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UA108759C2 - Производные 6,7-дигидро-5h-бензо[7]аннулена, способ их получения, фармацевтический препарат, содержащий их, и их применение для получения лекарственных средств - Google Patents

Производные 6,7-дигидро-5h-бензо[7]аннулена, способ их получения, фармацевтический препарат, содержащий их, и их применение для получения лекарственных средств

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Publication number
UA108759C2
UA108759C2 UAA201300738A UAA201300738A UA108759C2 UA 108759 C2 UA108759 C2 UA 108759C2 UA A201300738 A UAA201300738 A UA A201300738A UA A201300738 A UAA201300738 A UA A201300738A UA 108759 C2 UA108759 C2 UA 108759C2
Authority
UA
Ukraine
Prior art keywords
preparation
annulen
benzo
dihydro
pharmaceutical
Prior art date
Application number
UAA201300738A
Other languages
English (en)
Ukrainian (uk)
Inventor
Тім Вінтермантель
Карстен Мьоллер
Ульріх Боте
Райнхард Нуббемайєр
Людвіг Цорн
Дірк Коземунд
Лак Антоніус Тер
Рольф Больманн
Ларс Вортманн
Дональд Бірер
Original Assignee
Байєр Інтеллектуал Проперті Гмбх
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44454656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA108759(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байєр Інтеллектуал Проперті Гмбх filed Critical Байєр Інтеллектуал Проперті Гмбх
Publication of UA108759C2 publication Critical patent/UA108759C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)

Abstract

Изобретение касается селективных модуляторов эстрогенных рецепторов (SERM) и способов их получения, их применения для лечения и/или профилактики заболеваний и их применения для получения лекарственных средств для лечения и/или профилактики заболеваний, в частности нарушений свертывания крови, остеопороза, эндометриоза, миом, гормонозависимых опухолей, для гормонозаместительной терапии и для контрацепции.
UAA201300738A 2010-06-25 2011-06-21 Производные 6,7-дигидро-5h-бензо[7]аннулена, способ их получения, фармацевтический препарат, содержащий их, и их применение для получения лекарственных средств UA108759C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010030538A DE102010030538A1 (de) 2010-06-25 2010-06-25 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP2011/060335 WO2011161101A1 (de) 2010-06-25 2011-06-21 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number Publication Date
UA108759C2 true UA108759C2 (ru) 2015-06-10

Family

ID=44454656

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201300738A UA108759C2 (ru) 2010-06-25 2011-06-21 Производные 6,7-дигидро-5h-бензо[7]аннулена, способ их получения, фармацевтический препарат, содержащий их, и их применение для получения лекарственных средств

Country Status (30)

Country Link
US (1) US20130252890A1 (ru)
EP (1) EP2585435A1 (ru)
JP (1) JP5530031B2 (ru)
KR (1) KR20130089238A (ru)
CN (1) CN103080080B (ru)
AR (1) AR081671A1 (ru)
AU (1) AU2011269067B2 (ru)
BR (1) BR112012032758A2 (ru)
CA (1) CA2803690A1 (ru)
CL (1) CL2012003648A1 (ru)
CO (1) CO6660506A2 (ru)
CR (1) CR20120657A (ru)
CU (1) CU24106B1 (ru)
DE (1) DE102010030538A1 (ru)
DO (1) DOP2012000325A (ru)
EA (1) EA022547B1 (ru)
EC (1) ECSP12012355A (ru)
GT (1) GT201200347A (ru)
IL (1) IL223770A (ru)
MA (1) MA34333B1 (ru)
MX (1) MX2013000181A (ru)
NZ (1) NZ605061A (ru)
PE (1) PE20131196A1 (ru)
PH (1) PH12012502550A1 (ru)
SG (1) SG186437A1 (ru)
TN (1) TN2012000618A1 (ru)
TW (1) TW201204347A (ru)
UA (1) UA108759C2 (ru)
UY (1) UY33470A (ru)
WO (1) WO2011161101A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013528223A (ja) 2010-06-10 2013-07-08 アラゴン ファーマシューティカルズ，インク． エストロゲン受容体モジュレーターおよびその用途
DE102011087987A1 (de) * 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
US9193714B2 (en) 2011-12-14 2015-11-24 Seragon Pharmaceuticals, Inc. Fluorinated estrogen receptor modulators and uses thereof
WO2015028409A1 (de) * 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
HRP20211043T1 (hr) * 2016-02-15 2021-10-01 Sanofi Derivati 6,7-dihidro-5h-benzo[7]anulena kao modulatori estrogenskih receptora
EP3541809B1 (en) 2016-11-17 2025-06-25 Sanofi Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
CN107325028B (zh) * 2017-08-16 2019-01-18 连云港恒运药业有限公司 氟维司群侧链中间体合成方法
CN109020795A (zh) * 2018-08-27 2018-12-18 上海华堇生物技术有限责任公司 4-甲氧基肉桂醛的制备方法
CN109020794A (zh) * 2018-08-27 2018-12-18 上海华堇生物技术有限责任公司 3-甲氧基肉桂醛的制备方法
CN112638869B (zh) 2018-09-07 2025-04-25 赛诺菲 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法
CN111377997A (zh) * 2018-12-29 2020-07-07 江苏豪森药业集团有限公司 氟维司群相关物质的制备方法
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TW202146007A (zh) 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合

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