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SG11201509938YA - 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS - Google Patents

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Info

Publication number
SG11201509938YA
SG11201509938YA SG11201509938YA SG11201509938YA SG11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA
Authority
SG
Singapore
Prior art keywords
dihydropyrazolo
pyrazin
compounds
allosteric modulators
negative allosteric
Prior art date
Application number
SG11201509938YA
Other languages
English (en)
Inventor
Gool Michiel Luc Maria Van
Diego Sergio-Alvar Alonso-De
José Maria Cid-Núñez
Óscar Delgado-González
Annelies Marie Antonius Decorte
Gregor James Macdonald
Antonius Adrianus Hendrikus Petrus Megens
Andrés Avelino Trabanco-Suárez
Aránzazu García-Molina
José Ignacio Andrés-Gil
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11201509938YA publication Critical patent/SG11201509938YA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Materials Engineering (AREA)
SG11201509938YA 2013-06-04 2014-06-03 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS SG11201509938YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13170447 2013-06-04
EP13173939 2013-06-27
EP14166450 2014-04-29
PCT/EP2014/061478 WO2014195311A1 (en) 2013-06-04 2014-06-03 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Publications (1)

Publication Number Publication Date
SG11201509938YA true SG11201509938YA (en) 2016-01-28

Family

ID=50884400

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201509938YA SG11201509938YA (en) 2013-06-04 2014-06-03 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Country Status (31)

Country Link
US (2) US10106542B2 (el)
EP (1) EP3004107B1 (el)
JP (1) JP6357533B2 (el)
KR (1) KR102223050B1 (el)
CN (2) CN105263935B (el)
AU (1) AU2014276963C1 (el)
BR (1) BR112015029982A2 (el)
CA (1) CA2910507C (el)
CL (1) CL2015003499A1 (el)
CY (1) CY1119499T1 (el)
DK (1) DK3004107T3 (el)
EA (1) EA030426B1 (el)
ES (1) ES2637295T3 (el)
HR (1) HRP20171051T1 (el)
HU (1) HUE033057T2 (el)
IL (1) IL242868B (el)
JO (1) JO3368B1 (el)
LT (1) LT3004107T (el)
ME (1) ME02949B (el)
MX (1) MX368861B (el)
MY (1) MY192029A (el)
PH (1) PH12015502685B1 (el)
PL (1) PL3004107T3 (el)
PT (1) PT3004107T (el)
RS (1) RS56128B1 (el)
SG (1) SG11201509938YA (el)
SI (1) SI3004107T1 (el)
SM (1) SMT201700374T1 (el)
TW (2) TWI632144B (el)
UA (1) UA117016C2 (el)
WO (1) WO2014195311A1 (el)

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JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
PH12019500127B1 (en) 2014-01-21 2022-05-04 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
EP3424535A1 (en) 2014-01-21 2019-01-09 Janssen Pharmaceutica NV Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
WO2015129821A1 (ja) * 2014-02-27 2015-09-03 国立大学法人東京大学 オートタキシン阻害活性を有する縮合ピラゾール誘導体
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
AU2015357167B2 (en) 2014-12-03 2020-06-25 Janssen Pharmaceutica Nv 6,7-dihydropyrazolo(1,5-alpha)pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors
US10967078B2 (en) 2014-12-03 2021-04-06 Janssen Pharmaceutica Nv Radiolabelled mGluR2 PET ligands
MA41338B1 (fr) * 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
TR201909160T4 (tr) 2015-07-15 2019-07-22 Hoffmann La Roche Metabotropik glutamat reseptörü modülatörleri olarak etinil türevleri.
JP2018154554A (ja) * 2015-07-29 2018-10-04 大日本住友製薬株式会社 新規リンカー部位を持つ縮合ピラゾール誘導体およびその医薬用途
RS60981B1 (sr) 2015-12-18 2020-11-30 Janssen Pharmaceutica Nv Radiooznačeni mglur2/3 pet ligandi
ES2820823T3 (es) 2015-12-18 2021-04-22 Janssen Pharmaceutica Nv Ligandos PET mGluR2/3 radiomarcados
JP6936305B2 (ja) 2016-07-18 2021-09-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft エチニル誘導体
PT3519416T (pt) 2016-09-27 2021-05-13 Merck Sharp & Dohme Derivados de cromano, isocromano e diidroisobenzofurano como moduladores alostericos mglur2-negativos, composições e sua utilização
EP3719023B1 (en) * 2017-11-24 2024-10-16 Sumitomo Pharma Co., Ltd. 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF
JP7266010B2 (ja) * 2019-05-30 2023-04-27 住友ファーマ株式会社 6,7-ジヒドロピラゾロ[1,5-a]ピラジノン誘導体又はその塩を含有する医薬
KR102797536B1 (ko) 2020-04-29 2025-04-22 릴레이 테라퓨틱스, 인크. PI3Kα 억제제 및 이의 사용 방법
WO2023288242A1 (en) * 2021-07-13 2023-01-19 Relay Therapeutics, Inc. PI3Kα INHIBITORS AND METHODS OF USE THEREOF
US12396981B2 (en) 2023-03-09 2025-08-26 William Shulman Methods of using DMT

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