RU2477150C2 - Method of treating patients with craniocerebral injury with underlying acute hypertension syndrome - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely neurosurgery and efferent therapy, and may be used in treating patients with a craniocerebral injury with underlying acute hypertension syndrome. That is ensured by blood sampling from a patient with erythrocyte 50 ml recovered. Erythrocytes are enriched with dexamethasone 1 ml and injected into the patient's blood circulatory system. The procedure is performed once a day every 2-3 days. The therapeutic course is 5 procedures.

EFFECT: method enables reducing a length of treatment in the given category of the patients due to more adequate drug delivery provided by patient's erythrocytes enrichment.

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Description

The invention relates to medicine, and specifically to methods for treating patients with traumatic brain injury.

There is a method of treating patients with traumatic brain injury on the background of hypertension syndrome by taking blood from patients, mixing it with medicinal solutions and returning it to the patient’s circulatory system (Handbook for a doctor on duty // Recommendations for practitioners on the treatment of emergency conditions. Bulletin of the Department of Anesthesiology and Resuscitation Gorno - Altai Republican Hospital No. 8.3, 2007, p. 3, 7; Doronin B.M. et al. Mexidol in the prevention of intracranial hypertension syndrome in the aftermath of closed craniocerebral trauma, No. 1 9, 2006, sections: introduction, materials and methods, conclusion; RU 2289405 C2, 12.20.2006, formula; RU 2008133449 A, 02.20.2010, abstract; Zolotukhin O.V. et al. Extracorporeal saturation of blood cells with antibiotics for targeted Transport, Bulletin of the Voronezh State University, series: Chemistry, Biology, Pharmacy, No. 1, 2009, p. 62 number 2, paragraph 3, p. 63 number 2, paragraph 2, p. 64 Fig. 2, 3).

The disadvantage of this method is the lack of effectiveness and the long duration of treatment.

The aim of the invention is to increase efficiency and reduce treatment time. This goal is achieved by extracting 50 ml of red blood cells from the patient’s blood, mixing red blood cells with 1 ml of dexamethasone under the influence of a laser, and returning it to the patient’s circulatory system once a day after 1-2 days with 5 treatments.

Comparison of the proposed method with methods known in the field of medicine showed its compliance with the criteria of the invention.

The differences of the proposed method:

- patients with a history of hypertension syndrome are treated, and then received a traumatic brain injury in the acute period;

- isolated from the blood of the patient and mixed 50 ml of red blood cells and 1 ml of dexamethasone when exposed to a laser by stirring on a vibrating table for 15 minutes;

- incubation and storage of red blood cells mixed with dexamethasone are not needed, because they are introduced into the body of the victim after mixing.

The method is implemented as follows.

One of the known methods is that 120 ml of blood is taken from a patient, from which 50 ml of red blood cells are isolated by centrifugation. Washed from plasma in an isotonic solution of 0.9% sodium chloride. Red blood cells are isolated and, when exposed to a laser, they are mixed with 1 ml of dexamethasone in a standard manner on a vibrating table for 15 minutes, after which the red blood cells are returned to the patient's circulatory system. The criterion for mixing red blood cells with dexamethasone when exposed to a laser is the formation of a homogeneous red blood cell mass. The process is controlled by microscopic examination, confirming the integrity of red blood cells. The ratio of 50 ml of red blood cells and 1 ml of dexamethasone and a mixing time of 15 minutes were obtained empirically and are optimal.

Dexamethasone mixes well with red blood cells, fixed on them and ends up in the right place.

Clinical example

Patient M., 41 years old, was admitted to the department with a diagnosis of Closed fracture of the arch and base of the skull. Brain injury of the 2nd degree, right-sided central hemiparesis. Hypertension syndrome. In addition to standard treatment. One of the known methods for taking blood from a patient, from which 50 ml of red blood cells is isolated by centrifugation. Washed from plasma in an isotonic solution of 0.9% sodium chloride. Red blood cells are isolated and, when exposed to a laser, they are mixed with 1 ml of dexamethasone in a standard manner on a vibrating table for 15 minutes, after which the red blood cells are returned to the patient's circulatory system.

Dexamethasone mixes well with red blood cells, fixed on them and ends up in the right place.

This patient underwent five procedures with 1 ml dexamethasone with an interval of 1-2 days.

After treatment, there was a change in the clinical picture for the better: stability in the Romberg position, a less pronounced Mann-Gurevich symptom, the disappearance of tremor of the fingers, facial asymmetry disappeared, frontal and nasolabial folds were compared, and the strength of the muscles of the hands was equalized.

The course of treatment of this patient was reduced by a third and 5 ampoules of dexamethasone, 1 ml each, were consumed. According to this technique, in a hospital, we treated 232 patients. In 214 patients a positive result of treatment, in 18 patients a doubtful result.

The treatment cycle is 5 procedures once a day after 1-2 days.

Using the proposed method can improve efficiency and reduce treatment time, as well as reduce treatment costs.

Information sources

1. The allowance of the attendant // Recommendations for practitioners on the treatment of emergency conditions. Bulletin of the Department of Anesthesiology and Resuscitation of the Gorno-Altai Republican Hospital No. 8.3, 2007, pp. 3, 7.

2. Doronin B.M. et al. Mexidol in the prevention of intracranial hypertension syndrome in the aftermath of closed traumatic brain injury, No. 19, 2006, sections: introduction, materials and methods, conclusion.

3. RU 2289405 C2, 12.20.2006, formula.

4. RU 2008133449 A, 02.20.2010, abstract.

5. Zolotukhin OV and other extracorporeal saturation of blood cells with antibiotics for targeted transport. Bulletin of the Voronezh State University, series: Chemistry. Biology. Pharmacy, No. 1, 2009, p. 62 col. 2 paragraph 3, p. 63 col. 2 paragraph 2, p. 64 fig. 2, 3.

6. Abel J.J., Rowntree L.G., Turner B.B. Plasma removal with return of corpuscles (plasmapheresis) // J Pharmacol. Exp. Ther. -1913-1914. - Vol. 5 - P.625.

7. Yurevich V.A., Rosenberg N.K. To the question of washing blood outside the body and the vitality of red blood balls // Russian doctor. - 1914. - T.13, No. 18. - S. 637-639.

Claims (1)

A method of treating patients with traumatic brain injury on the background of hypertension syndrome in the acute period by taking blood, saturating it with a drug and returning it to the patient's circulatory system, characterized in that 50 ml of red blood cells are isolated from the patient’s blood, saturated with 1 ml of dexamethasone and returned into the circulatory system of the patient 1 time a day after 2-3 days with a course of treatment of 5 procedures.