HRP20020259A2 - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number: HRP20020259A2
Authority: HR; Croatia
Prior art keywords: benzodiazepine derivatives; benzodiazepine; derivatives
Prior art date: 1999-10-15

Application number

HR20020259A

Other languages

English (en)

Inventor

Geo Adam

Alexander Alanine

Erwin Goetschi

Vincent Mutel

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-15

Filing date

2000-09-29

Publication date

2004-04-30

2000-09-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-04-30 Publication of HRP20020259A2 publication Critical patent/HRP20020259A2/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HR20020259A 1999-10-15 2000-09-29 Benzodiazepine derivatives HRP20020259A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99120520		1999-10-15
PCT/EP2000/009553 WO2001029011A2 (en)	1999-10-15	2000-09-29	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists

Publications (1)

Publication Number	Publication Date
HRP20020259A2 true HRP20020259A2 (en)	2004-04-30

Family

ID=8239207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020259A HRP20020259A2 (en)	1999-10-15	2000-09-29	Benzodiazepine derivatives

Country Status (34)

Country	Link
US (1)	US6407094B1 (da)
EP (1)	EP1224174B1 (da)
JP (1)	JP3857138B2 (da)
KR (1)	KR100480320B1 (da)
CN (1)	CN1195522C (da)
AR (1)	AR026029A1 (da)
AT (1)	ATE250039T1 (da)
AU (1)	AU774451B2 (da)
BR (1)	BR0014859A (da)
CA (1)	CA2386974C (da)
CO (1)	CO5261604A1 (da)
CZ (1)	CZ20021653A3 (da)
DE (1)	DE60005386T2 (da)
DK (1)	DK1224174T3 (da)
EG (1)	EG24079A (da)
ES (1)	ES2204704T3 (da)
GC (1)	GC0000263A (da)
HR (1)	HRP20020259A2 (da)
HU (1)	HUP0203142A3 (da)
IL (2)	IL148816A0 (da)
JO (1)	JO2262B1 (da)
MA (1)	MA26831A1 (da)
MY (1)	MY125540A (da)
NO (1)	NO327817B1 (da)
NZ (1)	NZ517999A (da)
PE (1)	PE20010681A1 (da)
PL (1)	PL357418A1 (da)
PT (1)	PT1224174E (da)
RU (1)	RU2259360C2 (da)
SI (1)	SI1224174T1 (da)
TR (1)	TR200201023T2 (da)
WO (1)	WO2001029011A2 (da)
YU (1)	YU26202A (da)
ZA (1)	ZA200202544B (da)

