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PE20170684A1 - Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias - Google Patents

Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias

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Publication number
PE20170684A1
PE20170684A1 PE2017000166A PE2017000166A PE20170684A1 PE 20170684 A1 PE20170684 A1 PE 20170684A1 PE 2017000166 A PE2017000166 A PE 2017000166A PE 2017000166 A PE2017000166 A PE 2017000166A PE 20170684 A1 PE20170684 A1 PE 20170684A1
Authority
PE
Peru
Prior art keywords
alkyl
metabolic
inflammatory
treatment
autoimmune diseases
Prior art date
Application number
PE2017000166A
Other languages
English (en)
Inventor
Glad Sanne Ormholt Schrøder
Nørager Niels Henrik Grøn
Ian David Sarvary
Gouliaev Alex Haahr
Lene Teuber
Luigi Piero Stasi
Original Assignee
Nuevolution As
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Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Publication of PE20170684A1 publication Critical patent/PE20170684A1/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se refiere a un derivado de heterociclilo opcionalmente condensado de pirimidina de formula (I) o las sales, hidratos, solvatos, polimorfos y estereoisomeros de los mismos, donde: Y es NR u O; R es H o alquilo C1-C4 opcionalmente sustituido; R1 es H, -OH, entre otros; R2 es H, halogeno, entre otros; R3a es alquilo C1-C6, alcoxi C1-C6 opcionalmente sustituidos, entre otros; R3b y R3c son H, -CN, entre otros o se combinan para formar un grupo oxo; R4a es H, halogeno, entre otros; R4b es H, oxo, entre otros; R5 es (CR8R9)pOR12, entre otros; n y p son enteros de 0 a 4; R6a y R6b son H, halogeno, alquilo C1-C6, entre otros; R8, R9 y R12 son H, alquilo C1-C6 opcionalmente sustituido, entre otros; B es un sistema de anillo tal como arilo, heteroarilo, entre otros. Es un compuesto seleccionado: N6-ciclopropil-5-fluoro-N4-[[4-(1H-tetrazol-5-ilmetil)fenil]metil]-N6-[[4-(trifluorometil)fenil]metil]pirimidina-4,6-diamina; entre otros. Tambien se refiere a una composicion. Estos compuestos modulan la actividad de un receptor huerfano relacionado con el receptor de acido retinoico (ROR). Dicho compuesto es util en el tratamiento de enfermedades inflamatorias, metabolicas y autoinmunes
PE2017000166A 2014-08-04 2015-07-31 Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias PE20170684A1 (es)

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