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PE20142019A1 - Nuevos derivados de acidos indaniloxidihidrobenzofuranilaceticos y sus usos como agonistas del receptor gpr40 - Google Patents

Nuevos derivados de acidos indaniloxidihidrobenzofuranilaceticos y sus usos como agonistas del receptor gpr40

Info

Publication number
PE20142019A1
PE20142019A1 PE2014001462A PE2014001462A PE20142019A1 PE 20142019 A1 PE20142019 A1 PE 20142019A1 PE 2014001462 A PE2014001462 A PE 2014001462A PE 2014001462 A PE2014001462 A PE 2014001462A PE 20142019 A1 PE20142019 A1 PE 20142019A1
Authority
PE
Peru
Prior art keywords
agonists
acids
indanyloxidihidrobenzofuranilaceticos
phenyl
new derivatives
Prior art date
Application number
PE2014001462A
Other languages
English (en)
Inventor
Matthias Eckhardt
Sara Frattini
Dieter Hamprecht
Frank Himmelsbach
Elke Langkopf
Iain Lingard
Stefan Peters
Holger Wagner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142019(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20142019A1 publication Critical patent/PE20142019A1/es

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ACIDOS INDANILOXIDIHIDROBENZOFURANILACETICOS DE FORMULA (I) DONDE R1 ES FENILO, TETRAZOLILO O UN ANILLO HETEROAROMATICO DE 5 A 6 MIEMBROS; R2 ES R2-G1 QUE CONSISTE EN F, Cl, Br, ALQUILO(C1-C4), CICLOALQUILO(C3-C6), CN, ENTRE OTROS; m ES DE 0 A 3. SON COMPUESTOS PREFERIDOS: ACIDO 2-((S)-6-((R)-4-(2,6-DIMETIL-4-((3-METILOXETAN-3-IL)METOXI)FENIL)-7-FLUORO-2,3-DIHIDRO-1H-INDEN-1-ILOXI)-2,3-DIHIDROBENZOFURAN-3-IL)ACETICO; ACIDO 2-((3S)-6-((1R)-4-(2,6-DIMETIL-4-((TETRAHIDROFURAN-3-IL)METOXI)FENIL)-7-FLUORO-2,3-DIHIDRO-1H-INDEN-1-ILOXI)-2,3-DIHIDROBENZOFURAN-3-IL)ACETICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR 40 ACOPLADO A LA PROTEINA G (GPR40) SIENDO UTILES EN EL TRATAMIENTO DE LA DIABETES TIPO 2, OBESIDAD, DISLIPIDEMIA
PE2014001462A 2012-03-26 2013-03-25 Nuevos derivados de acidos indaniloxidihidrobenzofuranilaceticos y sus usos como agonistas del receptor gpr40 PE20142019A1 (es)

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