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JP2007516404A (ja)	2003-05-21	2007-06-21	アレックザファーマシューティカルズ，インコーポレイテッド	光学点火されたかまたは電気点火された内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
PL1651234T3 (pl) *	2003-07-25	2008-02-29	Hoffmann La Roche	Kompozycja antagonisty mGluR2 i inhibitora AChE do leczenia ostrych i/lub przewlekłych zaburzeń neurologicznych
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CN102232074B (zh)	2008-11-28	2014-12-03	奥梅-杨森制药有限公司	作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
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JP2012153674A (ja) *	2011-01-28	2012-08-16	Astellas Pharma Inc	ジ（アリールアミノ）アリール化合物の製造方法及びその合成中間体
AR093077A1 (es)	2012-10-23	2015-05-20	Hoffmann La Roche	ANTAGONISTAS DE mGlu2/3 PARA EL TRATAMIENTO DE LOS TRASTORNOS AUTISTAS
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
EP3096790B1 (en)	2014-01-21	2019-07-10	Janssen Pharmaceutica, N.V.	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
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US9895324B2 (en)	2014-03-26	2018-02-20	University Of Kentucky Research Foundation	Halogenated diarylacetylenes and methods of treating cancer
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EP3154954B1 (en)	2014-06-10	2022-02-09	Sanford-Burnham Medical Research Institute	Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof
CN106243050B (zh) *	2016-08-10	2019-09-06	安徽恒星制药有限公司	一种适合工业化生产氯巴占的方法
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2000
- 2000-09-29 DK DK00969347T patent/DK1224174T3/da active
- 2000-09-29 BR BR0014859-8A patent/BR0014859A/pt not_active Application Discontinuation
- 2000-09-29 KR KR10-2002-7004838A patent/KR100480320B1/ko not_active Expired - Fee Related
- 2000-09-29 NZ NZ517999A patent/NZ517999A/en unknown
- 2000-09-29 CZ CZ20021653A patent/CZ20021653A3/cs unknown
- 2000-09-29 PT PT00969347T patent/PT1224174E/pt unknown
- 2000-09-29 SI SI200030210T patent/SI1224174T1/xx unknown
- 2000-09-29 AT AT00969347T patent/ATE250039T1/de not_active IP Right Cessation
- 2000-09-29 JP JP2001531811A patent/JP3857138B2/ja not_active Expired - Fee Related
- 2000-09-29 DE DE60005386T patent/DE60005386T2/de not_active Expired - Lifetime
- 2000-09-29 HU HU0203142A patent/HUP0203142A3/hu unknown
- 2000-09-29 AU AU79102/00A patent/AU774451B2/en not_active Ceased
- 2000-09-29 TR TR2002/01023T patent/TR200201023T2/xx unknown
- 2000-09-29 IL IL14881600A patent/IL148816A0/xx active IP Right Grant
- 2000-09-29 YU YU26202A patent/YU26202A/sh unknown
- 2000-09-29 CN CNB008142742A patent/CN1195522C/zh not_active Expired - Fee Related
- 2000-09-29 RU RU2002110104/04A patent/RU2259360C2/ru not_active IP Right Cessation
- 2000-09-29 HR HR20020259A patent/HRP20020259A2/xx not_active Application Discontinuation
- 2000-09-29 EP EP00969347A patent/EP1224174B1/en not_active Expired - Lifetime
- 2000-09-29 PL PL00357418A patent/PL357418A1/xx unknown
- 2000-09-29 WO PCT/EP2000/009553 patent/WO2001029011A2/en not_active Ceased
- 2000-09-29 CA CA002386974A patent/CA2386974C/en not_active Expired - Fee Related
- 2000-09-29 ES ES00969347T patent/ES2204704T3/es not_active Expired - Lifetime
- 2000-10-10 PE PE2000001083A patent/PE20010681A1/es not_active Application Discontinuation
- 2000-10-10 JO JO2000169A patent/JO2262B1/en active
- 2000-10-11 GC GCP2000950 patent/GC0000263A/en active
- 2000-10-12 CO CO00077957A patent/CO5261604A1/es not_active Application Discontinuation
- 2000-10-13 AR ARP000105386A patent/AR026029A1/es unknown
- 2000-10-13 MY MYPI20004817A patent/MY125540A/en unknown
- 2000-10-13 US US09/687,240 patent/US6407094B1/en not_active Expired - Fee Related
- 2000-10-14 EG EG20001310A patent/EG24079A/xx active
2002
- 2002-03-21 IL IL148816A patent/IL148816A/en not_active IP Right Cessation
- 2002-03-28 ZA ZA200202544A patent/ZA200202544B/xx unknown
- 2002-04-10 NO NO20021690A patent/NO327817B1/no not_active IP Right Cessation
- 2002-04-15 MA MA26601A patent/MA26831A1/fr unknown

