SI3325483T1 - Metode priprave derivatov citotoksičnega benzodiazepina - Google Patents

Metode priprave derivatov citotoksičnega benzodiazepina

Info

Publication number: SI3325483T1
Authority: SI; Slovenia
Prior art keywords: methods; benzodiazepine derivatives; cytotoxic benzodiazepine; preparing cytotoxic; preparing
Prior art date: 2015-07-21

Application number

SI201630578T

Other languages

English (en)

Inventor

Baudouin Gerard

Manami Shizuka

Michael Louis Miller

Richard A. Silva

Original Assignee

Immunogen, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-07-21

Filing date

2016-07-21

Publication date

2020-03-31

2016-07-21 Application filed by Immunogen, Inc. filed Critical Immunogen, Inc.

2020-03-31 Publication of SI3325483T1 publication Critical patent/SI3325483T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pyridine Compounds (AREA)

SI201630578T 2015-07-21 2016-07-21 Metode priprave derivatov citotoksičnega benzodiazepina SI3325483T1 (sl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201562195023P	2015-07-21	2015-07-21
US201662327973P	2016-04-26	2016-04-26
EP16745961.9A EP3325483B1 (en)	2015-07-21	2016-07-21	Methods of preparing cytotoxic benzodiazepine derivatives
PCT/US2016/043406 WO2017015496A1 (en)	2015-07-21	2016-07-21	Methods of preparing cytotoxic benzodiazepine derivatives

Publications (1)

Publication Number	Publication Date
SI3325483T1 true SI3325483T1 (sl)	2020-03-31

Family

ID=56557925

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201630578T SI3325483T1 (sl)	2015-07-21	2016-07-21	Metode priprave derivatov citotoksičnega benzodiazepina
SI201630923T SI3325482T1 (sl)	2015-07-21	2016-07-21	Postopki za pripravo citotoksičnih benzodiazepinskih derivatov

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SI201630923T SI3325482T1 (sl)	2015-07-21	2016-07-21	Postopki za pripravo citotoksičnih benzodiazepinskih derivatov

Country Status (23)

Country	Link
US (11)	US9890179B2 (sl)
EP (7)	EP3325483B1 (sl)
JP (8)	JP6787995B2 (sl)
KR (5)	KR102659706B1 (sl)
CN (5)	CN108026103B (sl)
AU (7)	AU2016297607A1 (sl)
CA (4)	CA2991305C (sl)
CY (2)	CY1122553T1 (sl)
DK (2)	DK3325482T3 (sl)
ES (4)	ES2764548T3 (sl)
HK (1)	HK1252322A1 (sl)
HR (1)	HRP20201479T1 (sl)
HU (1)	HUE051541T2 (sl)
IL (10)	IL286788B2 (sl)
LT (2)	LT3325483T (sl)
PL (2)	PL3325483T3 (sl)
PT (2)	PT3325483T (sl)
RS (2)	RS59806B1 (sl)
RU (3)	RU2746322C2 (sl)
SG (2)	SG10202106529XA (sl)
SI (2)	SI3325483T1 (sl)
SM (2)	SMT202000506T1 (sl)
WO (3)	WO2017015495A1 (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3325483B1 (en)	2015-07-21	2019-10-02	ImmunoGen, Inc.	Methods of preparing cytotoxic benzodiazepine derivatives
EP4036956A1 (de)	2016-03-22	2022-08-03	EV Group E. Thallner GmbH	Vorrichtung zum bonden von substraten
KR20250044934A (ko)	2016-10-19	2025-04-01	인벤라 인코포레이티드	항체 구조물
EP3559039A1 (en)	2016-12-22	2019-10-30	Università Degli Studi Magna Graecia Catanzaro	A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43
HRP20230002T1 (hr)	2017-01-25	2023-02-17	Immunogen, Inc.	Postupci pripreme citotoksičnih derivata benzodiazepina
CN120795120A (zh)	2018-06-05	2025-10-17	伦敦大学国王学院	向胃肠系统递送酬载的btnl3/8导引构建体
CA3119358A1 (en) *	2018-11-12	2020-05-22	Immunogen, Inc.	Methods of preparing cytotoxic benzodiazepine derivatives
IL283047B2 (en) *	2018-11-12	2024-04-01	Immunogen Inc	Methods for preparing cytotoxic benzodiazepine derivatives
TW202102506A (zh) *	2019-03-29	2021-01-16	美商伊繆諾金公司	苯二氮平衍生物
CN119486758A (zh)	2022-06-30	2025-02-18	东丽株式会社	癌的治疗和/或预防用药物组合物

