SI1224174T1 - Benzodiazepine derivatives as metabotropic glutamate receptor antagonists - Google Patents

Benzodiazepine derivatives as metabotropic glutamate receptor antagonists

Info

Publication number: SI1224174T1
Authority: SI; Slovenia
Prior art keywords: receptor antagonists; glutamate receptor; metabotropic glutamate; benzodiazepine derivatives; benzodiazepine
Prior art date: 1999-10-15

Application number

SI200030210T

Other languages

English (en)

Slovenian (sl)

Inventor

Geo Adam

Alexander Alanine

Erwin Goetschi

Vincent Mutel

Thomas Johannes Woltering

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-15

Filing date

2000-09-29

Publication date

2003-12-31

2000-09-29 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2003-12-31 Publication of SI1224174T1 publication Critical patent/SI1224174T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SI200030210T 1999-10-15 2000-09-29 Benzodiazepine derivatives as metabotropic glutamate receptor antagonists SI1224174T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99120520		1999-10-15
EP00969347A EP1224174B1 (en)	1999-10-15	2000-09-29	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
PCT/EP2000/009553 WO2001029011A2 (en)	1999-10-15	2000-09-29	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists

Publications (1)

Publication Number	Publication Date
SI1224174T1 true SI1224174T1 (en)	2003-12-31

Family

ID=8239207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200030210T SI1224174T1 (en)	1999-10-15	2000-09-29	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists

Country Status (34)

