PT2358674E - Processo de preparação de compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina - Google Patents

Processo de preparação de compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina

Info

Publication number: PT2358674E
Authority: PT; Portugal
Prior art keywords: fluorophenoxymethyl; phenyl; preparing; piperidine compounds; piperidine
Prior art date: 2008-11-14

Application number

PT97526875T

Other languages

English (en)

Inventor

Miroslav Rapta

Eric L Stangeland

Original Assignee

Theravance Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-14

Filing date

2009-11-13

Publication date

2013-03-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41666409&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2358674(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-11-13 Application filed by Theravance Inc filed Critical Theravance Inc

2013-03-05 Publication of PT2358674E publication Critical patent/PT2358674E/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Gynecology & Obstetrics (AREA)
Child & Adolescent Psychology (AREA)
Nutrition Science (AREA)
Addiction (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)

PT97526875T 2008-11-14 2009-11-13 Processo de preparação de compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina PT2358674E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11454108P	2008-11-14	2008-11-14

Publications (1)

Publication Number	Publication Date
PT2358674E true PT2358674E (pt)	2013-03-05

Family

ID=41666409

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PT97529887T PT2358676E (pt)	2008-11-14	2009-11-13	Forma cristalina de um composto 4-[2-(2-fluorofenoximetil)fenil]piperidina
PT97526875T PT2358674E (pt)	2008-11-14	2009-11-13	Processo de preparação de compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina
PT97526883T PT2358675E (pt)	2008-11-14	2009-11-13	Compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT97529887T PT2358676E (pt)	2008-11-14	2009-11-13	Forma cristalina de um composto 4-[2-(2-fluorofenoximetil)fenil]piperidina

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT97526883T PT2358675E (pt)	2008-11-14	2009-11-13	Compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina

Country Status (28)

Country	Link
US (23)	US8304432B2 (pt)
EP (3)	EP2358675B9 (pt)
JP (6)	JP5598798B2 (pt)
KR (3)	KR101656338B1 (pt)
CN (3)	CN102216272B (pt)
AR (3)	AR074350A1 (pt)
AU (3)	AU2009313949B2 (pt)
BR (3)	BRPI0921593B8 (pt)
CA (3)	CA2742105C (pt)
CL (2)	CL2011001088A1 (pt)
CO (2)	CO6361988A2 (pt)
CY (3)	CY1113622T1 (pt)
DK (3)	DK2358676T3 (pt)
ES (3)	ES2397247T3 (pt)
HR (3)	HRP20120897T1 (pt)
IL (2)	IL212230A (pt)
MX (3)	MX2011005088A (pt)
MY (2)	MY151211A (pt)
NZ (2)	NZ592543A (pt)
PL (3)	PL2358674T3 (pt)
PT (3)	PT2358676E (pt)
RU (2)	RU2515612C2 (pt)
SG (1)	SG171311A1 (pt)
SI (3)	SI2358676T1 (pt)
SM (3)	SMT201200063B (pt)
TW (3)	TWI461407B (pt)
WO (3)	WO2010056941A1 (pt)
ZA (1)	ZA201103495B (pt)

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DK2358676T3 (da) *	2008-11-14	2013-01-14	Theravance Inc	Krystallinsk form af en 4-[2-(2-fluorphenoxymethyl)phenyl]-piperidinforbindelse
JP5705239B2 (ja)	2010-01-11	2015-04-22	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	セロトニンおよびノルエピネフリン再取込みインヒビターとしての１−（２−フェノキシメチルフェニル）ピペラジン化合物
US8530663B2 (en) *	2010-03-22	2013-09-10	Theravance, Inc.	1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
JP5774091B2 (ja) *	2010-04-22	2015-09-02	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	疼痛治療のためのセロトニン・ノルエピネフリン再取り込みインヒビターとオピオイド作動物質との組み合わせ
CA2830882C (en)	2011-03-22	2021-03-16	Dinesh Barawkar	Substituted fused tricyclic compounds, compositions and medicinal applications thereof
US9544692B2 (en) *	2012-11-19	2017-01-10	Bitwave Pte Ltd.	System and apparatus for boomless-microphone construction for wireless helmet communicator with siren signal detection and classification capability
US10238642B2 (en) *	2016-08-30	2019-03-26	Theravance Biopharma R&D Ip, Llc	Methods for treating neurogenic orthostatic hypotension
ES2960492T3 (es)	2018-06-01	2024-03-05	Theravance Biopharma R&D Ip Llc	Procedimiento para la preparación de ácido 2-(1-(terc-butoxicarbonil)piperidín-4-il)benzoico
CA3252091A1 (en)	2022-03-28	2023-10-05	Theravance Biopharma R&D Ip, Llc	Ampreloxetine is intended for use in the treatment of multiple system atrophy.
CN114957098B (zh) *	2022-06-02	2024-03-29	和鼎（南京）医药技术有限公司	一种制备喷他佐辛中间体的方法

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EP2358675A1 (en)	2011-08-24
HK1160452A1 (en)	2012-08-17
BRPI0921593B1 (pt)	2021-05-04
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CN102216272B (zh)	2014-02-05
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IL212452A0 (en)	2011-06-30
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