[go: up one dir, main page]

CO6361993A2 - Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina - Google Patents

Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina

Info

Publication number
CO6361993A2
CO6361993A2 CO11064614A CO11064614A CO6361993A2 CO 6361993 A2 CO6361993 A2 CO 6361993A2 CO 11064614 A CO11064614 A CO 11064614A CO 11064614 A CO11064614 A CO 11064614A CO 6361993 A2 CO6361993 A2 CO 6361993A2
Authority
CO
Colombia
Prior art keywords
compounds
fluorophenoximethyl
piperidine
phenyl
formula
Prior art date
Application number
CO11064614A
Other languages
English (en)
Inventor
Lori Jean Patterson
Eric L Stangeland
Sheila Zipfel
Daniel D Long
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41666409&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6361993(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of CO6361993A2 publication Critical patent/CO6361993A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

La invención se refiere a los compuestos de la fórmula I:donde a, R1 y R3-6 son como se definen en la memoria descriptiva, o una sal farmacéuticamente aceptable del mismo. Los compuestos de la fórmula I son inhibidores de la recaptación de serotonina y norepinefrina. La invención también se refiere a composiciones farmacéuticas que comprenden dichos compuestos; métodos para usar dichos compuestos; y procesos e intermediarios para preparar dichos compuestos.
CO11064614A 2008-11-14 2011-05-25 Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina CO6361993A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11454108P 2008-11-14 2008-11-14
PCT/US2009/064308 WO2010056941A1 (en) 2008-11-14 2009-11-13 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds

Publications (1)

Publication Number Publication Date
CO6361993A2 true CO6361993A2 (es) 2012-01-20

Family

ID=41666409

Family Applications (2)

Application Number Title Priority Date Filing Date
CO11056556A CO6361988A2 (es) 2008-11-14 2011-05-09 Forma cristalina de un compuesto de 4-[2-(2-fluorofenoximetil)fenil]piperidina.
CO11064614A CO6361993A2 (es) 2008-11-14 2011-05-25 Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CO11056556A CO6361988A2 (es) 2008-11-14 2011-05-09 Forma cristalina de un compuesto de 4-[2-(2-fluorofenoximetil)fenil]piperidina.

Country Status (28)