Country	Link
US (1)	US6407094B1 (da)
EP (1)	EP1224174B1 (da)
JP (1)	JP3857138B2 (da)
KR (1)	KR100480320B1 (da)
CN (1)	CN1195522C (da)
AR (1)	AR026029A1 (da)
AT (1)	ATE250039T1 (da)
AU (1)	AU774451B2 (da)
BR (1)	BR0014859A (da)
CA (1)	CA2386974C (da)
CO (1)	CO5261604A1 (da)
CZ (1)	CZ20021653A3 (da)
DE (1)	DE60005386T2 (da)
DK (1)	DK1224174T3 (da)
EG (1)	EG24079A (da)
ES (1)	ES2204704T3 (da)
GC (1)	GC0000263A (da)
HR (1)	HRP20020259A2 (da)
HU (1)	HUP0203142A3 (da)
IL (2)	IL148816A0 (da)
JO (1)	JO2262B1 (da)
MA (1)	MA26831A1 (da)
MY (1)	MY125540A (da)
NO (1)	NO327817B1 (da)
NZ (1)	NZ517999A (da)
PE (1)	PE20010681A1 (da)
PL (1)	PL357418A1 (da)
PT (1)	PT1224174E (da)
RU (1)	RU2259360C2 (da)
SI (1)	SI1224174T1 (da)
TR (1)	TR200201023T2 (da)
WO (1)	WO2001029011A2 (da)
YU (1)	YU26202A (da)
ZA (1)	ZA200202544B (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ518037A (en)	1999-10-15	2004-04-30	F	Benzodiazepine derivatives useful as metabotropic glutamate receptors
KR100566178B1 (ko) *	2001-04-12	2006-03-29	에프. 호프만-라 로슈 아게	ｍＧｌｕＲ2 길항물질 Ｉ로서의디하이드로-벤조[ｂ][1,4]디아제핀-2-온 유도체
HRP20030792A2 (en) *	2001-04-12	2005-10-31	F. Hoffmann - La Roche Ag	DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US6949542B2 (en) *	2002-02-06	2005-09-27	Hoffman-La Roche Inc.	Dihydro-benzo[b][1,4]diazepin-2-one derivatives
EP1539149B1 (en) *	2002-09-10	2012-01-04	Novartis AG	Combinations of metabotropic glutamate receptor antagonists and their use in treating addictive disorders
JP2007516404A (ja)	2003-05-21	2007-06-21	アレックザファーマシューティカルズ，インコーポレイテッド	光学点火されたかまたは電気点火された内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
PL1651234T3 (pl) *	2003-07-25	2008-02-29	Hoffmann La Roche	Kompozycja antagonisty mGluR2 i inhibitora AChE do leczenia ostrych i/lub przewlekłych zaburzeń neurologicznych
FR2862969A1 (fr) *	2003-11-28	2005-06-03	Oreal	Procede de preparation de derives paraphenylenediamine a groupement pyrrolidinyle, substitue par un radical azote, et composes intermediaires
DE102004010893A1 (de) *	2004-03-06	2005-09-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue ß-Ketoamid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en)	2004-08-12	2012-11-21	Alexza Pharmaceuticals, Inc.	Aerosol drug delivery device incorporating percussively activated heating unit
US7459563B2 (en)	2004-11-05	2008-12-02	Hoffmann-La Roche Inc.	Process for the preparation of isonicotinic acid derivatives
AP2007004047A0 (en)	2005-01-20	2007-06-30	Pfizer Ltd	Substituted triazole derivatives as oxtocin antagonists
AR059898A1 (es) *	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
EP2121088B1 (en)	2007-03-09	2016-07-13	Alexza Pharmaceuticals, Inc.	Heating unit for use in a drug delivery device
ATE519751T1 (de) *	2007-04-19	2011-08-15	Hoffmann La Roche	Dihydro-benzoäbüä1,4üdiazepin-2-on- sulfonamidderivate
NZ584152A (en)	2007-09-14	2011-11-25	Ortho Mcneil Janssen Pharm	1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
TW200927731A (en) *	2007-09-14	2009-07-01	Ortho Mcneil Janssen Pharm	1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
HRP20110278T1 (hr)	2007-09-14	2011-05-31	Ortho-Mcneil-Janssen Pharmaceuticals	1',3'-disupstituirani-4-fenil,3,4,5,6-tetrahidro-2h,1'h[1,4']bipiridinil-2'-oni
CN101815437A (zh) *	2007-09-26	2010-08-25	辛乃山医学院	氮杂胞苷类似物和其应用
ES2637794T3 (es) *	2007-11-14	2017-10-17	Janssen Pharmaceuticals, Inc.	Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
JP5547194B2 (ja)	2008-09-02	2014-07-09	ジャンセンファーマシューティカルズ，インコーポレイテッド．	代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
MX2011003691A (es)	2008-10-16	2011-09-06	Ortho Mcneil Janssen Pharm	Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico.
CN102232074B (zh)	2008-11-28	2014-12-03	奥梅-杨森制药有限公司	作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
CA2760259C (en)	2009-05-12	2018-05-01	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
US8642626B2 (en)	2010-07-29	2014-02-04	Taisho Pharmaceutical Co., Ltd.	Ethinyl-pyrazole derivative
CA2814996C (en)	2010-11-08	2019-10-01	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CA2815002C (en)	2010-11-08	2019-10-22	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103261195B (zh)	2010-11-08	2015-09-02	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
JP2012153674A (ja) *	2011-01-28	2012-08-16	Astellas Pharma Inc	ジ（アリールアミノ）アリール化合物の製造方法及びその合成中間体
AR093077A1 (es)	2012-10-23	2015-05-20	Hoffmann La Roche	ANTAGONISTAS DE mGlu2/3 PARA EL TRATAMIENTO DE LOS TRASTORNOS AUTISTAS
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
EP3096790B1 (en)	2014-01-21	2019-07-10	Janssen Pharmaceutica, N.V.	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
KR20200036063A (ko)	2014-01-21	2020-04-06	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
US9895324B2 (en)	2014-03-26	2018-02-20	University Of Kentucky Research Foundation	Halogenated diarylacetylenes and methods of treating cancer
JP2017513844A (ja)	2014-04-23	2017-06-01	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	知的障害の処置のためのｍＧｌｕ２／３アンタゴニスト
EP3154954B1 (en)	2014-06-10	2022-02-09	Sanford-Burnham Medical Research Institute	Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof
CN106243050B (zh) *	2016-08-10	2019-09-06	安徽恒星制药有限公司	一种适合工业化生产氯巴占的方法
CN109836356B (zh) *	2017-11-24	2022-03-08	沈阳化工研究院有限公司	一种芳甲醚衍生物及其应用
KR102852740B1 (ko)	2018-02-02	2025-08-29	알렉스자 파마스티칼즈, 인크.	전기적 응축 에어로졸 디바이스
RU2702358C1 (ru) *	2019-06-04	2019-10-08	Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук	Способ получения 2,2,4-триалкил-2,3-дигидро-1Н-1,5-бензодиазепинов
CN114349779B (zh) *	2021-12-29	2023-09-26	智仑超纯环氧树脂(西安)有限公司	一种改性二氧化硅颗粒除氯剂及其制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU437924A1 (ru) *	1972-07-28	1974-07-30	Институт Горного Дела Ан Казахской Сср	Цифровой автоматический измеритель скорости распространени упругих волн
SU749836A1 (ru) *	1978-02-13	1980-07-23	Днепропетровский Ордена Трудового Красного Знамени Государственный Университет Им. 300-Летия Воссоединения Украины С Россией	Способ получени 4-метил2,3-дигидро1н-1,5-бензодиазепинонов-2
AU6514296A (en) *	1995-07-31	1997-02-26	Novo Nordisk A/S	Heterocyclic compounds, their preparation and use
JP2001524468A (ja) *	1997-11-21	2001-12-04	エヌピーエスファーマシューティカルズインコーポレーテッド	中枢神経系疾患を治療するための代謝調節型グルタミン酸受容体アンタゴニスト

