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SI3341367T1 - Biciklične kondenzirane heteroarilne ali arilne sestavine kot modulatorji IRAK-4 - Google Patents

Biciklične kondenzirane heteroarilne ali arilne sestavine kot modulatorji IRAK-4

Info

Publication number
SI3341367T1
SI3341367T1 SI201631154T SI201631154T SI3341367T1 SI 3341367 T1 SI3341367 T1 SI 3341367T1 SI 201631154 T SI201631154 T SI 201631154T SI 201631154 T SI201631154 T SI 201631154T SI 3341367 T1 SI3341367 T1 SI 3341367T1
Authority
SI
Slovenia
Prior art keywords
bicyclic
fused heteroaryl
aryl compounds
irak4
modulators
Prior art date
Application number
SI201631154T
Other languages
English (en)
Inventor
Katherine Lin Lee
Christophe Philippe Allais
Christoph Martin Dehnhardt
Lori Krim Gavrin
Seungil Han
David Hepworth
Arthur Lee
Frank Eldridge Lovering
John Paul Mathias
Dafydd Rhys Owen
Nikolaos Papaioannou
Eddine Saiah
Joseph Walter Strohbach
John David Trzupek
Stephen Wayne Wright
Christoph Wolfgang Zapf
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of SI3341367T1 publication Critical patent/SI3341367T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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SI201631154T 2015-08-27 2016-08-16 Biciklične kondenzirane heteroarilne ali arilne sestavine kot modulatorji IRAK-4 SI3341367T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210573P 2015-08-27 2015-08-27
EP16762869.2A EP3341367B1 (en) 2015-08-27 2016-08-16 Bicyclic-fused heteroaryl or aryl compounds as irak4 modulators
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Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106458912B (zh) 2014-04-04 2020-10-27 辉瑞公司 双环稠合的杂芳基或芳基化合物以及它们作为irak4拟制剂的用途
DK3341367T3 (da) 2015-08-27 2021-04-12 Pfizer Bicyklisk-fusionerede heteroaryl- eller arylforbindelser som irak4-modulatorer
CN116270646A (zh) 2015-10-16 2023-06-23 艾伯维公司 制备咪唑并[1,2-a]吡咯并[2,3-e]吡嗪类化合物及其固态形式的方法
US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US12365689B2 (en) 2015-10-16 2025-07-22 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
ES2889926T3 (es) * 2017-05-11 2022-01-14 Bristol Myers Squibb Co Tienopiridinas y benzotiofenos útiles como inhibidores de IRAK4
EP3684365A4 (en) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. PROTEIN DEGRADATION AGENTS AND USES OF SUCH
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
KR20200128379A (ko) * 2017-10-30 2020-11-12 신블리아 테라퓨틱스 인코포레이티드 Irak4 억제제 및 이의 용도
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
US11542246B2 (en) * 2018-01-31 2023-01-03 Merck Patent Gmbh Quinoline compounds as IRAK inhibitors and uses thereof
CN108853112B (zh) * 2018-06-13 2021-02-02 四川理工学院 化合物或其在药学上可接受的盐在制备治疗痛风、高尿酸血症药物中的应用
US12454520B2 (en) 2018-07-06 2025-10-28 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
GB201902327D0 (en) * 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
WO2020106059A1 (ko) 2018-11-21 2020-05-28 한국화학연구원 Irak4 저해제로서 신규의 삼중고리 화합물
KR102329235B1 (ko) 2018-11-21 2021-11-22 한국화학연구원 Irak4 저해제로서 신규의 삼중고리 화합물
PH12021500026A1 (en) 2018-11-30 2022-05-11 Kymera Therapeutics Inc Irak degraders and uses thereof