Country Link
US (23) US8304433B2 (es)
EP (3) EP2358674B1 (es)
JP (6) JP5598798B2 (es)
KR (3) KR101685186B1 (es)
CN (3) CN102216272B (es)
AR (3) AR074350A1 (es)
AU (3) AU2009313949B2 (es)
BR (3) BRPI0921593B8 (es)
CA (3) CA2742114C (es)
CL (2) CL2011001088A1 (es)
CO (2) CO6361988A2 (es)
CY (3) CY1113622T1 (es)
DK (3) DK2358676T3 (es)
ES (3) ES2401224T3 (es)
HR (3) HRP20130300T1 (es)
IL (2) IL212230A (es)
MX (3) MX2011005089A (es)
MY (2) MY151211A (es)
NZ (2) NZ592413A (es)
PL (3) PL2358675T3 (es)
PT (3) PT2358674E (es)
RU (2) RU2515612C2 (es)
SG (1) SG171311A1 (es)
SI (3) SI2358675T1 (es)
SM (3) SMT201200063B (es)
TW (3) TWI443087B (es)
WO (3) WO2010056941A1 (es)
ZA (1) ZA201103495B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011005089A (es) 2008-11-14 2011-07-29 Theravance Inc Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina.
WO2011085291A1 (en) * 2010-01-11 2011-07-14 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
ES2543064T3 (es) * 2010-03-22 2015-08-14 Theravance Biopharma R&D Ip, Llc Compuestos de 1-(2-fenoximetilheteroaril)piperidina y piperazina
ES2532204T3 (es) * 2010-04-22 2015-03-25 Theravance Biopharma R&D Ip, Llc Combinación de un inhibidor de la recaptación de serotonina y norepinefrina y un agonista opioide para el tratamiento de dolor
WO2012127506A1 (en) 2011-03-22 2012-09-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
US9544692B2 (en) * 2012-11-19 2017-01-10 Bitwave Pte Ltd. System and apparatus for boomless-microphone construction for wireless helmet communicator with siren signal detection and classification capability
NZ750392A (en) 2016-08-30 2020-08-28 Theravance Biopharma R&D Ip Llc Compound for use in the treatment of neurogenic orthostatic hypotension
EP3784655B1 (en) 2018-06-01 2023-10-04 Theravance Biopharma R&D IP, LLC Process for preparing 2-(1-(tert-butoxycarbonyl)piperidine-4-yl)benzoic acid
EP4499096A1 (en) 2022-03-28 2025-02-05 Theravance Biopharma R&D IP, LLC Ampreloxetine for use for treating multiple system atrophy
CN114957098B (zh) * 2022-06-02 2024-03-29 和鼎（南京）医药技术有限公司 一种制备喷他佐辛中间体的方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DE2549999A1 (de) * 1975-11-07 1977-05-12 Boehringer Mannheim Gmbh Piperidin-derivate und verfahren zu ihrer herstellung
US4241071A (en) 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
IL56369A (en) 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
US4198417A (en) 1979-01-10 1980-04-15 American Hoechst Corporation Phenoxyphenylpiperidines
EP0190496A3 (en) 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
US4956388A (en) 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
DE3835291A1 (de) 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
GB9324018D0 (en) 1993-11-23 1994-01-12 Merck Sharp & Dohme Therapeutic agents
AU4637899A (en) * 1998-07-10 2000-02-01 Astrazeneca Ab N-substituted naphthalene carboxamides as neurokinin-receptor antagonists
GB9922521D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
ES2157148B1 (es) * 1998-11-18 2002-03-01 Faes Fabrica Espanola De Produ Nuevas piperidinas 4-sustituidas.
US6518284B2 (en) * 1998-11-18 2003-02-11 Faes, Fabrica Espanola De Productos Quimicos Y Farmaceuticos S.A. 4-substituted piperidines
SK13752001A3 (sk) * 1999-12-27 2002-07-02 Japan Tobacco, Inc. Zlúčeniny s fúzovanými kruhmi a ich použitie ako liečiv
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6630504B2 (en) 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
US7294637B2 (en) * 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
EP1534291B1 (en) 2002-08-23 2008-11-12 Eli Lilly And Company 2-(phenylthiomethyl)- morpholine derivatives for use as selective norepinephrine reuptake inhibitors
AR043966A1 (es) * 2003-04-04 2005-08-17 Lundbeck & Co As H Derivados de 4- ( 2-feniloxifenil) - piperidina o 1,2,3,6 -tetrahidropiridina como inhibidores de la recaptacion de la serotonina
EP1635828B1 (en) * 2003-04-04 2008-04-23 H. Lundbeck A/S 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
AU2004247487B2 (en) 2003-06-17 2010-05-20 Pfizer Inc. N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
BRPI0506844A (pt) 2004-01-13 2007-06-12 Pfizer derivados de piperazina que apresentam atividade como inibidores da reabsorção de serotonina noradrenalina
EP1725518A1 (en) 2004-03-05 2006-11-29 Eli Lilly And Company Pharmaceutical compounds
EA200601798A1 (ru) 2004-04-30 2007-04-27 Уорнер-Ламберт Компани Ллс Замещенные соединения морфолина для лечения расстройств центральной нервной системы
GB0505437D0 (en) 2005-03-17 2005-04-20 Merck Sharp & Dohme Therapeutic agents
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives
US20070249607A1 (en) * 2006-04-17 2007-10-25 Bristol-Myers Squibb Company Nk-1 and serotonin transporter inhibitors
CA2661187A1 (en) 2006-08-23 2008-02-28 Pfizer Products Inc. Piperidine derivatives
EP2068867A2 (en) * 2006-09-27 2009-06-17 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor modulators
US8026257B2 (en) 2007-07-11 2011-09-27 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
WO2009081259A1 (en) 2007-12-21 2009-07-02 Pfizer Inc. Phenoxy-pyridyl derivatives
AU2009271414A1 (en) 2008-06-20 2010-01-21 Metabolex, Inc. Aryl GPR119 agonists and uses thereof
JP5405571B2 (ja) 2008-07-24 2014-02-05 セラヴァンス， インコーポレーテッド ３−（フェノキシフェニルメチル）ピロリジン化合物
MX2011005089A (es) 2008-11-14 2011-07-29 Theravance Inc Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina.
WO2011085291A1 (en) 2010-01-11 2011-07-14 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
ES2543064T3 (es) 2010-03-22 2015-08-14 Theravance Biopharma R&D Ip, Llc Compuestos de 1-(2-fenoximetilheteroaril)piperidina y piperazina
NZ750392A (en) * 2016-08-30 2020-08-28 Theravance Biopharma R&D Ip Llc Compound for use in the treatment of neurogenic orthostatic hypotension

