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SE9103572D0 - Organic salts of n,n'-diacetyl cystine - Google Patents

Organic salts of n,n'-diacetyl cystine

Info

Publication number
SE9103572D0
SE9103572D0 SE9103572A SE9103572A SE9103572D0 SE 9103572 D0 SE9103572 D0 SE 9103572D0 SE 9103572 A SE9103572 A SE 9103572A SE 9103572 A SE9103572 A SE 9103572A SE 9103572 D0 SE9103572 D0 SE 9103572D0
Authority
SE
Sweden
Prior art keywords
organic salts
diacetyl cystine
cystine
diacetyl
processes
Prior art date
Application number
SE9103572A
Other languages
English (en)
Swedish (sv)
Inventor
Carl-Magnus Andersson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9103572A priority Critical patent/SE9103572D0/xx
Publication of SE9103572D0 publication Critical patent/SE9103572D0/xx
Priority to NZ245077A priority patent/NZ245077A/en
Priority to ZA928739A priority patent/ZA928739B/xx
Priority to IL10377892A priority patent/IL103778A/xx
Priority to YU99092A priority patent/YU48594B/sh
Priority to APAP/P/1992/000448A priority patent/AP350A/en
Priority to HR9103572-5A priority patent/HRP921322B1/xx
Priority to TNTNSN92108A priority patent/TNSN92108A1/fr
Priority to IS3949A priority patent/IS1645B/is
Priority to MA23006A priority patent/MA22716A1/fr
Priority to HU9401473A priority patent/HU215390B/hu
Priority to AU30996/92A priority patent/AU657827B2/en
Priority to CZ941297A priority patent/CZ282085B6/cs
Priority to RU94027569/04A priority patent/RU2135468C1/ru
Priority to PCT/SE1992/000807 priority patent/WO1993011104A1/fr
Priority to JP51003993A priority patent/JP3302018B2/ja
Priority to SG1996004497A priority patent/SG73962A1/en
Priority to SK632-94A priority patent/SK281697B6/sk
Priority to FI942504A priority patent/FI942504A7/fi
Priority to AT92924975T priority patent/ATE141913T1/de
Priority to PL92303924A priority patent/PL170787B1/pl
Priority to MYPI92002155A priority patent/MY110523A/en
Priority to KR1019940701815A priority patent/KR100256185B1/ko
Priority to EP92924975A priority patent/EP0621862B1/fr
Priority to DK92924975.3T priority patent/DK0621862T3/da
Priority to PL92314567A priority patent/PL171336B1/pl
Priority to CA002123516A priority patent/CA2123516A1/fr
Priority to DZ920148A priority patent/DZ1637A1/fr
Priority to ES92924975T priority patent/ES2090713T3/es
Priority to DE69213256T priority patent/DE69213256T2/de
Priority to US07/981,373 priority patent/US5385904A/en
Priority to MX9206851A priority patent/MX9206851A/es
Priority to CN92113666A priority patent/CN1039586C/zh
Priority to SI19929200351A priority patent/SI9200351A/sl
Priority to NO941968A priority patent/NO301325B1/no
Priority to US08/335,941 priority patent/US5693858A/en
Priority to EE9400378A priority patent/EE03025B1/xx
Priority to US08/476,218 priority patent/US5650538A/en
Priority to US08/477,387 priority patent/US5804582A/en
Priority to US08/484,143 priority patent/US5824681A/en
Priority to GR960402920T priority patent/GR3021546T3/el
Priority to HK62297A priority patent/HK62297A/en
Priority to LVP-97-158A priority patent/LV11949B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9103572A 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine SE9103572D0 (sv)

