PE20191787A1 - Derivados de indol n-sustituidos - Google Patents
Derivados de indol n-sustituidosInfo
- Publication number
- PE20191787A1 PE20191787A1 PE2019002413A PE2019002413A PE20191787A1 PE 20191787 A1 PE20191787 A1 PE 20191787A1 PE 2019002413 A PE2019002413 A PE 2019002413A PE 2019002413 A PE2019002413 A PE 2019002413A PE 20191787 A1 PE20191787 A1 PE 20191787A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- methyl
- substitute derivatives
- compound
- derivatives
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- BTPBTZKFLVYUPZ-UHFFFAOYSA-N 4-[6-[2-(2-methylindol-1-yl)ethylamino]pyrimidin-4-yl]benzoic acid Chemical compound CC=1N(C2=CC=CC=C2C=1)CCNC1=CC(=NC=N1)C1=CC=C(C(=O)O)C=C1 BTPBTZKFLVYUPZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 N-substituted indole Chemical class 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Referido a derivados de indol N-sustituidos, un compuesto de formula I, en donde R1 es H o metilo; R2 es metilo, Br, Cl o ciano; o una sal farmaceutica aceptable del mismo. Un compuesto preferido es: acido 4-{6-[2-(2-metil-indol-1-il)-etilamino]-pirimidin-4-il}-benzoico. Estos compuestos son moduladores del receptor EP2 de la prostaglandina 2. Tambien se refiere a metodos para su preparacion, y su uso como composicion farmaceutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2017062008 | 2017-05-18 | ||
| PCT/EP2018/062865 WO2018210995A1 (en) | 2017-05-18 | 2018-05-17 | N-substituted indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191787A1 true PE20191787A1 (es) | 2019-12-24 |
Family
ID=62186481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019002413A PE20191787A1 (es) | 2017-05-18 | 2018-05-17 | Derivados de indol n-sustituidos |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20200069686A1 (es) |
| EP (1) | EP3625224B1 (es) |
| JP (1) | JP7065117B2 (es) |
| KR (1) | KR102650756B1 (es) |
| CN (1) | CN110621666A (es) |
| AR (1) | AR111806A1 (es) |
| AU (1) | AU2018269667B2 (es) |
| BR (1) | BR112019024114A2 (es) |
| CA (1) | CA3063637A1 (es) |
| CL (1) | CL2019003257A1 (es) |
| CO (1) | CO2019010804A2 (es) |
| CR (1) | CR20190567A (es) |
| CY (1) | CY1124528T1 (es) |
| DK (1) | DK3625224T3 (es) |
| EA (1) | EA039630B1 (es) |
| ES (1) | ES2894124T3 (es) |
| HR (1) | HRP20211532T1 (es) |
| HU (1) | HUE056406T2 (es) |
| IL (1) | IL270616B (es) |
| LT (1) | LT3625224T (es) |
| MA (1) | MA49127B1 (es) |
| MX (1) | MX394108B (es) |
| PE (1) | PE20191787A1 (es) |
| PH (1) | PH12019502562B1 (es) |
| PL (1) | PL3625224T3 (es) |
| PT (1) | PT3625224T (es) |
| RS (1) | RS62441B1 (es) |
| SG (1) | SG11201908660RA (es) |
| SI (1) | SI3625224T1 (es) |
| TW (1) | TWI768043B (es) |
| UA (1) | UA124748C2 (es) |
| WO (1) | WO2018210995A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| CA3063788A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| CA3060394A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as pge2 receptor modulators |
| WO2018210987A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as pge2 receptor modulators |
| WO2021060281A1 (ja) * | 2019-09-24 | 2021-04-01 | Ａｇｃ株式会社 | プロスタグランジンｅ２レセプターｅｐ２／ｅｐ４デュアルアンタゴニスト |
| WO2021205367A1 (en) * | 2020-04-08 | 2021-10-14 | Askat Inc. | Use of ep4 receptor antagonists for the treatment of liver cancer, melanoma, lymphoma and leukemia |
| EP4245301A4 (en) | 2020-11-13 | 2024-08-21 | ONO Pharmaceutical Co., Ltd. | TREATMENT OF CANCER BY COMBINED USE OF AN EP4 ANTAGONIST AND AN IMMUNE CHECKPOINT INHIBITOR |
