RU2386342C1 - Forage for prevention of metabolic disorders, immunity and hepatoprotection function fortification of agricultural, domestic animals, birds and fish - Google Patents

Abstract

FIELD: agriculture. ^ SUBSTANCE: invention refers to veterinary. Forage composition contains the following components: riboxinum, calcium glycerophosphate, fructose, methyluracul, vitamin B12, ascorbic acid, citric acid, succinic acid, folic acid, glucose, chitosan, olygofructose and inuline at ratio 30/70, sources of protein, fats and poly- non-saturated fat acids at specified ratio of components. As components retarding lipogenesis in liver forage also contains: phospholipids - lecithin, L-carnitine, and -carotene. As protein sources forage also contains soya bean flour, soya bean ground oil cake, and rape-cake. Also as sources of fats and poly-non-saturated fatty acids forage contains fish oil and linseed oil. ^ EFFECT: forage provides fortification of immunity and can be used for accelerated growth and for retarding development of liver hepatosis of agricultural and domestic animals and birds and fish. ^ 4 tbl, 3 ex

Description

Insufficiently well-balanced feeds based on carbon and nitrogen sources, and most importantly, not containing regulatory complexes, lead to the development of lipogenesis, liver hepatosis, depression of the immune system and the emergence of a number of diseases. As a result, productivity of farm animals decreases (growth rate, milk synthesis, egg production, etc.). Animals and birds get sick, life expectancy is shortened. Extremely dangerous is the development of type II diabetes, cardiovascular disease, decreased reproduction functions. Tumor processes occur in domestic animals, and kidney stone disease develops. Thus, it became apparent that a special block of metabolism receptor substances should be present in the feed, the functions of which are to stabilize energy flows, depress lipogenesis and maintain a positive energy balance. We previously proposed a special drug, Purivetin, for introduction into feeds that contained carefully selected components (patent No. 2259832, reg. 10.09.2005).

This drug is highly effective when used in pig breeding, poultry farming, for growing young farm animals. High efficiency was established when using the drug "Purivetin" in domestic animals. A significant increase in immunity, detoxifying liver function, and a slowdown in aging were observed. Nevertheless, when analyzing the results, we noticed that the feed used did not fully reduce lipogenesis, during special periods (calving, pregnancy, stress, etc.) we observe a negative energy balance with the further development of type II diabetes, a decrease in hormonal background, impaired mineral metabolism. The situation is complicated by an increase in the load of toxins coming constantly with feed and adversely affecting liver function.

In this regard, we considered it necessary to introduce the following regulatory substances in addition to our analogue:

- chitosan - for sorption of mycotoxins in feed; - phospholipids (lecithin) - contain choline chloride - phosphatidylcholines, polyunsaturated fatty acids, enhances the detoxifying function of the liver; - L-carnitine - inhibits lipogenesis in the liver, enhances the metabolism of fatty acids; - β-carotene - a strong antioxidant, a precursor of vitamin A, enhances the detoxifying function of the liver, immunity, and reproduction function. Used in bioavailable (liposomal) form; - Oligofructose and inulin in a ratio of 30/70 - used as digestive activators, gluconeogenesis enhancer (glucose synthesis) -Fats and polyunsaturated fatty acids - fish oil, linseed oil - sources of additional energy. Omega 3 - Sources of protein - soy flour, soybean meal, rapeseed cake - to enhance the propionate pathway, glucose production

Thus, our proposed composition "Purivitin-Food" is presented as follows.

Table 1 Name of components G / kg Riboxin 300 Calcium Glycerophosphate 150 Fructose fifty Methyluracil thirty Vitamin B ₁₂ 0.2 Vitamin C twenty Lemon acid 10 succinic acid twenty Folic acid 10 Glucose twenty Chitosan 10 Phospholipids (Lecithin) 80 L-carnitine 40 β-carotene 80 Oligofructose and inulin in a ratio of 30/70 80 Fats and polyunsaturated fatty acids (fish oil, linseed oil) 40 Sources of protein (soybean meal, soybean meal, rapeseed cake) Up to 1 kg

This composition was significantly more effective than the existing one (prototype) and provided better results when tested on various farm animals, poultry and fish, which is confirmed by the following examples:

Example 1

At the Lipetsk pig farm, lactating sows (100 animals), Purivitin-Feed of the proposed formulation (see Table 1) was introduced into the main feed in the amount of 250 g / t feed. The control group (100 goals) in the main feed was injected drug Purivetin "composition described in patent No. 2259832, reg. 09/10/2005 “A preparation for enhancing metabolic processes and immunity in farm animals and poultry”, namely:

Riboxin thirty% Calcium Glycerophosphate fifteen% Vitamin B ₁₂ 0.02% Vitamin C 2.0% succinic acid 2.0% Lemon acid 2.0% Folic acid 1,0% Fructose 5.0% Glucose 42.58%

Both drugs were used as part of the feed, both before pregnancy and after pregnancy. The results of comparative tests are presented in table.2.

table 2 Indicators Experience (proposed composition "Purivitin-Feed") Control (according to patent No. 2259832. Reg. 09/10/2005) Number of Piglets eighteen 16 Survival rate (%) 99 97 Liver diseases (including hepatosis) (%) one 3

From the data of table 2 it follows that the proposed composition of the feed helps to obtain the best results for the most important indicators.

Example 2

In CJSC Krasnoarmeysky, Leningrad Region, 2 groups of calves (10 goals each) at the age of 3 months were formed. One group (experience) received, as part of the milk replacer (whole milk substitute), Purivitin-Feed in the amount of 12 g per 10 calves; another group (control) under the same conditions received Purivetin according to patent No. 2259832, registration on 09/10/2005. The duration of the experiment is 30 days. The results are summarized in table 3.

Table 3 Indicators Experience (proposed composition "Purivitin-Feed") Control (according to patent No. 2259832. Reg. 09/10/2005) Incidence (diarrhea, bronchopneumonia) (%) 2.5 3,5 Hepatosis of the liver (%) one 3 Daily gain, g 750 600

As can be seen from the data of table 3, the proposed composition provides better results in comparison with the prototype.

Example 3

Production tests of the Purivitin-Korm composition that we offer were carried out at the Narva plant of the Leningrad Region for salmon farming in juvenile salmon. Purivitin-Feed in the form of an aqueous suspension was sprayed onto the main feed (Denmark). The prototype (the usual "Purivetin" according to patent No. 2259832, reg. 10.09.2005) was also sprayed onto the main feed. The dosage in both versions is 100 g / t feed. Food was given to juvenile salmon for 6 months. The results are presented in table 4.

Table 4 Indicators Experience (proposed composition "Purivitin-Feed") Control (according to Patent No. 2259832. Reg. 10.09.2005) Growth (cm / month) 6 four Fin Disease (%) four 25 Liver pathology (%) absent 2

From the data of table 4 it is seen that the proposed composition helps to reduce the incidence of juveniles, including liver function, and enhances the process of biomass formation.

As follows from our examples of the method, results were obtained on various animals and fish, which convincingly indicate a solution using the new Purivitin-Korm formulation of the liver hepatosis problem, which is associated with many metabolic disorders. It has been established that this pathology is reduced by at least 50% and, as a result, immunity is strengthened (safety, disease resistance), weight gain is increased, which is associated with increased metabolic processes. Thus, our decision to introduce a number of additional regulatory substances, including a toxin neutralizer (chitosan), dietary fiber (oligosugar), phospholipids (lecithin), turned out to be correct and effective.

Information sources

1. Patent No. 2259832, reg. 09/10/2005. "A drug to enhance metabolic processes and immunity in farm animals and poultry."

Claims (1)

Food for the prevention of metabolic disorders, enhancing immunity and hepatoprotective function in agricultural, domestic animals, poultry and fish, characterized in that it contains riboxin, calcium glycerophosphate, fructose, methyluracil, vitamin B ₁₂ , ascorbic acid, citric acid, succinic acid, folic acid glucose, chitosan; phospholipids-lecithin; L-carnitine, β-carotene, oligofructose and inulin in a ratio of 30/70; fats and polyunsaturated fatty acids - fish oil, linseed oil; protein sources - soy flour, soybean meal, rapeseed cake; in the following ratio of ingredients, g / kg:
Riboxin 300 Calcium Glycerophosphate 150 Fructose fifty Methyluracil thirty Vitamin B ₁₂ 0.2 Vitamin C twenty Lemon acid 10 succinic acid twenty Folic acid 10 Glucose twenty Chitosan 10 Phospholipids-Lecithin 80 L-carnitine 40 β-carotene 80 Oligofructose and inulin in a ratio of 30/70 80 Fats and polyunsaturated fatty acids - fish oil, linseed oil 40 Sources of protein - soy flour, soybean meal, rapeseed cake up to 1 kg