Also Published As

Publication number	Publication date
AR026029A1 (es)	2002-12-26
CA2386974C (en)	2009-10-13
HUP0203142A3 (en)	2003-03-28
SI1224174T1 (en)	2003-12-31
WO2001029011A2 (en)	2001-04-26
NO327817B1 (no)	2009-09-28
IL148816A (en)	2006-10-31
ZA200202544B (en)	2003-09-23
PE20010681A1 (es)	2001-06-28
EP1224174A2 (en)	2002-07-24
RU2259360C2 (ru)	2005-08-27
DE60005386T2 (de)	2004-06-24
ES2204704T3 (es)	2004-05-01
JP2003512359A (ja)	2003-04-02
WO2001029011A3 (en)	2001-11-08
GC0000263A (en)	2006-11-01
DK1224174T3 (da)	2004-01-26
JO2262B1 (en)	2004-10-07
IL148816A0 (en)	2002-09-12
EG24079A (en)	2008-05-11
NO20021690L (no)	2002-04-10
CN1379765A (zh)	2002-11-13
CO5261604A1 (es)	2003-03-31
CN1195522C (zh)	2005-04-06
KR20020038954A (ko)	2002-05-24
AU7910200A (en)	2001-04-30
YU26202A (sh)	2004-12-31
MY125540A (en)	2006-08-30
EP1224174B1 (en)	2003-09-17
JP3857138B2 (ja)	2006-12-13
BR0014859A (pt)	2002-07-16
PL357418A1 (en)	2004-07-26
PT1224174E (pt)	2004-01-30
US6407094B1 (en)	2002-06-18
CZ20021653A3 (cs)	2002-08-14
CA2386974A1 (en)	2001-04-26
ATE250039T1 (de)	2003-10-15
TR200201023T2 (tr)	2002-09-23
KR100480320B1 (ko)	2005-04-07
HK1051038A1 (en)	2003-07-18
HUP0203142A2 (hu)	2003-02-28
MA26831A1 (fr)	2004-12-20
DE60005386D1 (de)	2003-10-23
NZ517999A (en)	2004-07-30
NO20021690D0 (no)	2002-04-10
AU774451B2 (en)	2004-06-24

Publication	Publication Date	Title
GC0000207A (en)	2006-03-29	Benzodiazepine derivatives
GC0000263A (en)	2006-11-01	Benzodiazepine derivatives
EG23817A (en)	2007-09-19	4-Phenyl-pyridine derivatives
IL148167A0 (en)	2002-09-12	Amino-triazolopyridine derivatives
GC0000183A (en)	2006-03-29	3-Phenyl-pyridine derivatives
GC0000338A (en)	2007-03-31	5-Phenyl-pyrimidine derivatives
IL145739A0 (en)	2002-07-25	13-methyl-erythromycin derivatives
IL148058A0 (en)	2002-09-12	Substituted 2-dialkylaminoalkylbiphenyl derivatives
IL148837A0 (en)	2002-09-12	Isoxazolecarboxamide derivatives
GC0000191A (en)	2006-03-29	4-Phenyl-pyrimidine derivatives
IL155035A0 (en)	2003-10-31	Benzodiazepine derivatives
GC0000256A (en)	2006-11-01	Ethanesulfonyl-piperidine derivatives
GB9925880D0 (en)	1999-12-29	B-Carboline derivatives
IL150132A0 (en)	2002-12-01	Cyclopenteneone derivatives
IL147636A0 (en)	2002-08-14	3-amino-2-benzyl-1-phenyl-propane derivatives
IL145949A0 (en)	2002-07-25	1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
PL351407A1 (en)	2003-04-22	Thio-oxindole derivatives
IL146282A0 (en)	2002-07-25	Thio-oxindole derivatives
GB9907134D0 (en)	1999-05-19	Antimor napthylcombretastatin derivatives
SI1178984T1 (en)	2003-08-31	1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
SI1226131T1 (en)	2004-04-30	Isoxazolecarboxamide derivatives
SI1200445T1 (en)	2004-02-29	Thienopyranecarboxamide derivatives

Legal Events

Date	Code	Title
2004-04-30	A1OB	Publication of a patent application
2004-10-19	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2008-12-09	OBST	Application withdrawn