12 2002-04-02 Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten ATE299868T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109125		2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number	Publication Date
ATE299868T1 true ATE299868T1 (de)	2005-08-15

Family

ID=8177126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02737911T ATE299868T1 (de)	2001-04-12	2002-04-02	Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten

Country Status (37)

Country	Link
US (1)	US6544985B2 (de)
EP (1)	EP1379511B1 (de)
JP (1)	JP4071115B2 (de)
KR (1)	KR100566171B1 (de)
CN (1)	CN1264825C (de)
AR (1)	AR035816A1 (de)
AT (1)	ATE299868T1 (de)
AU (1)	AU2002312788B2 (de)
BG (1)	BG108254A (de)
BR (1)	BR0208891A (de)
CA (1)	CA2442557C (de)
CZ (1)	CZ20033003A3 (de)
DE (1)	DE60205100T2 (de)
DK (1)	DK1379511T3 (de)
EC (1)	ECSP034797A (de)
ES (1)	ES2246012T3 (de)
GT (1)	GT200200073A (de)
HR (1)	HRP20030792A2 (de)
HU (1)	HUP0400851A3 (de)
IL (2)	IL157873A0 (de)
JO (1)	JO2285B1 (de)
MA (1)	MA27012A1 (de)
MX (1)	MXPA03009311A (de)
MY (1)	MY140271A (de)
NO (1)	NO20034576L (de)
NZ (1)	NZ528315A (de)
PA (1)	PA8543301A1 (de)
PE (1)	PE20021041A1 (de)
PL (1)	PL367064A1 (de)
PT (1)	PT1379511E (de)
RU (1)	RU2263112C2 (de)
SI (1)	SI1379511T1 (de)
SK (1)	SK13682003A3 (de)
UY (1)	UY27258A1 (de)
WO (1)	WO2002083652A1 (de)
YU (1)	YU79003A (de)
ZA (1)	ZA200307243B (de)

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EP1925614A1 (de) *	2002-03-28	2008-05-28	Wisys Technology Foundation, Inc.	Anxiolytische Mittel mit reduzierter sedativer und ataxischer Wirkung
KR100865410B1 (ko)	2002-03-28	2008-10-24	위시스 테크놀로지 파운데이션, 인크.	진정 및 운동실조 효과가 감소된 항불안제
SI1651234T1 (sl) *	2003-07-25	2008-02-29	Hoffmann La Roche	Kombinacija antagonista mglur2 in inhibitorja ache za zdravljenje akutnih in/ali kronicnih nevroloskih motenj
US7329662B2 (en)	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
US20060160823A1 (en) *	2004-05-28	2006-07-20	Leonore Witchey-Lakshmanan	Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
AU2005254657B2 (en) *	2004-06-21	2011-03-17	F. Hoffmann-La Roche Ag	Pyrrazolo-pyrimidine derivatives
AU2006212457B2 (en) *	2005-02-11	2011-04-14	F. Hoffmann-La Roche Ag	Pyrazolo-pyrimidine derivatives as mGLuR2 antagonists
ATE460417T1 (de)	2005-03-23	2010-03-15	Hoffmann La Roche	Acetylenylpyrazolopyrimidinderivate als mglur2- antagonsten
KR20140000721A (ko) *	2005-06-23	2014-01-03	어레이 바이오파마 인크.	벤즈이미다졸 화합물의 제조 방법
EP1934214B1 (de)	2005-09-27	2010-04-07	F.Hoffmann-La Roche Ag	Oxadiazolylpyrazolopyrimidine als mglur2-antagonisten
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CN101657432B (zh)	2007-04-19	2013-04-10	弗·哈夫曼-拉罗切有限公司	二氢-苯并[b][1,4]二氮杂*-2-酮磺酰胺衍生物
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2002
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 AT AT02737911T patent/ATE299868T1/de not_active IP Right Cessation
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/en not_active Ceased
- 2002-04-02 CA CA002442557A patent/CA2442557C/en not_active Expired - Fee Related
- 2002-04-02 AU AU2002312788A patent/AU2002312788B2/en not_active Ceased
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 HR HR20030792A patent/HRP20030792A2/hr not_active Application Discontinuation
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
- 2002-04-02 SK SK1368-2003A patent/SK13682003A3/sk unknown
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 KR KR1020037013300A patent/KR100566171B1/ko not_active Expired - Fee Related
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 EP EP02737911A patent/EP1379511B1/de not_active Expired - Lifetime
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 BR BR0208891-6A patent/BR0208891A/pt not_active Application Discontinuation
- 2002-04-03 US US10/115,826 patent/US6544985B2/en not_active Expired - Fee Related
- 2002-04-09 AR ARP020101290A patent/AR035816A1/es not_active Application Discontinuation
- 2002-04-09 PA PA20028543301A patent/PA8543301A1/es unknown
- 2002-04-10 JO JO200232A patent/JO2285B1/en active
- 2002-04-10 PE PE2002000291A patent/PE20021041A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200073A patent/GT200200073A/es unknown
- 2002-04-11 UY UY27258A patent/UY27258A1/es not_active Application Discontinuation
- 2002-04-11 MY MYPI20021345A patent/MY140271A/en unknown
2003
- 2003-09-11 IL IL157873A patent/IL157873A/en not_active IP Right Cessation
- 2003-09-16 ZA ZA200307243A patent/ZA200307243B/en unknown
- 2003-10-08 EC EC2003004797A patent/ECSP034797A/es unknown
- 2003-10-08 MA MA27346A patent/MA27012A1/fr unknown
- 2003-10-10 NO NO20034576A patent/NO20034576L/no not_active Application Discontinuation
- 2003-10-10 BG BG108254A patent/BG108254A/bg unknown

