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ES2062313T3 - 13-bromo- y 13,14-dibromo-ergolinas, a su preparacion y a su utilizacion en medicamentos. - Google Patents

13-bromo- y 13,14-dibromo-ergolinas, a su preparacion y a su utilizacion en medicamentos.

Info

Publication number
ES2062313T3
ES2062313T3 ES90250235T ES90250235T ES2062313T3 ES 2062313 T3 ES2062313 T3 ES 2062313T3 ES 90250235 T ES90250235 T ES 90250235T ES 90250235 T ES90250235 T ES 90250235T ES 2062313 T3 ES2062313 T3 ES 2062313T3
Authority
ES
Spain
Prior art keywords
preparation
ergolinas
dibromo
medicines
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90250235T
Other languages
English (en)
Inventor
Gerhard Dr Sauer
Thomas Dr Brumby
Helmut Dr Wachtel
Jonathan Dr Turner
Peter Andreas Loschmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2062313T3 publication Critical patent/ES2062313T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA I (FORMULA) ASI COMO SU PRODUCCION Y UTILIZACION EN MEDICAMENTOS Y LOS PRODUCTOS INTERMEDIOS PARA LA PRODUCCION DE ESTOS COMPUESTOS.
ES90250235T 1989-09-20 1990-09-13 13-bromo- y 13,14-dibromo-ergolinas, a su preparacion y a su utilizacion en medicamentos. Expired - Lifetime ES2062313T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931819A DE3931819A1 (de) 1989-09-20 1989-09-20 13-brom und 13, 14-dibrom-ergoline, ihre herstellung und verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
ES2062313T3 true ES2062313T3 (es) 1994-12-16

Family

ID=6390055

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90250235T Expired - Lifetime ES2062313T3 (es) 1989-09-20 1990-09-13 13-bromo- y 13,14-dibromo-ergolinas, a su preparacion y a su utilizacion en medicamentos.

Country Status (12)

Country Link
EP (1) EP0418990B1 (es)
JP (1) JPH03120277A (es)
AT (1) ATE97130T1 (es)
CA (1) CA2025744A1 (es)
CZ (1) CZ278319B6 (es)
DD (1) DD295848A5 (es)
DE (2) DE3931819A1 (es)
DK (1) DK0418990T3 (es)
ES (1) ES2062313T3 (es)
HU (1) HU206346B (es)
IE (1) IE65416B1 (es)
PT (1) PT95350A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4123587A1 (de) * 1991-07-12 1993-01-14 Schering Ag 2,14-disubstituierte ergoline, deren herstellung und verwendung in arzneimitteln
US9657020B2 (en) 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
JP2018502889A (ja) * 2015-01-20 2018-02-01 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ イソエルゴリン化合物およびその使用
AU2018275873A1 (en) 2017-06-01 2019-12-19 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1413068A (en) * 1972-06-22 1975-11-05 Farmaceutici Italia Bromoergolines
DE2802023A1 (de) * 1977-01-28 1978-08-03 Sandoz Ag Neue ergotderivate, ihre herstellung und verwendung
GB2074566B (en) * 1980-04-03 1983-11-02 Erba Farmitalia Ergoline derivatives
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3730124A1 (de) * 1987-09-08 1989-03-16 Eich Eckart Neue festuclavin- und pyroclavin-derivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
HU206346B (en) 1992-10-28
CA2025744A1 (en) 1991-03-21
DK0418990T3 (da) 1994-03-14
PT95350A (pt) 1991-05-22
EP0418990B1 (de) 1993-11-10
HUT54682A (en) 1991-03-28
IE903369A1 (en) 1991-04-10
CZ278319B6 (en) 1993-11-17
EP0418990A2 (de) 1991-03-27
DE59003446D1 (de) 1993-12-16
ATE97130T1 (de) 1993-11-15
DD295848A5 (de) 1991-11-14
JPH03120277A (ja) 1991-05-22
IE65416B1 (en) 1995-10-18
CZ458290A3 (en) 1993-04-14
DE3931819A1 (de) 1991-03-28
EP0418990A3 (en) 1991-07-03

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