RU2063770C1 - Method of purulent-inflammatory lung disease treatment - Google Patents

Abstract

FIELD: medicine, pulmonology. SUBSTANCE: method involves inhalation administration of antibiotics gentamycin and rifampicin as liposomes. Single dose of liposome set containing 80 mg gentamycin, 8 mg rifampicin, 35 mg lecithin and 2.5 mg extericide is diluted before use in 20-25 ml extericide. Inhalations were carried out twice per 24 hr for 10 days. EFFECT: improved method of treatment.

Description

 The claimed invention relates to medicine, namely to pulmonology.

 Known methods of treating inflammatory-purulent lung diseases, including the use of antibiotics, expectorant medicines, respiratory gymnastics / Sokol S. B. Treatment of chronic suppurative lung diseases. K. "Health", 1985; Putov N.V. Handbook of pulmonology. L. 1988 /.

 Closest to the claimed method is a method for the treatment of chronic infectious-purulent diseases of the lungs, including inhaled administration of antibiotics. Many antibiotics are insoluble or slightly soluble in water, which excludes their inhalation use.

, в которые включено (флакон содержит): 8 мг рифампицина, 80 мг гентамицина, лецитина стандарт 35 мг, эктерицида высушенного 2,5 мл.To enable the inclusion of sparingly soluble toxic substances and ensure biocompatibility with enzymes and immunological systems of the body in a known method of treatment, including inhalation of antibacterial and antiseptic agents, they are used in the form of liposomes, which are limited volumes arising from the self-assembly of amphiphilic lipoid complexes, with sizes liposomes 150 500

which includes (the bottle contains): 8 mg of rifampicin, 80 mg of gentamicin, lecithin standard 35 mg, dried etericide 2.5 ml.

 Comparative analysis with the prototype led to the conclusion that the claimed method differs from the known inhalation of antibiotics and antiseptics in the form of liposomes.

Liposome dosage forms have several advantages over others:
the possibility of incorporating sparingly soluble and toxic substances;
a special set of biological properties characteristic of the function of cell membranes;
certain pharmacodynamics in the body with a sequential distribution and accumulation in organs and tissues;
biocompatibility with enzymatic and immunological organisms;
the special nature of the interaction with cells in the form of endocytosis or their membranes.

 Such forms of interaction of liposomes with cells provide their ability to overcome some of the anatomical and biological barriers of the body and their targeted transport to the pathological focus.

 Thus, the claimed method of treatment meets the criterion of "novelty."

 When comparing the proposed method with a well-known in this field, the features that distinguish it from the prototype were not identified, which allows us to conclude that the criterion of "inventive step".

 The method is as follows: a vial with a liposome set is dissolved in 20 25 ml of extericide. Pour the cuvette of the ultrasonic inhaler "Dysonic", bring the nipple 0.5-2 cm to the patient's mouth and continue inhalation for 7 10 minutes.

 Inhalations are repeated 2 times a day for 10 days. This creates a high concentration of antibiotics and antiseptic substances in the lungs.

 Example 1

 Patient O. 26 years old, medical history N 19307. He was admitted to the thoracic department of the Poltava Regional Clinical Hospital on November 26, 1991. Diagnosis: inflammatory exudative staphylococcal moderate pleurisy. Repeated puncture of the pleural cavity, administration of parenteral antibiotics for 15 days / ampicillin 0.5x4 times / m, rifampicin 2 capsules 2 times did not lead to a complete cure. 12/10/91, prescribed inhalation 2 times a day for 7 minutes with liposomal complexes. After 7 days, the fluid in the pleural cavity resolved, the lung straightened out, the body temperature returned to normal, blood counts and on 20.12.91 the patient was discharged in satisfactory condition under the supervision of a local therapist.

 Example 2

Patient K., 62 years old, medical history N 1787. He was admitted to the thoracic department on 11.11.91 with a diagnosis of cancer of the right lung, stage III, central form (T ₄ ; N, M ₀ ). On 17.11.91, the patient underwent surgery: thoracotomy, biopsy, drainage of the pleural cavity. Due to the prevalence of the process, the tumor could not be removed. The postoperative period was complicated by a bronchial fistula, the lung did not straighten, inflammation continued, accompanied by a high temperature of up to 39 ^o C, temperature, a shift of the leukocyte formula to the left. Parenteral administration of antibiotics: ampicillin 0.5x4 p. kanamycin 0.5x2 p. did not improve the patient's condition.

11/21/91, liposome inhalations were prescribed 2 times a day for 10 minutes. After 7 days, the bronchial fistula closed, the lung straightened, the body temperature returned to normal, the leukocytosis decreased from 17.7 to 10.5 / 10 ⁹ mm / L and the patient was transferred to the regional oncology dispensary for radiation and chemotherapy.

 During the 30-day course of treatment in the oncologic dispensary, inflammatory purulent complications of the lungs were not observed.

Claims (1)

 A method of treating purulent-inflammatory lung diseases, including inhaled administration of antibiotics, characterized in that gentamicin and rifampicin are administered in the form of liposomes, with a single dose of liposome kit containing 80 mg of gentamicin, 8 mg of rifampicin, 35 mg of lecithin and 2.5 mg of ectericide , before use, diluted in 20-25 ml of ectericide and inhalation is carried out 2 times a day for 10 days.