2000
- 2000-09-29 DK DK00969347T patent/DK1224174T3/da active
- 2000-09-29 BR BR0014859-8A patent/BR0014859A/pt not_active Application Discontinuation
- 2000-09-29 KR KR10-2002-7004838A patent/KR100480320B1/ko not_active Expired - Fee Related
- 2000-09-29 NZ NZ517999A patent/NZ517999A/en unknown
- 2000-09-29 CZ CZ20021653A patent/CZ20021653A3/cs unknown
- 2000-09-29 PT PT00969347T patent/PT1224174E/pt unknown
- 2000-09-29 SI SI200030210T patent/SI1224174T1/xx unknown
- 2000-09-29 AT AT00969347T patent/ATE250039T1/de not_active IP Right Cessation
- 2000-09-29 JP JP2001531811A patent/JP3857138B2/ja not_active Expired - Fee Related
- 2000-09-29 DE DE60005386T patent/DE60005386T2/de not_active Expired - Lifetime
- 2000-09-29 HU HU0203142A patent/HUP0203142A3/hu unknown
- 2000-09-29 AU AU79102/00A patent/AU774451B2/en not_active Ceased
- 2000-09-29 TR TR2002/01023T patent/TR200201023T2/xx unknown
- 2000-09-29 IL IL14881600A patent/IL148816A0/xx active IP Right Grant
- 2000-09-29 YU YU26202A patent/YU26202A/sh unknown
- 2000-09-29 CN CNB008142742A patent/CN1195522C/zh not_active Expired - Fee Related
- 2000-09-29 RU RU2002110104/04A patent/RU2259360C2/ru not_active IP Right Cessation
- 2000-09-29 HR HR20020259A patent/HRP20020259A2/xx not_active Application Discontinuation
- 2000-09-29 EP EP00969347A patent/EP1224174B1/en not_active Expired - Lifetime
- 2000-09-29 PL PL00357418A patent/PL357418A1/xx unknown
- 2000-09-29 WO PCT/EP2000/009553 patent/WO2001029011A2/en not_active Ceased
- 2000-09-29 CA CA002386974A patent/CA2386974C/en not_active Expired - Fee Related
- 2000-09-29 ES ES00969347T patent/ES2204704T3/es not_active Expired - Lifetime
- 2000-10-10 PE PE2000001083A patent/PE20010681A1/es not_active Application Discontinuation
- 2000-10-10 JO JO2000169A patent/JO2262B1/en active
- 2000-10-11 GC GCP2000950 patent/GC0000263A/en active
- 2000-10-12 CO CO00077957A patent/CO5261604A1/es not_active Application Discontinuation
- 2000-10-13 AR ARP000105386A patent/AR026029A1/es unknown
- 2000-10-13 MY MYPI20004817A patent/MY125540A/en unknown
- 2000-10-13 US US09/687,240 patent/US6407094B1/en not_active Expired - Fee Related
- 2000-10-14 EG EG20001310A patent/EG24079A/xx active
2002
- 2002-03-21 IL IL148816A patent/IL148816A/en not_active IP Right Cessation
- 2002-03-28 ZA ZA200202544A patent/ZA200202544B/xx unknown
- 2002-04-10 NO NO20021690A patent/NO327817B1/no not_active IP Right Cessation
- 2002-04-15 MA MA26601A patent/MA26831A1/fr unknown