Priority Applications (43)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine
NZ245077A NZ245077A (en) 1991-11-29 1992-11-10 Isomeric forms of n,n'-diacetyl cystine salt with an organic base, preparation and pharmaceutical compositions thereof
ZA928739A ZA928739B (en) 1991-11-29 1992-11-12 Organic salts of N,N'-diacetyl cystine.
IL10377892A IL103778A (en) 1991-11-29 1992-11-17 Organic salts of N,N'-diacetyl cystine process for their preparation and pharmaceutical compositions containing them
YU99092A YU48594B (sh) 1991-11-29 1992-11-18 Organske soli n-n'-diacetilcistina i postupak njihovog dobijanja
APAP/P/1992/000448A AP350A (en) 1991-11-29 1992-11-20 Organic salts of N,N-Diacetyl cystine.
HR9103572-5A HRP921322B1 (en) 1991-11-29 1992-11-23 Organic salts of n,n'-diacetyl cystine
TNTNSN92108A TNSN92108A1 (fr) 1991-11-29 1992-11-23 Sels organiques de n, n' -diacetyl cystine
IS3949A IS1645B (is) 1991-11-29 1992-11-24 Hliðstæð aðferð við að framleiða salt af lýsini og N,N'-tvíasetýlsystíni
MA23006A MA22716A1 (fr) 1991-11-29 1992-11-24 Sels organiques de n,n'-diacetyl cystine
US07/981,373 US5385904A (en) 1991-11-29 1992-11-25 Organic salts of N,N'-diacetyl cystine
PL92303924A PL170787B1 (en) 1991-11-29 1992-11-25 Method of obtaining an organic salt and n,n'-diacetlocystine
DZ920148A DZ1637A1 (fr) 1991-11-29 1992-11-25 Sels organiques de n'n'-diacétyl cystine.
CZ941297A CZ282085B6 (cs) 1991-11-29 1992-11-25 Organické soli N,N'-diacetylcystinu
RU94027569/04A RU2135468C1 (ru) 1991-11-29 1992-11-25 Органические соли n,n'-диацетилцистина, способы их получения, фармацевтическая композиция, способ лечения
PCT/SE1992/000807 WO1993011104A1 (fr) 1991-11-29 1992-11-25 Sels organiques de cystine de n, n'-diacetyle
JP51003993A JP3302018B2 (ja) 1991-11-29 1992-11-25 Ｎ，ｎ’−ジアセチルシスチンの有機塩
SG1996004497A SG73962A1 (en) 1991-11-29 1992-11-25 Organic salts of n, n'-diacetyl cystine
SK632-94A SK281697B6 (sk) 1991-11-29 1992-11-25 Soľ organickej bázy a n,n'-diacetylcystínu, spôsob jej výroby, jej použitie a farmaceutický prostriedok s jej obsahom
FI942504A FI942504A7 (fi) 1991-11-29 1992-11-25 N,N'-diasetyylikystiinin orgaanisia suoloja
AT92924975T ATE141913T1 (de) 1991-11-29 1992-11-25 Organische salze von n, n'-diacetylcystin
HU9401473A HU215390B (hu) 1991-11-29 1992-11-25 Eljárás N,N'-diacetil-cisztin szerves bázisokkal képzett sói és az ezeket tartalmazó gyógyászati készítmények előállítására
MYPI92002155A MY110523A (en) 1991-11-29 1992-11-25 Organic salts of n, n''-dicetyl cystine
KR1019940701815A KR100256185B1 (ko) 1991-11-29 1992-11-25 N,n'-디아세틸 시스틴의 유기염
EP92924975A EP0621862B1 (fr) 1991-11-29 1992-11-25 Sels organiques de cystine de n, n'-diacetyle
DK92924975.3T DK0621862T3 (da) 1991-11-29 1992-11-25 Organiske salte af N,N-diacetylcystin
PL92314567A PL171336B1 (en) 1991-11-29 1992-11-25 Method of obtaining an organic salt and n,n'-diacetylocystine
CA002123516A CA2123516A1 (fr) 1991-11-29 1992-11-25 Sels organiques de la n,n'-diacetylcystine
AU30996/92A AU657827B2 (en) 1991-11-29 1992-11-25 Organic salts of N, N'-diacetyl cystine
ES92924975T ES2090713T3 (es) 1991-11-29 1992-11-25 Sales organicas de n,n'-diacetil-cistina.
DE69213256T DE69213256T2 (de) 1991-11-29 1992-11-25 Organische salze von n, n'-diacetylcystin
MX9206851A MX9206851A (es) 1991-11-29 1992-11-27 Sales organicas de n,n'-diacetil cistina, proceso para su preparacion y composicion farmaceutica que las contiene.
CN92113666A CN1039586C (zh) 1991-11-29 1992-11-28 制备n,n′－二乙酰胱氨酸的有机盐的方法
SI19929200351A SI9200351A (en) 1991-11-29 1992-11-30 Organic salts of n,n'-diacetyl cystine
NO941968A NO301325B1 (no) 1991-11-29 1994-05-26 Organiske salter av N,N'-diacetylcystin, farmasöytisk preparat samt anvendelse av saltene
US08/335,941 US5693858A (en) 1991-11-29 1994-11-08 Organic salts of N,N'-diacetyl cystine
EE9400378A EE03025B1 (et) 1991-11-29 1994-11-17 Immunomoduleeriva toimega N,N'-diatsetüültsüstiini orgaanilised soolad, nende valmistamine ja kasutamine
US08/476,218 US5650538A (en) 1991-11-29 1995-06-07 Organic salts of N,N'-diacetyl cystine
US08/477,387 US5804582A (en) 1991-11-29 1995-06-07 Method for the treatment of diseases due to defects the immune system
US08/484,143 US5824681A (en) 1991-11-29 1995-06-07 Organic salts of N,N'-diacetyl cystine
GR960402920T GR3021546T3 (en) 1991-11-29 1996-11-06 Organic salts of n, n'-diacetyl cystine.
HK62297A HK62297A (en) 1991-11-29 1997-05-08 Organic salts of n, n'-diacetyl cystine
LVP-97-158A LV11949B (en) 1991-11-29 1997-08-28 N, N'-DIACETYL-CISTIN ORGANIC SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (1)