Also Published As

Publication number	Publication date
NO20034576L (no)	2003-11-12
SI1379511T1 (en)	2005-10-31
RU2003130637A (ru)	2005-04-10
HUP0400851A3 (en)	2010-03-29
PL367064A1 (en)	2005-02-21
SK13682003A3 (sk)	2004-07-07
ECSP034797A (es)	2003-12-01
CA2442557C (en)	2008-12-23
HRP20030792A2 (en)	2005-10-31
YU79003A (sh)	2006-05-25
CN1264825C (zh)	2006-07-19
KR100566171B1 (ko)	2006-03-29
AR035816A1 (es)	2004-07-14
JP2004529925A (ja)	2004-09-30
IL157873A (en)	2008-11-26
JO2285B1 (en)	2005-09-12
MY140271A (en)	2009-12-31
WO2002083652A1 (en)	2002-10-24
NO20034576D0 (no)	2003-10-10
PT1379511E (pt)	2005-10-31
MXPA03009311A (es)	2004-02-12
ZA200307243B (en)	2004-12-16
MA27012A1 (fr)	2004-12-20
EP1379511B1 (de)	2005-07-20
PA8543301A1 (es)	2003-01-24
BR0208891A (pt)	2004-04-20
EP1379511A1 (de)	2004-01-14
CZ20033003A3 (cs)	2004-05-12
AU2002312788B2 (en)	2005-11-10
ES2246012T3 (es)	2006-02-01
UY27258A1 (es)	2002-10-31
DE60205100D1 (de)	2005-08-25
US20020193367A1 (en)	2002-12-19
HK1068888A1 (en)	2005-05-06
GT200200073A (es)	2002-11-07
DE60205100T2 (de)	2006-06-01
CA2442557A1 (en)	2002-10-24
DK1379511T3 (da)	2005-11-07
PE20021041A1 (es)	2002-11-19
JP4071115B2 (ja)	2008-04-02
BG108254A (bg)	2004-09-30
CN1535266A (zh)	2004-10-06
NZ528315A (en)	2005-04-29
RU2263112C2 (ru)	2005-10-27
US6544985B2 (en)	2003-04-08
KR20030087076A (ko)	2003-11-12
HUP0400851A2 (hu)	2004-07-28
IL157873A0 (en)	2004-03-28

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