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3860600A (en)	1972-07-10	1975-01-14	Sterling Drug Inc	Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US3763183A (en)	1972-07-10	1973-10-02	Sterling Drug Inc	1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US4678784A (en)	1984-04-11	1987-07-07	Mcneilab, Inc.	Method for the treatment of LHRH diseases and conditions
US5208020A (en)	1989-10-25	1993-05-04	Immunogen Inc.	Cytotoxic agents comprising maytansinoids and their therapeutic use
GB9205051D0 (en)	1992-03-09	1992-04-22	Cancer Res Campaign Tech	Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
DE69231123T2 (de)	1992-03-25	2001-02-15	Immunogen Inc	Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
ATE240334T1 (de)	1998-08-27	2003-05-15	Spirogen Ltd	Pyrrolobenzodiazepine
GB9818731D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Compounds
JP2003514903A (ja)	1999-11-24	2003-04-22	イムノージェンインコーポレーテッド	タキサンを含有する細胞傷害薬とその治療への利用
US6548042B2 (en) *	2000-08-07	2003-04-15	Arstad Erik	Bis-phosphonate compounds
UA75093C2 (en) *	2000-10-06	2006-03-15	Dimensional Pharm Inc	Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors
US6441163B1 (en)	2001-05-31	2002-08-27	Immunogen, Inc.	Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6716821B2 (en)	2001-12-21	2004-04-06	Immunogen Inc.	Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
US6756397B2 (en)	2002-04-05	2004-06-29	Immunogen, Inc.	Prodrugs of CC-1065 analogs
JP2005539009A (ja)	2002-08-02	2005-12-22	イミュノジェン・インコーポレーテッド	新規の効力のあるタキサンを含む細胞毒性物質、および、それらの治療用途
ATE499116T1 (de)	2002-08-16	2011-03-15	Immunogen Inc	Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
RU2314309C2 (ru)	2003-03-31	2008-01-10	Каунсил Оф Сайентифик Энд Индастриал Рисерч	Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
EP1608663B1 (en)	2003-03-31	2008-11-05	Council of Scientific and Industrial Research	Pyrrolo (2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof
RU2338747C2 (ru)	2003-03-31	2008-11-20	Каунсил Оф Сайентифик Энд Индастриал Рисерч	ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
DE60326060D1 (de)	2003-03-31	2009-03-19	Council Scient Ind Res	Nichtvernetzende pyrroloä2,1-cüä1,4übenzodiazepine als potentielle antitumor-agentien und ihre herstellung
US8088387B2 (en)	2003-10-10	2012-01-03	Immunogen Inc.	Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en)	2003-05-20	2007-10-02	Immunogen Inc.	Cytotoxic agents comprising new maytansinoids
US7511032B2 (en)	2003-10-22	2009-03-31	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
JP4520411B2 (ja)	2003-12-31	2010-08-04	カウンシルオブサイエンティフィクアンドインダストリアルリサーチ	ピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン・ハイブリッドの調製方法
AU2005219626B2 (en) *	2004-03-01	2010-11-18	Medimmune Limited	11-hydroxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of C2 substituted pyrrolobenzodiazepines
GB0404578D0 (en)	2004-03-01	2004-04-07	Spirogen Ltd	Pyrrolobenzodiazepines
GB0410725D0 (en)	2004-05-13	2004-06-16	Spirogen Ltd	Pyrrolobenzodiazepine therapeutic agents
GB0412492D0 (en) *	2004-06-04	2004-07-07	Sterix Ltd	Compound
GB0508084D0 (en) *	2005-04-21	2005-06-01	Spirogen Ltd	Pyrrolobenzodiazepines
DE602006011300D1 (de)	2005-04-21	2010-02-04	Spirogen Ltd	Pyrrolobenzodiazepine
WO2007039752A1 (en)	2005-10-05	2007-04-12	Spirogen Limited	Alkyl 4- [4- (5-oxo-2, 3, 5, 11a-tetrahyd0-5h-pyrr0l0 [2, 1-c] [1, 4] benzodiazepine-8-yloxy) -butyrylamino]-1h-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease
EP1979349B1 (en) *	2005-12-21	2010-07-28	Abbott Laboratories	Anti-viral compounds
PT1813614E (pt)	2006-01-25	2012-01-09	Sanofi Sa	Agentes citotóxicos compreendendo novos derivados de tomaimicina
JP2009526778A (ja)	2006-02-13	2009-07-23	カウンシルオブサイエンティフィクアンドインダストリアルリサーチ	抗腫瘍剤としてのビス−ピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アントラキノン抱合体およびその製造方法
US8524865B2 (en)	2006-05-30	2013-09-03	Genentech, Inc.	Antibodies and immunoconjugates and uses therefor
DK2019104T3 (da)	2007-07-19	2013-12-16	Sanofi Sa	Cytotoksiske midler, der omfatter nye tomaymycinderivater, og terapeutisk anvendelse deraf
JP5404624B2 (ja)	2007-08-01	2014-02-05	カウンスィルオブサイエンティフィックアンドインダストリアルリサーチ	選択的な抗腫瘍薬として有用なピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−グリコシドプロドラッグ
CN102083461B (zh)	2008-04-30	2014-09-17	伊缪诺金公司	有效的偶联物和亲水性连接体
CN104524592B (zh)	2008-04-30	2018-06-05	伊缪诺金公司	交联剂和它们的用途
GB0819095D0 (en)	2008-10-17	2008-11-26	Spirogen Ltd	Pyrrolobenzodiazepines
GB0822260D0 (en)	2008-12-05	2009-01-14	Merten Christoph	Assay
EP2383263B1 (en) *	2008-12-30	2014-04-16	Industry-academic Cooperation Foundation, Chosun University	Novel thiazolidinedione derivative and use thereof
CN102365021B (zh)	2009-02-05	2015-07-15	伊缪诺金公司	新型苯并二氮杂*衍生物
JP2013506709A (ja)	2009-10-06	2013-02-28	イミュノジェン・インコーポレーテッド	有効なコンジュゲートおよび親水性リンカー
US8314250B2 (en)	2009-11-24	2012-11-20	Hoffmann-La Roche Inc.	Sultam derivatives
EP2511260B1 (en)	2009-12-08	2015-07-29	Gifu University	Aromatic compound, modification carrier that uses same and is used for synthesizing an oligonucleotide derivative, oligonucleotide derivative, and oligonucleotide construct
US8962279B2 (en) *	2009-12-30	2015-02-24	Intel Corporation	Solid-phase chelators and electronic biosensors
LT3202460T (lt) *	2010-02-11	2019-10-10	Celgene Corporation	Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus
SMT201700139T1 (it)	2010-02-24	2017-05-08	Immunogen Inc	Immunoconiugati contro il recettore 1 del folato e relativi usi
HRP20130953T1 (hr)	2010-04-15	2013-11-22	Spirogen Sàrl	Pirolobenzodiazepini i njihovi konjugati
US8697688B2 (en)	2010-04-15	2014-04-15	Seattle Genetics Inc.	Pyrrolobenzodiazepines used to treat proliferative diseases
MX2012011900A (es) *	2010-04-15	2013-03-21	Seattle Genetics Inc	Conjugados de pirrolobenzodiazepina diana.
SMT201900181T1 (it) *	2011-02-15	2019-05-10	Immunogen Inc	Metodi di preparazione di coniugati
CN102234253B (zh) *	2011-06-02	2013-07-03	重庆莱美药业股份有限公司	一种制备非布索坦中间体的方法
WO2014031566A1 (en) *	2012-08-22	2014-02-27	Immunogen, Inc.	Cytotoxic benzodiazepine derivatives
WO2015051045A2 (en) *	2013-10-04	2015-04-09	Novartis Ag	3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE
CN104628772A (zh) *	2013-11-07	2015-05-20	四川恒康发展有限责任公司	一种抗肿瘤前药及其激活剂、组合物和应用
CN103664896B (zh) *	2013-11-25	2016-03-02	济南精合医药科技有限公司	一种抗肿瘤分子靶向药物克里唑替尼的合成工艺方法
MX2017002758A (es)	2014-09-03	2017-10-20	Immunogen Inc	Derivados de benzodiazepina citotoxicos.
SG11201701565PA (en) *	2014-09-03	2017-03-30	Immunogen Inc	Conjugates comprising cell-binding agents and cytotoxic agents
US9381256B2 (en)	2014-09-03	2016-07-05	Immunogen, Inc.	Cytotoxic benzodiazepine derivatives
EP3325483B1 (en)	2015-07-21	2019-10-02	ImmunoGen, Inc.	Methods of preparing cytotoxic benzodiazepine derivatives
JP2019501139A (ja) *	2015-11-25	2019-01-17	イミュノジェン・インコーポレーテッド	医薬製剤及びその使用