Publication Number Publication Date
SE9103572D0 true SE9103572D0 (sv) 1991-11-29

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Country Status (38)

Country Link
US (5) US5385904A (fr)
EP (1) EP0621862B1 (fr)
JP (1) JP3302018B2 (fr)
KR (1) KR100256185B1 (fr)
CN (1) CN1039586C (fr)
AP (1) AP350A (fr)
AT (1) ATE141913T1 (fr)
AU (1) AU657827B2 (fr)
CA (1) CA2123516A1 (fr)
CZ (1) CZ282085B6 (fr)
DE (1) DE69213256T2 (fr)
DK (1) DK0621862T3 (fr)
DZ (1) DZ1637A1 (fr)
EE (1) EE03025B1 (fr)
ES (1) ES2090713T3 (fr)
FI (1) FI942504A7 (fr)
GR (1) GR3021546T3 (fr)
HK (1) HK62297A (fr)
HR (1) HRP921322B1 (fr)
HU (1) HU215390B (fr)
IL (1) IL103778A (fr)
IS (1) IS1645B (fr)
LV (1) LV11949B (fr)
MA (1) MA22716A1 (fr)
MX (1) MX9206851A (fr)
MY (1) MY110523A (fr)
NO (1) NO301325B1 (fr)
NZ (1) NZ245077A (fr)
PL (2) PL171336B1 (fr)
RU (1) RU2135468C1 (fr)
SE (1) SE9103572D0 (fr)
SG (1) SG73962A1 (fr)
SI (1) SI9200351A (fr)
SK (1) SK281697B6 (fr)
TN (1) TNSN92108A1 (fr)
WO (1) WO1993011104A1 (fr)
YU (1) YU48594B (fr)
ZA (1) ZA928739B (fr)

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SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
SE9602262D0 (sv) * 1996-06-06 1996-06-06 Astra Ab New use of derivatives of cystine
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
SE9800932D0 (sv) 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (fr) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulateur
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
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CA2643464C (fr) 2006-02-22 2018-09-04 Mannkind Corporation Procede pour ameliorer les proprietes pharmaceutiques de microparticules comprenant de la dicetopiperazine et un agent actif
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
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CN106039494B (zh) 2008-06-13 2019-12-24 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
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US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
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WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
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NO941968L (no) 1994-05-26
HUT70851A (en) 1995-11-28
CN1073683A (zh) 1993-06-30
ATE141913T1 (de) 1996-09-15
EE03025B1 (et) 1997-08-15
NO301325B1 (no) 1997-10-13
HU215390B (hu) 1998-12-28
DE69213256T2 (de) 1997-01-23
LV11949A (lv) 1998-01-20
US5385904A (en) 1995-01-31
HRP921322A2 (en) 1996-10-31
DZ1637A1 (fr) 2002-02-17
IL103778A0 (en) 1993-04-04
FI942504L (fi) 1994-05-27
NO941968D0 (no) 1994-05-26
WO1993011104A1 (fr) 1993-06-10
YU99092A (sh) 1995-12-04
CN1039586C (zh) 1998-08-26
FI942504A0 (fi) 1994-05-27
PL170787B1 (en) 1997-01-31
CZ282085B6 (cs) 1997-05-14
IL103778A (en) 1997-08-14
EP0621862A1 (fr) 1994-11-02
FI942504A7 (fi) 1994-05-27
YU48594B (sh) 1998-12-23
TNSN92108A1 (fr) 1993-06-08
IS3949A (is) 1993-05-30
SG73962A1 (en) 2000-07-18
KR100256185B1 (ko) 2000-05-15
US5693858A (en) 1997-12-02
HU9401473D0 (en) 1994-08-29
MY110523A (en) 1998-07-31
MX9206851A (es) 1993-05-01
SK63294A3 (en) 1995-02-08
HRP921322B1 (en) 1998-12-31
US5650538A (en) 1997-07-22
AP350A (en) 1994-08-09
LV11949B (en) 1998-07-20
GR3021546T3 (en) 1997-02-28
AU657827B2 (en) 1995-03-23
ES2090713T3 (es) 1996-10-16
DK0621862T3 (da) 1996-09-16
NZ245077A (en) 1995-04-27
DE69213256D1 (de) 1996-10-02
AP9200448A0 (en) 1993-01-31
IS1645B (is) 1997-03-25
US5824681A (en) 1998-10-20
JP3302018B2 (ja) 2002-07-15
JPH07501539A (ja) 1995-02-16
MA22716A1 (fr) 1993-07-01
EP0621862B1 (fr) 1996-08-28
RU2135468C1 (ru) 1999-08-27
AU3099692A (en) 1993-06-28
HK62297A (en) 1997-05-16
SI9200351A (en) 1993-06-30
CZ129794A3 (en) 1995-01-18
CA2123516A1 (fr) 1993-06-10
PL171336B1 (en) 1997-04-30
SK281697B6 (sk) 2001-06-11
US5804582A (en) 1998-09-08
ZA928739B (en) 1993-06-09

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