| WO2025229177A1 (en) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Crystalline forms of an n-substituted indole derivative |
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| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| GB0031302D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
| GB0031295D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
| GB0103269D0 (en) | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
| BR0309305A (pt) | 2002-04-12 | 2005-02-15 | Pfizer | Compostos de imidazol como agentes antiinflamatórios e analgésicos |
| WO2003087061A1 (en) | 2002-04-12 | 2003-10-23 | Pfizer Japan Inc. | Pyrazole compounds as anti-inflammatory and analgesic agents |
| JP2006506327A (ja) | 2002-05-23 | 2006-02-23 | セラテクノロジーズ インコーポレイティド | プロスタグランジンｅ２の受容体サブタイプｅｐ４のアンタゴニスト・ポリペプチド |
| CN100408570C (zh) | 2003-01-29 | 2008-08-06 | 阿斯特兰德英国有限公司 | Ep4受体拮抗剂 |
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| CN1867551B (zh) | 2003-09-03 | 2013-09-11 | 拉夸里亚创药株式会社 | 作为前列腺素e2拮抗剂的苯基或吡啶基酰胺化合物 |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| KR20070006891A (ko) | 2004-05-04 | 2007-01-11 | 화이자 인코포레이티드 | 치환된 메틸 아릴 또는 헤테로아릴 아미드 화합물 |
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-
2018
- 2018-05-17 HR HRP20211532TT patent/HRP20211532T1/hr unknown
- 2018-05-17 PT PT18725223T patent/PT3625224T/pt unknown
- 2018-05-17 CR CR20190567A patent/CR20190567A/es unknown
- 2018-05-17 WO PCT/EP2018/062865 patent/WO2018210995A1/en not_active Ceased
- 2018-05-17 BR BR112019024114-0A patent/BR112019024114A2/pt not_active Application Discontinuation
- 2018-05-17 MX MX2019013639A patent/MX394108B/es unknown
- 2018-05-17 UA UAA201911973A patent/UA124748C2/uk unknown
- 2018-05-17 PL PL18725223T patent/PL3625224T3/pl unknown
- 2018-05-17 CN CN201880031869.9A patent/CN110621666A/zh active Pending
- 2018-05-17 JP JP2019563494A patent/JP7065117B2/ja active Active
- 2018-05-17 PH PH1/2019/502562A patent/PH12019502562B1/en unknown
- 2018-05-17 ES ES18725223T patent/ES2894124T3/es active Active
- 2018-05-17 PE PE2019002413A patent/PE20191787A1/es unknown
- 2018-05-17 CA CA3063637A patent/CA3063637A1/en active Pending
- 2018-05-17 TW TW107116708A patent/TWI768043B/zh not_active IP Right Cessation
- 2018-05-17 AU AU2018269667A patent/AU2018269667B2/en not_active Ceased
- 2018-05-17 EP EP18725223.4A patent/EP3625224B1/en active Active
- 2018-05-17 SG SG11201908660R patent/SG11201908660RA/en unknown
- 2018-05-17 HU HUE18725223A patent/HUE056406T2/hu unknown
- 2018-05-17 EA EA201992679A patent/EA039630B1/ru unknown
- 2018-05-17 RS RS20211259A patent/RS62441B1/sr unknown
- 2018-05-17 US US16/614,268 patent/US20200069686A1/en not_active Abandoned
- 2018-05-17 KR KR1020197037058A patent/KR102650756B1/ko active Active
- 2018-05-17 LT LTEPPCT/EP2018/062865T patent/LT3625224T/lt unknown
- 2018-05-17 AR ARP180101311A patent/AR111806A1/es not_active Application Discontinuation
- 2018-05-17 MA MA49127A patent/MA49127B1/fr unknown
- 2018-05-17 SI SI201830413T patent/SI3625224T1/sl unknown
- 2018-05-17 DK DK18725223.4T patent/DK3625224T3/da active
-
2019
- 2019-09-30 CO CONC2019/0010804A patent/CO2019010804A2/es unknown
- 2019-11-13 IL IL270616A patent/IL270616B/en unknown
- 2019-11-14 CL CL2019003257A patent/CL2019003257A1/es unknown
-
2021
- 2021-09-27 CY CY20211100841T patent/CY1124528T1/el unknown
-
2022
- 2022-11-27 US US18/058,873 patent/US20230165859A1/en active Pending
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