CR20210383A (es) 2018-12-17 2021-09-22 Vertex Pharma Inhibidores de apol 1 y sus métodos de uso
CN111662295B (zh) * 2019-03-05 2021-09-10 珠海宇繁生物科技有限责任公司 一种irak4激酶抑制剂及其制备方法
US12286428B2 (en) 2019-07-18 2025-04-29 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as IRAK4 inhibitors
JP7620611B2 (ja) 2019-07-18 2025-01-23 ブリストル－マイヤーズ スクイブ カンパニー ＩＲＡＫ４阻害剤として有用なピラゾロ［３，４－ｄ］ピロロ［１，２－ｂ］ピリダジニル化合物
ES3036306T3 (en) 2019-07-23 2025-09-17 Bristol Myers Squibb Co Thienopyridinyl and thiazolopyridinyl compounds useful as irak4 inhibitors
JOP20220085A1 (ar) * 2019-10-07 2023-01-30 De Shaw Res Llc مركبات أريل ميثيلين حلقية غير متجانسة على هيئة حاصرات قناة بوتاسيوم Kv1.3 بجين شاكر
JP7697954B2 (ja) * 2019-10-07 2025-06-24 ディー．イー．ショウ リサーチ，エルエルシー Ｋｖ１．３カリウムシェーカーチャネル遮断薬としてのアリールメチレン芳香族化合物
CN112679472A (zh) * 2019-10-17 2021-04-20 北京桦冠医药科技有限公司 具有irak4抑制剂活性的异喹啉类化合物
US20230037448A1 (en) * 2019-11-01 2023-02-09 Janssen Biotech, Inc. Fluorinated quinoline and quinoxaline derivatives as dihydroorotate dehydrogenase (dhodh) inhibitors for the treatment of cancer, autoimmune and inflammatory diseases
WO2021094953A1 (en) * 2019-11-14 2021-05-20 Pfizer Inc. 1-(((2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide combinations and oral dosage forms
CN110845374A (zh) * 2019-11-22 2020-02-28 北京振东光明药物研究院有限公司 比卡鲁胺杂质化合物及其制备方法、检测方法和应用
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
MX2022007576A (es) 2019-12-17 2022-09-23 Kymera Therapeutics Inc Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
KR20220146458A (ko) * 2020-01-23 2022-11-01 마이오포르테 테라퓨틱스 인코포레이티드 Pgdh 억제제 및 그의 제조 및 사용 방법
US12116343B2 (en) 2020-01-29 2024-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
US12391702B2 (en) 2020-02-03 2025-08-19 Bristol-Myers Squibb Company Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors
TW202140459A (zh) * 2020-02-04 2021-11-01 美商維泰克斯製藥公司 Ａｐｏｌ１抑制劑之固體形式及其使用方法
KR20220151634A (ko) 2020-03-06 2022-11-15 버텍스 파마슈티칼스 인코포레이티드 Apol-1 의존성 국소 분절성 사구체경화증을 치료하는 방법
US20230149407A1 (en) 2020-04-04 2023-05-18 Pfizer Inc. Methods of Treating Coronavirus Disease 2019
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
AU2021286728A1 (en) 2020-06-12 2023-01-19 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and use of the same
AR123355A1 (es) 2020-08-26 2022-11-23 Vertex Pharma Inhibidores de apol1 y métodos para usar los mismos
CN116348472B (zh) * 2020-09-30 2024-12-03 旭化成制药株式会社 大环化合物
CN116710434A (zh) * 2020-10-21 2023-09-05 伊赛恩特制药公司 Mas相关g蛋白受体x2的调节剂和相关产物及其用途
CN112694426B (zh) * 2020-12-29 2022-11-04 山东铂源药业股份有限公司 一种阿普斯特中间体的合成方法
AU2021413371A1 (en) 2020-12-30 2023-07-13 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2022174268A1 (en) 2021-02-15 2022-08-18 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
KR20220138655A (ko) * 2021-04-06 2022-10-13 주식회사 온코크로스 신장 질환의 예방 또는 치료용 화합물
CA3217792A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc Cdk2 degraders and uses thereof
MX2024004264A (es) * 2021-10-08 2024-07-10 Azora Therapeutics Inc Derivados de agonistas de los receptores de aril hidrocarburos.
