PE20131196A1 - Derivados de 6, 7-dihidro-5h-benzo[7]anulenos, metodos para su preparacion, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos - Google Patents
Derivados de 6, 7-dihidro-5h-benzo[7]anulenos, metodos para su preparacion, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentosInfo
- Publication number
- PE20131196A1 PE20131196A1 PE2012002470A PE2012002470A PE20131196A1 PE 20131196 A1 PE20131196 A1 PE 20131196A1 PE 2012002470 A PE2012002470 A PE 2012002470A PE 2012002470 A PE2012002470 A PE 2012002470A PE 20131196 A1 PE20131196 A1 PE 20131196A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- benzo
- integer
- anulenes
- dihidro
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 3,5-DIFLUOROPHENYL Chemical class 0.000 abstract 2
- CBCIHIVRDWLAME-UHFFFAOYSA-N hexanitrodiphenylamine Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O CBCIHIVRDWLAME-UHFFFAOYSA-N 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 108700001623 hexadecaisoleucinomycin Proteins 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 abstract 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C—CHEMISTRY; METALLURGY
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- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1, R2, R3 Y R4 SON INDEPENDIENTEMENTE H O F; R5, R6 Y R7 SON INDEPENDIENTEMENTE H, F, Cl Br, ETILO, ENTRE OTROS; X ES ALQUIL (C1-C6), CICLOALQUIL (C3-C8), ALQUENILO (C2-C6), ALQUILCARBONIL (C1-C6), ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; Y ES ALQUILO (C1-C4) O CICLOALQUILO (C3-C8) PERFLUORADOS O PARCIALMENTE PERFLUORADOS; m ES UN ENTERO DE 4 A 7; n ES UN ENTERO DE 2 A 6; p ES UN ENTERO DE 0 A 2; q ES UN ENTERO DE 0 A 6. SON COMPUESTOS PREFERIDOS: 8-(3,5-DIFLUOROFENIL)-9-[6-(METIL{3-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFONIL]PROPIL}AMINO)HEXIL]-6,7-DIHIDRO-5H-BENZO[7]ANULEN-3-OL; N-{6-[8-(4-FLUOROFENIL)-3-HIDROXI-6,7-DIHIDRO-5H-BENZO[7]ANULEN-9-IL]HEXIL}-N-{4-[(4,4,4,-TRIFLUOROBUTIL)SULFONIL]BUTIL}-BETA-ALANINA; ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES SELECTIVOS DEL RECEPTOR DE ESTROGENO (SERM) SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES GINECOLOGICAS, ACNE, OSTEOPOROSIS, ARTERIOESCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010030538A DE102010030538A1 (de) | 2010-06-25 | 2010-06-25 | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131196A1 true PE20131196A1 (es) | 2013-10-25 |
Family
ID=44454656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012002470A PE20131196A1 (es) | 2010-06-25 | 2011-06-21 | Derivados de 6, 7-dihidro-5h-benzo[7]anulenos, metodos para su preparacion, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20130252890A1 (es) |
| EP (1) | EP2585435A1 (es) |
| JP (1) | JP5530031B2 (es) |
| KR (1) | KR20130089238A (es) |
| CN (1) | CN103080080B (es) |
| AR (1) | AR081671A1 (es) |
| AU (1) | AU2011269067B2 (es) |
| BR (1) | BR112012032758A2 (es) |
| CA (1) | CA2803690A1 (es) |
| CL (1) | CL2012003648A1 (es) |
| CO (1) | CO6660506A2 (es) |
| CR (1) | CR20120657A (es) |
| CU (1) | CU24106B1 (es) |
| DE (1) | DE102010030538A1 (es) |
| DO (1) | DOP2012000325A (es) |
| EA (1) | EA022547B1 (es) |
| EC (1) | ECSP12012355A (es) |
| GT (1) | GT201200347A (es) |
| IL (1) | IL223770A (es) |
| MA (1) | MA34333B1 (es) |
| MX (1) | MX2013000181A (es) |
| NZ (1) | NZ605061A (es) |
| PE (1) | PE20131196A1 (es) |
| PH (1) | PH12012502550A1 (es) |
| SG (1) | SG186437A1 (es) |
| TN (1) | TN2012000618A1 (es) |
| TW (1) | TW201204347A (es) |
| UA (1) | UA108759C2 (es) |
| UY (1) | UY33470A (es) |
| WO (1) | WO2011161101A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011264858B2 (en) | 2010-06-10 | 2016-04-21 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| DE102011087987A1 (de) * | 2011-12-08 | 2013-06-13 | Bayer Intellectual Property Gmbh | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| BR112014014124A2 (pt) | 2011-12-14 | 2017-08-22 | Seragon Pharmaceutical Inc | Moduladores do receptor de estrogênio fluorados e usos dos mesmos |
| WO2015028409A1 (de) * | 2013-08-27 | 2015-03-05 | Bayer Pharma Aktiengesellschaft | 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| HRP20211043T1 (hr) | 2016-02-15 | 2021-10-01 | Sanofi | Derivati 6,7-dihidro-5h-benzo[7]anulena kao modulatori estrogenskih receptora |
| ES3039455T3 (en) | 2016-11-17 | 2025-10-21 | Sanofi Sa | Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
| EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
| CN107325028B (zh) * | 2017-08-16 | 2019-01-18 | 连云港恒运药业有限公司 | 氟维司群侧链中间体合成方法 |
| CN109020795A (zh) * | 2018-08-27 | 2018-12-18 | 上海华堇生物技术有限责任公司 | 4-甲氧基肉桂醛的制备方法 |
| CN109020794A (zh) * | 2018-08-27 | 2018-12-18 | 上海华堇生物技术有限责任公司 | 3-甲氧基肉桂醛的制备方法 |
| HUE059527T2 (hu) | 2018-09-07 | 2022-11-28 | Sanofi Sa | Eljárás metil-6-(2,4-diklórfenil)-5-[4-[(3S)-1-(3-fluorpropil)pirrolidin-3-il]oxifenil]-8,9 -dihidro-7H-benzo[7]annulén-2-karboxilát és sójának elõállítására |
| CN111377996A (zh) * | 2018-12-29 | 2020-07-07 | 江苏豪森药业集团有限公司 | 一种氟维司群有关物质的合成方法 |
| CN111377997A (zh) * | 2018-12-29 | 2020-07-07 | 江苏豪森药业集团有限公司 | 氟维司群相关物质的制备方法 |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
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