RU2195838C2 - Preparation for stimulating the growth and increasing the resistance in farm and domestic animals and poultry - Google Patents

Abstract

FIELD: veterinary science. SUBSTANCE: the suggested preparation contains components affecting practically all the sides of metabolism, nitrogenous bases: riboxin, methyluracyl, vitamins B12 and C, activator of glycolysis - fructoso-1.6-calcium diphosphate. It is demonstrated the efficiency in treating domestic animals (dogs); application of the suggested preparation in fur farming provides to obtain decreased death rate in pups and their accelerated growth characteristics. EFFECT: higher efficiency. 5 tbl

Description

 The invention relates to veterinary medicine and can be used to accelerate growth, reduce morbidity and increase the survival rate of young animals.

 We named the indicated drug Purivetin. Tests were conducted under this name.

 The main problem in veterinary medicine and agriculture is the provision of animals with balanced feed. Full-fledged feeding of various types of farm animals and poultry ensures the preservation of their health, fertility and high productivity. The content of vitamins and microelements in complete and balanced mixed feeds is provided by the obligatory inclusion of appropriate premixes in recipes.

 The inclusion of enzymes in the formulation facilitates the digestion of feed; antibiotics increase resistance, has growth - a stimulating effect.

 Specialists are constantly making adjustments to feeding programs for farm animals and poultry in order to improve product quality and economic indicators.

 Nevertheless, as numerous studies show, in real conditions there are many reasons for the decrease in resistance of animals, leading to various pathologies: growth retardation and development, poor absorption syndrome, etc.

 The problem is solved by adding biological additives to the feed containing energy and immunostimulants, protobiotics, etc.

 Known feed additives containing, as components that increase resistance, carotene-containing biomass of yeast (RU 2122807 C1, 1998); mumiye extract (RU 2125380 C1, 1999); pumpkin meal (RU 2125881 C1, 1999); dry technical blood concentrate - published application of the Russian Federation 96124004 A1, 1999.

 However, they do not solve the problem in full. All listed or similar dietary supplements contain components of animal, plant or microbial origin as an active principle; their multicomponent and non-standard features do not allow achieving sustainable positive results.

 The aim of the invention is the creation of an effective tool for the prevention of disease in agricultural, domestic animals and poultry, accelerate their growth, reduce mortality.

 This goal is achieved using a complex preparation containing nitrogen bases, glycolysis activator and vitamins.

 As nitrogen bases, we use a purine base - inosine (riboxin) - 10.0% and a pyrimidine base - methyluracil (thymine) - 30.0%, which are part of the structure of nucleic acids in nucleotides and are widely used in medicine as energy transfer activators.

 As an activator of glycolysis, the composition of the drug includes fructose-1,6-diphosphate of calcium - 30.0% - the product of the key reaction of the glycolytic pathway.

 Citric acid - 0.3%, which is part of the drug, is one of the intermediate products of the tricarboxylic acid cycle, aimed at obtaining the greatest energy in the process of metabolism.

 Since a significant part of sugar interconversions proceeds through the formation of nucleoside diphosphates sugars, the introduction of substances that are intermediate compounds in the most important metabolic pathway leads to the activation of energy exchange.

Vitamin B ₁₂ = 0.02%, included in the formulation in the most active coenzyme form, is part of the enzyme that provides the transfer and introduction of methyl groups.

 Ascorbic acid - 0.5% is involved in redox processes and performs a number of vital functions of the body. Glucose up to 100.0%.

The pharmacological properties of the components of the drug are as follows:
1. Riboxin regulates protein synthesis, restores liver function, has a detoxifying and adaptogenic effect.

 2. Methyluracil accelerates the processes of cellular regeneration, stimulates leukopoiesis.

 3. Fructose-1,6-calcium diphosphate - the source of the most easily assimilated calcium and phosphorus, has a general strengthening and immunostimulating effect.

4. Vitamin B ₁₂ regulates hematopoiesis, is a factor in the absorption of vegetable protein, has hepatoprotective and anabolic effects.

 5. Ascorbic acid contributes to the breakdown and restoration of tissues, preservation of bones, muscles, blood vessels in the norm, increases resistance to infections.

 For the first time, a scientifically-based combination of the listed components was used, which made it possible to create a complex preparation that takes into account many aspects of metabolism.

The use of the drug for therapeutic and prophylactic purposes in critical periods of animal life provides an increase in the safety of newborn animals;
increase in the rate of increase in live weight, resistance to disease;
quick recovery of sick animals.

