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DK0539204T3 - Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre - Google Patents

Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre

Info

Publication number
DK0539204T3
DK0539204T3 DK92309684T DK92309684T DK0539204T3 DK 0539204 T3 DK0539204 T3 DK 0539204T3 DK 92309684 T DK92309684 T DK 92309684T DK 92309684 T DK92309684 T DK 92309684T DK 0539204 T3 DK0539204 T3 DK 0539204T3
Authority
DK
Denmark
Prior art keywords
antiviral
deoxy
alpha
substituted
neuraminic acid
Prior art date
Application number
DK92309684T
Other languages
English (en)
Inventor
Itzstein Von
Wen-Yang Wu
Tho Van Phan
Betty Jin
Original Assignee
Biota Scient Management
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scient Management filed Critical Biota Scient Management
Application granted granted Critical
Publication of DK0539204T3 publication Critical patent/DK0539204T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK92309684T 1991-10-23 1992-10-22 Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre DK0539204T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK905191 1991-10-23

Publications (1)

Publication Number Publication Date
DK0539204T3 true DK0539204T3 (da) 1998-09-07

Family

ID=3775765

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92309684T DK0539204T3 (da) 1991-10-23 1992-10-22 Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre

Country Status (10)

Country Link
EP (1) EP0539204B1 (da)
JP (1) JP2925863B2 (da)
AT (1) ATE161836T1 (da)
AU (1) AU659501B2 (da)
CA (1) CA2081068C (da)
DE (1) DE69223914T2 (da)
DK (1) DK0539204T3 (da)
ES (1) ES2113413T3 (da)
GR (1) GR3026218T3 (da)
ZA (1) ZA928170B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
SI9620042A (sl) * 1995-02-27 1998-12-31 Gilead Sciences, Inc. Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz
CN101172957B (zh) * 1995-02-27 2012-11-14 吉里德科学公司 新颖化合物,其合成方法及治疗用途
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
ATE206116T1 (de) * 1995-05-19 2001-10-15 Biota Scient Management 6-carboxamido-dihydropyran-derivate
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
PT823428E (pt) * 1996-07-22 2002-04-29 Sankyo Co Derivados do acido neuraminico sua preparacao e sua utilizacao em medicina
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
PT934939E (pt) * 1996-08-13 2003-07-31 Sankyo Co Compostos de acido neuraminico
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
AU711845B2 (en) * 1996-09-10 1999-10-21 Daikin Industries, Ltd. 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
CA2268756A1 (en) * 1996-10-21 1998-04-30 Gilead Sciences, Inc. Piperidine compounds
US5994377A (en) * 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
TR199901081T2 (xx) * 1996-11-14 1999-08-23 Biota Scientific Management Pty.Ltd. Y�ntem ve bu y�ntemde kullan�lan yeni bile�imler.
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
TW480247B (en) * 1997-12-12 2002-03-21 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
PL215419B1 (pl) 2003-02-10 2013-12-31 Nippon Catalytic Chem Ind Srodek pochlaniajacy wode
CA2675934C (en) 2007-01-23 2015-09-15 Therapicon Srl Antiviral compounds
JPWO2009004899A1 (ja) * 2007-06-15 2010-08-26 国立大学法人北海道大学 シアリダーゼ阻害剤
EP2358695B1 (en) 2008-11-28 2014-07-02 Cipla Limited Process for preparing zanamivir and intermediates for use in the process
EA201101564A1 (ru) 2009-05-15 2012-07-30 Редкс Фарма Лимитед Редокс производные лекарственных средств
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
EP2678324A1 (en) 2011-02-24 2014-01-01 Cadila Healthcare Limited Process for the preparation of zanamivir
DE102011117128A1 (de) * 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
GR3026218T3 (en) 1998-05-29
AU659501B2 (en) 1995-05-18
CA2081068A1 (en) 1993-04-24
EP0539204B1 (en) 1998-01-07
ZA928170B (en) 1993-11-15
ATE161836T1 (de) 1998-01-15
CA2081068C (en) 2005-11-29
JPH0625209A (ja) 1994-02-01
HK1015137A1 (en) 1999-10-08
DE69223914T2 (de) 1998-04-30
EP0539204A1 (en) 1993-04-28
JP2925863B2 (ja) 1999-07-28
ES2113413T3 (es) 1998-05-01
AU2724292A (en) 1993-04-29
DE69223914D1 (de) 1998-02-12

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