AR127505A1 (es) 2021-10-29 2024-01-31 Kymera Therapeutics Inc Degradadores irak-4 y síntesis de los mismos
CN113995757B (zh) * 2021-12-03 2023-03-14 合肥工业大学 罗沙司他在治疗偏头痛药物中的应用及含有罗沙司他的药物
WO2023147594A2 (en) 2022-01-31 2023-08-03 Kymera Therapeutics, Inc. Irak degraders and uses thereof
CN114617967A (zh) * 2022-02-17 2022-06-14 苏州大学 降低脑内铁含量的药物在制备治疗和/或预防神经精神疾病药物中的应用
CN114527213A (zh) * 2022-02-22 2022-05-24 正大制药（青岛）有限公司 一种用于托匹司他的质量检测方法
WO2023235433A1 (en) * 2022-06-01 2023-12-07 Rigel Pharmaceuticals, Inc. Bicyclic inhibitors of irak
WO2024148049A1 (en) * 2023-01-04 2024-07-11 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
WO2025143096A1 (ja) * 2023-12-29 2025-07-03 キッセイ薬品工業株式会社 含窒素縮環化合物
CN118978508B (zh) * 2024-08-02 2025-09-16 上海信诺维生物医药有限公司 一种含氮杂环化合物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3065190D1 (en) 1979-11-05 1983-11-10 Beecham Group Plc Enzyme derivatives, and their preparation
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
DK1094816T3 (da) 1998-07-06 2009-04-06 Bristol Myers Squibb Co Biphenylsulfonamider som dobbelte angiotensin-endothelin-receptorantagonister
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
WO2002032872A1 (fr) * 2000-10-20 2002-04-25 Eisai Co., Ltd. Composes a noyau aromatique azote
PL372887A1 (en) 2002-02-27 2005-08-08 Pfizer Products Inc. Acc inhibitors
JPWO2005080377A1 (ja) * 2004-02-20 2007-10-25 キリンホールディングス株式会社 ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物
GEP20084421B (en) 2004-05-12 2008-07-10 Pfizer Prod Inc Proline derivatives and their use as dipeptidyl peptidase iv inhibitors
CA2648852C (en) 2006-04-20 2012-12-11 Pfizer Products Inc. Fused phenyl amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases
AP2009004880A0 (en) 2006-11-29 2009-06-30 Pfizer Prod Inc Spiroketone acetyl-COA carboxylase inhibitors
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
ES2545231T3 (es) 2008-05-28 2015-09-09 Pfizer Inc. Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa
EP2297164A1 (en) 2008-05-28 2011-03-23 Pfizer Inc. Pyrazolospiroketone acetyl-coa carboxylase inhibitors
WO2010013161A1 (en) 2008-07-29 2010-02-04 Pfizer Inc. Fluorinated heteroaryls
ES2380408T3 (es) 2008-08-28 2012-05-11 Pfizer Inc. Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol
TW201038580A (en) 2009-02-02 2010-11-01 Pfizer 4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl derivatives
CA2754681C (en) 2009-03-11 2014-01-07 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
WO2010103438A1 (en) 2009-03-11 2010-09-16 Pfizer Inc. Substituted indazole amides and their use as glucokinase activators
CA2754523A1 (en) 2009-03-20 2010-09-23 Pfizer Inc. 3-oxa-7-azabicyclo[3.3.1]nonanes
WO2010128414A1 (en) 2009-05-08 2010-11-11 Pfizer Inc. Gpr 119 modulators
JP2012526097A (ja) 2009-05-08 2012-10-25 ファイザー・インク Ｇｐｒ１１９調節因子
PE20120399A1 (es) 2009-06-05 2012-04-24 Pfizer Derivados del l-(piperidin-4-il)-pirazol como moduladores de gpr 119
WO2011005611A1 (en) 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Neuromedin u receptor agonists and uses thereof
EA024845B1 (ru) * 2011-07-26 2016-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные хинолины и их применение в качестве лекарственных средств
DE102014007350A1 (de) 2013-10-11 2015-04-16 Pfanner Schutzbekleidung Gmbh Schutzhelm
CN106458912B (zh) * 2014-04-04 2020-10-27 辉瑞公司 双环稠合的杂芳基或芳基化合物以及它们作为irak4拟制剂的用途
CA2995153A1 (en) * 2015-08-13 2017-02-16 Pfizer Inc. Bicyclic-fused heteroaryl or aryl compounds
DK3341367T3 (da) 2015-08-27 2021-04-12 Pfizer Bicyklisk-fusionerede heteroaryl- eller arylforbindelser som irak4-modulatorer

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