 Purivetin is used for 15 days at a dose of 5-10 mg per 1 kg of the animal’s weight with drink or food. Purivetin can be used as an addition to traditional methods of treatment, or on its own.

 Exceeding these dosage limits is possible, since the drug is not toxic.

 A study of toxicity in mice showed that the use of purivetin in doses of 0.05 to 2 g / kg body weight did not have an adverse effect on the body of white mice by the oral route of administration.

 Example 1

 A study of the effect of purivetin on the treatment of domestic animals was carried out on dogs with gastritis, exhaustion, enteritis.

 The experiment was conducted on dogs aged 1 year to 5 years. Animals received purivetin at a dose of 5 mg per 1 kg of live weight. Experimental animals along with purivetin received traditional treatment. Control animals received only traditional treatment. The results of the experiment are presented in table 1.

 As you know, the alpha-globulin fraction includes proteins of the acute and chronic phase; their increased content is characteristic of the inflammatory process. Under the influence of purivetin, the protective functions of the body increase, which is manifested in an increase in gamma globulins. A faster recovery of animals, an improvement in the quality of the coat was noted — it had luster and strength. The work was performed on the basis of the Department of Biochemistry of the St. Petersburg State Academy of Veterinary Medicine in conjunction with the Veterinary Office of Dr. V.V. Tihanina.

 The results are set out in the "Purivetin Dog Test Report" of October 5, 1999.

 Example 2

 To increase the productivity of animals, we used a biostimulator purivetin on female minks at the Rodniki fur farm.

 For the experiment, three groups of minks were formed. Group 1 - control, groups 2 and 3 received, in addition to the main diet, purivetin at a dose of 5 mg / kg body weight every 10 days (the drug was administered for 10 days, a break for 10 days). Experimental feeding lasted from February 15 to May 23. The results are presented in table 2.

 As can be seen from the table, the introduction of biologically active substances (purivetin) into the mink diet increases the yield of young animals to the female mink by 0.75 puppies, reduces pre-registration waste by 2%.

 Research conducted on the basis of the research institute of fur farming and rabbit breeding them. V. A. Afanasyeva (NIIPZK) (Report "Use of promising new biostimulants in feeding minks", agreement 43/1 of November 30, 1993).

 Example 3

 Purivetin tests on broiler chickens. In the control and experimental groups, there were 8 broiler chickens. Purivetin was given to chickens with food, starting from 3 to 10 days of age daily at a dose of 0.1; 0.2; 0.3 g / kg

 We took into account the general condition, live weight, total protein in the blood serum, the number of red blood cells, hemoglobin and lysozyme activity. The results are presented in table 3.

 The results shown in the table show that the use of purivetin has a positive effect on blood counts, the growth rate of chickens is 7.4-7.8% higher than in the control.

 Thus, purivetin activates protein synthesis, increases the live weight of animals, their resistance and survival of offspring.

 Example 4

 A study of the effect on resistance in piglets was carried out on the basis of the pig-breeding complex "Romanovka, Vsevolozhsk District, Leningrad Region."

 2 groups of 50 animals were formed, the feeding and keeping conditions of both groups were the same.

 The experimental group received purivetin at a dose of 5 mg / kg body weight 1 time per day for 15 days. The test results are presented in table 4.

 The data obtained show that purivetin has a positive effect on the body of young pigs, which is manifested in an increase in natural resistance.

 Table 5 shows the effect of purivetin on the change in live weight of piglets.

 15 days after the full course of the drug, the average daily gain in experimental animals was 2 times higher than in the control.

 Thus, under the action of purivetin, metabolic processes in the body are normalized.

 The results of the experiment are presented in the Report "Development of recommendations for the use of purivetin in pig breeding for the submission of documentation to the Vetfarmsovet."

Claims (1)

A preparation to stimulate the growth and increase the resistance of agricultural, domestic animals and poultry, containing nitrogen bases, a glycolysis activator and vitamins, characterized in that it contains riboxin and methyluracil as nitrogen bases, and fructose-1,6-calcium diphosphate as a glycolysis activator, vitamins - vitamin B ₁₂ and ascorbic acid, as well as additional citric acid and glucose in the following ratio of ingredients, weight. %:
Riboxin - 10.0
Methyluracil - 30.0
Fructose-1,6-Calcium Diphosphate - 30.0
Vitamin B ₁₂ - 0.02
Ascorbic acid - 0.05
Citric Acid - 0.3
Glucose - Up to 100%

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