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PE20130184A1 - Compuesto heterociclico - Google Patents

Compuesto heterociclico

Info

Publication number
PE20130184A1
PE20130184A1 PE2012001253A PE2012001253A PE20130184A1 PE 20130184 A1 PE20130184 A1 PE 20130184A1 PE 2012001253 A PE2012001253 A PE 2012001253A PE 2012001253 A PE2012001253 A PE 2012001253A PE 20130184 A1 PE20130184 A1 PE 20130184A1
Authority
PE
Peru
Prior art keywords
methyl
pyrimidin
pyrazole
compounds
optionally substituted
Prior art date
Application number
PE2012001253A
Other languages
English (en)
Inventor
Misaki Homma
Toru Miyazaki
Yuya Oguro
Osamu Kurasawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44482985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130184(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20130184A1 publication Critical patent/PE20130184A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS FUSIONADOS DE FORMULA (I) DONDE: R1 ES ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO CON HALOGENO; R2 ES UN GRUPO HIDROCARBONADO, GRUPO HETEROCICLICO O GRUPO HETEROCICLIL-CARBONILO NO AROMATICO OPCIONALMENTE SUSTITUIDOS; X ES S; Y ES CH O UNA DE SUS SALES. SON COMPUESTOS PREFERIDOS: 2-(2-CLOROFENIL)-6-(5-METIL-1H-PIRAZOL-4-IL)TIENO[3,2-d]PIRIMIDIN-4(3H)-ONA, 2-{[(3S)-3-FLUOROPIRROLIDIN-1-IL]METIL}-6-(5-METIL-1H-PIRAZOL-4-IL)TIENO[3,2-d]PIRIMIDIN-4(3H)-ONA, ENTRE OTROS. DICHOS COMPUESTOS TIENEN UNA ACTIVIDAD INHIBIDORA DEL CICLO DE DIVISION CELULAR 7 (Cdc7) SIENDO UTIL PARA LA PREVENCION O EL TRATAMIENTO DE CANCER
PE2012001253A 2010-02-17 2011-02-16 Compuesto heterociclico PE20130184A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010031899 2010-02-17
JP2010131950 2010-06-09

Publications (1)

Publication Number Publication Date
PE20130184A1 true PE20130184A1 (es) 2013-03-09

Family

ID=44482985

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012001253A PE20130184A1 (es) 2010-02-17 2011-02-16 Compuesto heterociclico

Country Status (37)

Country Link
US (6) US8722660B2 (es)
EP (2) EP2540728B1 (es)
JP (1) JP5689454B2 (es)
KR (1) KR101735868B1 (es)
CN (1) CN102844320B (es)
AU (1) AU2011216404B2 (es)
BR (1) BR112012020311B1 (es)
CA (1) CA2790284C (es)
CL (1) CL2012002250A1 (es)
CO (1) CO6592104A2 (es)
CR (1) CR20120448A (es)
CY (1) CY1121792T1 (es)
DK (1) DK2540728T3 (es)
DO (1) DOP2012000224A (es)
EA (1) EA020724B1 (es)
EC (1) ECSP12012160A (es)
ES (1) ES2733221T3 (es)
GE (1) GEP20146202B (es)
HR (1) HRP20190947T1 (es)
HU (1) HUE043514T2 (es)
IL (1) IL221442A0 (es)
LT (1) LT2540728T (es)
MA (1) MA34064B1 (es)
ME (1) ME03410B (es)
MX (1) MX353500B (es)
MY (1) MY164776A (es)
NZ (1) NZ602089A (es)
PE (1) PE20130184A1 (es)
PH (1) PH12012501650B1 (es)
PL (1) PL2540728T3 (es)
PT (1) PT2540728T (es)
RS (1) RS58796B1 (es)
SG (1) SG183304A1 (es)
SI (1) SI2540728T1 (es)
SM (1) SMT201900385T1 (es)
TN (1) TN2012000401A1 (es)
WO (1) WO2011102399A1 (es)

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BR112022000734A2 (pt) * 2019-07-19 2022-04-12 Takeda Pharmaceuticals Co Método para tratar câncer em um paciente, uso de composto 1, e, composto 1
CN114127077B (zh) * 2019-08-20 2023-08-01 正大天晴药业集团股份有限公司 用作Cdc7抑制剂的四并环类化合物
US20230101747A1 (en) * 2019-12-06 2023-03-30 Schrödinger, Inc. Cyclic compounds and methods of using same
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WO2022111729A1 (zh) * 2020-11-30 2022-06-02 正大天晴药业集团股份有限公司 作为Cdc7抑制剂的盐型及其晶型
CN112661770B (zh) * 2020-12-24 2022-11-08 南京正济医药研究有限公司 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法
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TW202300150A (zh) * 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法
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Also Published As

Publication number Publication date
CO6592104A2 (es) 2013-01-02
ECSP12012160A (es) 2013-03-28
PH12012501650B1 (en) 2018-11-07
US20170209452A1 (en) 2017-07-27
CY1121792T1 (el) 2020-07-31
CN102844320B (zh) 2016-03-23
PT2540728T (pt) 2019-07-11
HRP20190947T1 (hr) 2019-07-26
MA34064B1 (fr) 2013-03-05
WO2011102399A1 (ja) 2011-08-25
BR112012020311A2 (pt) 2017-03-01
EP3533797A1 (en) 2019-09-04
ES2733221T3 (es) 2019-11-28
NZ602089A (en) 2014-05-30
AU2011216404B2 (en) 2016-04-07
AU2011216404A1 (en) 2012-09-20
US9655900B2 (en) 2017-05-23
US8921354B2 (en) 2014-12-30
CN102844320A (zh) 2012-12-26
TN2012000401A1 (en) 2014-01-30
EP2540728A4 (en) 2013-11-06
CA2790284A1 (en) 2011-08-25
US20130029969A1 (en) 2013-01-31
LT2540728T (lt) 2019-06-25
GEP20146202B (en) 2014-11-25
US20140228352A1 (en) 2014-08-14
MX2012009602A (es) 2012-12-17
KR101735868B1 (ko) 2017-05-15
SI2540728T1 (sl) 2019-06-28
SMT201900385T1 (it) 2019-09-09
EP2540728B1 (en) 2019-04-10
KR20130001246A (ko) 2013-01-03
EA201290800A1 (ru) 2013-03-29
HUE043514T2 (hu) 2019-08-28
DOP2012000224A (es) 2013-01-31
EA020724B1 (ru) 2015-01-30
CA2790284C (en) 2019-01-08
MX353500B (es) 2018-01-16
ME03410B (me) 2020-01-20
SG183304A1 (en) 2012-09-27
US20150158882A1 (en) 2015-06-11
US9388195B2 (en) 2016-07-12
JPWO2011102399A1 (ja) 2013-06-17
DK2540728T3 (da) 2019-05-13
EP3533797B1 (en) 2023-12-20
IL221442A0 (en) 2012-10-31
US20140235615A1 (en) 2014-08-21
US8722660B2 (en) 2014-05-13
RS58796B1 (sr) 2019-07-31
MY164776A (en) 2018-01-30
EP2540728A1 (en) 2013-01-02
US8933069B2 (en) 2015-01-13
CL2012002250A1 (es) 2013-02-08
US20160310494A1 (en) 2016-10-27
JP5689454B2 (ja) 2015-03-25
BR112012020311B1 (pt) 2019-01-29
CR20120448A (es) 2012-11-13
PL2540728T3 (pl) 2019-09-30
PH12012501650A1 (en) 2012-10-22

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