Also Published As

Publication number	Publication date
AR026029A1 (es)	2002-12-26
CA2386974C (en)	2009-10-13
HUP0203142A3 (en)	2003-03-28
WO2001029011A2 (en)	2001-04-26
NO327817B1 (no)	2009-09-28
IL148816A (en)	2006-10-31
ZA200202544B (en)	2003-09-23
PE20010681A1 (es)	2001-06-28
EP1224174A2 (en)	2002-07-24
RU2259360C2 (ru)	2005-08-27
DE60005386T2 (de)	2004-06-24
ES2204704T3 (es)	2004-05-01
JP2003512359A (ja)	2003-04-02
WO2001029011A3 (en)	2001-11-08
GC0000263A (en)	2006-11-01
DK1224174T3 (da)	2004-01-26
JO2262B1 (en)	2004-10-07
IL148816A0 (en)	2002-09-12
EG24079A (en)	2008-05-11
NO20021690L (no)	2002-04-10
CN1379765A (zh)	2002-11-13
CO5261604A1 (es)	2003-03-31
CN1195522C (zh)	2005-04-06
KR20020038954A (ko)	2002-05-24
AU7910200A (en)	2001-04-30
YU26202A (sh)	2004-12-31
MY125540A (en)	2006-08-30
EP1224174B1 (en)	2003-09-17
JP3857138B2 (ja)	2006-12-13
BR0014859A (pt)	2002-07-16
PL357418A1 (en)	2004-07-26
PT1224174E (pt)	2004-01-30
US6407094B1 (en)	2002-06-18
CZ20021653A3 (cs)	2002-08-14
CA2386974A1 (en)	2001-04-26
ATE250039T1 (de)	2003-10-15
HRP20020259A2 (en)	2004-04-30
TR200201023T2 (tr)	2002-09-23
KR100480320B1 (ko)	2005-04-07
HK1051038A1 (en)	2003-07-18
HUP0203142A2 (hu)	2003-02-28
MA26831A1 (fr)	2004-12-20
DE60005386D1 (de)	2003-10-23
NZ517999A (en)	2004-07-30
NO20021690D0 (no)	2002-04-10
AU774451B2 (en)	2004-06-24

Publication	Publication Date	Title
PL357433A1 (en)	2004-07-26	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
SI1224174T1 (en)	2003-12-31	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
AU4797400A (en)	2000-12-05	Metabotropic glutamate receptor antagonists
AU9384701A (en)	2002-04-15	Metabotropic glutamate receptor antagonists
IL136250A0 (en)	2001-05-20	Metabotropic glutamate receptor antagonist compounds
AU6144098A (en)	1998-09-08	Amide derivatives as selective neuropeptide y receptor antagonists
IL125903A0 (en)	1999-04-11	Indole derivatives useful as endothelin receptor antagonists
PL365377A1 (en)	2005-01-10	Amide derivatives as nmda receptor antagonists
AU1211802A (en)	2002-03-04	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
HUP0202757A3 (en)	2006-03-28	Heteropolycyclic compounds, pharmaceutical compositions containing them and their use as metabotropic glutamate receptor antagonists
AU2660399A (en)	1999-09-06	Substituted quinoxaline derivatives as interleukin-8 receptor antagonists
PL356990A1 (en)	2004-07-12	Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
IL153837A0 (en)	2003-07-31	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
EP1226164A4 (en)	2005-07-20	HUMAN METABOTROPE GLUTAMATE RECEPTOR
IL145166A0 (en)	2002-06-30	Biphenyl derivatives as antagonists of the neurokinine-1 receptor
IL144299A0 (en)	2002-05-23	N-triazolymethyl-piperazine derivatives as neurokinin receptor antagonists
IL127304A0 (en)	1999-09-22	Indoline derivatives useful as 5-ht-2c receptor antagonists
IL150272A0 (en)	2002-12-01	Indole derivatives as mcp-1 receptor antagonists
AU3611099A (en)	1999-12-20	Oxindole derivatives used as neurokinin receptor antagonists
HUP9903439A3 (en)	2002-12-28	Indoline derivatives useful as 5-ht-2c receptor antagonists
AU2574801A (en)	2001-07-03	Selective iGLUR5 receptor antagonists
AU2943899A (en)	1999-10-11	Indole derivatives as 5-ht2a receptor antagonists
IL139262A (en)	2005-06-19	Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists
AU2512800A (en)	2000-08-25	Alpha1-adrenergic receptor antagonists
AU2230697A (en)	1997-09-22	Quinoxaline derivatives as glutamate receptor antagonists