Also Published As

Publication number Publication date
RU2011123890A (ru) 2012-12-20
BRPI0921593B1 (pt) 2021-05-04
KR101685186B1 (ko) 2016-12-09
TW201024263A (en) 2010-07-01
PL2358675T3 (pl) 2013-03-29
US20200316047A1 (en) 2020-10-08
EP2358676B1 (en) 2012-10-10
MX2011005088A (es) 2011-06-01
EP2358676A1 (en) 2011-08-24
EP2358675A1 (en) 2011-08-24
HK1160452A1 (en) 2012-08-17
HK1160449A1 (en) 2012-08-17
KR20110082197A (ko) 2011-07-18
HRP20120920T1 (hr) 2013-01-31
TWI443087B (zh) 2014-07-01
JP5529150B2 (ja) 2014-06-25
US20240316024A1 (en) 2024-09-26
CN102209712B (zh) 2016-04-06
US9162982B2 (en) 2015-10-20
BRPI0921596B1 (pt) 2021-10-26
RU2515612C2 (ru) 2014-05-20
DK2358674T3 (da) 2013-04-08
AR114965A2 (es) 2020-11-11
RU2011123875A (ru) 2012-12-20
US20190142816A1 (en) 2019-05-16
CA2742105A1 (en) 2010-05-20
AU2009313951A1 (en) 2010-05-20
SMT201300033B (it) 2013-05-06
US20180055830A1 (en) 2018-03-01
PT2358676E (pt) 2012-12-06
KR101656339B1 (ko) 2016-09-09
US10226454B2 (en) 2019-03-12
AU2009313948A1 (en) 2010-05-20
IL212452A0 (en) 2011-06-30
WO2010056941A1 (en) 2010-05-20
MX2011005089A (es) 2011-07-29
US20100125141A1 (en) 2010-05-20
SI2358674T1 (sl) 2013-04-30
CA2742105C (en) 2016-09-13
US8604058B2 (en) 2013-12-10
SMT201200065B (it) 2013-03-08
EP2358674B1 (en) 2013-01-02
EP2358674A1 (en) 2011-08-24
KR20110082085A (ko) 2011-07-15
AU2009313949A1 (en) 2010-05-20
JP2012508759A (ja) 2012-04-12
US20180050024A1 (en) 2018-02-22
US10946007B2 (en) 2021-03-16
US20140323735A1 (en) 2014-10-30
BRPI0921596A2 (pt) 2018-03-20
HRP20120897T1 (hr) 2012-12-31
JP2012508761A (ja) 2012-04-12
US20120277438A1 (en) 2012-11-01
CY1113623T1 (el) 2016-06-22
CY1113855T1 (el) 2016-07-27
MY151211A (en) 2014-04-30
US9073859B2 (en) 2015-07-07
CL2011001088A1 (es) 2011-10-14
US20160022660A1 (en) 2016-01-28
CN102216271B (zh) 2013-09-25
US20100125092A1 (en) 2010-05-20
US20210290608A1 (en) 2021-09-23
US20180289687A1 (en) 2018-10-11
BRPI0921595B8 (pt) 2021-05-25
PT2358674E (pt) 2013-03-05
US11596624B2 (en) 2023-03-07
US10441579B2 (en) 2019-10-15
CN102216272A (zh) 2011-10-12
US10722504B2 (en) 2020-07-28
TW201024264A (en) 2010-07-01
NZ592413A (en) 2013-02-22
US8802857B2 (en) 2014-08-12
CA2742114C (en) 2016-09-13
JP2014098033A (ja) 2014-05-29
US9187423B2 (en) 2015-11-17
ES2401224T3 (es) 2013-04-17
US20130030020A1 (en) 2013-01-31
CL2011001093A1 (es) 2011-09-02
KR20110082196A (ko) 2011-07-18
DK2358675T3 (da) 2013-01-14
US20130030185A1 (en) 2013-01-31
US20190134019A1 (en) 2019-05-09
CY1113622T1 (el) 2016-06-22
US8304433B2 (en) 2012-11-06
MY151229A (en) 2014-04-30
DK2358676T3 (da) 2013-01-14
TWI441810B (zh) 2014-06-21
IL212230A0 (en) 2011-06-30
BRPI0921595B1 (pt) 2020-10-13
US20140045892A1 (en) 2014-02-13
CA2742114A1 (en) 2010-05-20
AR074128A1 (es) 2010-12-22
CN102216272B (zh) 2014-02-05
HRP20130300T1 (hr) 2013-04-30
US20160184288A1 (en) 2016-06-30
SI2358675T1 (sl) 2013-01-31
AR074350A1 (es) 2011-01-12
US10034870B2 (en) 2018-07-31
AU2009313951B2 (en) 2015-03-12
US20200000792A1 (en) 2020-01-02
PL2358676T3 (pl) 2013-03-29
BRPI0921593B8 (pt) 2021-05-25
PL2358674T3 (pl) 2013-06-28
RU2503662C2 (ru) 2014-01-10
US20220087995A1 (en) 2022-03-24
HK1160448A1 (en) 2012-08-17
IL212230A (en) 2014-12-31
EP2358675B1 (en) 2012-10-03
CA2739992A1 (en) 2010-05-20
JP2014139209A (ja) 2014-07-31
TWI461407B (zh) 2014-11-21
US11723900B2 (en) 2023-08-15
US20100125093A1 (en) 2010-05-20
KR101656338B1 (ko) 2016-09-09
ES2397247T3 (es) 2013-03-05
US8247433B2 (en) 2012-08-21
US20140057944A1 (en) 2014-02-27
US10946006B2 (en) 2021-03-16
CA2739992C (en) 2016-09-20
US12239638B2 (en) 2025-03-04
MX2011005090A (es) 2011-09-06
NZ592543A (en) 2013-02-22
CO6361988A2 (es) 2012-01-20
JP5506813B2 (ja) 2014-05-28
JP2012508760A (ja) 2012-04-12
ZA201103495B (en) 2012-01-25
WO2010056938A1 (en) 2010-05-20
SMT201200063B (it) 2013-01-14
US9675599B2 (en) 2017-06-13
AU2009313949B2 (en) 2015-03-19
WO2010056939A1 (en) 2010-05-20
JP5598798B2 (ja) 2014-10-01
ES2396583T3 (es) 2013-02-22
CN102216271A (zh) 2011-10-12
SG171311A1 (en) 2011-07-28
US8304432B2 (en) 2012-11-06
US20230201181A1 (en) 2023-06-29
US8592596B2 (en) 2013-11-26
CN102209712A (zh) 2011-10-05
US10576073B2 (en) 2020-03-03
AU2009313948B2 (en) 2015-03-12
SI2358676T1 (sl) 2013-01-31
BRPI0921593A2 (pt) 2015-08-18
US10206913B2 (en) 2019-02-19
TW201022206A (en) 2010-06-16
US20200316048A1 (en) 2020-10-08
PT2358675E (pt) 2012-12-12
JP2014101384A (ja) 2014-06-05
EP2358675B9 (en) 2019-09-11