2016
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh not_active Expired - Fee Related
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en not_active Withdrawn
- 2016-07-21 SM SM20200506T patent/SMT202000506T1/it unknown
- 2016-07-21 CA CA2991305A patent/CA2991305C/en active Active
- 2016-07-21 PT PT167459619T patent/PT3325483T/pt unknown
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 CA CA2992082A patent/CA2992082A1/en active Pending
- 2016-07-21 RU RU2018105609A patent/RU2746322C2/ru active
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 CN CN201680051138.1A patent/CN108290895B/zh not_active Expired - Fee Related
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en not_active Ceased
- 2016-07-21 HU HUE16745598A patent/HUE051541T2/hu unknown
- 2016-07-21 EP EP19200626.0A patent/EP3653628B1/en active Active
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en not_active Ceased
- 2016-07-21 PL PL16745961T patent/PL3325483T3/pl unknown
- 2016-07-21 ES ES16745961T patent/ES2764548T3/es active Active
- 2016-07-21 IL IL283355A patent/IL283355B/en unknown
- 2016-07-21 CN CN202110219412.4A patent/CN113004288A/zh active Pending
- 2016-07-21 LT LTEP16745961.9T patent/LT3325483T/lt unknown
- 2016-07-21 RS RS20191647A patent/RS59806B1/sr unknown
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IL286788A (en)	2021-10-31	Methods for the preparation of cytotoxic benzodiazepine compounds
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