Similar Documents

Publication Publication Date Title
CO6361993A2 (es) Compuestos de 4-[2-(2-fluorofenoximetil)fenil]piperidina
MX342212B (es) Inhibidores de neprilisina.
CO6531458A2 (es) Nuevos compuestos de espiropiperidina
ECSP12011930A (es) Nuevos compuestos de espiropiperidina
CO6511251A2 (es) Compuestos quimicos
CO6741228A2 (es) Inhibidores de la neprilisina
CR20150045A (es) Inhibidores de hepatitis c
DOP2014000133A (es) Triazolopiridinas sustituidas
UY30809A1 (es) Derivados de n-[3-[4-fenil)piperidin-1-carbonil]fenil]sulfonamidas sustituidas, procesos de preparacion y aplicaciones
UY32153A (es) Inhibidores de piridomidinona de pi13ka(alfa) y mtor
ECSP12012103A (es) Inhibidores de virus flaviviridae.
CU20140072A7 (es) Derivados de dihidro-oxazina y dihidro-pirido-oxazina
MX2012004311A (es) Derivados de ciclohexano spiro condensados como inhibidores de lipasa sensible a hormonas (hsl) utiles en el tratamiento de diabetes.
PE20141167A1 (es) Piridopirazinas sustituidas como inhibidores novedosos de ptk
ECSP11011045A (es) 1-(arilsulfonil)-4-(piperazin-1-il)-1h-benzimidazoles como ligandos de 5-hidroxitriptamina-6
CL2009001346A1 (es) Compuestos derivados heterociclicos, inhibidores de la adn girasa; proceso de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso para el tratamiento de una infeccion bacteriana.
ATE499367T1 (de) 1,3-dihydroimidazol-2-thionderivate als inhibitoren von dopamin-beta-hydroxylase
CO6270285A2 (es) Derivados de 4-[(4-amino-1, 3, 5-triazin-2-il)amino]-n-arilmetilcicloalquilcarboxamida
PE20170914A1 (es) 1-[2-(aminometil)bencil]-2-tioxo-1,2,3,5-tetrahidro-4h-pirrolo[3,2-d]pirimidin-4-onas como inhibidores de mieloperoxidasa
MX2012000685A (es) Compuesto de 3-fenoximetilpirrolidina.
AR080025A1 (es) Derivados de 8-aza-biciclo[3,2,1] oct-3-iloxi)-cromen-2-ona, utiles como inhibidores de la recaptacion del neurotransmisor monoamina
DOP2011000053A (es) Agentes antifungicos
AR085909A1 (es) Derivados de azaespirodecanona, composiciones farmaceuticas que los contienen, procedimiento para prepararlos y uso de los mismos para el tratamiento de diabetes, obesidad y enfermedades cardiovasculares, entre otras
EA201000611A1 (ru) 4,4-дизамещенные пиперидины
RU2014126321A (ru) Производное пароксетина

Legal Events

Date Code Title Description
FG Application granted